Side Effects of flunisolide oral inhalation: A Synthesis of Findings from 16 Studies

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Original Abstract of the Article

Main Research Findings

Flunisolide inhalation is an effective treatment for airway inflammation in asthma, according to 12 . It can reduce the need for oral steroids and improve symptoms in patients using bronchodilators. 13 states that flunisolide is a potent and effective inhaled corticosteroid, with a low risk of severe systemic side effects. Flunisolide nasal spray is also effective for treating perennial allergic rhinitis, showing significant improvement over placebo in relieving symptoms like sneezing, nasal obstruction, and post-nasal drip, as found in 2 . 6 suggests that nebulized flunisolide may be a particularly effective method for treating asthma in infants and children.

Reasons for side effects

Side effects of flunisolide inhalation are primarily due to its absorption into the body and subsequent systemic effects. While inhaled medications target the lungs, some portions are absorbed into the bloodstream and circulate throughout the body. 8 notes that flunisolide can suppress the release of endogenous cortisol, which is a major systemic side effect of inhaled corticosteroids.

Common Side Effects

Oral Candidiasis

One common side effect of flunisolide inhalation is oral candidiasis. 11 suggests that oral candidiasis can occur with the use of flunisolide inhalation.

Dysphonia

Another common side effect associated with flunisolide inhalation is dysphonia, or hoarseness. 11 indicates that dysphonia can be a possible side effect.

Nasal Irritation

Flunisolide nasal spray can cause nasal irritation in some individuals. 4 reports that a significant number of patients using flunisolide nasal spray experienced nasal irritation.

Nasal Bleeding

Flunisolide nasal spray may lead to nasal bleeding in some cases. 10 mentions nasal bleeding as a possible side effect of flunisolide nasal spray.

Sore Throat

Sore throat is another side effect that can occur with flunisolide inhalation. 10 lists sore throat as a potential adverse effect.

Side Effects Management

Oral Candidiasis Management

To prevent oral candidiasis, rinsing your mouth after inhalation and maintaining good oral hygiene is crucial. 11 suggests that proper usage and good oral hygiene can help minimize the risk of oral candidiasis.

Dysphonia Management

Rinsing your mouth after inhalation and being mindful of your speaking technique can help prevent hoarseness. 11 suggests that proper usage and vocal habits can impact the risk of dysphonia.

Nasal Irritation Management

If you experience nasal irritation, talk to your doctor about switching to a different medication or reducing your dosage. 4 suggests that nasal irritation can be influenced by the type and dosage of medication.

Nasal Bleeding Management

Keep your nasal passages clean, avoid blowing your nose forcefully, and talk to your doctor about other possible solutions. 10 suggests that nasal bleeding is influenced by factors such as medication type, usage, and nasal health.

Sore Throat Management

Rinsing your mouth after inhalation and staying hydrated can help prevent sore throat. 10 suggests that sore throat can be influenced by medication type, usage, and throat health.

Comparison between Studies

Commonalities

A majority of research consistently demonstrates that flunisolide inhalation is an effective treatment for respiratory illnesses.

Differences

Variations in the effectiveness, side effects, and their occurrence may exist between studies due to differences in patient groups, dosages, study duration, and other factors.

Considerations for Real-Life Application

Flunisolide inhalation is a valuable treatment for respiratory illnesses, but the possibility of side effects must be acknowledged. It is crucial to use the medication as directed by your doctor. If you have concerns about side effects, consult your healthcare provider.

Limitations of Current Research

Research on flunisolide inhalation is still ongoing. More studies are needed to understand the long-term effects, the impact on different patient groups, and optimal dosage and administration methods.

Future Directions for Research

Future research should focus on investigating the long-term effects of flunisolide inhalation, its impact on diverse patient populations, exploring optimal dosages and administration methods, and developing strategies for preventing and mitigating side effects.

Conclusion

Flunisolide inhalation is an effective treatment for respiratory illnesses, but it can have side effects. It is important to use the medication as directed by your doctor, and consult your physician if you experience any concerns. While research on flunisolide inhalation is progressing, further research is needed to ensure its safe and effective use.

Literature analysis of 16 papers
Positive Content
16
Neutral Content
0
Negative Content
0
Article Type
6
0
0
6
16
1.

Treatment of perennial rhinitis with flunisolide corticosteroid spray.

Author: JonesL M, SpectorS L, EnglishG M, Taylor-DawsonK

Reduced eosinophils
Candida infection

Flunisolide nasal spray was not significantly different from placebo in treating perennial rhinitis. Both groups showed a decrease in eosinophils on nasal smears.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Flunisolide--a new intranasal steroid for the treatment of allergic rhinitis.

Author: SahayJ N, ChatterjeeS S, EnglerC

Improved everyday life
Improved sleep quality
Relieved nasal obstruction
Relieved sneezing
Minor side effects

A study of 50 patients with perennial allergic rhinitis found that flunisolide nasal spray (200 micrograms daily) was significantly more effective than a placebo in reducing symptoms of sneezing, nasal congestion, post-nasal drip, and improving sleep and daily life. Both patients and doctors preferred the flunisolide spray. Minor side effects were reported during both placebo and flunisolide phases, and no evidence of adrenal suppression was observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Flunisolide nasal spray for perennial rhinitis in children.

Author: SarsfieldJ K, ThomsonG E

Effective rhinitis treatment
No adrenal axis effect
Safe for children
Nasal stinging

A study of 27 children with perennial rhinitis found that flunisolide nasal spray was significantly more effective than a placebo in relieving symptoms. Patients, doctors, and diary card assessments all favored flunisolide. The most common side effect was temporary nasal stinging. Flunisolide treatment was safe and did not affect the pituitary-adrenal axis. The study concluded that flunisolide is a safe and effective treatment for perennial rhinitis in children.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

A comparative trial testing budesonide and flunisolide nasal sprays in patients with seasonal allergic rhinitis.

Author: PipkornU, GeterudA

Effective for rhinitis
Nasal irritation

Both budesonide and flunisolide nasal sprays were effective in controlling nasal symptoms in patients with seasonal allergic rhinitis. However, flunisolide was associated with a higher incidence of nasal irritation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Short-term efficacy trial and twenty-four-month follow-up of flunisolide nasal spray in the treatment of perennial rhinitis.

Author: ClaytonD E, KooistraJ B, GellerM, OuelletteJ, CohenM, ReedC E, BusseW

No adrenal suppression
Safe and effective

Flunisolide nasal spray was found to be safe and effective in treating perennial rhinitis. No serious side effects were observed over a two-year follow-up period.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

7.

Comparative efficacy and safety of inhaled corticosteroids in asthma.

Author: JacksonL D, PolygenisD, McIvorR A, WorthingtonI

Asthma control
Reduced side effects
Adrenal suppression
Bone mineral density reduction
Growth retardation

Inhaled corticosteroids are effective for asthma, but long-term use can cause side effects. This review recommends maximum daily doses for adults and children to avoid serious side effects like growth retardation, adrenal suppression, bone mineral density loss, and cataract formation.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

A pharmacokinetic/pharmacodynamic approach to predict the cumulative cortisol suppression of inhaled corticosteroids.

Author: MeibohmB, HochhausG, MöllmannH, BarthJ, WagnerM, KriegM, StöckmannR, DerendorfH

Asthma treatment
Cortisol suppression prediction
Cortisol suppression

This study developed a PK/PD model to predict the cumulative cortisol suppression (CCS) associated with inhaled corticosteroid therapy. The model accurately predicted CCS after single and multiple doses of various inhaled corticosteroids, suggesting its utility in comparing different dosing regimens and steroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Budesonide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy in asthma and rhinitis.

Author: ClissoldS P, HeelR C

Asthma treatment
Rhinitis treatment
Candidiasis
Dry nose
Dysphonia
Nasal bleeding
Nasal stinging
Sore throat
Throat irritation

Budesonide is a non-halogenated glucocorticosteroid effective for asthma and rhinitis. It's comparable to other inhaled steroids, with fewer side effects. Further research is needed to compare it with other steroids for long-term use.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

Corticosteroid aerosols in the treatment of asthma.

Author: TseC S, BernsteinI L

Asthma treatment
Dysphonia
Oral candidiasis

Corticosteroid aerosols are effective for treating asthma. Four newer steroids have been evaluated in clinical trials, with minimal side effects, mainly oral candidiasis and dysphonia. They are most effective when used prophylactically and not during acute attacks.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

Inhaled steroids in asthma.

Author: DworskiR, ShellerJ

Asthma treatment
Reduced steroid use
Systemic side effects

Inhaled corticosteroids are a relatively safe treatment for asthma. Higher doses may cause systemic side effects, but these are less than those incurred by using oral prednisone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

[Beclomethasone dipropionate, budesonide and flunisolide in the treatment of bronchial asthma (a review of the literature and the authors' own research)].

Author: KakhnovskiĭI M, SolomatinA S

Discontinue oral steroids
Effective against asthma
Reduce dose of oral steroids
Safe for patients
Side effects

Inhalation corticosteroids, such as beclometasone dipropionate, budesonide, and flunisolide, are effective and safe for treating bronchial asthma. Flunisolide is the most potent and effective of these drugs, with the lowest incidence of side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Russian

14.

[Glucocorticosteroids: mechanism of action, pharmacological effects, pharmacokinetics and adverse effects].

Author: Tarchalska-KryńskaB

Effective treatment
Reduced risk of systemic side effects
Prolonged use
Serious side effects

This review summarizes the state of our knowledge on glucocorticosteroids. Oral steroids are very effective in the treatment of asthma, but they can have serious side effects when given in high doses or for prolonged periods. Inhaled steroids, such as budesonide and flunisolide, have a lower risk of systemic side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Polish

15.

Intranasal flunisolide spray as an adjunct to oral antibiotic therapy for sinusitis.

Author: MeltzerE O, OrgelH A, BackhausJ W, BusseW W, DruceH M, MetzgerW J, MitchellD Q, SelnerJ C, ShapiroG G, Van BavelJ H

Improved symptoms
Normalized ultrasound scans
Reduced inflammatory cells
Regression of abnormalities
Gastrointestinal symptoms
Headache

The addition of flunisolide topical nasal spray as an adjunct to antibiotic therapy was most effective in global evaluations, tended to improve symptoms, to decrease inflammatory cells in nasal cytograms, to normalize ultrasound scans, and to aid regression of radiographic abnormalities compared with placebo spray.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Treatment of idiopathic pulmonary hemosiderosis with inhaled flunisolide.

Author: TutorJ D, EidN S

IPH treatment

Inhaled flunisolide successfully treated a patient with idiopathic pulmonary hemosiderosis, offering a potential alternative to systemic corticosteroids.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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