Side Effects of fluocinolone topical: A Synthesis of Findings from 5 Studies

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Original Abstract of the Article

Major Research Findings

Several studies have shown that fluocinolone is an effective medication for the treatment of allergic rhinitis. 2 , 3 , 5 , 4 , 1 These studies have shown that fluocinolone improves symptoms such as sneezing, nasal congestion, and runny nose. It has also been shown to improve sleep quality and quality of life.

Reasons for Side Effects

Fluocinolone is a medication that is sprayed directly into the nose. Therefore, side effects mainly appear in the nose. Fluocinolone is a steroid medication that works on the nasal mucosa to reduce inflammation. This action can cause side effects such as nasal irritation and dryness.

Common Side Effects

Nasal Irritation

The most common side effect of fluocinolone is nasal irritation. 3 , 4 This is because fluocinolone works on the nasal mucosa to reduce inflammation, temporarily making the nasal mucosa sensitive. This symptom usually subsides within a few days of starting treatment.

Nasal Dryness

Fluocinolone can dry out the nasal mucosa. 3 This is because fluocinolone removes moisture from the nasal mucosa. This symptom, like nasal irritation, usually subsides within a few days of starting treatment.

Nosebleeds

Fluocinolone can rarely cause nosebleeds. 3 This is because fluocinolone dries out the nasal mucosa, making the nasal mucosa more prone to injury. If you experience a nosebleed, consult your doctor.

Side Effects Countermeasures

Nasal Irritation Countermeasures

If you are concerned about nasal irritation, it is a good idea to irrigate your nose before spraying fluocinolone. Nasal saline solution is available at drugstores. Also, after spraying fluocinolone, gently wiping your nose with a tissue can reduce irritation.

Nasal Dryness Countermeasures

If you are concerned about nasal dryness, you should apply a moisturizer to your nose. Moisturizer is available at drugstores. Increasing the humidity indoors is also effective. Use a humidifier or hang laundry indoors.

Nosebleed Countermeasures

If you experience a nosebleed, pinch your nose lightly and remain still for about 10 minutes. If it does not stop, consult your doctor.

Comparison of Studies

Commonalities of Studies

Multiple studies have shown that fluocinolone is effective in treating allergic rhinitis. 2 , 3 , 5 , 4 , 1 These studies have also shown that side effects of fluocinolone are generally mild and temporary.

Differences in Studies

The effectiveness and frequency of side effects of fluocinolone may vary from study to study. 2 , 3 , 5 , 4 , 1 This is thought to be due to differences in the age of the subjects, the severity of allergic rhinitis, and the dosage of fluocinolone.

Precautions for Real-Life Applications

Fluocinolone is effective in improving symptoms of allergic rhinitis, but it does not work for all patients. Fluocinolone can also cause side effects. Therefore, consult your doctor before using fluocinolone. Your doctor will determine if fluocinolone is right for you based on your symptoms and medical history.

Limitations of Current Research

There is still not enough research on fluocinolone. In particular, there is not enough data on long-term side effects. Also, the interactions of fluocinolone with other medications are still not well understood.

Directions for Future Research

Further research is needed on the long-term safety and efficacy of fluocinolone and its interactions with other medications. Further research is also needed on the optimal dosage and duration of use of fluocinolone.

Conclusion

Fluocinolone is an effective medication for the treatment of allergic rhinitis. However, side effects may occur. Consult your doctor before using fluocinolone.

Literature analysis of 5 papers
Positive Content
5
Neutral Content
0
Negative Content
0
Article Type
5
0
0
0
5
1.

Treatment of perennial rhinitis with flunisolide corticosteroid spray.

Author: JonesL M, SpectorS L, EnglishG M, Taylor-DawsonK

Reduced eosinophils
Candida infection

Flunisolide nasal spray was not significantly different from placebo in treating perennial rhinitis. Both groups showed a decrease in eosinophils on nasal smears.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Flunisolide--a new intranasal steroid for the treatment of allergic rhinitis.

Author: SahayJ N, ChatterjeeS S, EnglerC

Improved everyday life
Improved sleep quality
Relieved nasal obstruction
Relieved sneezing
Minor side effects

A study of 50 patients with perennial allergic rhinitis found that flunisolide nasal spray (200 micrograms daily) was significantly more effective than a placebo in reducing symptoms of sneezing, nasal congestion, post-nasal drip, and improving sleep and daily life. Both patients and doctors preferred the flunisolide spray. Minor side effects were reported during both placebo and flunisolide phases, and no evidence of adrenal suppression was observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Flunisolide nasal spray for perennial rhinitis in children.

Author: SarsfieldJ K, ThomsonG E

Effective rhinitis treatment
No adrenal axis effect
Safe for children
Nasal stinging

A study of 27 children with perennial rhinitis found that flunisolide nasal spray was significantly more effective than a placebo in relieving symptoms. Patients, doctors, and diary card assessments all favored flunisolide. The most common side effect was temporary nasal stinging. Flunisolide treatment was safe and did not affect the pituitary-adrenal axis. The study concluded that flunisolide is a safe and effective treatment for perennial rhinitis in children.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

A comparative trial testing budesonide and flunisolide nasal sprays in patients with seasonal allergic rhinitis.

Author: PipkornU, GeterudA

Effective for rhinitis
Nasal irritation

Both budesonide and flunisolide nasal sprays were effective in controlling nasal symptoms in patients with seasonal allergic rhinitis. However, flunisolide was associated with a higher incidence of nasal irritation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Short-term efficacy trial and twenty-four-month follow-up of flunisolide nasal spray in the treatment of perennial rhinitis.

Author: ClaytonD E, KooistraJ B, GellerM, OuelletteJ, CohenM, ReedC E, BusseW

No adrenal suppression
Safe and effective

Flunisolide nasal spray was found to be safe and effective in treating perennial rhinitis. No serious side effects were observed over a two-year follow-up period.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

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