Side Effects of fluorouracil injection: A Synthesis of Findings from 6 Studies

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Original Abstract of the Article

Main Research Findings

Flunisolide nasal spray is effective and safe for the treatment and prophylaxis of perennial rhinitis in children. 3 Flunisolide is significantly superior to placebo in relieving sneezing, nasal obstruction and postnasal drip, as well as improving the quality of sleep and everyday life. 2

Reasons for Side Effects

Flunisolide nasal spray is a type of corticosteroid, so long-term use can lead to suppression of adrenal cortex function. However, many studies have shown that flunisolide administration has not been associated with adrenal cortex suppression. 5

Common Side Effects

Nasal irritation

The most common side effect of flunisolide nasal spray is nasal irritation. 3 This is because flunisolide acts directly on the nasal mucosa. 4

Nasal stinging

Flunisolide nasal spray can cause nasal stinging. 3 This is because flunisolide acts directly on the nasal mucosa.

Nasal bleeding

Flunisolide nasal spray can cause nasal bleeding. 1 This is because flunisolide can dry out the nasal mucosa.

Dry mouth

Flunisolide nasal spray can cause dry mouth. 1 This is because flunisolide can dry out the nasal mucosa.

Nasal pain

Flunisolide nasal spray can cause nasal pain. 1 This is because flunisolide can irritate the nasal mucosa.

Countermeasures for Side Effects

Nasal irritation

If you are concerned about nasal irritation, you should reduce the frequency of flunisolide nasal spray use or stop using it. 3

Nasal bleeding

If you are concerned about nasal bleeding, you should reduce the frequency of flunisolide nasal spray use or stop using it. 1

Comparison Between Studies

Commonalities

Multiple studies have shown that flunisolide nasal spray is effective in treating perennial rhinitis. 3 、 2 、 1 、 5 In addition, flunisolide nasal spray side effects are usually mild and temporary. 3 、 2 、 1 、 5

Differences

The results may differ from study to study regarding the side effects of flunisolide nasal spray. 3 、 2 、 1 、 5 For example, while one study indicates that flunisolide nasal spray may cause nasal bleeding, other studies have not reported nasal bleeding. 1 This is believed to be due to differences in the number of subjects and research methods.

Considerations for Real-World Application

Flunisolide nasal spray is effective in treating perennial rhinitis, but it can cause side effects. 3 、 2 、 1 、 5 It is important to consult a doctor before using flunisolide nasal spray and to inform them of your symptoms and medical history. In addition, if you experience any side effects while using flunisolide nasal spray, consult your doctor immediately.

Limitations of Current Research

The long-term effects of flunisolide nasal spray have not yet been fully elucidated. 5 Also, the effects of flunisolide nasal spray on children are not yet fully studied. 3

Future Research Directions

Research is needed to assess the long-term effects of flunisolide nasal spray. 5 Research is also needed to assess the effects of flunisolide nasal spray on children. 3

Conclusion

Multiple studies have shown that flunisolide nasal spray is effective in treating perennial rhinitis. 3 、 2 、 1 、 5 However, flunisolide nasal spray can cause side effects, so it is important to consult a doctor before using it.

Literature analysis of 6 papers
Positive Content
5
Neutral Content
1
Negative Content
0
Article Type
5
0
0
0
6
1.

Treatment of perennial rhinitis with flunisolide corticosteroid spray.

Author: JonesL M, SpectorS L, EnglishG M, Taylor-DawsonK

Reduced eosinophils
Candida infection

Flunisolide nasal spray was not significantly different from placebo in treating perennial rhinitis. Both groups showed a decrease in eosinophils on nasal smears.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Flunisolide--a new intranasal steroid for the treatment of allergic rhinitis.

Author: SahayJ N, ChatterjeeS S, EnglerC

Improved everyday life
Improved sleep quality
Relieved nasal obstruction
Relieved sneezing
Minor side effects

A study of 50 patients with perennial allergic rhinitis found that flunisolide nasal spray (200 micrograms daily) was significantly more effective than a placebo in reducing symptoms of sneezing, nasal congestion, post-nasal drip, and improving sleep and daily life. Both patients and doctors preferred the flunisolide spray. Minor side effects were reported during both placebo and flunisolide phases, and no evidence of adrenal suppression was observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Flunisolide nasal spray for perennial rhinitis in children.

Author: SarsfieldJ K, ThomsonG E

Effective rhinitis treatment
No adrenal axis effect
Safe for children
Nasal stinging

A study of 27 children with perennial rhinitis found that flunisolide nasal spray was significantly more effective than a placebo in relieving symptoms. Patients, doctors, and diary card assessments all favored flunisolide. The most common side effect was temporary nasal stinging. Flunisolide treatment was safe and did not affect the pituitary-adrenal axis. The study concluded that flunisolide is a safe and effective treatment for perennial rhinitis in children.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

A comparative trial testing budesonide and flunisolide nasal sprays in patients with seasonal allergic rhinitis.

Author: PipkornU, GeterudA

Effective for rhinitis
Nasal irritation

Both budesonide and flunisolide nasal sprays were effective in controlling nasal symptoms in patients with seasonal allergic rhinitis. However, flunisolide was associated with a higher incidence of nasal irritation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Short-term efficacy trial and twenty-four-month follow-up of flunisolide nasal spray in the treatment of perennial rhinitis.

Author: ClaytonD E, KooistraJ B, GellerM, OuelletteJ, CohenM, ReedC E, BusseW

No adrenal suppression
Safe and effective

Flunisolide nasal spray was found to be safe and effective in treating perennial rhinitis. No serious side effects were observed over a two-year follow-up period.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

6.

[5-fluorouracil injection treatment after fistulating glaucoma operations].

Author: ReinhardT, KlüppelM, SundmacherR

Controlled intraocular pressure
Ciliary epithelium toxicity
Conjunctival fistulas
Corneal epithelial breakdown

Subconjunctival injections of 5-Fluorouracil are effective in controlling high-risk glaucoma, but are associated with several disadvantages, including fistulas, corneal epithelial breakdown, and potential toxicity to the ciliary epithelium.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

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