Effects of fluticasone nasal spray: A Synthesis of Findings from 15 Studies

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Original Abstract of the Article

Major Research Findings

Fluticasone nasal spray is an effective treatment for allergic rhinitis, which is a common condition caused by allergens. 2 Fluticasone works by reducing inflammation in the nasal passages, which helps to relieve symptoms such as nasal congestion, runny nose, sneezing, and itchy nose. 2 Studies have shown that fluticasone nasal spray can be just as effective as other treatments for allergic rhinitis, such as oral antihistamines and intranasal antihistamines. 2 Furthermore, fluticasone nasal spray can be used in combination with other medications to provide additional relief from symptoms. 12 , 14 , 11 , 10 For example, fluticasone combined with azelastine has been shown to be more effective than either medication alone. 14 , 11 Fluticasone also has the potential to be effective in treating chronic rhinosinusitis. 7 , 8

Benefits and Risks

Benefit Summary

Fluticasone nasal spray effectively alleviates allergic rhinitis symptoms, including nasal congestion, runny nose, sneezing, and itchy nose. 2 Fluticasone, when used in combination with other medications for allergic rhinitis, can provide enhanced symptom relief. 12 , 14 , 11 , 10 Combining fluticasone with azelastine, for instance, can lead to greater symptom improvement compared to using either medication alone. 14 , 11 Fluticasone also holds promise as a treatment for chronic rhinosinusitis. 7 , 8

Risk Summary

Fluticasone has been linked to potential side effects such as decreased adrenal function and reduced bone density. 1 It is crucial to follow your doctor's instructions carefully when using fluticasone.

Comparison Across Studies

Similarities Among Studies

Numerous studies consistently demonstrate that fluticasone nasal spray effectively relieves allergic rhinitis symptoms. 2 , 7 , 13 , 12 , 14 , 11 , 10 , , 8 , 1 , 5 Furthermore, these studies indicate that combining fluticasone with other medications for allergic rhinitis can enhance its effectiveness. 12 , 14 , 11 , 10 For example, combining fluticasone and azelastine has shown promise in providing greater symptom improvement compared to using either medication alone. 14 , 11 Fluticasone has shown potential as a treatment for chronic rhinosinusitis. 7 , 8

Differences Among Studies

The effectiveness and side effects of fluticasone can vary depending on the specific study. 2 , 7 , 13 , 12 , 14 , 11 , 10 , , 8 , 1 , 5 For instance, some studies indicate that fluticasone is more effective when used in combination with azelastine compared to using it alone. 14 , 11 However, other studies have reported side effects of fluticasone, including decreased adrenal function and reduced bone density. 1 It is essential to comprehensively assess the research findings and consult with a doctor to determine the most appropriate treatment plan.

Consistency and Inconsistencies in Results

While numerous studies consistently demonstrate the effectiveness of fluticasone nasal spray in treating allergic rhinitis symptoms, the effectiveness and side effects can vary depending on the study. 2 , 7 , 13 , 12 , 14 , 11 , 10 , , 8 , 1 , 5 Therefore, it is crucial to consult with your doctor to determine the best treatment approach for your individual needs.

Considerations for Real-World Application

Fluticasone nasal spray is a proven treatment for allergic rhinitis symptoms. 2 , 7 , 13 , 12 , 14 , 11 , 10 , , 8 , 1 , 5 However, it is essential to remember that fluticasone carries a risk of side effects. 1 Always adhere to your doctor's instructions and the recommended dosage for fluticasone. If you experience any side effects, promptly consult your doctor.

Limitations of Current Research

Research on fluticasone nasal spray is not yet exhaustive. 2 , 7 , 13 , 12 , 14 , 11 , 10 , , 8 , 1 , 5 Specifically, long-term side effects are not yet fully understood. Additional research is required to determine the long-term safety and efficacy of fluticasone.

Future Research Directions

Further research is necessary to determine the long-term safety and effectiveness of fluticasone nasal spray. 2 , 7 , 13 , 12 , 14 , 11 , 10 , , 8 , 1 , 5 Additionally, further investigation is needed to understand the combined effects of fluticasone with other medications.

Conclusion

While fluticasone nasal spray effectively treats allergic rhinitis symptoms, the potential for side effects must be considered. 2 , 7 , 13 , 12 , 14 , 11 , 10 , , 8 , 1 , 5 Consult with your doctor to determine the best treatment approach for you. Remember to adhere to your doctor's instructions and the prescribed dosage of fluticasone. If you experience any side effects, promptly seek medical advice.

Literature analysis of 15 papers
Positive Content
10
Neutral Content
2
Negative Content
3
Article Type
7
0
0
1
14
1.

Systemic effects of fluticasone nasal spray: report of 2 cases.

Author: LicataAngelo A

Adrenal insufficiency
Bone mineral density decrease

Overuse of fluticasone nasal spray may cause serious side effects such as adrenal insufficiency and decreased bone mineral density. Patients should be warned to follow the prescribed dosing carefully.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Technologies for Type 1 Diabetes and Contact Dermatitis: Therapeutic Tools and Clinical Outcomes in a Cohort of Pediatric Patients.

Author: PassanisiStefano, SalzanoGiuseppina, GallettaFrancesca, AramnejadSara, CaminitiLucia, PajnoGiovanni B, LombardoFortunato

Contact dermatitis
Treatment discontinuation

Contact dermatitis is a significant complication for diabetes patients using technological devices like insulin pumps and continuous glucose monitors. While topical corticosteroids are commonly used for treatment, only half of patients achieved complete resolution, with almost 40% discontinuing their devices. Collaboration between healthcare providers and device manufacturers is crucial for preventing and managing this complication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

4.

Comparative nasal airflow with loratadine-pseudoephedrine and fluticasone nasal spray for allergic rhinitis.

Author: NgCharlene C, RomaikinDaniel, SteacyLisa M, StevensDavid A, WalkerTerry J, AdamsDaniel E, EllisAnne K

Faster onset
Misinterpretation of effectiveness

Oral antihistamine-pseudoephedrine combination tablets have a faster onset of action compared to intranasal corticosteroid sprays for allergic rhinitis, although the magnitude of change has not been quantified.

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Evaluation of a novel natural drop for treatment of chronic rhinosinusitis without nasal polyps: a single blind randomized trial.

Author: VazifehkahShima, Shams-ArdekaniMohammad Reza, KamalinejadMohammad, SaderhosseinSeyed Mousa, HosseiniHamed, ShamsSeyed Mohammad, AbbassiShirin, EghtesadSareh, SaediBabak

Effective sinusitis treatment
Improved quality of life
None reported

This single-blinded randomized trial compared the effectiveness of a Pimpinella anisum-based herbal medicine (Sinupim) to fluticasone nasal spray for treating chronic rhinosinusitis without polyps. Both treatments were effective, but Sinupim was associated with significantly better results, especially for postnasal drip and nasal obstruction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Comparison of intranasal fluticasone spray, budesonide atomizer, and budesonide respules in patients with chronic rhinosinusitis with polyposis after endoscopic sinus surgery.

Author: NeubauerPaul D, SchwamZachary G, ManesR Peter

CRSwNP management

The study investigated the effectiveness of budesonide respules delivered to the sinonasal cavities, an off-label use, in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) after endoscopic sinus surgery (ESS), compared to traditional nasal steroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Stabbing headache in an 8-year-old girl: primary or drug induced headache?

Author: BiedrołAgnieszka, KaciłskiMarek, Skowronek-BałaBarbara

Adverse drug reaction

An 8-year-old girl experiencing stabbing headaches that were linked to physical activity was found to have a reaction to an antihistamine drug. After discontinuing the drug, her headaches resolved. This case highlights the importance of considering adverse drug reactions when diagnosing stabbing headaches.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Efficacy and safety of montelukast add-on therapy in allergic rhinitis.

Author: ModgillV, BadyalD K, VergheseA

Allergic rhinitis treatment
Effective control of symptoms
Adverse effects
Psychomotor impairment

Montelukast, a leukotriene receptor antagonist, is as effective as conventional therapies in controlling allergic rhinitis symptoms, but is more effective in controlling nighttime symptoms. Furthermore, montelukast does not cause psychomotor impairment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Double-blind, placebo-controlled study of azelastine and fluticasone in a single nasal spray delivery device.

Author: HampelFrank C, RatnerPaul H, Van BavelJulius, AmarN J, DaftaryPramila, WheelerWilliam, SacksHarry

Additive benefit
Symptom improvement

A combination of azelastine and fluticasone nasal spray provided statistically significant improvement in nasal symptoms and greater benefit compared to either agent alone in patients with moderate-to-severe seasonal allergic rhinitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Evaluation of olopatadine hydrochloride nasal spray, 0.6%, used in combination with an intranasal corticosteroid in seasonal allergic rhinitis.

Author: LaForceCraig F, CarrWarner, TillesStephen A, ChippsBradley E, StormsWilliam, MeltzerEli O, EdwardsMichael

SAR symptom relief
Safety

This study evaluated the safety and efficacy of olopatadine hydrochloride nasal spray, 0.6% (OLO), administered in combination with fluticasone nasal spray, 50 micrograms (FNS), relative to azelastine nasal spray, 0.1% (AZE), administered in combination with FNS in the treatment of SAR. OLO, when administered adjunctively with FNS, is effective, safe, and well-tolerated in patients with SAR.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Combination therapy with azelastine hydrochloride nasal spray and fluticasone propionate nasal spray in the treatment of patients with seasonal allergic rhinitis.

Author: RatnerPaul H, HampelFrank, Van BavelJulius, AmarN J, DaftaryPramila, WheelerWilliam, SacksHarry

Improved TNSS

Azelastine nasal spray and fluticasone nasal spray in combination showed a greater improvement in the TNSS compared with either agent alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Azelastine hydrochloride: a review of pharmacology, pharmacokinetics, clinical efficacy and tolerability.

Author: BernsteinJonathan A

Rapid onset of action
Rhinitis relief
Bitter taste
Somnolence

Azelastine nasal spray, a second-generation intranasal antihistamine, effectively improved nasal symptoms associated with seasonal allergic rhinitis (SAR) and nonallergic vasomotor rhinitis (VMR). Azelastine provided a rapid onset of action and was generally well tolerated. Combining azelastine with fluticasone propionate nasal spray offered significantly greater relief than either agent alone in patients with SAR.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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