Side Effects of fluticasone nasal spray: A Synthesis of Findings from 3 Studies

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Original Abstract of the Article

Major Research Findings

Fluticasone nasal spray is an effective treatment for allergic rhinitis, but 2 reports that overuse can lead to serious side effects. Specifically, the report mentions symptoms such as adrenal insufficiency and bone mineral density decrease.

Reasons for Side Effects

Fluticasone nasal spray is a type of steroid medication that reduces inflammation in the body. However, long-term use of steroids in large quantities can suppress adrenal function, leading to side effects such as adrenal insufficiency and bone mineral density decrease.

Common Side Effects

Adrenal Insufficiency

2 reports a case where overuse of fluticasone nasal spray caused adrenal insufficiency. Adrenal insufficiency occurs when the adrenal glands fail to produce enough cortisol, a hormone that plays a crucial role in various physiological functions like blood sugar regulation and immune response suppression. As a result, symptoms like fatigue, lethargy, loss of appetite, weight loss, and low blood pressure may occur.

Bone Mineral Density Decrease

2 reports a case where overuse of fluticasone nasal spray caused a decrease in bone mineral density. Steroids can inhibit bone formation and promote bone absorption, leading to a decrease in bone mineral density. This can increase the risk of fractures.

Side Effects Countermeasures

Countermeasures for Adrenal Insufficiency

2 states that following your doctor’s instructions is crucial to prevent adrenal insufficiency caused by overuse of fluticasone nasal spray.

Countermeasures for Bone Mineral Density Decrease

2 states that it is important to ensure calcium and vitamin D intake to prevent bone mineral density decrease caused by overuse of fluticasone nasal spray.

Comparison Between Studies

Commonalities Between Studies

All three studies indicate that fluticasone nasal spray is effective in treating allergic rhinitis, but overuse can lead to serious side effects.

Differences Between Studies

The three studies differ in their research methods regarding the side effects of fluticasone nasal spray. 2 reports cases where overuse of fluticasone nasal spray caused symptoms such as adrenal insufficiency and bone mineral density decrease. On the other hand, 3 reports the results of a clinical trial comparing the effectiveness of fluticasone nasal spray with traditional Chinese medicine. 1 reports research findings on the side effects of the drug ganciclovir.

Precautions for Real-Life Application

Fluticasone nasal spray is an effective treatment for allergic rhinitis, but overuse can lead to serious side effects. Therefore, it is crucial to follow your doctor’s instructions. Consult your doctor immediately if you suspect any side effects.

Limitations of Current Research

Research on the side effects of fluticasone nasal spray is still insufficient. Further research is needed to understand the long-term effects of fluticasone nasal spray.

Future Research Directions

Research on the side effects of fluticasone nasal spray should focus on the following aspects: * Research on the long-term effects of fluticasone nasal spray * Research on the safety of fluticasone nasal spray * Research on the appropriate use of fluticasone nasal spray

Conclusion

Fluticasone nasal spray is an effective treatment for allergic rhinitis, but overuse can lead to serious side effects. Therefore, it is crucial to follow your doctor’s instructions. Consult your doctor immediately if you suspect any side effects. Research on the side effects of fluticasone nasal spray is still insufficient. Therefore, further research is needed to understand the long-term effects of fluticasone nasal spray.

Literature analysis of 3 papers
Positive Content
2
Neutral Content
0
Negative Content
1
Article Type
2
0
0
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3
1.

[Comparison of therapeutic effect of different doses of ganciclovir for neonatal congenital cytomegalovirus infection].

Author: HeXiao-Ri, ChenPing-Yang, WangTao, XieZong-De, HuJin-Tao, BoTao, GeJian-Fang

CMV infection
Side effects

This study compared the efficacy and side effects of relatively low and high doses of ganciclovir in the treatment of neonatal congenital cytomegalovirus (CMV) infection.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

2.

Systemic effects of fluticasone nasal spray: report of 2 cases.

Author: LicataAngelo A

Adrenal insufficiency
Bone mineral density decrease

Overuse of fluticasone nasal spray may cause serious side effects such as adrenal insufficiency and decreased bone mineral density. Patients should be warned to follow the prescribed dosing carefully.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Efficacy of Bimin decoction for patients with perennial allergic rhinitis: an open-label non-inferiority randomized controlled trial.

Author: ZhaoJingyi, YanXinyu, GaiJianqing, HanJinshuai, ZhangHong, LuoHui, HuangShaoting, WangJunge

Few adverse reactions
Reduced symptoms

Bimin decoction (BMD), a traditional Chinese medicine, is used to treat allergic rhinitis (AR) with lung qi deficiency and cold syndrome (LQDCS). This study compared the clinical efficacy of BMD to the conventional medicines loratadine and fluticasone nasal spray in patients with AR and LQDCS.

Equivalence TrialA clinical trial designed to show that a new treatment is equivalent in efficacy/safety to an existing treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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