Effects of fluticasone oral inhalation: A Synthesis of Findings from 5 Studies

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Original Abstract of the Article

Major Research Findings

Fluphenazine is an antipsychotic medication used to treat schizophrenia. Fluphenazine decanoate is a long-acting formulation of fluphenazine. 2 , 1 , 5 , 4 , 3 These studies investigated the relationship between fluphenazine decanoate plasma levels and clinical response, as well as the side effects associated with its use. These studies suggest that higher fluphenazine decanoate plasma levels are linked to improvement in schizophrenia symptoms. 2 , 3 Fluphenazine decanoate is known to cause extrapyramidal side effects, such as Parkinsonism. 1 Additionally, fluphenazine decanoate may lead to depressive symptoms. 1

Benefits and Risks

Benefit Summary

Fluphenazine decanoate may help improve symptoms of schizophrenia. 2 , 3

Risk Summary

Fluphenazine decanoate can cause extrapyramidal side effects such as Parkinsonism. 1 It can also cause depression. 1

Study Comparisons

Commonalities Across Studies

All of these studies investigated the relationship between fluphenazine decanoate plasma levels and clinical response. They all found that fluphenazine decanoate can cause side effects.

Differences Between Studies

The studies differed in the symptoms and side effects investigated, the study design, and the population studied. For example, 2 investigated the relationship between fluphenazine decanoate plasma levels and psychotic exacerbations. 1 compared the effectiveness of medications to reduce side effects of fluphenazine decanoate. 5 compared the effectiveness of oral fluphenazine to placebo. 4 compared the effectiveness of flupenthixol decanoate to fluphenazine decanoate. 3 investigated the relationship between fluphenazine plasma levels and improvement in schizophrenia symptoms, as well as side effects.

Consistency and Contradictions in Results

These studies indicate a potential relationship between fluphenazine decanoate plasma levels and improvement in schizophrenia symptoms. 2 , 3 However, they have not consistently shown the incidence or type of side effects.

Practical Implications and Considerations

These studies suggest that fluphenazine decanoate may be an effective medication for treating schizophrenia. However, it is important to remember that fluphenazine decanoate can also cause side effects. It is important to consult with a doctor and find a treatment plan that works for you.

Limitations of Current Research

All of these studies were relatively small. Therefore, it is difficult to generalize the results of these studies. Also, these studies did not investigate the long-term effects of fluphenazine decanoate.

Future Directions for Research

It is necessary to investigate the long-term effects and safety of fluphenazine decanoate. Also, ways to reduce the side effects of fluphenazine decanoate need to be studied.

Conclusion

These studies suggest that fluphenazine decanoate may be an effective medication for treating schizophrenia. However, it is important to remember that fluphenazine decanoate can also cause side effects. It is important to consult with a doctor and find a treatment plan that works for you.

Literature analysis of 5 papers
Positive Content
4
Neutral Content
0
Negative Content
1
Article Type
4
0
1
1
5
1.

A comparative trial of orphenadrine and tofenacin in the control of depression and extrapyramidal side-effects associated with fluphenazine decanoate therapy.

Author: CapstickN, PudneyH

Depression control
Parkinsonism control

Both orphenadrine hydrochloride and its metabolite, tofenacin hydrochloride, effectively controlled Parkinsonian side effects in patients receiving fluphenazine decanoate. However, orphenadrine was significantly better (p < 0.05) at controlling depressive side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Plasma levels of fluphenazine in patients receiving fluphenazine decanoate. Relationship to clinical response.

Author: MarderS R, MidhaK K, Van PuttenT, AravagiriM, HawesE M, HubbardJ W, McKayG, MintzJ

Psychotic exacerbations

Fluphenazine decanoate, a long-acting antipsychotic, required three months to reach a steady-state plasma level in patients receiving 25 mg every two weeks. Lower fluphenazine plasma levels were associated with an increased risk of psychotic exacerbations.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

3.

Plasma fluphenazine levels and clinical response in newly admitted schizophrenic patients.

Author: Van PuttenT, AravagiriM, MarderS R, WirshingW C, MintzJ, ChabertN

Improves psychosis
Disabling side effects

Higher plasma fluphenazine levels were associated with greater improvement in schizophrenia symptoms, but also with a higher rate of disabling side effects. Nearly 90% of patients experienced side effects that negated the therapeutic benefits. Fluphenazine N-oxide, a metabolite, was more strongly linked to side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Comparative double-blind study of flupenthixol decanoate and fluphenazine decanoate in the treatment of patients relapsing in a schizophrenic symptomatology.

Author: WistedtB, RantaJ

Improved depressive symptoms
Improved schizophrenic symptomatology

Flupenthixol decanoate and fluphenazine decanoate were similar in their therapeutic effects and side effects for the first 6 months in patients with schizophrenia. After one year, flupenthixol decanoate showed a trend towards a better effect on schizophrenic and depressive symptoms. The need for additional neuroleptics was similar for both drugs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Fluphenazine (oral) versus placebo for schizophrenia.

Author: MatarHosam E, AlmerieMuhammad Q, SampsonStephanie

Schizophrenia treatment
Adverse effects

This review examined the effects of oral fluphenazine compared to placebo in seven randomized controlled trials involving 439 participants with schizophrenia. Fluphenazine was found to be a potent antipsychotic but with considerable adverse effects, suggesting that other drugs may be preferable.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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