Effects of frovatriptan: A Synthesis of Findings from 28 Studies

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Original Abstract of the Article

Main Study Findings

Frovatriptan is a medication used to treat migraine headaches. It is a triptan, a class of drugs that work by constricting blood vessels in the brain. Frovatriptan has been shown to be effective in treating migraines, especially those that occur in association with menstruation. 3 reviewed studies on frovatriptan and concluded that it was effective and well-tolerated for treating migraines. Frovatriptan has also been shown to be effective in preventing menstrual migraines. 6 studied the use of frovatriptan as a short-term preventative treatment for migraines that occurred exclusively around menstruation and found that it was effective. Frovatriptan has also been shown to be effective for treating migraines that last longer than 24 hours. 7 looked at the effects of frovatriptan on migraines of different durations and found it to be effective regardless of duration.

Frovatriptan is generally well-tolerated, but it can cause some side effects. 3 found that Frovatriptan was better tolerated than sumatriptan in a head-to-head comparison study. 12 studied Frovatriptan in Korean migraineurs and found it to be effective and well-tolerated. The most common side effects include dizziness, tingling sensations, dry mouth, fatigue, and flushing. It is important to note that Frovatriptan can cause vasoconstriction and should not be used by people with coronary artery disease. 25 found that Frovatriptan constricted blood vessels in the coronary arteries of dogs. 4 reported a case where naratriptan, another triptan, caused acute coronary syndrome. However, 17 found that frovatriptan was safe to use in patients with coronary artery disease.

Compared to other triptans, Frovatriptan has been shown to have a longer duration of action, which makes it suitable for treating longer lasting migraines. 16 states that Frovatriptan has a longer half-life than other triptans. 3 also states that Frovatriptan has a longer half-life than other triptans. The studies also suggest that Frovatriptan may be more effective than other triptans for treating menstrual migraines. 28 found that Frovatriptan had a significantly lower recurrence rate compared to other triptans for treating menstrual migraines. 13 found that Frovatriptan was as effective as rizatriptan for treating menstrual migraines. 27 also found that Frovatriptan was more effective than other triptans for treating migraines induced by oral contraceptives.

Benefits and Risks

Benefit Summary

Frovatriptan is an effective medication for treating migraines, particularly those that occur in association with menstruation. It has a longer duration of action than other triptans, making it a good option for longer lasting headaches. It is also generally well-tolerated, and studies suggest that it may be safer for patients with coronary artery disease than other triptans.

Risk Summary

Like other triptans, Frovatriptan can cause side effects, such as dizziness, tingling sensations, dry mouth, fatigue, and flushing. Frovatriptan, like other triptans, can cause vasoconstriction and should not be used by people with coronary artery disease. It is also important to note that Frovatriptan may have drug interactions with other medications. It is important to talk to your doctor before taking Frovatriptan.

Comparison Between Studies

Similarities

Many studies have found that Frovatriptan is an effective treatment for migraines. The studies have also found that Frovatriptan is generally well-tolerated. Additionally, many studies have found that Frovatriptan may be particularly useful for treating menstrual migraines.

Differences

The effects of Frovatriptan on the coronary arteries have been found to vary depending on the study. While some studies have found that Frovatriptan can constrict the coronary arteries, others have found that it may be safer for patients with coronary artery disease than other triptans. It is important to note that the effects of Frovatriptan on the coronary arteries may vary between individuals.

Consistency and Contradictions in Results

The results of studies on Frovatriptan have been generally consistent. However, there have been some contradictions in the findings regarding the effects of Frovatriptan on the coronary arteries. More research is needed to fully understand the effects of Frovatriptan on the coronary arteries. Additional studies are also needed to understand the differences in the effectiveness of Frovatriptan between different populations, such as those with coronary artery disease or those who experience menstrual migraines.

Implications for Everyday Life

If you experience migraines, talk to your doctor about whether Frovatriptan is right for you. If you have coronary artery disease, it is important to inform your doctor and discuss the risks and benefits of Frovatriptan before taking it. It is also important to talk to your doctor about any other medications you are taking to avoid potential drug interactions.

Limitations of Current Research

More research is needed to fully understand the effects of Frovatriptan on the coronary arteries and to determine if there are differences in the effectiveness of Frovatriptan between different populations.

Future Research Directions

Future research should focus on the effects of Frovatriptan on the coronary arteries. Researchers should also look into the differences in the effectiveness of Frovatriptan between different populations, such as those with coronary artery disease or those who experience menstrual migraines.

Conclusion

Frovatriptan is an effective treatment for migraines, particularly those that occur in association with menstruation. It is generally well-tolerated, and studies suggest that it may be safer for patients with coronary artery disease than other triptans. However, more research is needed to understand the effects of Frovatriptan on the coronary arteries and to determine if there are differences in the effectiveness of Frovatriptan between different populations. If you are experiencing migraines, it is important to talk to your doctor to determine the best course of treatment for you.

Keywords
Benefit Keywords
HIV-1 treatment
1
Better tolerated than sumatriptan
Well tolerated
2
Migraine treatment
3
Migraine treatment
5
Reduced menstrual migraine
6
Effective treatment
Migraine duration reduction
7
Cardiac function
Coronary artery relaxation
Myocardial infarction treatment
8
Migraine prevention
9
Effective treatment
Reduced headache duration
Reduced headache pain
Well tolerated
10
Frovatriptan
zolmitriptan
or naratriptan may be useful for short-term prevention
Magnesium
estrogen
naproxen sodium
or dihydroergotamine may be useful for short-term prevention
Rizatriptan is best for acute treatment
11
Long duration of action
Low incidence of side effects
Treatment of migraine
12
Migraine treatment
13
Reduced functional disability
Reduced headache progression
Reduced pain
Reduced pain burden
Reduced re-medication
14
Headache prevention
Migraine relief
15
Effective migraine treatment
16
No cardiovascular abnormalities
Well tolerated
17
Menstrual migraine treatment
18
Fast headache relief
Low recurrence rate
19
Cluster headache treatment
Migraine treatment
20
Frovatriptan effective for migraine
Sustained antimigraine effect
21
Migraine treatment
22
Effective migraine treatment
Long-lasting relief
Safe for patients with coronary artery disease
23
Improved headache
Reduced migraine attacks
Reduced nausea
Reduced phonophobia
Reduced photophobia
24
Migraine treatment
26
Pain relief
27
Migraine treatment
28
Risk Keywords
Arrhythmia
QTc prolongation
1
Acute coronary syndrome
4
Antiepileptic medications may affect OCs and hormonal treatments
MM can be difficult to treat
11
Headache recurrence
16
Cardiovascular events
20
Migraine more severe in women
21
Adverse effects
22
Side effects
23
Side effects
24
Coronary artery constriction
25
Literature analysis of 28 papers
Positive Content
26
Neutral Content
0
Negative Content
2
Article Type
7
0
0
11
28
1.

Effects of Temsavir, Active Moiety of Antiretroviral Agent Fostemsavir, on QT Interval: Results From a Phase I Study and an Exposure-Response Analysis.

Author: LagishettyChakradhar, MooreKaty, AckermanPeter, LlamosoCyril, MageeMindy

HIV-1 treatment
Arrhythmia
QTc prolongation

Fostemsavir, a prodrug of temsavir, was found to be safe for treating multidrug-resistant HIV infection at therapeutic doses. However, supratherapeutic doses showed a potential for QTc prolongation.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Tolerability and safety of frovatriptan with short- and long-term use for treatment of migraine and in comparison with sumatriptan.

Author: GéraudGilles, SpieringsEgilius L H, KeywoodCharlotte

Better tolerated than sumatriptan
Well tolerated

Frovatriptan 2.5 mg was well tolerated by patients with migraine, with similar tolerability to placebo and better tolerability than sumatriptan 100 mg.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Frovatriptan review.

Author: MarkusFärkkilä, MikkoKallela

Migraine treatment

Frovatriptan, a triptan compound, demonstrated effectiveness and tolerability in the acute treatment of migraine, with a lower headache recurrence rate than other triptans. It is particularly suitable for slowly progressing or predictable migraine attacks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Triptans and troponin: a case report.

Author: WederClaudia R, SchneemannMarkus

Acute coronary syndrome

This case report describes the first instance of acute coronary syndrome occurring in a patient after taking naratriptan, a medication used to treat migraine. The case highlights the potential for triptans to cause acute coronary syndromes, even in patients without pre-existing heart disease.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Effects of the novel high-affinity 5-HT(1B/1D)-receptor ligand frovatriptan in human isolated basilar and coronary arteries.

Author: ParsonsA A, RavalP, SmithS, TilfordN, KingF D, KaumannA J, HunterJ

Migraine treatment

Frovatriptan, a 5-HT(1B/1D) ligand, contracted human isolated basilar and coronary arteries. However, it showed a complex response in coronary arteries, suggesting a potential for adverse effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Scheduled short-term prevention with frovatriptan for migraine occurring exclusively in association with menstruation.

Author: SilbersteinStephen D, BernerTodd, TobinJohn, XiangQinfang, CampbellJohn C

Reduced menstrual migraine

Scheduled short-term preventive frovatriptan therapy effectively reduced the occurrence of menstrual migraine in women with attacks occurring exclusively in association with menstruation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Treatment response and tolerability of frovatriptan in patients reporting short- or long-duration migraines at baseline.

Author: KelmanLeslie, HarperSamira Q, HuXiaojun, CampbellJohn C

Effective treatment
Migraine duration reduction

Frovatriptan effectively reduced migraine duration in patients reporting long- (24-72 h) or short-duration (<24 h) migraines at baseline. Patients were 26.8-fold more likely to experience decreased versus increased headache duration.

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Frovatriptan as preemptive treatment for fasting-induced migraine.

Author: LatskoMeryl, SilbersteinStephen, RosenNoah

Migraine prevention

Frovatriptan, a migraine medication, did not demonstrate a statistically significant benefit in preventing fasting-induced migraine compared to placebo, although more subjects in the placebo group experienced headaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Frovatriptan is Effective and Well Tolerated in Korean Migraineurs: A Double-Blind, Randomized, Placebo-Controlled Trial.

Author: MoonHeui-Soo, ChuMin Kyung, ParkJeong Wook, OhKyungmi, ChungJae Myun, ChoYong Jin, KimEung Gyu, DoJin Kuk, JungHyong Gi, KwonSun Uck

Long duration of action
Low incidence of side effects
Treatment of migraine

Frovatriptan is a selective 5-HT(1B/1D) agonist used to treat migraine. This study investigates its efficacy and safety in Asian, including Korean, patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Efficacy of frovatriptan in the acute treatment of menstrually related migraine: analysis of a double-blind, randomized, cross-over, multicenter, Italian, comparative study versus rizatriptan.

Author: SaviLidia, OmboniStefano, LisottoCarlo, ZanchinGiorgio, FerrariMichel D, ZavaDario, PinessiLorenzo

Migraine treatment

Frovatriptan and rizatriptan were equally effective in treating menstrually related migraine attacks, but frovatriptan demonstrated a lower rate of migraine recurrence.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Randomized, placebo-controlled comparison of early use of frovatriptan in a migraine attack versus dosing after the headache has become moderate or severe.

Author: CadyRoger, ElkindArthur, GoldsteinJerome, KeywoodCharlotte

Reduced functional disability
Reduced headache progression
Reduced pain
Reduced pain burden
Reduced re-medication

Early use of frovatriptan for migraine attacks was found to be more effective than later use, resulting in a higher, earlier, and sustained pain-free response. It also prevented headache progression and reduced pain burden and functional disability.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Acute treatment of migraine and the role of triptans.

Author: FreitagF G

Headache prevention
Migraine relief

Triptans have improved migraine treatment, with all currently available options showing comparable efficacy and tolerability. Future triptans may offer enhanced efficacy, tolerability, and headache recurrence rates. Early treatment of migraine with triptans, including mini-prophylaxis at the menses, has shown promising results.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

16.

Triptans in migraine: a comparative review of pharmacology, pharmacokinetics and efficacy.

Author: Tfelt-HansenP, De VriesP, SaxenaP R

Effective migraine treatment
Headache recurrence

This study reviews the triptan class of medications for migraine treatment. While triptans have shown effectiveness, there are subtle differences in their pharmacokinetic profiles and efficacy. More research is needed to establish the optimal use of triptans in migraine therapy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

Frovatriptan use in migraineurs with or at high risk of coronary artery disease.

Author: ElkindArthur H, SatinLawrence Z, NilaAlice, KeywoodCharlotte

No cardiovascular abnormalities
Well tolerated

Frovatriptan 2.5 mg was well tolerated and safe for migraine patients with or at high risk of coronary artery disease. It did not increase the incidence of cardiovascular abnormalities, while placebo showed higher incidence of electrocardiogram changes and arrhythmias.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

The use of triptans in the management of menstrual migraine.

Author: MannixLisa K, FilesJulia A

Menstrual migraine treatment

Triptans are effective for the acute treatment of both menstrual and non-menstrual migraines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

Rapid responders to frovatriptan in acute migraine treatment: results from a long-term, open-label study.

Author: SpieringsEgilius L H, KeywoodCharlotte

Fast headache relief
Low recurrence rate

Frovatriptan is an effective treatment for migraine headaches, providing a rapid headache response in more than one-third of migraineurs, with low headache recurrence and rescue medication intake.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Safety profile of the triptans.

Author: TepperStewart J, MillsonDavid

Cluster headache treatment
Migraine treatment
Cardiovascular events

Triptans are a class of drugs used to treat migraines and cluster headaches. They work by stimulating 5-HT(1B/1D) receptors, which are found in blood vessels in the brain. Seven triptans are available worldwide. The most common side effects are cardiovascular, but the overall safety profile of triptans is considered excellent.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

21.

Gender and triptan efficacy: a pooled analysis of three double-blind, randomized, crossover, multicenter, Italian studies comparing frovatriptan vs. other triptans.

Author: FranconiFlavia, FinocchiCinzia, AllaisGianni, OmboniStefano, TulloVincenzo, CampesiIlaria, ReggiardoGiorgio, BenedettoChiara, BussoneGennaro

Frovatriptan effective for migraine
Sustained antimigraine effect
Migraine more severe in women

This pooled analysis of three randomized studies assessed the efficacy of frovatriptan versus other triptans in treating migraine, considering gender differences. Frovatriptan showed similar efficacy in both men and women, with a lower rate of relapse compared to other triptans, regardless of gender.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

22.

Comparative aspects of triptans in treating migraine.

Author: AdelmanJ U, LewitE J

Migraine treatment
Adverse effects

Triptans, beginning with sumatriptan, have revolutionized the treatment of migraine. New triptans in several formulations will soon become available in the United States. Subcutaneous sumatriptan has the most rapid onset of action and greatest efficacy but the most adverse effects. Intranasal sumatriptan also has rapid onset of action, but at 2 hours its efficacy is comparable to that of oral zolmitriptan. Of the oral triptans, rizatriptan seems to have the greatest early efficacy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

23.

Frovatriptan succinate, a 5-HT1B/1D receptor agonist for migraine.

Author: BalbisiE A

Effective migraine treatment
Long-lasting relief
Safe for patients with coronary artery disease
Side effects

Frovatriptan is a serotonin receptor agonist used for the acute management of migraine. It has a high affinity for serotonin receptors 1B and 1D and a long elimination half-life, making it suitable for patients with long-duration or recurrent migraines. Frovatriptan is generally well tolerated, with mild and manageable side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

26.

Oral contraceptive-induced menstrual migraine. Clinical aspects and response to frovatriptan.

Author: AllaisGianni, BussoneGennaro, AirolaGisella, BorgognoPaola, GabellariIlaria Castagnoli, De LorenzoCristina, PaviaElena, BenedettoChiara

Migraine treatment

Oral contraceptive-induced menstrual migraine (OCMM) is a type of migraine that is triggered by the cyclic pill suspension. This study investigated the efficacy of frovatriptan, a migraine medication, in the treatment of OCMM.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Efficacy of frovatriptan versus other triptans in the acute treatment of menstrual migraine: pooled analysis of three double-blind, randomized, crossover, multicenter studies.

Author: AllaisGianni, TulloVincenzo, OmboniStefano, BenedettoChiara, SancesGrazia, ZavaDario, FerrariMichel D, BussoneGennaro

Migraine treatment

Frovatriptan was found to be as effective as other triptans in treating menstrual migraine, with a lower recurrence rate and similar safety profile.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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