Side Effects of frovatriptan: A Synthesis of Findings from 9 Studies

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Original Abstract of the Article

Main Research Findings

Frovatriptan is a migraine medication that is effective in treating acute migraine attacks and is well-tolerated. It has a longer duration of action than other triptans, leading to a lower incidence of headache recurrence. 5 2

Frovatriptan has also been shown to be effective in preventing menstrual migraine. 3

Reasons for Side Effects

Frovatriptan is a serotonin receptor agonist. Serotonin is a neurotransmitter that plays an important role in the brain. Frovatriptan is believed to work by binding to serotonin receptors, which causes vasoconstriction and inhibits the transmission of pain signals. 4

Common Side Effects

Dizziness

Dizziness has been reported as a side effect of frovatriptan. 3

Nausea

Nausea has been reported as a side effect of frovatriptan. 3

Fatigue

Fatigue has been reported as a side effect of frovatriptan. 3

Chest pain

Chest pain has been reported as a side effect of frovatriptan. 3

Countermeasures for Side Effects

Dizziness

If you experience dizziness after taking frovatriptan, rest and see how you feel. Consult a doctor if your symptoms do not improve. 3

Nausea

If you experience nausea after taking frovatriptan, avoid eating and drink plenty of fluids. Consult a doctor if your symptoms do not improve. 3

Fatigue

If you experience fatigue after taking frovatriptan, get enough sleep and rest. Consult a doctor if your symptoms do not improve. 3

Chest pain

If you experience chest pain after taking frovatriptan, consult a doctor immediately. 3

Comparison between Studies

Common Points

Multiple studies have shown that frovatriptan is effective in treating migraine. 5 , 3 , 4

Differences in Studies

The reported side effects of frovatriptan vary from study to study. For example, dizziness was reported in one study, but not in another. 3 , 4

Precautions for Real-Life Application

Frovatriptan is an effective drug for treating migraine, but it can cause side effects. Consult your doctor before taking it and take it as directed. 5 , 3 , 4

Limitations of Current Research

Long-term side effects of frovatriptan have not been adequately studied. 3

Future Research Directions

Further research is needed on the long-term side effects of frovatriptan and comparisons with other triptans. 3 , 4

Conclusion

Frovatriptan is an effective drug for treating migraine, but it can cause side effects. Consult your doctor before taking it and take it as directed. If you are concerned about side effects, consult your doctor. 5 , 3 , 4

Literature analysis of 9 papers
Positive Content
9
Neutral Content
0
Negative Content
0
Article Type
1
0
1
7
9
1.

Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.

Author: SheaBeverley, SwindenMichael V, GhogomuElizabeth Tanjong, OrtizZulma, KatchamartWanruchada, RaderTamara, BombardierClaire, WellsGeorge A, TugwellPeter

Reduces GI side effects
Reduces hepatic dysfunction

Folic acid or folinic acid supplementation while receiving methotrexate (MTX) therapy for rheumatoid arthritis (RA) reduced the incidence of gastrointestinal side effects by 26%, abnormal serum transaminase elevation by 76.9%, and discontinuation of MTX treatment for any reason by 60.8%.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

Clinical and economic comparison of frovatriptan versus other oral triptans in the treatment of acute migraine in the real-world setting.

Author: GuidottiMario, RavasioRoberto

Migraine relief
Reduced recurrence

Frovatriptan, a triptan medication, has demonstrated effectiveness and good tolerability in the treatment of acute migraine. This review discusses the benefits of frovatriptan compared to other triptans, including its lower recurrence rate, improved patient satisfaction, and cost-effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Safety and tolerability of short-term preventive frovatriptan: a combined analysis.

Author: MacGregorE Anne, BrandesJan L, SilbersteinStephen, JekaSlawomir, CzapinskiPiotr, ShawBob, PawseyStephen

Menstrual migraine prevention
Chest discomfort
Chest pain
Dizziness
Dysmenorrhea
Fatigue
Hypertension
Influenza
Migraine
Nausea
Neck pain
Upper respiratory tract infection

The safety and tolerability of frovatriptan for short-term prevention of menstrual migraine was similar to that observed with acute use of triptans during treatment of up to 12 perimenstrual periods over a 12- to 15-month period.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Frovatriptan: a review.

Author: GoldsteinJerome

Good tolerability
Long duration effect
Low recurrence
Side effects

Frovatriptan, a triptan medication, has a long half-life, is well-tolerated, and is effective in treating migraine headaches. It is particularly suitable for patients with long-duration migraines, those prone to recurrence, and those who experience side effects from other triptans.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Frovatriptan is Effective and Well Tolerated in Korean Migraineurs: A Double-Blind, Randomized, Placebo-Controlled Trial.

Author: MoonHeui-Soo, ChuMin Kyung, ParkJeong Wook, OhKyungmi, ChungJae Myun, ChoYong Jin, KimEung Gyu, DoJin Kuk, JungHyong Gi, KwonSun Uck

Long duration of action
Low incidence of side effects
Treatment of migraine

Frovatriptan is a selective 5-HT(1B/1D) agonist used to treat migraine. This study investigates its efficacy and safety in Asian, including Korean, patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Comparative aspects of triptans in treating migraine.

Author: AdelmanJ U, LewitE J

Migraine treatment
Adverse effects

Triptans, beginning with sumatriptan, have revolutionized the treatment of migraine. New triptans in several formulations will soon become available in the United States. Subcutaneous sumatriptan has the most rapid onset of action and greatest efficacy but the most adverse effects. Intranasal sumatriptan also has rapid onset of action, but at 2 hours its efficacy is comparable to that of oral zolmitriptan. Of the oral triptans, rizatriptan seems to have the greatest early efficacy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Pharmacological approaches to migraine.

Author: DienerH Ch

Treats migraine

This review summarizes new treatment options for both acute migraine attacks and migraine prophylaxis. Triptans are highly effective in treating migraine attacks. For migraine prophylaxis, beta-blockers, calcium channel blockers, and antiepileptic drugs are effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

Pharmacotherapy for Cluster Headache.

Author: BrandtRoemer B, DoesborgPatty G G, HaanJoost, FerrariMichel D, FronczekRolf

Cluster headache treatment
Cardiac side effects
Liver and kidney effects

Cluster headache is a severe type of headache characterized by intense pain on one side of the head. Treatment options include abortive medications (such as sumatriptan and high-flow oxygen), preventive medications (such as verapamil and lithium), and transitional treatments (such as greater occipital nerve injection).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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