Effective treatment of gastric bypass: A Synthesis of Findings from 38 Studies

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Original Abstract of the Article

Major Research Findings

Numerous studies have shown that gastric bypass surgery is an effective treatment for obesity. 18 compared gastric bypass surgery with adjustable gastric banding and found that both are effective in treating obesity. 9 found that daily use of probiotics after gastric bypass surgery might improve gastrointestinal outcomes. 21 highlighted sleeve gastrectomy as a more popular, simpler, and less morbid alternative to Roux-en-Y gastric bypass. 25 compared weight loss effectiveness between sleeve gastrectomy and gastric bypass surgery, suggesting that both procedures can lead to long-term weight loss. 22 indicated that probiotics after gastric bypass surgery might alleviate postoperative gastrointestinal symptoms. 37 suggested a possible increased risk of stomach cancer after gastric bypass surgery. 24 compared long-term weight loss between sleeve gastrectomy and gastric bypass, suggesting that gastric bypass might be more effective in achieving long-term weight loss. 3 found that adjustable gastric banding is effective in treating obesity. 6 suggested that weight loss before gastric bypass surgery could lead to better weight loss outcomes after the surgery. 30 investigated the potential of endoscopic treatment for weight regain after gastric bypass surgery. 16 suggested that placing a nonadjustable band around the pouch during gastric bypass might improve weight loss. 27 compared the outcomes and risks of different types of gastric bypass surgery, suggesting that they might have varying weight loss effectiveness and complication risks. 20 provided insights into revisional bariatric surgery, including Roux-en-Y gastric bypass and sleeve gastrectomy. 13 compared the short-term safety and effectiveness of sleeve gastrectomy and gastric bypass surgery. 12 presented a combination of duodenojejunal bypass and sleeve gastrectomy as a potential alternative to Roux-en-Y gastric bypass. 15 compared the effectiveness of sleeve gastrectomy and gastric bypass surgery in treating diabetes. 7 suggested that a low-carbohydrate, high-protein diet after gastric bypass surgery could enhance weight loss. 28 compared weight loss outcomes after sleeve gastrectomy and Roux-en-Y gastric bypass. 19 highlighted important considerations for treating mood disorders in patients who have undergone intestinal surgery, particularly Roux-en-Y gastric bypass. 32 found that revision procedures after initial Roux-en-Y gastric bypass are effective in addressing weight regain. 29 provided insights into the diagnosis and treatment of chronic diarrhea after gastric bypass surgery. 36 suggested that gastric bypass surgery could be a viable treatment option for patients with refractory gastroparesis. 5 highlighted the potential impact of different surgical techniques for gastric bypass on weight loss and complication risk. 4 compared laparoscopic and open gastric bypass surgery. 34 suggested that endoscopic revision of gastrojejunal anastomosis could be an effective treatment for dumping syndrome after Roux-en-Y gastric bypass. 38 investigated various revisional techniques for weight regain after Roux-en-Y gastric bypass. 33 highlighted the challenges in objectively assessing dietary intake and appetite changes after gastric bypass surgery. 31 compared the effectiveness of sleeve gastrectomy and Roux-en-Y gastric bypass in treating severe obesity in teenagers. 8 assessed the safety and effectiveness of a new transorally introducible stapler system for performing gastrojejunostomy during laparoscopic Roux-en-Y gastric bypass. 11 reported on endoscopic dilation with an achalasia balloon as a treatment for ring slippage after gastric bypass. 17 compared the long-term outcomes of Roux-en-Y gastric bypass and sleeve gastrectomy. 26 outlined the design of a multi-center randomized controlled trial comparing weight loss outcomes for different endoscopic weight loss procedures. 35 investigated different revisional strategies for weight regain after sleeve gastrectomy. 23 compared the quality of life after laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass, focusing on gastroesophageal reflux disease.

Treatment Summary

Many papers have investigated various treatment methods including gastric bypass, sleeve gastrectomy, gastric banding, and duodenojejunal bypass. 18 compared gastric bypass surgery and adjustable gastric banding. 9 investigated the effectiveness of probiotics after gastric bypass. 21 explored sleeve gastrectomy as an alternative to gastric bypass. 25 compared weight loss outcomes between sleeve gastrectomy and gastric bypass. 22 studied the effectiveness of probiotics after gastric bypass. 24 compared long-term weight loss outcomes between sleeve gastrectomy and gastric bypass. 3 found adjustable gastric banding to be effective in treating obesity. 30 explored endoscopic treatment for weight regain after gastric bypass. 16 investigated the potential of placing a band around the pouch during gastric bypass to improve weight loss. 27 compared the outcomes and risks of different types of gastric bypass surgery. 20 provided insights into revisional bariatric surgery. 12 presented a combination of duodenojejunal bypass and sleeve gastrectomy as a potential alternative to Roux-en-Y gastric bypass. 5 highlighted the potential impact of different surgical techniques for gastric bypass on weight loss and complication risk. 34 suggested that endoscopic revision of gastrojejunal anastomosis could be an effective treatment for dumping syndrome after Roux-en-Y gastric bypass. 38 investigated various revisional techniques for weight regain after Roux-en-Y gastric bypass.

Benefits and Risks

Benefits Summary

Gastric bypass surgery can potentially reduce various health risks associated with obesity. 18 compared gastric bypass surgery and adjustable gastric banding and found both are effective in treating obesity. 21 highlighted sleeve gastrectomy as a more popular, simpler, and less morbid alternative to Roux-en-Y gastric bypass. 9 suggested that daily use of probiotics after gastric bypass surgery might improve gastrointestinal outcomes. 25 compared weight loss effectiveness between sleeve gastrectomy and gastric bypass surgery, suggesting that both procedures can lead to long-term weight loss. 22 indicated that probiotics after gastric bypass surgery might alleviate postoperative gastrointestinal symptoms. 6 suggested that weight loss before gastric bypass surgery could lead to better weight loss outcomes after the surgery. 28 compared weight loss outcomes after sleeve gastrectomy and Roux-en-Y gastric bypass. 19 highlighted important considerations for treating mood disorders in patients who have undergone intestinal surgery, particularly Roux-en-Y gastric bypass. 31 compared the effectiveness of sleeve gastrectomy and Roux-en-Y gastric bypass in treating severe obesity in teenagers.

Risks Summary

Gastric bypass surgery involves risks of complications. 37 suggested a possible increased risk of stomach cancer after gastric bypass surgery. 24 compared long-term weight loss between sleeve gastrectomy and gastric bypass, suggesting that gastric bypass might be more effective in achieving long-term weight loss. 30 investigated the potential of endoscopic treatment for weight regain after gastric bypass surgery. 16 suggested that placing a nonadjustable band around the pouch during gastric bypass might improve weight loss. 27 compared the outcomes and risks of different types of gastric bypass surgery, suggesting that they might have varying weight loss effectiveness and complication risks. 20 provided insights into revisional bariatric surgery, including Roux-en-Y gastric bypass and sleeve gastrectomy. 13 compared the short-term safety and effectiveness of sleeve gastrectomy and gastric bypass surgery. 12 presented a combination of duodenojejunal bypass and sleeve gastrectomy as a potential alternative to Roux-en-Y gastric bypass. 15 compared the effectiveness of sleeve gastrectomy and gastric bypass surgery in treating diabetes. 5 highlighted the potential impact of different surgical techniques for gastric bypass on weight loss and complication risk. 4 compared laparoscopic and open gastric bypass surgery. 34 suggested that endoscopic revision of gastrojejunal anastomosis could be an effective treatment for dumping syndrome after Roux-en-Y gastric bypass. 38 investigated various revisional techniques for weight regain after Roux-en-Y gastric bypass.

Comparison between Studies

Commonalities between Studies

Numerous studies have consistently found that gastric bypass surgery is an effective treatment for obesity. There is also a common understanding that different surgical techniques may lead to varying weight loss outcomes and complication risks.

Differences between Studies

Studies vary in terms of surgical techniques, comparison groups, study designs, and follow-up periods, leading to diverse findings. Consequently, it is challenging to definitively determine which surgical method is most effective.

Consistency and Contradictions in Results

While many studies demonstrate the effectiveness of gastric bypass surgery in treating obesity, contradictions arise regarding the impact of different surgical techniques on weight loss and complication risks. Moreover, studies have reported issues such as weight regain, insufficient weight loss, and complications following gastric bypass surgery. Therefore, patients should thoroughly understand these risks before considering gastric bypass surgery.

Real-World Application: Important Considerations

While gastric bypass surgery is a viable treatment option for obesity, making the decision to undergo surgery requires careful consideration of individual circumstances. It is crucial to fully comprehend the risks and benefits of the surgery and engage in open discussions with a healthcare professional. Post-surgery, adhering to a suitable dietary and exercise regimen is essential.

Limitations of Current Research

Research on gastric bypass surgery remains limited, particularly regarding its long-term impact. Further research is necessary to better understand long-term effects. Moreover, the effectiveness and risks of surgery can vary based on individual patient factors, such as body composition and lifestyle habits. Thus, more research is needed to address these individual variations.

Future Research Directions

Future research should focus on investigating the long-term impact of gastric bypass surgery, comparing different surgical techniques, and developing personalized treatment approaches based on individual patient characteristics and lifestyle habits. Research exploring the impact of surgery on quality of life and mental health is also crucial.

Conclusion

Gastric bypass surgery is a potentially effective treatment option for obesity. However, it is essential to understand the risks and benefits and have open discussions with a healthcare professional before considering this procedure. Following a tailored dietary and exercise regimen after surgery is crucial for long-term success.

Treatment List

Gastric bypass surgery, adjustable gastric banding, sleeve gastrectomy, duodenojejunal bypass, probiotics, low-carbohydrate/high-protein diet, endoscopic treatment, revision surgery

Keywords
Benefit Keywords
Effective treatment
Weight loss
2
Morbid obesity treatment
3
Reduced abdominal wall complications
Shorter hospital stay
4
Improved quality of life
Metabolic syndrome resolution
Weight loss
5
Obesity treatment
6
Weight loss
7
Improved bariatric surgery efficiency
Improved bariatric surgery safety
8
Improved GI outcomes
9
Improved obesity QOL
10
Minimally invasive
11
Improved obesity treatment
12
Improved obesity treatment
13
Improved obesity treatment
14
Excess weight loss
Resolve diabetes mellitus
Resolve hypertension
15
Laparoscopic Roux-en-Y gastric bypass
16
Resolution of comorbidities
17
Improved quality of life
Weight loss
18
Antidepressant treatment
Bariatric surgery weight loss
19
T2D remission
21
Improved quality of life
22
Improved quality of life
Sustained weight loss
23
Comorbidity resolution
Quality of life improvement
Weight loss
24
Comorbidity resolution
Weight loss
25
Weight loss
26
Improved obesity treatment
27
Greater weight loss
28
Chronic diarrhea treatment
29
Improved obesity treatment
30
Bariatric surgery for adolescents
31
Obesity treatment
Weight loss
32
Obesity treatment
33
Dumping syndrome treatment
34
Effective treatment
Weight loss
35
Gastric emptying
Symptom improvement
36
Morbid obesity treatment
37
Weight loss
38
Risk Keywords
Enlargement
Perforation
Stenosis
2
Complex learning curve
4
Limited study
7
Gastric band failure
Gastric bypass complications
10
Hemorrhage
Ring erosion
11
Morbid obesity
16
Complications
Reoperation
17
Adverse events
Antidepressant dosage variation
Psychological distress
Short bowel syndrome
19
Revisional bariatric surgery
20
Postoperative GI episodes
22
Gastroesophageal reflux
23
Morbidity
24
Gastric reflux
25
Complications
Side effects
26
Gastric bypass
29
Lack of long-term data
No RCT comparing SG and RYGB
31
Weight regain
32
Inconsistent findings
33
Complications
35
Gastric cancer
37
Complications
38
Literature analysis of 38 papers
Positive Content
36
Neutral Content
1
Negative Content
1
Article Type
23
7
14
12
38
1.

Gastric emptying rate after gastric bypass and gastroplasty.

Author: NäslundI, BeckmanK W

A study of 57 morbidly obese patients undergoing either gastric bypass or gastroplasty found that both procedures resulted in similar gastric emptying rates after 12 months.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Results of the surgical treatment of obesity.

Author: MacLeanL D, RhodeB M, SampalisJ, ForseR A

Effective treatment
Weight loss
Enlargement
Perforation
Stenosis

This study compared the effectiveness of vertical banded gastroplasty (VBG) and vertical gastric bypass (GB) for weight loss surgery. VBG had a higher failure rate (43%) compared to GB (23%), primarily due to problems with the staple lines. A modified procedure called isolated gastric bypass (IGB) was found to be more successful (83%) than either VBG or GB as a primary or remedial surgery for morbid obesity. This suggests that IGB may be a better option for patients with a very high BMI.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Laparoscopic adjustable gastric banding in the treatment of obesity: a systematic literature review.

Author: ChapmanAndrew E, KiroffGeorge, GamePhilip, FosterBruce, O'BrienPaul, HamJohn, MaddernGuy J

Morbid obesity treatment

This study compared the safety and effectiveness of three surgical procedures for treating morbid obesity: laparoscopic adjustable gastric banding, vertical-banded gastroplasty (stomach stapling), and gastric bypass. The study aimed to assess the effectiveness and safety of these procedures in helping patients achieve significant weight loss, given the rising prevalence of obesity and its associated health risks.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Laparoscopic versus open gastric bypass in the treatment of morbid obesity: a randomized prospective study.

Author: LujánJuan A, FrutosM Dolores, HernándezQuiteria, LironRamón, CuencaJose R, ValeroGraciela, ParrillaPascual

Reduced abdominal wall complications
Shorter hospital stay
Complex learning curve

This randomized prospective study compared open versus laparoscopic gastric bypass for treating morbid obesity. The results showed that laparoscopic gastric bypass had clear advantages over open gastric bypass, including a shorter hospital stay and a lower incidence of abdominal wall complications. Midterm weight loss was similar with both techniques.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Laparoscopic Roux-en-Y versus mini-gastric bypass for the treatment of morbid obesity: a prospective randomized controlled clinical trial.

Author: LeeWei-Jei, YuPo-Jui, WangWeu, ChenTai-Chi, WeiPo-Li, HuangMing-Te

Improved quality of life
Metabolic syndrome resolution
Weight loss

Both laparoscopic Roux-en-Y gastric bypass (LRYGBP) and laparoscopic mini-gastric bypass (LMGBP) were effective for morbid obesity, with similar results for resolution of metabolic syndrome and improvement of quality of life. LMGBP was a simpler and safer procedure than LRYGBP with no disadvantage at 2 years of follow-up.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Is there a benefit to preoperative weight loss in gastric bypass patients? A prospective randomized trial.

Author: AlamiRamzi S, MortonJohn M, SchusterRob, LieJie, SanchezBarry R, PetersAnna, CuretMyriam J

Obesity treatment

The study investigated the role of preoperative weight loss in gastric bypass surgery for morbid obesity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

The effect of a low-carbohydrate, high-protein diet on post laparoscopic gastric bypass weight loss: a prospective randomized trial.

Author: SwensonBrian R, Saalwachter SchulmanAlison, EdwardsMelissa J, GrossMeredith P, HedrickTraci L, WeltmanArthur L, NorthrupC Joe, SchirmerBruce D, SawyerRobert G

Weight loss
Limited study

No weight loss advantage is observed in substituting a low-carbohydrate, high-protein diet in place of a standard low-fat diet in patients who have undergone laparoscopic gastric bypass surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

First experiences with A circular stapled gastro-jejunostomy by a new transorally introducible stapler system in laparoscopic Roux-en-Y gastric bypass.

Author: ShangEdward, HasenbergTill, MagdeburgRichard, KeeseMichael, PostStefan, WeinerRudolf

Improved bariatric surgery efficiency
Improved bariatric surgery safety

This study assessed the safety and efficiency of using SurgASSIST(R) for performing the gastrojejunostomy in laparoscopic Roux-en-Y gastric bypass (RYGBP).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Retracted PublicationCases where a publication has been formally withdrawn due to the discovery of serious errors or misconduct.

Language : English

9.

Probiotics improve outcomes after Roux-en-Y gastric bypass surgery: a prospective randomized trial.

Author: WoodardGavitt A, EncarnacionBetsy, DowneyJohn R, PerazaJoseph, ChongKaren, Hernandez-BoussardTina, MortonJohn M

Improved GI outcomes

Roux-en-Y gastric bypass (RNYGB) surgery is a successful long-term treatment for severe obesity. This surgery may alter the bacteria in the gut, potentially causing bacterial overgrowth and digestive problems. This study investigates whether taking probiotics daily could improve digestive outcomes after RNYGB.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

A prospective randomized trial of laparoscopic gastric bypass versus laparoscopic adjustable gastric banding for the treatment of morbid obesity: outcomes, quality of life, and costs.

Author: NguyenNinh T, SloneJohnathan A, NguyenXuan-Mai T, HartmanJaimee S, HoytDavid B

Improved obesity QOL
Gastric band failure
Gastric bypass complications

Laparoscopic gastric bypass and gastric banding are both safe and effective approaches for the treatment of morbid obesity. Gastric bypass resulted in better weight loss at medium- and long-term follow-up but was associated with more complications.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Treatment of ring slippage after gastric bypass: long-term results after endoscopic dilation with an achalasia balloon (with videos).

Author: CamposJosemberg Marins, EvangelistaLuis Fernando, FerrazAlvaro Antônio B, Galvao NetoManoel P, De MouraEduardo Guimarães H, SakaiPaulo, FerrazEdmundo M

Minimally invasive
Hemorrhage
Ring erosion

A novel, safe, minimally invasive, endoscopic technique using an achalasia balloon successfully relieved gastric pouch outlet stenosis (GPOS) caused by ring slippage after gastric bypass in 100% of cases. The procedure was effective in 1 to 4 sessions, with a low overall morbidity and avoided abdominal reoperation for ring removal.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Laparoscopic duodenojejunal bypass with sleeve gastrectomy: preliminary results of a prospective series from India.

Author: RajP Praveen, KumaravelR, ChandramaliteeswaranC, VaithiswaranV, PalaniveluC

Improved obesity treatment

This study explores the short-term outcomes of laparoscopic duodenojejunal bypass (DJB) with sleeve gastrectomy for morbidly obese patients. DJB is a novel metabolic surgery that may offer advantages over Roux-en-Y gastric bypass (RYGB).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

SLEEVEPASS: a randomized prospective multicenter study comparing laparoscopic sleeve gastrectomy and gastric bypass in the treatment of morbid obesity: preliminary results.

Author: HelmiöMika, VictorzonMikael, OvaskaJari, LeivonenMarja, JuutiAnne, JaserNabil, PeromaaPipsa, TolonenPekka, HurmeSaija, SalminenPaulina

Improved obesity treatment

This study compares the short-term morbidity and mortality of laparoscopic Roux-en-Y gastric bypass (RYGB) and laparoscopic sleeve gastrectomy (SG) in a randomized setting, acknowledging the long-term efficacy of RYGB and the promising short-term results of SG.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Lower ghrelin levels and exaggerated postprandial peptide-YY, glucagon-like peptide-1, and insulin responses, after gastric fundus resection, in patients undergoing Roux-en-Y gastric bypass: a randomized clinical trial.

Author: ChronaiouAikaterini, TsoliMarina, KehagiasIoannis, LeotsinidisMichalis, KalfarentzosFotis, AlexandridesTheodore K

Improved obesity treatment

Laparoscopic Roux-en-Y gastric bypass (LRYGBP) is a common surgery for severe obesity. Weight loss after this surgery is linked to changes in gut hormones, which affect metabolism and appetite. This study aimed to determine if removing a portion of the stomach (gastric fundus resection) during LRYGBP would improve weight loss, blood sugar control, and hormone levels.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Laparoscopic Roux-en-Y gastric bypass vs. laparoscopic sleeve gastrectomy for morbid obesity and diabetes mellitus: a meta-analysis of sixteen recent studies.

Author: LiPing, FuPing, ChenJie, WangLiu-Hua, WangDao-Rong

Excess weight loss
Resolve diabetes mellitus
Resolve hypertension

LRYGB is more effective than LSG in resolving diabetes mellitus and excess weight loss at 12 months, with a similar effect in resolving hypertension.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

16.

Banded Roux-en-Y gastric bypass for the treatment of morbid obesity.

Author: HeneghanHelen M, AnnaberdyevShorat, EldarShai, RogulaTomasz, BrethauerStacy, SchauerPhilip

Laparoscopic Roux-en-Y gastric bypass
Morbid obesity

Laparoscopic Roux-en-Y gastric bypass (LRYGB) is the most effective treatment for morbid obesity. This study compares outcomes of LRYGB with and without a nonadjustable band placed around the pouch to determine if banding provides additional benefits.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Comparison of the long-term results of Roux-en-Y gastric bypass and sleeve gastrectomy for morbid obesity: a systematic review and meta-analysis of randomized and nonrandomized trials.

Author: LiJian-Fang, LaiDan-Dan, LinZhi-Hong, JiangTian-Ye, ZhangAi-Min, DaiJian-Feng

Resolution of comorbidities
Complications
Reoperation

A meta-analysis of 32 studies comparing Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) for the treatment of morbid obesity found that RYGB was more effective than SG in resolving type 2 diabetes mellitus, hypertension, hypercholesterolemia, gastroesophageal reflux disease, and arthritis. However, RYGB had a higher incidence of complications and reoperation, and a longer operation time than SG.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

The By-Band study: gastric bypass or adjustable gastric band surgery to treat morbid obesity: study protocol for a multi-centre randomised controlled trial with an internal pilot phase.

Author: RogersChris A, WelbournRichard, ByrneJames, DonovanJenny L, ReevesBarnaby C, WordsworthSarah, AndrewsRobert, ThompsonJanice L, RoderickPaul, MahonDavid, NobleHamish, KellyJamie, MazzaGraziella, PikeKatie, ParamasivanSangeetha, BlencoweNatalie, PerkinsMary, PorterTanya, BlazebyJane M

Improved quality of life
Weight loss

A randomized controlled trial will compare the effectiveness, cost-effectiveness, and acceptability of gastric band (Band) versus gastric bypass (Bypass) in adults with severe and complex obesity. The trial will test the hypotheses that Bypass is non-inferior to Band with respect to more than 50% excess weight loss and that Bypass is superior to Band with respect to health-related quality of life at three years.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Treating mood disorders in patients with a history of intestinal surgery: a systematic review.

Author: Lloret-LinaresCélia, BellivierFrank, HeronKyle, BessonMarie

Antidepressant treatment
Bariatric surgery weight loss
Adverse events
Antidepressant dosage variation
Psychological distress
Short bowel syndrome

This review explores the challenges of managing depression and anxiety in bariatric and short bowel syndrome (SBS) patients, focusing on the impact of surgery on drug absorption and metabolism.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

Revisional Roux-en-Y Gastric Bypass and Sleeve Gastrectomy: a Systematic Review of Comparative Outcomes with Respective Primary Procedures.

Author: MahawarKamal K, GrahamYitka, CarrWilliam R J, JenningsNeil, SchroederNorbert, BalupuriShlok, SmallPeter K

Revisional bariatric surgery

This review compares outcomes of revisional bariatric surgery with those of primary bariatric surgery. While primary bariatric surgery is well-established, revisional surgery is more controversial. The review examines the effectiveness and risks of revisional Roux-en-Y gastric bypass and revisional sleeve gastrectomy, comparing them to the respective primary procedures.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

Effect of sleeve gastrectomy on type 2 diabetes as an alternative treatment modality to Roux-en-Y gastric bypass: systemic review and meta-analysis.

Author: ChoJun-Min, KimHyun Jung, Lo MenzoEmanuele, ParkSungsoo, SzomsteinSamuel, RosenthalRaul J

T2D remission

SG has a similar effect on T2D remission as RYGB.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

Effect of probiotics on postoperative quality of gastric bypass surgeries: a prospective randomized trial.

Author: ChenJung-Chien, LeeWei-Jei, TsouJun-Juin, LiuTsang-Pai, TsaiPei-Ling

Improved quality of life
Postoperative GI episodes

This study found that administering probiotics or digestive enzymes to patients who have undergone gastric bypass surgery may improve symptomatic gastrointestinal episodes and improve quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Quality of Life 1 Year After Laparoscopic Sleeve Gastrectomy Versus Laparoscopic Roux-en-Y Gastric Bypass: a Randomized Controlled Trial Focusing on Gastroesophageal Reflux Disease.

Author: BiterL Ulas, van BuurenMichiel M A, MannaertsGuido H H, ApersJan A, DunkelgrünMartin, VijgenGuy H E J

Improved quality of life
Sustained weight loss
Gastroesophageal reflux

This study compared the quality of life (QOL) after laparoscopic sleeve gastrectomy (LSG) with that after laparoscopic Roux-en-Y gastric bypass (LRYGB), investigating the association with gastroesophageal reflux.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss at 5 Years Among Patients With Morbid Obesity: The SLEEVEPASS Randomized Clinical Trial.

Author: SalminenPaulina, HelmiöMika, OvaskaJari, JuutiAnne, LeivonenMarja, Peromaa-HaavistoPipsa, HurmeSaija, SoinioMinna, NuutilaPirjo, VictorzonMikael

Comorbidity resolution
Quality of life improvement
Weight loss
Morbidity

The study found that use of laparoscopic sleeve gastrectomy compared with use of laparoscopic Roux-en-Y gastric bypass did not meet criteria for equivalence in terms of percentage excess weight loss at 5 years.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Equivalence TrialA clinical trial designed to show that a new treatment is equivalent in efficacy/safety to an existing treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss in Patients With Morbid Obesity: The SM-BOSS Randomized Clinical Trial.

Author: PeterliRalph, WölnerhanssenBettina Karin, PetersThomas, VetterDiana, KröllDino, BorbélyYves, SchultesBernd, BeglingerChristoph, DreweJürgen, SchiesserMarc, NettPhilipp, BueterMarco

Comorbidity resolution
Weight loss
Gastric reflux

The study found that there was no significant difference in excess BMI loss between laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass at 5 years of follow-up after surgery.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Design of the Weight-loss Endoscopy Trial (WET): a multi-center, randomized, controlled trial comparing weight loss in endoscopically implanted duodenal-jejunal bypass liners vs. intragastric balloons vs. a sham procedure.

Author: HollenbachMarcus, PrettinChristiane, GundlingFelix, ScheppWolfgang, SeufertJochen, SteinJürgen, RöschThomas, AberleJens, FeisthammelJürgen, PetroffDavid, HoffmeisterAlbrecht

Weight loss
Complications
Side effects

A review of endoscopic procedures for obesity found that intragastric balloon (IB) and duodenal-jejunal bypass liner (DJBL) are less invasive and may be effective, but a randomized comparison between these devices has not been undertaken or shown to be superior to a sham procedure.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

27.

Efficacy and safety of one anastomosis gastric bypass versus Roux-en-Y gastric bypass for obesity (YOMEGA): a multicentre, randomised, open-label, non-inferiority trial.

Author: RobertMaud, EspalieuPhilippe, PelasciniElise, CaiazzoRobert, SterkersAdrien, KhamphommalaLita, PoghosyanTigran, ChevallierJean-Marc, MalherbeVincent, ChouillardElie, RecheFabian, TorciviaAdriana, Maucort-BoulchDelphine, Bin-DorelSylvie, Langlois-JacquesCarole, DelaunayDominique, PattouFrançois, DisseEmmanuel

Improved obesity treatment

This randomized trial (YOMEGA) compares the outcomes of one anastomosis gastric bypass (OAGB) versus standard Roux-en-Y gastric bypass (RYGB) for the treatment of morbid obesity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

28.

WEIGHT LOSS COMPARISON AFTER SLEEVE AND ROUX-EN-Y GASTRIC BYPASS: SYSTEMATIC REVIEW.

Author: BarrosFernando de, NegrãoMayara Galisse, NegrãoGiovana Galisse

Greater weight loss

This systematic review of 7 studies found that gastric bypass had a greater weight loss than vertical gastrectomy in all evaluated studies.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

29.

Diagnostic and Therapeutic Management of Post-Gastric Bypass Chronic Diarrhea: a Systematic Review.

Author: SollierCamille, BarsamianCharles, BretaultMarion, PoghosyanTigran, RahmiGabriel, ChevallierJean-Marc, BouillotJean-Luc, CaretteClaire, CzernichowSébastien, Rives-LangeClaire

Chronic diarrhea treatment
Gastric bypass

This systematic review explores the common side effect of chronic diarrhea following gastric bypass surgery, proposing a sequential approach to diagnose and treat potential causes, including bacterial overgrowth and pancreatic insufficiency.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

30.

Endoscopic Argon Plasma Coagulation vs. Multidisciplinary Evaluation in the Management of Weight Regain After Gastric Bypass Surgery: a Randomized Controlled Trial with SHAM Group.

Author: de QuadrosLuiz Gustavo, NetoManoel Galvão, MarchesiniJoão Caetano, TeixeiraAndré, GreccoEduardo, JuniorRoberto Luiz Kaiser, ZundelNatan, FilhoIdiberto José Zotarelli, de SouzaThiago Ferreira, FilhoAdmar Concon, da SilvaLyz Bezerra, RamosAlmino Cardoso, FerrazÁlvaro Antônio Bandeira, CamposJosemberg Marins

Improved obesity treatment

This study investigates the use of argon plasma coagulation (APC) for narrowing the anastomosis in patients who have undergone Roux-en-Y gastric bypass surgery and experienced weight loss relapse.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

31.

Laparoscopic roux-en-Y gastric bypass versus sleeve gastrectomy for teenagers with severe obesity - TEEN-BEST: study protocol of a multicenter randomized controlled trial.

Author: BonouvrieDaniëlle S, BeamishAndrew J, LeclercqWouter K G, van MilEdgar G A H, LuijtenArijan A P M, HazebroekEric J, VreugdenhilAnita C E, OlbersTorsten, van DielenFrançois M H

Bariatric surgery for adolescents
Lack of long-term data
No RCT comparing SG and RYGB

Recent data support the use of bariatric surgery in adolescents with severe obesity following unsuccessful non-surgical treatments. Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) have demonstrated reasonably similar weight loss and reduction of obesity related comorbidities in randomized trials in adults. SG has internationally become the most commonly used procedure in adolescents, yet long-term outcome data are lacking. No randomized controlled trial comparing SG and RYGB has been performed in adolescents.

Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

32.

Revision procedures after initial Roux-en-Y gastric bypass, treatment of weight regain: a systematic review and meta-analysis.

Author: KermansaraviMohammad, Davarpanah JaziAmir Hossein, Shahabi ShahmiriShahab, EghbaliFoolad, ValizadehRohollah, RezvaniMasoud

Obesity treatment
Weight loss
Weight regain

This systematic review examined various revision procedures for patients who experienced weight regain or weight loss failure after Roux-en-Y gastric bypass surgery. DRGB and BPD-DS/SADI-S emerged as potentially more effective procedures for long-term weight management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Methodological issues in assessing change in dietary intake and appetite following gastric bypass surgery: A systematic review.

Author: RedpathTamsyn L, LivingstoneM Barbara E, DunneAoibheann A, BoydAdele, le RouxCarel W, SpectorAlan C, PriceRuth K

Obesity treatment
Inconsistent findings

This systematic review evaluates the current literature on changes in dietary intake and appetite following gastric bypass surgery, finding that only a reduction in overall energy intake and an increase in postprandial satiety are maintained beyond 6-month post-surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

34.

Endoscopic revision of gastrojejunal anastomosis for the treatment of dumping syndrome in patients with Roux-en-Y gastric bypass: a systematic review and meta-analysis.

Author: BazarbashiAhmad Najdat, DolanRussell D, McCartyThomas R, JirapinyoPichamol, ThompsonChristopher C

Dumping syndrome treatment

Endoscopic gastrojejunal anastomosis (GJA) revision is a potential treatment option for patients with dumping syndrome after Roux-en-Y gastric bypass (RYGB).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

35.

Treatment Options for Weight Regain or Insufficient Weight Loss After Sleeve Gastrectomy: a Systematic Review and Meta-analysis.

Author: FrankenRutger J, SluiterNina R, FrankenJosephine, de VriesRalph, SouvereinDennis, GerdesVitor E A, de BrauwMaurits

Effective treatment
Weight loss
Complications

This meta-analysis evaluated the effectiveness of various revisional strategies for weight regain or insufficient weight loss after sleeve gastrectomy (SG). The analysis found that all techniques resulted in weight loss, but revisional OAGB appeared to be the most effective, although more research is needed to confirm this.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

36.

Systematic review on sleeve gastrectomy or Roux-en-Y gastric bypass surgery for refractory gastroparesis.

Author: MascleeGwen M C, KeszthelyiDaniel, ConchilloJosé M, KruimelJoanna W, BouvyNicole D, MascleeAd A M

Gastric emptying
Symptom improvement

Sleeve gastrectomy and Roux-en-Y gastric bypass surgery may be effective for refractory gastroparesis after diet, prokinetics, and long-term nutritional support have failed. A systematic review of 19 studies showed symptom improvement and gastric emptying in patients who underwent these procedures.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

37.

Gastric cancer after Bariatric Bypass Surgery. Do they relate? (A Systematic Review).

Author: DoukasSotirios G, DoukasPanagiotis G, VageliDimitra P, BroderArkady

Morbid obesity treatment
Gastric cancer

This systematic review showed an increasing trend of gastric cancer cases after bariatric bypass surgery, suggesting the need for gastric cancer risk assessment and post-operative surveillance.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

38.

Efficacy and safety of revisional treatments for weight regain or insufficient weight loss after Roux-en-Y gastric bypass: A systematic review and meta-analysis.

Author: FrankenRutger J, FrankenJosephine, SluiterNina R, de VriesRalph, EuserSjoerd, GerdesVictor E A, de BrauwMaurits

Weight loss
Complications

This systematic review and meta-analysis evaluated the effectiveness of different revisional techniques for addressing weight regain or inadequate weight loss after Roux-en-Y gastric bypass surgery. The review found that all techniques resulted in short-term weight loss, with surgical revisions leading to greater long-term weight loss but also higher complication rates.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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