Side Effects of gatifloxacin ophthalmic: A Synthesis of Findings from 1 Studies

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Original Abstract of the Article

Main Research Findings

This systematic review investigated the benefits and harms of folic acid and folinic acid in reducing the mucosal, gastrointestinal, hepatic, and hematologic side effects of methotrexate (MTX) in patients with rheumatoid arthritis (RA) receiving MTX, and assessed whether folic or folinic acid supplementation had any effect on MTX benefit. Six double-blind, randomized, placebo-controlled clinical trials (624 patients) were included in the analysis, and supplementation with either folic acid or folinic acid showed beneficial effects in reducing the side effects of MTX.

Reasons for Side Effects

Methotrexate works by inhibiting folate metabolism in the body. Therefore, supplementing with folic acid or folinic acid is believed to reduce the side effects of methotrexate.

Common Side Effects

Gastrointestinal Side Effects

The study showed that supplementation with folic acid or folinic acid reduced the incidence of gastrointestinal side effects (such as nausea, vomiting, or abdominal pain) due to methotrexate by 26%.

Hepatic Side Effects

Supplementation with folic acid or folinic acid was reported to reduce elevated serum transaminase levels caused by methotrexate by 76.9%.

Side Effect Management

Gastrointestinal Side Effects

Supplementation with folic acid or folinic acid can reduce gastrointestinal side effects.

Hepatic Side Effects

Supplementation with folic acid or folinic acid can reduce hepatic side effects.

Comparison Between Studies

Commonalities Among Studies

All studies showed that supplementation with folic acid or folinic acid reduced the side effects of methotrexate.

Differences Among Studies

No difference in effectiveness between folic acid and folinic acid was observed. Also, differences in the incidence of side effects and the magnitude of the reduction effect were found among studies.

Implications for Everyday Life

If you are taking methotrexate, you need to consult your doctor and get instructions on supplementing with folic acid or folinic acid. It is important not to start supplementing on your own or adjust the dosage without consulting your doctor.

Limitations of Current Research

Since all participants in this paper were RA patients, the effects of folic acid or folinic acid supplementation on methotrexate use in other diseases are unknown.

Future Research Directions

Research on the effects of folic acid or folinic acid supplementation on methotrexate use in diseases other than RA and at different MTX dosages needs to be conducted.

Conclusion

This paper showed that supplementation with folic acid or folinic acid in RA patients taking methotrexate reduced gastrointestinal and hepatic side effects and promoted continuation of MTX treatment. It is important to consult your doctor and get instructions on supplementing with folic acid or folinic acid if you are taking methotrexate.

Keywords
Benefit Keywords
Reduces GI side effects
Reduces hepatic dysfunction
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Risk Keywords
Literature analysis of 1 papers
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Negative Content
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Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.

Author: SheaBeverley, SwindenMichael V, GhogomuElizabeth Tanjong, OrtizZulma, KatchamartWanruchada, RaderTamara, BombardierClaire, WellsGeorge A, TugwellPeter

Reduces GI side effects
Reduces hepatic dysfunction

Folic acid or folinic acid supplementation while receiving methotrexate (MTX) therapy for rheumatoid arthritis (RA) reduced the incidence of gastrointestinal side effects by 26%, abnormal serum transaminase elevation by 76.9%, and discontinuation of MTX treatment for any reason by 60.8%.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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