Effective treatment of gluten sensitivity: A Synthesis of Findings from 17 Studies

  1. Home
  2. Effective treatment of gluten sensitivity
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effective treatment of gluten sensitivity: A Synthesis of Findings from 17 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effective treatment of gluten sensitivity: A Synthesis of Findings from 17 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Key Research Findings

Gluten sensitivity is a condition that affects individuals differently, ranging from digestive discomfort to more severe neurological symptoms. 6 Research indicates that consuming gluten can disrupt gut health, leading to digestive issues. 11 Moreover, studies suggest that gluten may influence brain function, potentially impacting motor skills. 11 Inflammation in the intestines, a common consequence of gluten sensitivity, can hinder nutrient absorption and lead to digestive issues. 16 The symptoms associated with gluten sensitivity vary from person to person, extending beyond digestive problems to include mental and neurological symptoms. 9 Due to the potential for mimicking other conditions, gluten sensitivity can be challenging to diagnose. 4

Treatment Summary

Currently, the most effective treatment for gluten sensitivity is a strict gluten-free diet (GFD). 2 While GFD is highly effective for celiac disease, it might not fully alleviate symptoms for everyone with gluten sensitivity. 2 To address this, new treatment options like enzyme therapy are being explored. 2 Enzyme therapy aims to break down gluten in the digestive tract, reducing its absorption into the bloodstream. 2 This approach holds promise for individuals who don't see sufficient improvement with GFD alone. 2 However, enzyme therapy is still under development, and further clinical trials are needed. 2

Benefits and Risks

Benefits Summary

Following a GFD can effectively manage gluten sensitivity and improve symptoms. 2 It also plays a role in preventing celiac disease. 2 Enzyme therapy shows potential as an effective treatment option for individuals who don't fully benefit from GFD. 2

Risks Summary

GFD can pose a risk of nutrient deficiencies due to its strict limitations. 2 The social and dietary restrictions associated with GFD can lead to psychological stress. 2 Enzyme therapy, being in its early stages of development, carries the potential for side effects. 2

Comparison Across Studies

Commonalities

Many studies highlight the individualized nature of gluten sensitivity, emphasizing that symptoms vary significantly among individuals. 4 Another common theme is the difficulty in diagnosing gluten sensitivity, as it can mimic other conditions and autoimmune disorders. 4

Differences

The recommended treatments for gluten sensitivity diverge across studies. 2 While numerous studies demonstrate the effectiveness of GFD, some research suggests that it might not provide complete symptom relief for everyone. 2 Newer treatment approaches, like enzyme therapy, are still in research phases, with their efficacy and safety yet to be fully established. 2

Consistency and Contradictions in Results

The research landscape for gluten sensitivity is still evolving, with limitations in the existing body of knowledge. 2 As a result, inconsistencies exist in the findings, highlighting the need for further investigation. 2

Practical Application and Considerations

For individuals diagnosed with gluten sensitivity, adhering to a strict GFD is crucial. 2 Given the strict dietary restrictions of GFD, seeking guidance from healthcare professionals is essential. 2 It's also important to be vigilant in avoiding any foods that may contain gluten. 2 As gluten sensitivity symptoms vary, finding the right treatment plan is vital. 4 Consult with a healthcare provider to determine the best course of action for your specific needs. 4

Limitations of Current Research

Current research on gluten sensitivity is still limited. 2 Significant gaps remain in understanding the mechanisms underlying gluten sensitivity and in developing effective treatments beyond GFD. 2

Future Research Directions

Further research is needed to unravel the mechanisms behind gluten sensitivity. 2 Developing treatments beyond GFD, such as alternative therapies or targeted approaches, is crucial. 2

Conclusion

Gluten sensitivity has emerged as a significant health concern, with a wide range of symptoms affecting individuals differently. 4 A strict GFD is the mainstay of treatment for gluten sensitivity, but it may not always provide complete symptom relief. 2 New therapies like enzyme therapy hold potential for those who don't see full improvement with GFD. 2 While more research is necessary, advancements in understanding gluten sensitivity and its treatment are promising. 2 If you suspect you may have gluten sensitivity, consult a healthcare professional for proper diagnosis and management. 4

Treatment List

Gluten-free diet (GFD) 2 Enzyme therapy 2

Literature analysis of 17 papers
Positive Content
14
Neutral Content
1
Negative Content
2
Article Type
1
0
0
5
16
1.

Evaluation of Non-Celiac Gluten Sensitivity in Patients with Previous Diagnosis of Irritable Bowel Syndrome: A Randomized Double-Blind Placebo-Controlled Crossover Trial.

Author: BaroneMichele, GemelloEugenio, ViggianiMaria Teresa, CristoforiFernanda, RennaCaterina, IannoneAndrea, Di LeoAlfredo, FrancavillaRuggiero

Improved NCGS diagnosis

This study investigated the diagnostic criteria for non-celiac gluten sensitivity (NCGS) in patients with a previous diagnosis of irritable bowel syndrome (IBS). The study found that a low FODMAP-gluten-free diet followed by a gluten/placebo challenge could better identify patients with NCGS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Effective Degradation of Gluten and Its Fragments by Gluten-Specific Peptidases: A Review on Application for the Treatment of Patients with Gluten Sensitivity.

Author: DunaevskyYakov E, TereshchenkovaValeriia F, BelozerskyMikhail A, FilippovaIrina Y, OppertBrenda, ElpidinaElena N

CD treatment
Gluten sensitivity

This narrative review examines the current treatment options for celiac disease, an autoimmune disorder triggered by gluten consumption. While a gluten-free diet is the cornerstone of management, enzyme therapy, involving the intake of peptidases to digest gluten peptides, shows promise as a supplemental treatment, potentially improving symptom control and enhancing quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Treatment of Neurological Manifestations of Gluten Sensitivity and Coeliac Disease.

Author: ZisPanagiotis, HadjivassiliouMarios

Improved neurological manifestations

Gluten-related disorders, such as coeliac disease and gluten sensitivity, can cause a range of neurological problems, including ataxia and peripheral neuropathy. A strict gluten-free diet is the most effective treatment, though some patients may require additional immunosuppressive treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

The perspective of celiac disease patients on emerging treatment options and non-celiac gluten sensitivity.

Author: GreuterThomas, SchmidlinSandra, LattmannJaqueline, StotzMatthias, LehmannRomina, ZeitzJonas, ScharlMichael, MisselwitzBenjamin, PohlDaniel, FriedMichael, TutuianRadu, FasanoAlessio, SchoepferAlain M, RoglerGerhard, BiedermannLuc, VavrickaStephan R

Emerging treatments
NCGS concerns

This study surveyed Celiac disease (CeD) patients in Switzerland to assess their perceptions of non-celiac gluten sensitivity (NCGS) and emerging treatment options for CeD. The study found that perception of and attitude towards NCGS differed depending on sex, age and prior use of alternative medicine. Knowledge of the progress towards emerging treatment options was also limited.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Gluten Sensitivity Underlying Resistant "Laryngopharyngeal Reflux" Symptoms and Signs.

Author: BalouchBailey, MelleyLauren E, YeakelHeather, RanjbarParastou Azadeh, TongJane, EichornDaniel, AlnouriGhiath, BrennanMatthew, TranQuynh, SataloffRobert T

Gluten-free diet
LPR symptom relief
Gluten sensitivity
Laryngopharyngeal reflux

This study investigates the relationship between gluten sensitivity and laryngopharyngeal reflux (LPR), evaluating reflux finding score (RFS) improvement and symptom improvement following gluten elimination in patients with resistant LPR.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Effects of a Gluten-Free Diet in a Teenager Presenting With Psychosis.

Author: SelmiOlfa, KhalidBanan, Al-NuaimiSaleem

GFD
Gluten sensitivity
Psychiatric symptoms

Nonceliac gluten sensitivity (NCGS) can present with gastrointestinal and psychiatric symptoms. This case report describes a 15-year-old girl with anxiety and paranoid delusion who showed significant improvement after starting a gluten-free diet.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

10.

Nonceliac gluten sensitivity.

Author: CatassiCarlo, CatassiGiulia, NaspiLoris

Improved IBS symptoms
NCWS

Non-celiac wheat sensitivity (NCWS) is characterized by variable symptoms including irritable bowel syndrome (IBS)-like manifestations. A biomarker is still lacking, but the gluten-free diet (GFD) has proven effective in treating a significant proportion of NCWS-related IBS patients.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Immunologic profiling in schizophrenia and rheumatoid arthritis.

Author: EatonWilliam W, RodriguezKatrina M, ThomasMekha A, JohnsonJeanette, TalorMonica V, DohanCurtis, BinghamClifton O, MusciRashelle, RothKimberly, KellyDeanna L, CihakovaDaniela, DarrahErika

Cytokine-targeted treatment strategies
Stratification of SCZ patients

This study investigates the relationship between schizophrenia (SCZ) and rheumatoid arthritis (RA). It found that individuals with both SCZ and RA share specific genetic markers and cytokine profiles. The study suggests that identifying unique SCZ subgroups based on cytokine profiles could improve targeted treatment strategies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Gluten Induces Subtle Histological Changes in Duodenal Mucosa of Patients with Non-Coeliac Gluten Sensitivity: A Multicentre Study.

Author: RostamiKamran, EnsariArzu, MarshMichael N, SrivastavaAmitabh, VillanacciVincenzo, CarroccioAntonio, Asadzadeh AghdaeiHamid, BaiJulio C, BassottiGabrio, BecheanuGabriel, BellPhoenix, Di BellaCamillo, BozzolaAnna Maria, CadeiMoris, CasellaGiovanni, CatassiCarlo, CiacciCarolina, Apostol CiobanuDelia Gabriela, CrossSimon S, DanciuMihai, DasPrasenjit, Del SordoRachele, DrageMichael, ElliLuca, FasanoAlessio, FlorenaAda Maria, FuscoNicola, GoingJames J, GuandaliniStefano, HagenCatherine E, HaymanDavid T S, IshaqSauid, JerichoHilary, JohncillaMelanie, JohnsonMatt, KaukinenKatri, LeveneAdam, LiptrotSarah, LuLaura, MakhariaGovind K, MathewsSherly, MazzarellaGiuseppe, MaximRoxana, La Win MyintKhun, Mohaghegh-ShalmaniHamid, MoradiAfshin, MulderChris J J, RayRonnie, RicciChiara, Rostami-NejadMohammad, SaponeAnna, SandersDavid S, TaavelaJuha, VoltaUmberto, WalkerMarjorie, DerakhshanMohammad

Gluten sensitivity
NCGS

This study investigates histological changes in the duodenal mucosa of patients with non-coeliac gluten sensitivity (NCGS) compared to controls and celiac disease (CeD). The results show that NCGS is associated with distinct histological changes, including shorter villus height and increased intraepithelial lymphocyte (IEL) density, even in the absence of overt villous atrophy. These findings suggest that NCGS involves an intestinal response to gluten, even at early stages.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

17.

[Cereal related complaints in children].

Author: VerheggenT P, Van VeenL N, De GrootH

Wheat allergy prevention
Gluten-free diet harm

This article provides information on gluten, cereals, grasses, and their cross-reactivity to help address common questions about gluten sensitivity and wheat allergies. It outlines the differences between celiac disease, gluten sensitivity, and IgE-mediated wheat allergy, and describes diagnostics, treatment, and natural history of each condition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Dutch

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.