Major Research Findings

Grape seed extract has been shown to have a wide range of biological effects, including promoting bone health, inhibiting angiogenesis, protecting against heart damage, and possessing anticoagulant/antiplatelet properties. It has also been shown to have anti-inflammatory, anti-ulcer, and antioxidant properties, as well as protecting against various drug and chemical-induced toxicities. , , , , 1 , , , , , , , , , , 3 , , , , , , , , , 2 , , ,

Reasons for Side Effects

Grape seed extract is generally considered safe, but some people may experience side effects. Side effects are thought to be caused by the ingredients in grape seed extract, such as polyphenols, which can cause various reactions in the body.

Common Side Effects

Digestive System

Taking grape seed extract can cause digestive symptoms such as stomach pain, diarrhea, and constipation.

Allergy

Grape seed extract can cause allergic reactions in people who are allergic to grapefruit. 2

Others

Taking grape seed extract can cause symptoms such as headache, dizziness, nausea, and fatigue. , 2

Countermeasures for Side Effects

Digestive System

If you experience digestive symptoms such as stomach pain, reduce your intake or stop taking grape seed extract temporarily.

Allergy

If you are allergic to grapefruit, avoid taking grape seed extract. 2

Others

If you experience symptoms such as headache or dizziness, reduce your intake or stop taking grape seed extract temporarily. If your symptoms do not improve, consult a doctor. , 2

Comparison Between Studies

Commonalities

Many studies have shown that grape seed extract has various health benefits. In particular, antioxidant and anti-inflammatory effects have attracted attention.

Differences

Studies have reported different effects and side effects of grape seed extract. This is thought to be because the type, extraction method, and dosage of grape seed extract used in the studies differ.

Points to Note Regarding Application to Real Life

While grape seed extract is sold as a health food, it is important to consult with your doctor before taking it. In particular, pregnant or breastfeeding women and those undergoing medical treatment should refrain from taking it.

Limitations of Current Research

The effects and side effects of grape seed extract are not yet fully understood. More research is needed.

Future Research Directions

Large-scale clinical trials are needed to investigate the effects of grape seed extract on the human body. In addition, component analysis and research into the mechanism of action are important for a more detailed understanding of the effects and side effects of grape seed extract.

Conclusion

Grape seed extract is expected to have various health benefits. However, there is a possibility of side effects. When taking grape seed extract, it is important to consult a doctor and take the appropriate amount.