Main Research Findings

Several studies have shown that various plant-derived ingredients and treatments are effective in hair regeneration and hair loss treatment. For example, a study in demonstrated that Solanum chrysotrichum extract is as effective as ketoconazole in treating dandruff. Additionally, a study in suggests the potential of Aristotelia chilensis extract for antioxidant and hair growth promotion. A review in 4 highlights the potential effectiveness of various plant-derived ingredients and treatments in preventing androgenetic alopecia.

Reasons for Side Effects

These studies have reported some side effects along with the effectiveness of plant-derived ingredients and treatments. Side effects may vary depending on the ingredients and dosage of plant-derived ingredients, as well as individual constitutions. The incidence and severity of side effects may also differ depending on the treatment method. For example, a study in reported skin inflammation and endometrial hyperplasia as side effects in dogs with congenital growth hormone deficiency treated with medroxyprogesterone acetate. This is believed to be caused by medroxyprogesterone acetate affecting hormone balance.

Common Side Effects

Skin Inflammation

A study in reported skin inflammation as a side effect in dogs with congenital growth hormone deficiency treated with medroxyprogesterone acetate. Medroxyprogesterone acetate can affect hormone balance, potentially causing skin inflammation.

Endometrial Hyperplasia

A study in reported endometrial hyperplasia as a side effect in dogs with congenital growth hormone deficiency treated with medroxyprogesterone acetate. Medroxyprogesterone acetate can affect hormone balance, potentially causing endometrial hyperplasia.

Gastrointestinal Symptoms

A study in reported dysphagia, burning sensation, lip swelling, and gastrointestinal discomfort as side effects following topical cyclosporine administration. Cyclosporine is an immunosuppressant that can affect the gastrointestinal system.

Headache

A study in 2 reported headache as a side effect when using light therapy for seasonal affective disorder. Light therapy regulates the body clock by shining light into the eyes, but can cause side effects such as headaches.

Eye Strain

A study in 2 reported eye strain as a side effect when using light therapy for seasonal affective disorder. Light therapy regulates the body clock by shining light into the eyes, but can cause side effects such as eye strain.

Nausea

A study in 2 reported nausea as a side effect when using light therapy for seasonal affective disorder. Light therapy regulates the body clock by shining light into the eyes, but can cause side effects such as nausea.

Insomnia

A study in 2 reported insomnia as a side effect when using light therapy for seasonal affective disorder. Light therapy regulates the body clock by shining light into the eyes, but can cause side effects such as insomnia.

Hyperactivity

A study in 2 reported hyperactivity as a side effect when using light therapy for seasonal affective disorder. Light therapy regulates the body clock by shining light into the eyes, but can cause side effects such as hyperactivity.

Other Side Effects

A study in reported monocytosis in the spleen, elevated serum interleukin-6, and lesions in the skin, liver, and kidneys as side effects of tetra-arsenic tetrasulfide. A study in reported frontal alopecia as a side effect of hyperprolactinemia.

Side Effect Countermeasures

Skin Inflammation Countermeasures

A study in reported skin inflammation as a side effect in dogs with congenital growth hormone deficiency treated with medroxyprogesterone acetate. Countermeasures for skin inflammation include proper moisturizing, maintaining cleanliness, and avoiding irritating substances. Consult a doctor if symptoms are severe.

Endometrial Hyperplasia Countermeasures

A study in reported endometrial hyperplasia as a side effect in dogs with congenital growth hormone deficiency treated with medroxyprogesterone acetate. Countermeasures for endometrial hyperplasia include regular gynecological checkups and considering contraception methods. Consult a doctor if symptoms are severe.

Gastrointestinal Symptoms Countermeasures

A study in reported dysphagia, burning sensation, lip swelling, and gastrointestinal discomfort as side effects following topical cyclosporine administration. Countermeasures for gastrointestinal symptoms include paying attention to diet, avoiding irritants, chewing thoroughly and eating slowly. Consult a doctor if symptoms are severe.

Headache Countermeasures

A study in 2 reported headache as a side effect when using light therapy for seasonal affective disorder. Countermeasures for headache include shortening the irradiation time of light therapy, reducing the irradiation intensity, and staying adequately hydrated. Consult a doctor if symptoms are severe.

Eye Strain Countermeasures

A study in 2 reported eye strain as a side effect when using light therapy for seasonal affective disorder. Countermeasures for eye strain include shortening the irradiation time of light therapy, reducing the irradiation intensity, and resting your eyes. Consult a doctor if symptoms are severe.

Nausea Countermeasures

A study in 2 reported nausea as a side effect when using light therapy for seasonal affective disorder. Countermeasures for nausea include shortening the irradiation time of light therapy, reducing the irradiation intensity, and avoiding being on an empty stomach. Consult a doctor if symptoms are severe.

Insomnia Countermeasures

A study in 2 reported insomnia as a side effect when using light therapy for seasonal affective disorder. Countermeasures for insomnia include shifting the light therapy irradiation time to early morning, reducing the irradiation intensity, and relaxing before bedtime. Consult a doctor if symptoms are severe.

Hyperactivity Countermeasures

A study in 2 reported hyperactivity as a side effect when using light therapy for seasonal affective disorder. Countermeasures for hyperactivity include shortening the irradiation time of light therapy, reducing the irradiation intensity, and adjusting exercise levels. Consult a doctor if symptoms are severe.

Comparison Between Studies

Commonalities

Multiple studies have shown the potential effectiveness of plant-derived ingredients and treatments for hair regeneration and hair loss. Also, multiple side effects are reported. However, the incidence and severity of side effects may vary between studies.

Differences

The diseases, treatments, and evaluation items are different in each study, making it difficult to compare the results. For example, focuses on the treatment of dandruff, while 7 focuses on the treatment of androgenetic alopecia. Additionally, shows that Solanum chrysotrichum extract is as effective as ketoconazole, while 4 suggests the potential effectiveness of various plant-derived ingredients and treatments in preventing androgenetic alopecia. More research is needed to comprehensively assess these findings.

Precautions for Real-Life Application

Plant-derived ingredients and treatments, while potentially beneficial, also carry the risk of side effects. Therefore, it is crucial to consult a doctor and choose a suitable method for you, rather than making decisions independently. Before starting any treatment, it is important to fully understand the ingredients, usage, and potential side effects. This is especially important for pregnant women, breastfeeding mothers, and people with pre-existing medical conditions. Consult your doctor before using any treatment.

Current Research Limitations

Research on hair regeneration and hair loss treatment is still insufficient. In particular, there are limited studies evaluating the efficacy and safety of plant-derived ingredients. Therefore, more research is necessary to ensure the safe and effective use of these ingredients.

Future Research Directions

To evaluate the efficacy and safety of plant-derived ingredients and treatments, more long-term clinical trials with larger patient populations are needed. Research into identifying the active ingredients and mechanisms of action of these components is also important. Additionally, research focused on reducing the risk of side effects is necessary.

Conclusion

Plant-derived ingredients and treatments hold potential promise for hair regeneration and hair loss treatment. However, there are risks of side effects associated with their use. Therefore, it is vital to consult a doctor and make informed decisions about treatment options, rather than relying solely on self-assessment. We hope these research findings contribute to expanding hair regeneration and hair loss treatment options, benefiting a wider range of patients.