Side Effects of hawthorn: A Synthesis of Findings from 25 Studies

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Original Abstract of the Article

Major Research Findings

Hawthorn is a herb that has been traditionally used for its potential benefits in preventing and treating heart disease. 1 、 10 、 7 、 8 Research has shown that hawthorn extracts may have positive effects on heart health, such as improving heart function, lowering blood pressure, and reducing the risk of blood clots. 5 、 17 、 9 、 7 Additionally, hawthorn has shown antioxidant and anti-inflammatory properties, and it may also potentially help fight cancer cells. 7 、 8

Reasons for Side Effects

The exact mechanisms causing side effects from hawthorn are still being studied. However, it's suspected that certain components in hawthorn might interact with specific enzymes and receptors in the body, potentially leading to adverse reactions.

Common Side Effects

Digestive System

Taking hawthorn might result in digestive system side effects such as stomach upset, nausea, vomiting, and diarrhea. 12

Nervous System

Hawthorn can potentially influence the nervous system, causing side effects like dizziness, headache, and drowsiness. 3

Allergy

Hawthorn has the potential to trigger allergic reactions, which may manifest as skin rash, itching, and difficulty breathing. 14 Individuals with hawthorn allergies should avoid consuming it.

Countermeasures for Side Effects

Digestive System Side Effects

To mitigate digestive side effects, it's recommended to start with a small amount of hawthorn and gradually increase the dosage. Moreover, consuming it alongside meals might help reduce these side effects.

Nervous System Side Effects

To minimize nervous system side effects, it's advised to avoid driving or operating heavy machinery after taking hawthorn. Additionally, if you experience drowsiness, resting is recommended.

Allergy

If you have a hawthorn allergy, it's crucial to avoid taking it altogether. In case of experiencing any allergic symptoms, promptly seek medical attention.

Comparison between Studies

Commonalities of Studies

A common thread running through many studies is the recognition of hawthorn as an herb with potential benefits in preventing and treating heart disease. Another shared finding is that hawthorn is generally considered a safe herb.

Differences between Studies

Research on hawthorn's effects and side effects is still ongoing and incomplete. Consequently, there's variability in research findings. For instance, studies may present differing results regarding the amount of hawthorn required for effectiveness and the associated risk of side effects.

Precautions for Applying to Real Life

While hawthorn holds promise for preventing and treating heart disease, it's important to remember that research is still ongoing. Therefore, consulting with your doctor before taking hawthorn is advisable, especially if you are pregnant, breastfeeding, or currently taking other medications.

Limitations of Current Research

Research on hawthorn remains in its early stages and possesses limitations. For example, a complete understanding of hawthorn's active ingredients, mechanisms of action, and the mechanisms behind its side effects is still lacking. Additionally, many studies on hawthorn's effects and side effects have been conducted on a smaller scale, necessitating caution before generalizing their findings.

Future Research Directions

Further research on the effectiveness and safety of hawthorn is essential. Specifically, large-scale clinical trials are needed to establish the optimal dosage for hawthorn's effectiveness and to determine the associated risk of side effects. Basic research is equally important to gain a deeper understanding of hawthorn's active ingredients, mechanisms of action, and the mechanisms behind its side effects.

Conclusion

Hawthorn is an herb that holds potential for preventing and treating heart disease, but further research is needed. It's crucial to consult your doctor before using hawthorn, particularly if you are pregnant, breastfeeding, or taking other medications.

Literature analysis of 25 papers
Positive Content
22
Neutral Content
0
Negative Content
3
Article Type
3
0
1
7
25
2.

Phytochemicals from traditional medicinal plants used in the treatment of diarrhoea: modes of action and effects on intestinal function.

Author: PalomboEnzo A

Antidiarrhoeal activity
Potential toxicity

Medicinal plants have been used for thousands of years to treat various diseases. They can be effective in treating diarrhea by increasing water reabsorption in the colon, suppressing gut motility, and reducing electrolyte secretion. While tannins and flavonoids are thought to be the main active ingredients, some can be toxic. Clinical trials have shown minimal side effects, but further research is needed to ensure safety and effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence.

Author: SavageKaren, FirthJoseph, StoughCon, SarrisJerome

Anxiolytic effects
GABA modulation
Cognitive decrements
Withdrawal symptoms

This systematic review examined the anxiolytic effects of various phytomedicines and their interactions with the GABA system. Ten phytomedicines, including kava, valerian, pennywort, hops, chamomile, Ginkgo biloba, passionflower, ashwagandha, skullcap, and lemon balm, showed preclinical and clinical evidence for anxiolytic activity. These phytomedicines may offer a safe and effective alternative or adjunctive treatment option for anxiety disorders.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Traditional herbs: a remedy for cardiovascular disorders.

Author: RastogiSubha, PandeyMadan Mohan, RawatA K S

Cardiovascular disease treatment

This article explores the use of medicinal plants for the treatment of cardiovascular diseases. Traditional remedies derived from medicinal plants have been used for centuries, and renewed interest in natural products has led to a resurgence in their application.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

Protective effect of hawthorn extract against genotoxicity induced by methyl methanesulfonate in human lymphocytes.

Author: HosseinimehrSeyed Jalal, AzadbakhtMohammad, TanhaMohammad, MahmodzadehAziz, MohammadifarSohila

Reduced genotoxicity

Hawthorn fruit extract was found to protect human blood lymphocytes against genotoxicity induced by methyl methanesulfonate (MMS). The extract reduced the incidence of micronuclei in lymphocytes, suggesting its potential as a protective agent against genetic damage caused by harmful chemicals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Antithrombotic effects of ethanol extract of Crataegus orientalis in the carrageenan-induced mice tail thrombosis model.

Author: ArslanRana, BorZeynep, BektasNurcan, MeriçliAli Hikmet, OzturkYusuf

Cardiovascular disease treatment

Hawthorn, a medicinal plant with various constituents, shows potential for treating cardiovascular diseases. Its antithrombotic and thrombolytic properties offer a possible alternative to existing treatments with potential side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Nutraceutical support in heart failure: a position paper of the International Lipid Expert Panel (ILEP).

Author: CiceroArrigo F G, CollettiAlessandro, von HaehlingStephan, VinereanuDragos, Bielecka-DabrowaAgata, SahebkarAmirhossein, TothPeter P, ReinerŽeljko, WongNathan D, MikhailidisDimitri P, FerriClaudio, BanachMaciej,

Heart failure management

This expert opinion paper summarizes clinical evidence on the role of nutraceuticals in heart failure (HF) prevention and treatment. It suggests that hawthorn, coenzyme Q10, l-carnitine, d-ribose, carnosine, vitamin D, probiotics, n-3 PUFA, and beet nitrates may improve quality of life and functional parameters in HF patients, particularly in earlier stages.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

The chronic effects of a combination of herbal extracts (Euphytose<sup>&#174;</sup>) on psychological mood state and response to a laboratory stressor: A randomised, placebo-controlled, double blind study in healthy humans.

Author: DoddFiona, KennedyDavid, WightmanEmma, KhanJulie, PatanMichael, ElcoateRian, JacksonPhilippa

Reduced anxiety

Anxiety disorders are common, affecting approximately 16.6% of the population globally. Herbal approaches to reducing anxiety may be as effective as pharmacological treatments and are less likely to have adverse side effects. This review highlights the anxiolytic properties of valerian, passionflower, hawthorn, and ballota, which have a long history of use in traditional medicine.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Integrating supplementation in the management of patients with heart failure: an evidence-based review.

Author: RaddyshMikayla E, DelgadoDiego H

Disease progression slowed
Drug efficacy increased
Quality of life improved
Side effects reduced

This review explores the use of complementary, alternative, and integrative medicine (CAM) therapies in heart failure patients. While there is growing research, a gap exists between available knowledge and confident clinical recommendations regarding the efficacy and safety of these therapies for managing heart failure.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

16.

Kava for the treatment of generalised anxiety disorder (K-GAD): study protocol for a randomised controlled trial.

Author: SavageKaren M, StoughCon K, ByrneGerard J, ScholeyAndrew, BousmanChad, MurphyJenifer, MacdonaldPatricia, SuoChao, HughesMatthew, ThomasStuart, TeschkeRolf, XingChengguo, SarrisJerome

Reduced anxiety
Hepatotoxicity

This study investigates the efficacy and safety of kava (Piper methysticum) for treating generalized anxiety disorder (GAD). Kava has been shown to be a non-addictive, non-hypnotic anxiolytic with potential benefits for GAD. This study aims to assess the efficacy of a kava extract in a larger, longer-term study and investigate pharmacogenomic and neurobiological correlates of treatment response.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Oxaliplatin-induced changes in microbiota, TLR4+ cells and enhanced HMGB1 expression in the murine colon.

Author: StojanovskaVanesa, McQuadeRachel M, FraserSarah, PrakashMonica, GondaliaShakuntla, StavelyRhian, PalomboEnzo, ApostolopoulosVasso, SakkalSamy, NurgaliKulmira

Chemotherapy efficacy
Gastrointestinal inflammation
Immunosuppression

Oxaliplatin, a chemotherapy drug, causes changes in the gut microbiome, which may contribute to immunosuppression in the colon. The study found that oxaliplatin treatment increased the number of gram-negative bacteria and enhanced HMGB1 expression, a protein that triggers inflammation. These changes were associated with a reduction in macrophages and dendritic cells in the mesenteric lymph nodes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

The Patient Remote Intervention and Symptom Management System (PRISMS) - a Telehealth- mediated intervention enabling real-time monitoring of chemotherapy side-effects in patients with haematological malignancies: study protocol for a randomised controlled trial.

Author: BreenSibilah, RitchieDavid, SchofieldPenelope, HsuehYa-Seng, GoughKarla, SantamariaNick, KamaterosRose, MaguireRoma, KearneyNora, ArandaSanchia

Improved patient outcomes
Chemotherapy side effects

This paper presents the protocol for a Phase 3 multi-site randomized controlled trial evaluating a novel nurse-led Telehealth intervention for the remote monitoring and management of chemotherapy side-effects in patients with hematological malignancies. The study aims to improve patient outcomes, decrease morbidity, and limit hospital admissions by providing real-time monitoring and management of side-effects.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Towards equity: a qualitative exploration of the implementation and impact of a digital educational intervention for pharmacy professionals in England.

Author: LatifAsam, WaringJustin, PollockKristian, SolomonJosie, GulzarNargis, ChoudharyShahida, AndersonClaire

Medication problems

This study explores a new digital tool that helps patients manage their medications. The tool was designed to improve access to healthcare for people who are underserved by traditional healthcare systems.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Nutraceuticals and Dietary Supplements to Improve Quality of Life and Outcomes in Heart Failure Patients.

Author: CiceroArrigo F G, CollettiAlessandro

HF prevention
HF treatment

Heart failure (HF) is a condition that affects the heart's ability to pump blood effectively. Over 23 million people worldwide are affected by HF, which can occur due to various heart problems. Lifestyle changes and medications can help prevent HF, and certain supplements show promise in treating early stages of the disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

23.

Decoration of Material Surfaces with Complex Physicochemical Signals for Biointerface Applications.

Author: ShiYue, LiuKun, ZhangZhen, TaoXuelian, ChenHsien-Yeh, KingshottPeter, WangPeng-Yuan

Tissue regeneration
Immune responses

This review discusses the use of stimuli-presenting surfaces for biomaterial applications. The article describes different techniques for generating patterned surfaces with complex chemistries and topographies, which are beneficial for mimicking in vivo scenarios. The review highlights the challenges of creating such surfaces and explores the potential of these surfaces for biosensors, medical devices, and implants.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

24.

Albumin-stabilized layered double hydroxide nanoparticles synergized combination chemotherapy for colorectal cancer treatment.

Author: LiLi, QianYujin, SunLuyao, HanFelicity Y, ZhangRun, WangPeng-Yuan, XuZhi Ping

Inhibited tumor growth

This study developed a new nanomedicine system to simultaneously deliver two anti-tumor drugs, 5FU and ABX, for colorectal cancer treatment. The results suggest that this new approach may be a promising strategy for treating colorectal cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Mobile Health Intervention to Increase Oral Cancer Therapy Adherence in Patients With Chronic Myeloid Leukemia (The REMIND System): Clinical Feasibility and Acceptability Assessment.

Author: Pereira-SalgadoAmanda, WestwoodJennifer A, RussellLahiru, UgaldeAnna, OrtleppBronwen, SeymourJohn F, ButowPhyllis, CavedonLawrence, OngKevin, ArandaSanchia, BreenSibilah, KirsaSuzanne, DunlevieAndrew, SchofieldPenelope

CML Adherence
CML Self-Management

A mobile health system, REMIND, may be a useful tool to increase drug adherence and improve patient symptom self-management for those with chronic myeloid leukemia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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