Effects of heparin injection: A Synthesis of Findings from 29 Studies

  1. Home
  2. Effects of heparin injection
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of heparin injection: A Synthesis of Findings from 29 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of heparin injection: A Synthesis of Findings from 29 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Heparin injections are widely used to prevent and treat blood clots. However, they can have side effects such as bleeding, low platelet count, pain and bruising at the injection site. Research aims to find ways to reduce these side effects.

Studies like 24 and 22 suggest that injecting heparin slowly could reduce pain and bruising at the injection site. Additionally, applying cold before injection and pressure to the injection site may also reduce pain and bruising, as indicated by research in 16 and 12 . Further, suggests that a new method of injecting low-molecular-weight heparin could reduce bruising.

Studies 10 and 18 indicate that the way heparin is administered and the injection site can influence the frequency and severity of side effects. Research in 1 shows that even the type of heparin can affect the frequency of side effects.

Benefits and Risks

Benefit Summary

The primary benefit of heparin injections lies in their ability to prevent and treat blood clots. Heparin prevents blood from clotting, thus reducing the risk of heart disease and stroke. Appropriate administration can prevent serious complications from blood clots, preserving the health of the patient.

Risk Summary

The risks associated with heparin injections include bleeding, low platelet count, and pain or bruising at the injection site. These risks can vary depending on the dosage and method of administration. Individual differences in body constitution and health can also influence the likelihood and severity of side effects. Before receiving heparin injections, it is crucial to consult with a doctor or pharmacist, understand the risks and benefits, and proceed with caution.

Comparison Among Studies

Commonalities

Many studies have investigated ways to reduce side effects from heparin injections. Slowing down the injection, applying cold to the injection site, and applying pressure are commonly believed to be effective. Combining these methods may further reduce the likelihood of side effects.

Differences

It is impossible to directly compare study results because different studies utilize different types of heparin, methods of administration, side effect types and severity, and research participants and designs. These variations can influence the results. It is important to interpret each study's findings comprehensively and understand the risks and benefits of heparin injections.

Consistency and Contradictions in Results

Numerous studies have explored methods for mitigating side effects from heparin injections, but the findings exhibit both consistency and contradictions. For example, while studies 24 and 22 demonstrate the effectiveness of slowing down injections, study 3 did not find such an effect. This variability in results highlights the need for further research.

Considerations for Real-Life Application

Consult with a doctor or pharmacist before receiving heparin injections to thoroughly understand the risks and benefits. Proceed with caution and seek immediate medical attention if side effects occur. Proper administration techniques and careful monitoring can reduce the risk of adverse effects from heparin injections.

Limitations of Current Research

Many studies have limited sample sizes and different research designs, making it challenging to generalize their findings. Furthermore, the diverse conditions across studies, such as heparin type, administration method, and side effect types, make direct comparisons difficult. Additionally, the mechanisms behind side effects and methods to mitigate them are still not fully understood, necessitating further research.

Future Research Directions

Future research should involve larger sample sizes and more rigorous study designs. Studies should incorporate detailed considerations of heparin type, administration methods, and side effect types for a thorough understanding. Further research is crucial to elucidate the mechanisms behind side effects and uncover strategies for their mitigation.

Conclusion

Heparin injections are a valuable tool for preventing and treating blood clots, but they carry risks such as bleeding, low platelet count, and pain or bruising at the injection site. Proper administration techniques and careful monitoring are vital for minimizing these risks. It's essential to consult with a doctor or pharmacist before receiving heparin injections, fully understand the risks and benefits, and proceed with caution.

Literature analysis of 29 papers
Positive Content
23
Neutral Content
1
Negative Content
5
Article Type
4
5
5
2
29
1.

A comparison between subcutaneous low-dose sodium and calcium heparin. Prophylaxis of postoperative deep vein thrombosis and side effects of treatment.

Author: BergqvistD, HallböökT

Larger haematoma formation

Sodium heparin and calcium heparin were found to be equal in effect and side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Effect of syringe size on bruising following subcutaneous heparin injection.

Author: HadleyS A, ChangM, RogersK

Reduced induration
Smaller bruises

3-mL syringes are preferable to 1-mL syringes for heparin administration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Comparison of 3 methods to prevent pain and bruising after subcutaneous heparin administration.

Author: ŞendirMerdiye, BüyükyılmazFunda, ÇelikZuhal, Taşköprüİlknur

Reduced bruising
Reduced pain intensity

A subcutaneous heparin injection duration of 30 seconds combined with 5 minutes of local dry cold application before and after injection significantly decreased pain intensity and reduced the occurrence of bruising compared to a 10-second injection duration.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Mono-, di- and triacylglycerol concentrations in human plasma: effects of heparin injection and of a high-fat meal.

Author: FieldingB A, HumphreysS M, AllmanR F, FraynK N

Heparin injection significantly increases plasma monoacylglycerol concentration and decreases triacylglycerol concentration. A high-fat meal increases plasma di- and triacylglycerol concentrations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Effects of low-dose intravenous heparin therapy in aneurysmal subarachnoid hemorrhage: a randomized controlled clinical trial protocol.

Author: ZhangYifan, HuJiangang

Reduced CV
Bleeding

This study aims to compare the clinical outcomes of unfractionated heparin (UFH) and subcutaneous low-molecular-weight heparin (LMWH) in patients with subarachnoid hemorrhage caused by ruptured cerebral aneurysms. While subcutaneous heparin injection is considered safe and effective, there is no randomized clinical trial comparing UFH and LMWH injection in this population.

Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

The Impact of Heparin Therapy in Deceased Donors on Early Graft Survival for Kidney and Liver Recipients: A Clinical Trial Study.

Author: LatifiMarzieh, PourhoseinElahe, RahbanHabib, KhajaviMohammadreza, DehghaniSanaz

Graft survival

This study aimed to compare the effect of heparin therapy as a therapeutic dose after brain death confirmation on early graft survival in kidney and liver recipients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

A challenging case of heparin-induced skin necrosis without thrombocytopenia.

Author: ChidharlaAnusha, RapoportEliot A, NaffakhNoor, RobertsJonathan C

Skin necrosis

Heparin-induced skin necrosis (HISN) is a rare complication of heparin anticoagulation. This case report describes a patient who developed HISN while receiving therapeutic unfractionated heparin for a pulmonary embolism. The patient's symptoms resolved with the cessation of heparin and transition to bivalirudin. This case highlights the complex and variable presentation of HISN and underscores the need for careful monitoring of patients receiving heparin therapy.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Slow versus fast subcutaneous heparin injections for prevention of bruising and site pain intensity.

Author: MohammadyMina, RadmehrMaryam, JananiLeila

Heparin administration
Bruising
Haematoma
Pain

This review examines the impact of injection speed on pain, bruising, and hematoma formation after subcutaneous heparin injections. While previous studies have shown mixed results, this updated review indicates that faster injection speeds might increase the risk of pain, bruising, and hematoma formation at the injection site. This information is important for healthcare professionals to consider when administering heparin injections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

Influence of low-molecular-weight heparin injection sites on local bruising and pain: A systematic review and meta-analysis.

Author: LiYun, DongShujie, WangPanfeng, SunJianjun, JiangHua, LiuFang

Bruising
Haematoma
Pain

This systematic review and meta-analysis assessed the incidence and severity of bruising and pain after subcutaneous injection of low-molecular-weight heparin in different sites.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Statistical Analysis of Inter-attribute Relationships in Unfractionated Heparin Injection Problems.

Author: WangHaizhou, YangHui

Blood clotting prevention

This study examines the use of data-driven methods to solve problems related to unfractionated heparin (UFH), a drug commonly used to prevent blood clotting in intensive care units (ICUs). The study found that certain attributes in ICU time series data are highly related to UFH injection and can be used to help determine the optimal UFH injection policy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

12.

Effect of Cold Application on Bruising and Pain Following Heparin Subcutaneous Injection: A Systematic Review and Meta-Analysis.

Author: MohammadyMina, SadeghiNarges

Reduced hematoma
Reduced pain
Discomfort

Cold application for 3 to 5 minutes at the injection site before or after subcutaneous heparin administration is associated with less pain and fewer hematomas. Clinicians should consider patient comfort and minimize the duration of cold application if discomfort occurs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

Effects of rivaroxaban on activated clotting time in catheter ablation for atrial fibrillation in Chinese patients.

Author: SongqunHuang, ChunlingWang, ZhifuGuo, XinmiaoHuang, JiangCao

Atrial fibrillation ablation

This study aims to examine the determinants of heparin dosage in Chinese patients on rivaroxaban who are undergoing catheter ablation of atrial fibrillation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Effects of Vapocoolant Spray Prior to SC LMWH Injection: An Experimental Study.

Author: UnalNursemin, TosunBetul, AslanOzlem, TunayServet

Reduced pain
Vapocoolant spray effects

This randomized controlled study evaluated the effects of vapocoolant spray administration prior to subcutaneous (SC) low molecular weight heparin injection on local ecchymosis, hematoma, and pain. The study found that vapocoolant spray significantly reduced pain scores associated with heparin injections, suggesting a potential benefit for patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Subcutaneous Heparin Therapy for Patients with Cancer-Associated Stroke.

Author: KawanoHiroyuki, HondaYuko, AmanoTatsuo, OkanoHaruko, SuzukiRieko, ToriiMasataka, UnnoYoshiko, ShiokawaYoshiaki, HiranoTeruyuki

Cancer-associated stroke prevention
Anticoagulation therapy risk

This study examined the practical issues related to anticoagulation therapy and effects of subcutaneous heparin therapy for cancer-associated stroke.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

20.

Thrombodynamics-A new global hemostasis assay for heparin monitoring in patients under the anticoagulant treatment.

Author: BalandinaAnna N, SerebriyskiyIlya I, PoletaevAlexander V, PolokhovDmitry M, GrachevaMarina A, KoltsovaEkaterina M, VardanyanDavid M, TaranenkoIrina A, KrylovAlexey Yu, UrnovaEvdokiya S, LobastovKirill V, ChernyakovArtem V, ShulutkoElena M, MomotAndrey P, ShulutkoAlexander M, AtaullakhanovFazoil I

Heparin sensitivity assessment

Heparin therapy can lead to bleeding or thrombotic complications due to individual responses. The study aims to compare the sensitivity of a new thrombodynamics (TD) assay with other standard coagulation tests to better assess heparin's effect.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

A Case of Posterior Circulation Ischemic Stroke Caused by Heparin-Induced Thrombocytopenia after Detaining Hepatic Arterial Infusion Catheter.

Author: HirashitaKoji, MatsumotoAtsushi, YabunoSatoru, KandaTakahiro, YunokiMasatoshi, YoshinoKimihiro

HCC treatment
Posterior circulation ischemic stroke

This case report describes a 63-year-old man who developed posterior circulation ischemic stroke caused by heparin-induced thrombosis (HIT) after detaining a hepatic arterial infusion catheter for hepatocellular carcinoma (HCC) treatment.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

Slow versus fast subcutaneous heparin injections for prevention of bruising and site pain intensity.

Author: MohammadyMina, JananiLeila, Akbari SariAli

Reduced bruising
Reduced pain

Heparin, an anticoagulant drug, is typically injected subcutaneously, which can cause pain, bruising, and hematoma. The injection speed may influence these complications, but more research is needed to confirm this. This review summarizes previous studies and highlights the need for further investigation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

Venous thromboembolism after laparoscopic or robotic biliopancreatic diversion with duodenal switch. Ninety-days outcome of a 10 years' experience.

Author: HalawaniHamzeh M, Ripley-HagerCharis F, NaglakMary C, BonanniFernando, AntanaviciusGintaras

VTE risk

Biliopancreatic diversion with duodenal switch (BPD-DS) is a complex bariatric surgery with a risk of venous thromboembolism (VTE). More research is needed to understand the risk factors associated with VTE after BPD-DS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

24.

Slow versus fast subcutaneous heparin injections for prevention of bruising and site pain intensity.

Author: MohammadyMina, JananiLeila, Akbari SariAli

Heparin injection
Heparin injection complications

This review investigates the impact of injection speed on pain and bruising associated with subcutaneous heparin administration. While previous research has shown conflicting results, this review provides an updated analysis of the available evidence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

In vivo and in vitro performance of a China-made hemodialysis machine: a multi-center prospective controlled study.

Author: WangYong, ChenXiang-Mei, CaiGuang-Yan, LiWen-Ge, ZhangAi-Hua, HaoLi-Rong, ShiMing, WangRong, JiangHong-Li, LuoHui-Min, ZhangDong, SunXue-Feng

Dialysis performance
Malfunction rate

The in vivo performance of the SWS-4000 dialysis machine is roughly comparable to that of the Fresenius 4008 dialysis machine, but the malfunction rate of the former is higher.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

28.

Identifying optimal heparin management during cardiopulmonary bypass in obese patients: A prospective observational comparative study.

Author: HaasEmmanuel, FischerFrançois, LevyFrançois, DegirmenciSu-Emmanuelle, GrunebaumLelia, KindoMichel, CollangeOlivier, MertesPaul-Michel, SteibAnnick

Heparin regimen
Cardiac surgery
Obesity

The standard heparin regimen based on total body weight (TBW) during cardiopulmonary bypass (CPB) may lead to excessive heparin concentrations in obese patients. This can result in a significant intraoperative decrease in haemoglobin concentration. A revised heparin regimen based on ideal body weight may be more accurate.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.