Side Effects of hepatitis b vaccine: A Synthesis of Findings from 27 Studies

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Original Abstract of the Article

Major Research Findings

Multiple studies have revealed that the hepatitis B vaccine, while generally safe and effective, can cause various side effects, though they are rare. 25 reported a case of lupus panniculitis, a skin inflammation, recurring after receiving the hepatitis B vaccine. 21 found that the hepatitis B vaccine induced apoptosis (cell suicide) in mouse liver cells. 26 suggested that the hepatitis B vaccine might trigger neurological disorders like multiple sclerosis.

Reasons for Side Effects

Side effects of the hepatitis B vaccine are often associated with the components of the vaccine, particularly additives like aluminum. 21 found that aluminum-containing hepatitis B vaccines caused apoptosis in mouse liver cells. 1 suggested that vaccine additives could contribute to ASIA syndrome, an autoimmune disorder.

Common Side Effects

Local Side Effects

The injection site of the hepatitis B vaccine may experience pain, swelling, or redness. reported local reactions like discoloration, itching, and nodule formation at the injection site after intradermal administration of the hepatitis B vaccine. These reactions typically subside within a few days.

Systemic Side Effects

Fever, fatigue, headache, and muscle aches are some systemic symptoms that can occur after receiving the hepatitis B vaccine. 22 investigated the safety and immunogenicity of a modified hepatitis B vaccine and found that side effects were mild, with no systemic side effects reported.

Rare Side Effects

Rare side effects from the hepatitis B vaccine include lupus panniculitis, multiple sclerosis, and Guillain-Barré syndrome. 25 reported a case of lupus panniculitis recurring after receiving the hepatitis B vaccine. 26 suggested that the hepatitis B vaccine might trigger neurological disorders like multiple sclerosis. These side effects can improve with early treatment.

Measures for Side Effects

Measures for Local Side Effects

Applying a cold compress to the injection site can alleviate pain and swelling after receiving the hepatitis B vaccine. reported local reactions like discoloration, itching, and nodule formation at the injection site after intradermal administration of the hepatitis B vaccine. These reactions typically subside within a few days.

Measures for Systemic Side Effects

Rest and adequate hydration are crucial if you experience fever or fatigue after receiving the hepatitis B vaccine. 22 investigated the safety and immunogenicity of a modified hepatitis B vaccine and found that side effects were mild, with no systemic side effects reported. If symptoms are severe, consult a doctor.

Measures for Rare Side Effects

If you suspect rare side effects like lupus panniculitis, multiple sclerosis, or Guillain-Barré syndrome after receiving the hepatitis B vaccine, consult a doctor immediately. 25 reported a case of lupus panniculitis recurring after receiving the hepatitis B vaccine. 26 suggested that the hepatitis B vaccine might trigger neurological disorders like multiple sclerosis. These side effects can improve with early treatment.

Comparison between Studies

Commonalities between Studies

Many studies have concluded that the hepatitis B vaccine is safe and effective. 22 , 7 , 11 , 18 all confirmed the safety and efficacy of the hepatitis B vaccine.

Differences between Studies

The types and rates of side effects may vary between studies. 25 reported a case of recurring lupus panniculitis after receiving the hepatitis B vaccine, while other studies did not. reported local reactions at the injection site after intradermal administration of the hepatitis B vaccine, whereas other studies reported no systemic side effects. These differences may be attributed to variations in study populations, vaccine types, or administration methods.

Notes on Applying Research Findings in Real Life

The hepatitis B vaccine is a crucial tool for protecting against hepatitis B. 14 reported a decline in confidence in vaccines in China following media reports about infant deaths after receiving the hepatitis B vaccine. Vaccination is essential for maintaining a healthy lifestyle and protecting yourself from hepatitis B. 19 highlighted the low vaccination rates among dental surgeons in Benin City, Nigeria. The hepatitis B vaccine is particularly important for healthcare professionals. 5 suggested that the hepatitis B vaccine might have a role in treating glioblastoma. The hepatitis B vaccine holds potential for applications in various fields.

Limitations of Current Research

Research on the side effects of the hepatitis B vaccine is still inadequate. 9 pointed out the lack of research on the safety of hepatitis B vaccination during pregnancy. More research is needed on side effect rates, causes, and measures.

Future Research Directions

Further research on the side effects of the hepatitis B vaccine is essential. 8 suggested the possibility of sex-specific vaccination schedules. In particular, detailed research is needed on the impact of vaccine additives and the mechanisms behind rare side effects. Developing strategies to minimize side effects and creating vaccines with reduced side effect risks are also crucial.

Conclusion

The hepatitis B vaccine is a vital tool for protecting against hepatitis B. 16 highlighted the importance of pain management in infants. However, the hepatitis B vaccine may have rare side effects. 17 pointed out the potential for sex differences in side effects after vaccination. When considering hepatitis B vaccination, consult a doctor and fully understand the risks and benefits of vaccination.

Literature analysis of 27 papers
Positive Content
16
Neutral Content
1
Negative Content
10
Article Type
5
1
0
4
26
2.

Hepatitis B Vaccine and Multiple Sclerosis: Cause or Coincidence.

Author: LuhadiaKunjal, AbugrinMohamed, KianiRoudabeh, AhmadyAbolfazl, VirkJaswinder, YashiKanica

MS trigger

Multiple sclerosis (MS) is an autoimmune disease that can be triggered by various factors. This study presents a case of a patient who developed neurological symptoms one day after receiving the hepatitis B vaccine. The temporality of symptoms suggests a possible association between the hepatitis B vaccine and MS.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

3.

Intradermal, subcutaneous or intramuscular administration of hepatitis B vaccine: side effects and antibody response.

Author: WahlM, HermodssonS

Hepatitis B vaccination
Local reactions

Intradermal administration of a hepatitis B vaccine was as effective as intramuscular administration at a 10 times lower dose. The subcutaneous route was significantly less effective.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Hypothesis: Could Hepatitis B vaccine act as an immune adjuvant in glioblastoma? Clues to conduct further epidemiological analyses.

Author: AltinozMeric A, OzpinarAysel, OzpinarAlp, HackerEmily, Elmaciİlhan

GBM treatment
Neuroimmune side effects

This review discusses the potential use of Hepatitis B Virus (HBV) and HBV-Vaccine (HBV-V) antigens as immune stimulants in glioblastoma multiforme (GBM) treatment. The rationale is based on the observation that HBV-Vs can cause demyelination and multiple sclerosis, potentially through antigenic mimicry of oligodendroglial progenitors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Safety and immunogenicity of HBAI20 Hepatitis B vaccine in healthy naïve and nonresponding adults.

Author: KocÖ M, SavelkoulP H M, van LooI H M, PeetersA, Oude LashofA M L

Faster protection
Safe and well-tolerated

A new vaccine, HBAI20, containing recombinant human IL-2, shows promise as a safer and more effective treatment for hepatitis B.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Differences by sex in IgG levels following infant and childhood vaccinations: An individual participant data meta-analysis of vaccination studies.

Author: BoefAnna G C, van der KlisFiona R M, BerbersGuy A M, BuismanAnne-Marie, SandersElisabeth A M, KemmerenJeanet M, van der EndeArie, de MelkerHester E, RotsNynke Y, KnolMirjam J

Vaccination effectiveness
Sex-specific vaccination schedules

This study examined whether there are sex-related differences in immune responses to childhood vaccinations. It found no significant differences in antibody responses between boys and girls.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

10.

Unexpected drug-induced Raynaud phenomenon: Analysis from the French national pharmacovigilance database.

Author: BouquetÉmilie, UrbanskiGeoffrey, LavigneChristian, Lainé-CessacPascale

Raynaud phenomenon risk

This study using data from the French national pharmacovigilance database found that Raynaud phenomenon was associated with exposure to drugs for which Raynaud phenomenon is published or for which Raynaud phenomenon is not published.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Negative perceptions of hepatitis B vaccination among attendees of an urban free testing center for sexually transmitted infections in France.

Author: MoyroudLauranne, HustacheSarah, GoirandLaurence, HauzanneauMarianne, EpaulardOlivier

HBV vaccination

This study explored the extent of knowledge concerning HBV infection and HBV vaccine refusal among attendees at a free testing center for sexually transmitted infections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Quick assessment of the influence of the Hepatitis B vaccine event on children's vaccination.

Author: YueChenyan, SunXiaojin, WeiNing, YuWenzhou, CuiFuqiang, WangHuaqing, LiLi, ZhangLijie, ShiGuoqing, AnZhijie

Decreased coverage
Vaccine hesitancy

This study aimed to assess the impact of negative media reports about Hepatitis B vaccine safety on public attitudes and vaccination intentions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Loss of confidence in vaccines following media reports of infant deaths after hepatitis B vaccination in China.

Author: YuWenzhou, LiuDawei, ZhengJingshan, LiuYanmin, AnZhijie, RodewaldLance, ZhangGuomin, SuQiru, LiKeli, XuDisha, WangFuzhen, YuanPing, XiaWei, NingGuijun, ZhengHui, ChuYaozhu, CuiJian, DuanMengjuan, HaoLixin, ZhouYuqing, WuZhenhua, ZhangXuan, CuiFuqiang, LiLi, WangHuaqing

Reduced HBV infection
Infant deaths

Widespread media reports of infant deaths following hepatitis B vaccination in China threatened the success of a program that had reduced HBV infection by 90% among children under 5 years old.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Reasons for Refusal of Newborn Vitamin K Prophylaxis: Implications for Management and Education.

Author: HamrickHarvey James, GableElizabeth Kaye, FreemanEmily Hruska, DunnLaurie Louise, ZimmermanSarah Pritchett, RusinMolly Moriarty, LinthavongOlivia Reid, WrightMary Ellen, MossLeslie Ann, SkinnerAsheley Cockrell

Preventing vitamin K deficiency bleeding

The American Academy of Pediatrics recommends giving newborns vitamin K injections to prevent bleeding problems. This study investigated why some parents choose to refuse this injection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

The Effects of Instrumental Touching on Infant Pain Perception and the Effects of Eutectic Mixture of Local Anesthetics (EMLA) on the Reduction of Pain.

Author: KucukogluSibel, CelebiogluAyda, CanerIbrahim, OkGamze, MadenRukiye

Pain and stress in premature infants

This article discusses the importance of pain management in premature infants, emphasizing the negative long-term effects of uncontrolled pain on their development.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Childhood vaccination associated adverse events by sex: a literature review.

Author: WeberSandra Köhli, SchlagenhaufPatricia

Vaccine adverse events

This review found that serious adverse events related to the human papilloma virus vaccine, hepatitis B vaccine and measles-mumps-rubella vaccine were rare. The review also concluded that vaccine trials should be reported and published by sex.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

18.

Immunogenicity and safety of hepatitis E vaccine in healthy hepatitis B surface antigen positive adults.

Author: WuTing, HuangShou-Jie, ZhuFeng-Cai, ZhangXue-Feng, AiXing, YanQiang, WangZhong-Ze, YangChang-Lin, JiangHan-Min, LiuXiao-Hui, GuoMeng, DuHai-Lian, NgMun-Hon, ZhangJun, XiaNing-Shao

Safe and effective vaccine

Hecolin, a recombinant hepatitis E vaccine, is safe and effective in both HBsAg positive and negative individuals. It showed similar immunogenicity and safety profiles in both groups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Hepatitis-B vaccination status among dental surgeons in benin city, Nigeria.

Author: AzodoCc, EhizeleAo, UcheI, ErhaborP

Hepatitis B vaccination
Hepatitis B risk
Vaccination barriers

There was a low prevalence of complete hepatitis-B vaccination among dental surgeons in Benin City.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Intramuscular vs intradermal route for hepatitis B booster vaccine in celiac children.

Author: LeonardiSalvatore, PraticòAndrea Domenico, LionettiElena, SpinaMassimo, VitalitiGiovanna, La RosaMario

Hepatitis B vaccination

This study compared intradermal (ID) and intramuscular (IM) booster doses of hepatitis B vaccination in celiac individuals. Both ID and IM booster doses have been used in healthy and high-risk subjects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Hepatitis B vaccine induces apoptotic death in Hepa1-6 cells.

Author: HamzaHeyam, CaoJianhua, LiXinyun, LiChangchun, ZhuMengjin, ZhaoShuhong

Apoptosis
Cytotoxicity

Hepatitis B vaccine exposure induced apoptosis in mouse liver hepatoma cells (Hepa1-6) and mouse myoblast cells (C2C12) through the intrinsic apoptotic pathway, involving cytochrome c release and caspase activation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Safety and immunogenicity of a modified process hepatitis B vaccine in healthy neonates.

Author: MinerviniGianmaria, McCarsonBarbara J, ReisingerKeith S, MartinJason C, StekJon E, AtkinsBarbara M, NadigKarin B, LiskaVladimir, SchödelFlorian P, BhuyanPrakash K

Hepatitis B prevention

This study investigated the safety and immunogenicity of a modified process hepatitis B vaccine (mpHBV) in newborn infants. The mpHBV was previously shown to have an acceptable safety and immunogenicity profile in young adults.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Wheezing lower respiratory disease and vaccination of premature infants.

Author: MulloolyJohn P, SchulerRoberleigh, MesaJill, DrewLois, DeStefanoFrank,

Vaccinations premature

Routine vaccinations were not found to increase the risk of wheezing lower respiratory diseases (WLRD) in premature infants. In fact, there was evidence of a reduction in WLRD risk for some live attenuated vaccines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

24.

Hepatitis B vaccine and uveitis: an emerging hypothesis suggested by review of 32 case reports.

Author: FraunfelderFrederick W, SuhlerEric B, FraunfelderFrederick T

Uveitis

Hepatitis B vaccine may have a possible association with the development of uveitis in some patients. Immune complex deposition and adjuvant effects are potential pathogenic mechanisms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

25.

Exacerbation of lupus panniculitis following anti-hepatitis-B vaccination.

Author: ChoffrayA, PinquierL, BachelezH

Lupus panniculitis

This report describes a case of lupus panniculitis in a woman who experienced a flare following an anti-hepatitis-B vaccine injection. This suggests that hepatitis B vaccination may be associated with lupus panniculitis.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

27.

Parental vaccine safety concerns: results from the National Immunization Survey, 2001-2002.

Author: AllredNorma J, ShawKate M, SantibanezTammy A, RickertDonna L, SantoliJeanne M

Improve vaccination coverage

Vaccination coverage among US children aged 19-35 months remained near all-time highs in 2002. Maintaining this high coverage requires addressing parental concerns about vaccine safety, which have led to decreased coverage in other countries.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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