Effective treatment of high blood pressure: A Synthesis of Findings from 25 Studies

  1. Home
  2. Effective treatment of high blood pressure
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effective treatment of high blood pressure: A Synthesis of Findings from 25 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effective treatment of high blood pressure: A Synthesis of Findings from 25 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

High blood pressure, also known as hypertension, is a major health concern worldwide. It is a leading risk factor for cardiovascular disease, and it can lead to serious health complications. 13 Research has shown that effective treatment of high blood pressure can reduce the risk of cardiovascular disease and death. 12 However, many patients with hypertension do not achieve adequate blood pressure control, often due to factors like therapeutic inertia, lack of treatment adherence, and unhealthy lifestyle choices. 13

Lifestyle modifications, such as exercise and weight loss, have been recommended as an initial treatment strategy for lowering blood pressure. 2 However, the evidence for the effectiveness of these modifications remains somewhat controversial. 2 The 2017 High Blood Pressure Guidelines emphasize non-drug strategies, including a healthy diet, physical activity, reducing sodium intake, increasing potassium intake, limiting alcohol use, and weight loss. 24 These guidelines also recommend a risk-based approach to drug therapy, with individuals at higher risk of cardiovascular disease receiving medication for lower blood pressure thresholds.

The optimal way to organize and deliver care to patients with hypertension in order to reach treatment goals is not yet clearly identified. 6 4 8 9 There is a need for further research on effective interventions to improve blood pressure control in patients with hypertension. 3

In pregnant women, very high blood pressure poses a serious threat to both the mother and the baby. 11 5 While antihypertensive medications can lower blood pressure, their long-term effects and safety during pregnancy are still being studied. 11 5

Treatment Summary

Treatment for high blood pressure usually involves a combination of medication and lifestyle changes. 2 24 Lifestyle modifications include regular exercise, weight loss, a healthy diet, limiting sodium intake, increasing potassium intake, and reducing alcohol consumption. 2 24 The choice of medication and the specific treatment plan should be tailored to the individual patient's needs and risks. 24

Benefits and Risks

Benefits Summary

Treating high blood pressure can significantly reduce the risk of developing cardiovascular diseases, including heart disease and stroke. 12 It may also lower the risk of cognitive decline and dementia. 25

Risks Summary

Antihypertensive medications can have side effects, and some patients may not respond well to treatment. 11 5 It is crucial to work closely with a healthcare professional to find the most effective and safe treatment approach.

Research Comparison

Research Similarities

Many studies consistently highlight the benefit of treating high blood pressure in reducing cardiovascular disease risk. 12 1 A strong emphasis is placed on the importance of individualized treatment plans, taking into account a patient's specific risk factors and medical history. 24

Research Differences

While the benefits of high blood pressure treatment are consistently observed, the specific effects and risks can vary between studies. 11 5 Additionally, treatment approaches and medication choices may differ based on factors like patient characteristics and the specific study design. 13 24

Consistency and Contradictions

Research findings consistently demonstrate the effectiveness of high blood pressure treatment in reducing cardiovascular risk. 12 1 However, the risk profile associated with treatment can vary between studies. 11 5 Additionally, the specific methods used for treating high blood pressure can also differ across studies. 13 24

Practical Implications

High blood pressure treatment plans should be personalized to each patient's specific needs and risk factors. 24 It is essential to adopt both medication and lifestyle changes to effectively manage high blood pressure. 2 24 It is also crucial to follow the instructions and guidance of a healthcare professional for the best outcomes. 6 4 8 9

Research Limitations

Further research is necessary to thoroughly understand the long-term effects and risks associated with various treatment approaches for high blood pressure. 11 5 Additional studies are needed to evaluate the effectiveness and safety of different medication combinations and lifestyle interventions. 13 24

Future Research Directions

Future research should focus on expanding our understanding of the long-term benefits and risks of high blood pressure treatment, particularly in various patient populations. 11 5 Additionally, investigations into novel interventions and personalized treatment strategies are essential. 13 24

Conclusion

High blood pressure is a significant health issue with potentially serious consequences. Effective treatment can dramatically reduce the risk of developing cardiovascular disease. 12 1 A combined approach of medication and lifestyle changes is often necessary for optimal blood pressure control. 2 24 It is essential to work closely with a healthcare professional to develop a personalized treatment plan that considers your individual risks and needs. 24

Treatment List

Medication, Lifestyle modifications, Exercise, Weight loss, Healthy diet, Sodium restriction, Potassium supplementation, Alcohol reduction

Literature analysis of 25 papers
Positive Content
21
Neutral Content
2
Negative Content
2
Article Type
4
9
8
11
24
1.

Effect of antihypertensive treatment in patients having already suffered from stroke. Gathering the evidence. The INDANA (INdividual Data ANalysis of Antihypertensive intervention trials) Project Collaborators.

Author: GueyffierF, BoisselJ P, BoutitieF, PocockS, CoopeJ, CutlerJ, EkbomT, FagardR, FriedmanL, KerlikowskeK, PerryM, PrineasR, SchronE

Reduced cardiovascular risk

Treating high blood pressure has been shown to reduce the risk of cardiovascular problems. Stroke, which can cause death or disability, is particularly linked to high blood pressure and is among the most preventable complications. People who have already had a stroke are at higher risk of having another one. Past studies on lowering blood pressure in stroke survivors have had inconclusive results.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Exercise and weight loss reduce blood pressure in men and women with mild hypertension: effects on cardiovascular, metabolic, and hemodynamic functioning.

Author: BlumenthalJ A, SherwoodA, GulletteE C, BabyakM, WaughR, GeorgiadesA, CraigheadL W, TweedyD, FeinglosM, AppelbaumM, HayanoJ, HinderliterA

Improved metabolic functioning
Increased cardiac output
Reduced blood pressure
Reduced peripheral resistance

Aerobic exercise combined with weight loss is recommended for the management of elevated BP in sedentary, overweight individuals.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

3.

Interventions used to improve control of blood pressure in patients with hypertension.

Author: FaheyT, SchroederK, EbrahimS

Hypertension treatment
Uncontrolled hypertension

Many people with high blood pressure (hypertension) don't reach their treatment goals, a situation known as uncontrolled hypertension. There's no clear consensus on the best way to organize and deliver care to help these patients reach their goals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Interventions used to improve control of blood pressure in patients with hypertension.

Author: FaheyT, SchroederK, EbrahimS

Improved hypertension treatment
Hypertension

Many people with high blood pressure don't reach their treatment goals, a situation called uncontrolled hypertension. There's no clear agreement on the best way to organize and deliver care to help these patients achieve their goals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

Drugs for treatment of very high blood pressure during pregnancy.

Author: DuleyL, Henderson-SmartD J, MeherS

Fewer side effects
Lower persistent high blood pressure
Caesarean section
Higher risk of eclampsia
Higher risk of persistent high blood pressure
Hypotension
Respiratory difficulties

The choice of antihypertensive drug for very high blood pressure during pregnancy should depend on the clinician's experience and familiarity with the drug. Diazoxide, ketanserin, nimodipine, and magnesium sulfate should probably be avoided.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

6.

Interventions used to improve control of blood pressure in patients with hypertension.

Author: FaheyT, SchroederK, EbrahimS

Improved hypertension treatment
Hypertension

Many people with high blood pressure don't reach their treatment goals, a situation known as uncontrolled hypertension. There's no clear consensus on the best way to organize and deliver care to help these patients reach their goals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

7.

A multifaceted intervention to improve blood pressure control: The Guideline Adherence for Heart Health (GLAD) study.

Author: BondsDenise E, HoganPatricia E, BertoniAlain G, ChenHaiying, ClinchC Randall, HiottAnn E, RosenbergerErica L, GoffDavid C

Improved BP control

High blood pressure is a major cause of illness and death, but many people don't reach their blood pressure goals. This study examines the effects of a multi-faceted intervention aimed at improving how doctors follow high blood pressure guidelines in primary care settings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Interventions used to improve control of blood pressure in patients with hypertension.

Author: GlynnLiam G, MurphyAndrew W, SmithSusan M, SchroederKnut, FaheyTom

Improved blood pressure control
Lower mortality

An organized system of regular review and vigorous antihypertensive drug therapy reduced blood pressure and mortality. Self-monitoring, educational interventions, and appointment reminder systems may be useful adjuncts to improve blood pressure control.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

Self-monitoring and other non-pharmacological interventions to improve the management of hypertension in primary care: a systematic review.

Author: GlynnLiam G, MurphyAndrew W, SmithSusan M, SchroederKnut, FaheyTom

Reduced blood pressure
Reduced mortality

This systematic review found that self-monitoring was associated with net reductions in systolic and diastolic blood pressure in patients with hypertension. An organised system of regular review allied to vigorous antihypertensive drug therapy was shown to reduce blood pressure and all-cause mortality.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

Combination therapy as initial treatment for newly diagnosed hypertension.

Author: ByrdJames B, ZengChan, TavelHeather M, MagidDavid J, O'ConnorPatrick J, MargolisKaren L, SelbyJoe V, HoP Michael

Blood pressure control

Guidelines recommend using multiple medications to increase the chances of controlling high blood pressure. However, we lack information on how often doctors prescribe combinations of blood pressure medications when starting new treatment for hypertension.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

11.

Drugs for treatment of very high blood pressure during pregnancy.

Author: DuleyLelia, MeherShireen, JonesLeanne

Blood pressure reduction

Very high blood pressure during pregnancy can be dangerous for both mother and baby. While medications are used to lower blood pressure quickly and safely, there's uncertainty about which medications work best, their safety, and how they affect other pregnancy outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Association of Blood Pressure Lowering With Mortality and Cardiovascular Disease Across Blood Pressure Levels: A Systematic Review and Meta-analysis.

Author: BrunströmMattias, CarlbergBo

Reduced CVD risk
Reduced death risk
BP level dependence

Lowering blood pressure (BP) is associated with a reduced risk of death and cardiovascular disease (CVD) in individuals with baseline systolic BP (SBP) of 140 mm Hg or higher. This benefit was most pronounced in those with SBP of 160 mm Hg or above, where treatment was associated with a substantial reduction in major cardiovascular events. However, at lower BP levels, treatment was not associated with any benefit in primary prevention. In patients with previous coronary heart disease (CHD), treatment was associated with a reduced risk of major cardiovascular events, but not with survival.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

13.

Effectiveness of a multifactorial intervention, consisting of self-management of antihypertensive medication, self-measurement of blood pressure, hypocaloric and low sodium diet, and physical exercise, in patients with uncontrolled hypertension taking 2 or more antihypertensive drugs: The MEDICHY study.

Author: Unda VillafuerteFabián, Llobera CànavesJoan, Lorente MontalvoPatricia, Moreno SanchoMaría Lucía, Oliver OliverBartolomé, Bassante FloresPatricia, Estela MantolanAndreu, Pou BordoyJoan, Rodríguez RuizTomás, Requena HernándezAna, LeivaAlfonso, Torrent QuetglasMatíes, Coll BenejamJosé María, D'Agosto FortezaPilar, Rigo CarratalàFernando,

Hypertension treatment

High blood pressure is a major risk factor for heart disease, leading to serious health problems and death. While medication can help control blood pressure, less than half of people with high blood pressure reach their target. This is due to factors like delayed treatment, not taking medication as prescribed, and unhealthy habits (like eating too much fat and salt, not exercising enough, and being overweight). People with high blood pressure who are on medication but whose blood pressure isn't well-controlled have a higher risk of heart disease and death.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Prevalence, awareness, treatment and control of high blood pressure in a cohort in Northern Andean Peru.

Author: Sanchez-SamaniegoGiuliana, HartingerStella Maria, MäusezahlDaniel, HattendorfJan, FinkGünther, Probst-HenschNicole

Hypertension awareness
Hypertension control

A cross-sectional study of adults in the rural Peruvian Andes found that 18.9% had high blood pressure (HBP), with 72.2% unaware of their condition. Among those diagnosed or treated for hypertension, 58.4% had uncontrolled HBP.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

High blood pressure prevalence, awareness, treatment, and blood pressure control among Ugandans with rheumatic and musculoskeletal disorders.

Author: KiboneWinnie, BongominFelix, OkotJerom, NansubugaAngel Lisa, TentenaLincoln Abraham, NuwamanyaEdbert Bagasha, WinyiTitus, BalirwaWhitney, Sarah Kiguli, BalukuJoseph Baruch, MakhobaAnthony, KaddumukasaMark

Hypertension management

This study determined the prevalence of high blood pressure (HBP), awareness, treatment, and blood pressure control among patients with rheumatic and musculoskeletal disorders (RMDs) in Uganda. The study found a high prevalence of HBP and a need for improved awareness, treatment, and blood pressure control among patients with RMDs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

17.

Individualized Beta-Blocker Treatment for High Blood Pressure Dictated by Medical Comorbidities: Indications Beyond the 2018 European Society of Cardiology/European Society of Hypertension Guidelines.

Author: ManciaGiuseppe, KjeldsenSverre E, KreutzReinhold, PathakAtul, GrassiGuido, EslerMurray

Cardiovascular protection
Hypertension treatment
Depression risk
Erectile dysfunction risk

This narrative review focuses on multiple additional diseases and conditions that may occur and affect patients with hypertension.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

18.

Disease belief, medication belief and adherence to treatment in patients with high blood pressure

Author: Suárez-ArgüelloJazmín, Blanco-CastilloLeticia, Perea-RangelJosé A, Villarreal-RíosEnrique, Vargas-DazaEmma R, Galicia-RodríguezLiliana, Martínez-GonzálezLidia

Adherence to treatment

This study compared disease beliefs and medication beliefs with adherence to treatment in 137 adherent and 129 non-adherent patients with hypertension without diabetes. Adherent patients were more likely to have an adequate understanding of the disease, and this association was stronger when considering both disease beliefs and medication beliefs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Spanish

20.

[Interventional treatment of high blood pressure-Current state].

Author: van der GietM

Blood pressure reduction

Renal denervation (RDN) has emerged as a potential alternative treatment for hypertension. While initial studies showed promising results, subsequent sham-controlled studies demonstrated inconsistent results. Recent systematic studies have shown that RDN can effectively lower blood pressure in patients without medication, but further research is needed to confirm these findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

22.

Investigation and Treatment of High Blood Pressure in Young People: Too Much Medicine or Appropriate Risk Reduction?

Author: HintonThomas C, AdamsZoe H, BakerRichard P, HopeKatrina A, PatonJulian F R, HartEmma C, NightingaleAngus K

None mentioned
Cardiovascular events

Hypertension is common among young people. This review evaluates the current evidence regarding the association between blood pressure (BP) in young adult life and adverse cardiovascular outcomes later in life. It also discusses the pros and cons of drug treatment for raised BP in young people.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

23.

Prevalence of Apparent Treatment-Resistant Hypertension in the United States According to the 2017 High Blood Pressure Guideline.

Author: PatelKershaw V, LiXilong, KondamudiNitin, VaduganathanMuthiah, Adams-HuetBeverley, FonarowGregg C, VongpatanasinWanpen, PandeyAmbarish

Increased aTR-hypertension

The prevalence of apparent treatment-resistant hypertension (aTR-hypertension) in US adults with treated hypertension is 15.95% based on the 2017 high blood pressure guideline, an increase of 4% compared with the JNC 7 guideline. The prevalence of thiazide diuretic use remained less than 70%, and that of mineralocorticoid antagonist use remained less than 10% regardless of the guideline definition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

High blood pressure, Alzheimer disease and antihypertensive treatment.

Author: MarfanyAgustí, SierraCristina, CamafortMiguel, DoménechMónica, CocaAntonio

AD prevention
Hypertension

This review examines the relationship between chronic hypertension and Alzheimer's disease (AD). Hypertension is a modifiable risk factor for AD. Some studies suggest that antihypertensive drugs may reduce the risk of AD. The review focuses on current knowledge and potential therapeutic implications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.