Side Effects of indomethacin: A Synthesis of Findings from 12 Studies

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Original Abstract of the Article

Major Research Findings

Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used to treat a variety of conditions, including pain, inflammation, and fever. However, indomethacin can also cause a number of side effects, including gastrointestinal problems, kidney problems, and central nervous system problems. , 11 , , , , , , , , 9 , , 7 , 8 , 1 , , 12 , , , 10 , 6 , 3 , , , 2 , 5 , , , 4 .

Reasons for Side Effects

Indomethacin's side effects are largely due to its inhibition of prostaglandin production. Prostaglandins are hormone-like substances that play a role in a variety of bodily functions, including inflammation, pain, and the protection of the stomach lining. When indomethacin blocks the production of prostaglandins, it can lead to side effects such as stomach ulcers, kidney problems, and central nervous system problems.

Common Side Effects

Gastrointestinal

Indomethacin can cause gastrointestinal side effects, such as stomach ulcers, heartburn, nausea, vomiting, and diarrhea. , , 7 , 4 . These side effects are due to the inhibition of prostaglandins that protect the stomach lining.

Kidney

Indomethacin can cause kidney problems, including reduced urine output, increased blood urea nitrogen, and increased creatinine levels. 11 , 1 , 12 , 3 , . These side effects are due to the inhibition of prostaglandins that help maintain blood flow to the kidneys.

Central Nervous System

Indomethacin can cause central nervous system problems, including headaches, dizziness, drowsiness, and confusion. , 8 . These side effects are due to the effects of indomethacin on the brain.

Mental

Indomethacin can cause mental side effects, such as anxiety, depression, and hallucinations. 2 . These side effects are due to the effects of indomethacin on neurotransmitters in the brain.

Eye

Indomethacin can cause eye problems, such as eye inflammation. .

Measures to Counter Side Effects

Gastrointestinal

To reduce the risk of gastrointestinal side effects, it is recommended to take indomethacin with food or milk. 4 .

Kidney

People with pre-existing kidney problems should avoid taking indomethacin. 1 . It is also important to stay hydrated when taking indomethacin.

Central Nervous System

If you experience central nervous system side effects, you should stop taking indomethacin and consult your doctor.

Mental

If you experience mental side effects, you should stop taking indomethacin and consult your doctor.

Comparison of Studies

Commonalities of Studies

Many studies have reported that indomethacin can cause various side effects in the digestive system, kidneys, central nervous system, mental state, and eyes.

Differences of Studies

The severity and type of side effects can vary from person to person and study to study.

Cautions Regarding Application to Real Life

Indomethacin can cause a variety of side effects. It is important to talk to your doctor about the risks and benefits of taking indomethacin and to follow their instructions carefully.

Limitations of Current Research

More research is needed to fully understand the side effects of indomethacin.

Future Research Needs

Further research is needed to investigate the side effects of indomethacin in more detail and to develop ways to minimize the risk of these side effects.

Conclusion

Indomethacin is a powerful drug that can be effective in treating pain, inflammation, and fever. However, it is important to be aware of the potential side effects of indomethacin and to talk to your doctor about the risks and benefits of taking this medication.

Literature analysis of 12 papers
Positive Content
8
Neutral Content
0
Negative Content
4
Article Type
4
0
0
1
12
1.

Furosemide does not prevent indomethacin-induced renal side effects in preterm infants.

Author: RomagnoliC, ZeccaE, PapacciP, De CarolisM P, GianniniR, GalliniF, TortoroloG

Renal side effects

Furosemide did not prevent indomethacin-induced renal failure in preterm infants, but it did not negatively influence the therapeutic effectiveness of indomethacin.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

The use of dopamine for the prevention of the renal side effects of indomethacin in premature infants with patent ductus arteriosus.

Author: SeriI, TulassayT, KiszelJ, CsömörS

Prevent renal side effects

Dopamine prevented the renal side effects of indomethacin in preterm infants. Infants receiving indomethacin plus dopamine had better renal function. Dopamine can be used instead of furosemide in preterm infants requiring indomethacin.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Double-blind comparison of the antirheumatic activity and gastric side-effects of indomethacin used alone or in combination with a gastro-protective agent, proglumide.

Author: PipitoneV

Reduced gastric disturbance

Indomethacin (150 mg/day) and proglumide (900 mg/day) showed similar therapeutic effectiveness in patients with rheumatic disorders. However, proglumide was significantly better tolerated, with fewer gastric side effects reported.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

General practitioners' evaluation of side-effects and efficacy of oxamethacin as compared with indomethacin.

Author: PoldermanJ, ColonM

Effective anti-inflammatory
Pain relief
Side effects
Treatment discontinuation

Oxamethacin is more effective than indomethacin in treating inflammation and pain. It also has fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Can a cyclo-oxygenase type-2 selective tocolytic agent avoid the fetal side effects of indomethacin?

Author: LocatelliA, VerganiP, BelliniP, StrobeltN, GhidiniA

Preterm labor delay
Oligohydramnios

Nimesulide was associated with a prolongation of pregnancy in women with preterm labor.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Side Effects of Indomethacin in Refractory Post-traumatic Intracranial Hypertension: A comprehensive case study and review.

Author: GodoyDaniel Agustín, SuarezPablo David Guerrero, Moscote-SalazarLuis Rafael, NapoliMario Di

Intracranial hypertension treatment
Adverse effects

Intracranial hypertension is a serious condition that can occur after a severe brain injury. This case study describes a patient who experienced refractory intracranial hypertension and was treated with indomethacin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

A double-blind randomized study of fetal side effects during and after the short-term maternal administration of indomethacin, sulindac, and nimesulide for the treatment of preterm labor.

Author: SawdyRobert J, LyeShiromi, FiskNicholas M, BennettPhillip R

Fetal side effects

Nimesulide caused similar short-term fetal side effects to indomethacin and sulindac in pregnant women with preterm contractions.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Can dopamine prevent the renal side effects of indomethacin? A prospective randomized clinical study.

Author: BaenzigerO, WaldvogelK, GhelfiD, ArbenzU, FanconiS

Transient renal insufficiency

The additional use of dopamine did not reduce the renal side effects of indomethacin therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Furosemide prevents the renal side effects of indomethacin therapy in premature infants with patent ductus arteriosus.

Author: YehT F, WilksA, SinghJ, BetkerurM, LilienL, PildesR S

Patent ductus arteriosus closure

Furosemide, a diuretic, was shown to prevent the renal side effects of indomethacin therapy in premature infants with patent ductus arteriosus without affecting the efficacy of indomethacin in closing the ductus.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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