Effects of insulin lispro injection: A Synthesis of Findings from 6 Studies

  1. Home
  2. Effects of insulin lispro injection
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of insulin lispro injection: A Synthesis of Findings from 6 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of insulin lispro injection: A Synthesis of Findings from 6 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major findings

Several studies have shown that itraconazole, a type of antifungal medication, can be effective in treating fungal infections, but also interact with other medications. 6 found that combining terbinafine with itraconazole was more effective in treating fungal skin infections than using either medication alone. 3 showed that itraconazole and fluconazole, both azole antifungals, can affect the way the body processes midazolam, a sedative. This can potentially lead to increased levels of midazolam in the body and its effects. 5 indicated that posaconazole, another antifungal medication, can also interact with midazolam, suggesting that these interactions might extend to other antifungals. 4 investigated the interaction of itraconazole and triazolam, another sedative, finding that even a single dose of itraconazole can significantly increase the effects of triazolam when taken within 24 hours. 1 and 2 explored the use of itraconazole in patients with weakened immune systems (neutropenic patients), suggesting that it may be effective in treating fungal infections in these patients. However, further research is needed to confirm its efficacy and safety in this population.

Benefits and Risks

Benefit Summary

Itraconazole may be beneficial in treating fungal infections. 6 found that combining terbinafine with itraconazole was more effective in treating fungal skin infections than using either medication alone.

Risk Summary

Itraconazole can interact with other medications, potentially leading to increased levels and effects of those medications in the body. 3 found that itraconazole and fluconazole can affect the way the body processes midazolam, a sedative. 5 indicated that posaconazole can also interact with midazolam. 4 found that itraconazole can significantly increase the effects of triazolam when taken within 24 hours.

Study Comparisons

Study Similarities

All studies investigated the effects of itraconazole and its interactions with other medications.

Study Differences

The studies varied in terms of the specific medication itraconazole was compared with, the focus of the study (e.g. fungal infection treatment, drug interaction), the study design, and the population studied.

Consistency and Contradictions in Findings

The studies consistently showed that itraconazole can interact with other medications, leading to potentially significant changes in the way those medications are processed by the body. While itraconazole has demonstrated efficacy in treating fungal infections, further research is needed to understand its long-term safety and potential interactions with other medications.

Real-Life Application

It is important to inform your doctor about all medications you are taking, including over-the-counter medications and herbal supplements, before starting itraconazole treatment. This will help your doctor determine if itraconazole is safe for you to take and monitor for potential interactions.

Current Research Limitations

More research is needed to fully understand the long-term effects of itraconazole and its potential interactions with other medications.

Future Research Directions

Future research should focus on investigating the long-term safety and efficacy of itraconazole, especially in specific populations such as individuals with weakened immune systems or those taking other medications. It is also crucial to identify potential interactions with other medications and explore ways to minimize the risks associated with those interactions.

Conclusion

Itraconazole can be effective in treating fungal infections, but it is important to be aware of its potential interactions with other medications. Always discuss your medical history and current medications with your doctor before starting any new medication, including itraconazole.

Literature analysis of 6 papers
Positive Content
2
Neutral Content
3
Negative Content
1
Article Type
6
0
0
0
6
1.

Itraconazole in neutropenic patients.

Author: van't WoutJ W

Fungal infection treatment
Itraconazole absorption

A study of 32 neutropenic patients with fungal infections compared the effectiveness of itraconazole and amphotericin B. Both treatments were effective against Candida infections, with 9 out of 16 patients responding to amphotericin B and 10 out of 16 responding to itraconazole. Itraconazole was more effective against Aspergillus infections, with 6 out of 8 patients responding compared to 2 out of 5 on amphotericin B. While amphotericin B treatment was associated with three deaths from Aspergillus infections, no deaths occurred in the itraconazole group. The study suggests that itraconazole may be a promising treatment for systemic fungal infections in neutropenic patients, although further research is needed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

[Therapy of systemic mycoses in neutropenic patients using itraconazole. A comparative, randomized study with amphotericin B].

Author: van't WoutJ W, NovakovaI, VerhagenC A, FibbeW E, de PauwB E, van der MeerJ W

Effective against mycoses
Anaemia
Fever
Hypokalaemia
Hypotension
Nephrotoxicity
Renal tubular acidosis
Shivering
Side effects
Thrombocytopenia
Thrombophlebitis

A randomized comparative investigation was carried out to assess the efficacy of amphotericin B and itraconazole in the treatment of systemic mycoses in neutropenic patients.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

3.

The effects of the systemic antimycotics, itraconazole and fluconazole, on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam.

Author: OlkkolaK T, AhonenJ, NeuvonenP J

Sedation
Increased midazolam effects

Itraconazole and fluconazole, azole antimycotics, significantly increased the effects of oral midazolam, raising its AUC and peak concentration by 3.5-fold and two-fold, respectively. This interaction also led to a profound increase in psychomotor effects. While the interaction with IV midazolam was weak, large doses of IV midazolam could still lead to clinically significant interactions. Using oral midazolam with itraconazole and fluconazole should be avoided.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

The effect of ingestion time interval on the interaction between itraconazole and triazolam.

Author: NeuvonenP J, VarheA, OlkkolaK T

Increased triazolam effects

Itraconazole interacts considerably with triazolam when this hypnotic agent is ingested within 24 hours after itraconazole.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Effects of oral posaconazole on the pharmacokinetic properties of oral and intravenous midazolam: a phase I, randomized, open-label, crossover study in healthy volunteers.

Author: KrishnaGopal, MotonAllen, MaLei, SavantIshani, MartinhoMonika, SeiberlingMichael, McLeodJames

Drug interaction

This study aims to determine how the antifungal drug posaconazole affects the pharmacokinetic properties of midazolam, a short-acting benzodiazepine, due to their potential for drug interactions.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Terbinafine Hydrochloride Combined With Itraconazole for Fungal Skin Diseases: A Randomized Controlled Trial.

Author: ZhangDongxing, LiaoWanqing, ChenCanhua, LaiHongtao, LiuShi

Combined therapy efficacy
Fungal skin diseases treatment

Combined treatment with terbinafine and itraconazole achieved better therapeutic effects in patients with fungal skin diseases compared to monotherapy. The combination group had significantly decreased symptom scores, a higher cure rate, and shorter cure time. No adverse events or relapses were reported during follow-up.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.