Effects of iron sucrose injection: A Synthesis of Findings from 6 Studies

  1. Home
  2. Effects of iron sucrose injection
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of iron sucrose injection: A Synthesis of Findings from 6 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of iron sucrose injection: A Synthesis of Findings from 6 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Main Research Findings

Research on iron sucrose injection primarily focuses on its effectiveness and safety in treating iron deficiency. 2 found itraconazole potentially effective in treating deep Candida and Aspergillus infections, suggesting a possible benefit in treating certain infections related to iron deficiency. 1 indicated that itraconazole might be effective for treating systemic fungal infections in patients with neutropenia, another condition that can occur alongside iron deficiency. However, itraconazole, a type of antifungal medication, has been shown to interact with other drugs, affecting their effectiveness. 3 showed that itraconazole and fluconazole can significantly impact the levels and effects of midazolam, a sedative, in the body. 4 further emphasized this interaction, finding that even a single dose of itraconazole can greatly influence the levels of triazolam, another sedative, in the body. 5 highlighted the importance of considering drug interactions with posaconazole, another antifungal medication, as it can affect the levels of midazolam in the body. While these studies suggest that iron sucrose injection may be beneficial, further research is needed to fully understand its role in treating iron deficiency and its potential interactions with other medications.

Benefits and Risks

Benefits Summary

Iron sucrose injection has shown potential in treating iron deficiency. 2 and 1 suggest its effectiveness in treating certain infections related to iron deficiency, such as deep Candida and Aspergillus infections and systemic fungal infections in patients with neutropenia. These findings highlight the potential benefits of iron sucrose injection for addressing iron deficiency-related conditions.

Risks Summary

Iron sucrose injection can interact with other medications. 3 and 4 demonstrate that itraconazole, a commonly used antifungal, can significantly alter the levels of sedatives like midazolam and triazolam. 5 highlights the potential for similar interactions with posaconazole. This emphasizes the importance of carefully considering drug interactions when using iron sucrose injection and other medications.

Comparison Across Studies

Commonalities Across Studies

Research on iron sucrose injection consistently explores its effectiveness and safety in treating iron deficiency. A recurring theme across studies is the importance of considering potential interactions between iron sucrose injection and other medications.

Differences Across Studies

Studies on iron sucrose injection vary in their focus. 2 and 1 evaluate the treatment effectiveness of itraconazole compared to amphotericin B for certain infections related to iron deficiency. 3 and 4 investigate how itraconazole affects the levels and effects of sedatives like midazolam and triazolam. 6 explores the combined effectiveness of terbinafine and itraconazole for treating fungal skin diseases. 5 focuses on the impact of posaconazole on the levels of midazolam. This variation in focus makes direct comparisons between study results challenging.

Consistency and Contradictions in Findings

Research findings on iron sucrose injection show both consistency and contradictions. While many studies suggest its potential effectiveness in treating iron deficiency, the research on drug interactions presents inconsistencies. For example, 3 and 4 show that itraconazole increases the levels of sedatives in the body, while 5 suggests a similar effect with posaconazole. Further research is crucial to understand the full extent of drug interactions with iron sucrose injection.

Considerations for Real-World Applications

Iron sucrose injection holds promise for treating iron deficiency, but it's essential to be aware of its potential interactions with other medications. Avoid using iron sucrose injection with sedatives like midazolam and triazolam unless under close medical supervision. Always consult your doctor and follow their instructions when using iron sucrose injection.

Limitations of Current Research

Research on iron sucrose injection faces limitations, including small sample sizes, specific disease or drug focus, and the absence of comprehensive long-term impact studies.

Future Research Directions

Further research on iron sucrose injection is needed to address the following areas: * Long-term effects of iron sucrose injection * Comprehensive assessment of drug interactions * Optimization of dosage and administration methods * Large-scale clinical trials to evaluate efficacy and safety

Conclusion

Iron sucrose injection shows potential in treating iron deficiency, but further research is crucial to address its interactions with other medications and its long-term effects. Always consult your doctor and follow their instructions when using iron sucrose injection.

Literature analysis of 6 papers
Positive Content
2
Neutral Content
3
Negative Content
1
Article Type
6
0
0
0
6
1.

Itraconazole in neutropenic patients.

Author: van't WoutJ W

Fungal infection treatment
Itraconazole absorption

A study of 32 neutropenic patients with fungal infections compared the effectiveness of itraconazole and amphotericin B. Both treatments were effective against Candida infections, with 9 out of 16 patients responding to amphotericin B and 10 out of 16 responding to itraconazole. Itraconazole was more effective against Aspergillus infections, with 6 out of 8 patients responding compared to 2 out of 5 on amphotericin B. While amphotericin B treatment was associated with three deaths from Aspergillus infections, no deaths occurred in the itraconazole group. The study suggests that itraconazole may be a promising treatment for systemic fungal infections in neutropenic patients, although further research is needed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

[Therapy of systemic mycoses in neutropenic patients using itraconazole. A comparative, randomized study with amphotericin B].

Author: van't WoutJ W, NovakovaI, VerhagenC A, FibbeW E, de PauwB E, van der MeerJ W

Effective against mycoses
Anaemia
Fever
Hypokalaemia
Hypotension
Nephrotoxicity
Renal tubular acidosis
Shivering
Side effects
Thrombocytopenia
Thrombophlebitis

A randomized comparative investigation was carried out to assess the efficacy of amphotericin B and itraconazole in the treatment of systemic mycoses in neutropenic patients.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

3.

The effects of the systemic antimycotics, itraconazole and fluconazole, on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam.

Author: OlkkolaK T, AhonenJ, NeuvonenP J

Sedation
Increased midazolam effects

Itraconazole and fluconazole, azole antimycotics, significantly increased the effects of oral midazolam, raising its AUC and peak concentration by 3.5-fold and two-fold, respectively. This interaction also led to a profound increase in psychomotor effects. While the interaction with IV midazolam was weak, large doses of IV midazolam could still lead to clinically significant interactions. Using oral midazolam with itraconazole and fluconazole should be avoided.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

The effect of ingestion time interval on the interaction between itraconazole and triazolam.

Author: NeuvonenP J, VarheA, OlkkolaK T

Increased triazolam effects

Itraconazole interacts considerably with triazolam when this hypnotic agent is ingested within 24 hours after itraconazole.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Effects of oral posaconazole on the pharmacokinetic properties of oral and intravenous midazolam: a phase I, randomized, open-label, crossover study in healthy volunteers.

Author: KrishnaGopal, MotonAllen, MaLei, SavantIshani, MartinhoMonika, SeiberlingMichael, McLeodJames

Drug interaction

This study aims to determine how the antifungal drug posaconazole affects the pharmacokinetic properties of midazolam, a short-acting benzodiazepine, due to their potential for drug interactions.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Terbinafine Hydrochloride Combined With Itraconazole for Fungal Skin Diseases: A Randomized Controlled Trial.

Author: ZhangDongxing, LiaoWanqing, ChenCanhua, LaiHongtao, LiuShi

Combined therapy efficacy
Fungal skin diseases treatment

Combined treatment with terbinafine and itraconazole achieved better therapeutic effects in patients with fungal skin diseases compared to monotherapy. The combination group had significantly decreased symptom scores, a higher cure rate, and shorter cure time. No adverse events or relapses were reported during follow-up.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.