Effects of isradipine: A Synthesis of Findings from 26 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of isradipine: A Synthesis of Findings from 26 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

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Original Abstract of the Article

Major Research Findings

Isradipine is a calcium channel blocker that has been shown to be effective in treating hypertension. 13 found that isradipine was more effective in lowering blood pressure than prazosin. 6 found that isradipine reduced systolic and diastolic blood pressure in a dose-dependent manner. Isradipine is also effective in treating angina. 11 found that isradipine improved hemodynamics at rest and during exercise in patients with stable chronic angina. 9 found that isradipine was as effective as nifedipine in increasing exercise tolerance and reducing angina attacks. 20 found that isradipine and nifedipine had similar effects on angina frequency and severity. Isradipine has also been shown to have antiatherogenic properties in animal models of atherosclerosis. 14 suggests that isradipine may be effective in slowing the progression of atherosclerosis in humans.

A review of the cardiovascular effects of isradipine, 12 indicates that isradipine is a highly efficacious drug in monotherapy for hypertension and is well tolerated. Isradipine was found to have no clinically significant tachycardia or cardiodepressant effect, no fluid retention, and no orthostatic reactions.

Benefits and Risks

Benefit Summary

Isradipine is an effective treatment for hypertension and angina. It has also been shown to have antiatherogenic properties. It has also shown to be effective in reducing blood pressure in hypertensive patients treated with pindolol. 17 Isradipine may be a useful treatment for patients with exertional angina and hypertension, alone or associated with beta blocker medication. 3

Risk Summary

Isradipine is generally well tolerated, but it can cause side effects such as headache, dizziness, and flushing. 6 Isradipine can interact with other medications, so it is important to talk to your doctor about all the medications you are taking. 17 Isradipine may also cause a decrease in plasma beta-thromboglobulin levels, which may indicate a minor indirect effect on platelet function. 25 Isradipine may not be suitable for all patients, especially those with heart conditions. 11 Isradipine may not be effective in patients with chronic heart failure. 24

Comparison Across Studies

Commonalities Across Studies

Most studies have found that isradipine is effective in lowering blood pressure. Studies have also shown isradipine to be generally well tolerated.

Differences Across Studies

Some studies have found that isradipine is more effective than other calcium channel blockers or other antihypertensive drugs. 13 , 11 , 9 , 20 Other studies have found that isradipine is effective in treating angina. 11 , 9 , 20

Consistency and Discrepancies in Findings

There is some inconsistency in findings regarding the effects of isradipine on platelet function. Some studies suggest that isradipine may cause a minor indirect effect on platelet function, but this effect is not considered clinically significant. 25 More research is needed to understand the potential effects of isradipine on platelet function.

Notes on Applying Findings to Real Life

If you are considering using isradipine, it is important to talk to your doctor about your medical history and any other medications you are taking. Isradipine may not be appropriate for everyone, especially people with certain heart conditions. It is also important to note that the effects of isradipine may vary from person to person.

Limitations of Current Research

More research is needed to understand the long-term effects and safety of isradipine. Research is also needed to understand the potential interactions of isradipine with other medications. 17 Further research is also needed to understand the effectiveness of isradipine in treating chronic heart failure. 24

Future Directions for Research

Future research should focus on the long-term effects and safety of isradipine. It is also important to investigate the potential interactions of isradipine with other medications. Researchers should also investigate the potential benefits of isradipine in treating other cardiovascular conditions.

Conclusion

Isradipine appears to be a safe and effective treatment for hypertension and angina. 13 , 11 , 9 , 20 However, more research is needed to understand its long-term effects and safety. 24 If you are considering using isradipine, it is important to talk to your doctor about your medical history and any other medications you are taking.

Keywords
Benefit Keywords
Reduce blood pressure
Reduce heart rate
1
Angina treatment
2
Improves angina
Improves left ventricular function
3
Inhibits atherogenesis
Reduces blood pressure
4
Better tolerated
Reduces blood pressure
5
Favorable benefit-risk profile
Lower blood pressure
Well tolerated
6
Blood pressure reduction
7
Blood pressure reduction
8
Angina treatment
9
Hemodynamic improvement
10
Improved hemodynamics
Reduced angina
Safe and effective
11
Antiatherogenic
Cardioprotective
Improved blood flow
Reduced blood pressure
Reduced infarct size
12
Blood pressure reduction
Effective for hypertension
Good tolerability
13
Antiatherogenic properties
Reduced stroke risk
14
Lowers blood pressure
Well tolerated
15
Effective monotherapy
Hypertension treatment
Safe for elderly
16
Antihypertensive effect
17
Antihypertensive effect
18
Antianginal effect
19
Effective anti-anginal
Reduced blood pressure during exercise
Reduced double product during exercise
Similar anti-anginal effects to nifedipine
20
Increase exercise tolerance
21
Lowers blood pressure
22
Angina relief
Improved ventricular function
Reduced ischemia
23
Improved hemodynamics
24
Reduced blood pressure
25
Blood pressure control
26
Risk Keywords
Bradycardia
2
Inadequate regression
Metabolic disturbances
4
Flushing
Headache
5
Dizziness
Flushing
Headache
6
Side effects
9
None reported
11
None reported
12
Dizziness
Headache
13
Inadequate left ventricular hypertrophy regression
Insulin resistance
Metabolic disturbances
14
Facial erythema
Hot flushes
15
Mild adverse effects
16
Adverse events
17
Increased heart rate
18
Drug-related adverse events
21
Hypotension
22
Cardiovascular disease events
26
Literature analysis of 26 papers
Positive Content
25
Neutral Content
1
Negative Content
0
Article Type
26
0
0
1
26
1.

Comparison of negative inotropic and vasodilator effects of isradipine and nifedipine after complete autonomic blockade in ischemic heart disease.

Author: BurgerW, FuchsS, BurgerK J, KoberG

Reduce blood pressure
Reduce heart rate

This study compared the cardiodepressant and vasodilator effects of isradipine and nifedipine in patients with stable coronary heart disease. Isradipine produced a significantly greater reduction in total peripheral resistance compared to nifedipine, suggesting a potentially more favorable hemodynamic profile.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

[Comparison of the effects of diltiazem and isradipine in adrenergic beta receptor blockade in patients with stable angina pectoris].

Author: MeluzínJ, NovákM

Angina treatment
Bradycardia

A study of 20 patients with stable angina found that both diltiazem and isradipine, when combined with a beta-blocker (metipranolol), were more effective in reducing angina symptoms and improving exercise tolerance compared to placebo. Isradipine was considered safer than diltiazem because metipranolol prevented the increase in heart rate often seen with isradipine and also reduced the risk of side effects. While diltiazem can be effective, it should be used with caution due to the risk of severe bradycardia. The study concluded that isradipine combined with metipranolol is a safer and more effective treatment option for stable angina compared to diltiazem or monotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Czech

3.

Effects of oral isradipine on left ventricular function at rest and during exercise in patients with stable chronic angina: a double-blind, placebo-controlled crossover study.

Author: DeloncaJ, KipferP, RighettiA

Improves angina
Improves left ventricular function

Isradipine, a calcium antagonist, improved anginal symptoms, ST-segment depression, and left ventricular function in patients with stable chronic angina.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

MIDAS: hypertension and atherosclerosis. A trial of the effects of antihypertensive drug treatment on atherosclerosis. MIDAS Research Group.

Author: BorhaniN O, MillerS T, BruggerS B, SchnaperH W, CravenT E, BondM G, KhouryS, FlackJ

Inhibits atherogenesis
Reduces blood pressure
Inadequate regression
Metabolic disturbances

Isradipine, a calcium antagonist, may have antiatherogenic properties in addition to blood pressure-lowering effects. A 3-year trial is investigating its potential to inhibit atherogenesis in hypertensive patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Clinical equivalence of once-daily administration of a modified-release formulation of isradipine and twice-daily administration of the standard formulation. Multicentre Study Group.

Author: HolmesD, MoulletC

Better tolerated
Reduces blood pressure
Flushing
Headache

Once-daily modified-release isradipine was as effective and better tolerated than twice-daily standard isradipine in controlling blood pressure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Efficacy and tolerability of the new calcium antagonist isradipine in essential hypertension.

Author: KirchW, BurgerK J, WeidingerG, WelzelD

Favorable benefit-risk profile
Lower blood pressure
Well tolerated
Dizziness
Flushing
Headache

Isradipine is a new calcium antagonist that was found to be effective in lowering blood pressure in hypertensive patients. In a study of 86 patients, isradipine reduced both systolic and diastolic blood pressure in a dose-dependent manner. The normalization rate (diastolic blood pressure less than or equal to 90 mm Hg) was 5% with placebo and 29%, 55%, and 64% with isradipine 1.25, 2.5, and 5 mg b.i.d., respectively. The most common side effects were headache, dizziness, and flushing.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Electrophysiologic effects of the calcium antagonist isradipine, a double-blind placebo-controlled study.

Author: KühlkampV, MaierF, SeipelL

Blood pressure reduction

Isradipine, a calcium channel antagonist, significantly decreased systolic and diastolic blood pressure in 9 patients without significantly affecting atrioventricular conduction. The drug did not cause a significant change in sinus cycle length compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Isradipine twice daily lowers blood pressure over 24 H.

Author: Man in't VeldA J, HolmesD G, LasanceA, de ZwartP

Blood pressure reduction

Isradipine, a calcium channel antagonist, was found to effectively lower blood pressure over 24 hours. In a double-blind study of 187 patients, isradipine (2.5 mg twice daily) achieved a significantly higher rate of blood pressure normalization compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Isradipine therapy in chronic stable angina pectoris--comparison with nifedipine.

Author: CurrieP, SaltissiS

Angina treatment
Side effects

Isradipine, a new calcium antagonist, produced similar improvements in exercise tolerance and anginal symptoms as nifedipine in 18 patients with angina. However, isradipine was associated with fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

[The hemodynamic effects of isradipine and nifedipine in hypertension].

Author: GrossP, KoppenhagenK, WudelE, BurgerK J, WelzelD, DistlerG A

Hemodynamic improvement

Isradipine, a new calcium antagonist, improved hemodynamics in 12 patients with hypertension more favorably than nifedipine. Isradipine significantly decreased end-systolic volume and increased stroke volume, while nifedipine had no significant effect on these parameters.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

11.

Effects of the calcium antagonist, isradipine, and nifedipine on resting and exercise haemodynamics and the neurohumoral system in patients with stable chronic angina.

Author: MitrovicV, RieckmannC, KorneckiP, BurgerK J, WelzelD, SchlepperM

Improved hemodynamics
Reduced angina
Safe and effective
None reported

Isradipine is a calcium channel blocker that has favorable effects comparable to nifedipine in patients with chronic stable angina. It improved haemodynamics and reduced ST-segment depression.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Cardiovascular effects of isradipine (Lomir) with special emphasis on haemodynamics and antihypertensive efficacy. A review.

Author: DahlöfB

Antiatherogenic
Cardioprotective
Improved blood flow
Reduced blood pressure
Reduced infarct size
None reported

Isradipine is a well-tolerated antihypertensive drug that effectively lowers blood pressure without significant side effects. It has potential antiatherogenic properties that require further study.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

A multicenter comparison of isradipine and prazosin for treatment of essential hypertension.

Author: SwartzS L, GonasunL M, McAllisterR G, ThadaniU

Blood pressure reduction
Effective for hypertension
Good tolerability
Dizziness
Headache

Isradipine is a calcium-entry blocking agent that effectively lowers blood pressure compared to prazosin. It has a more pronounced effect on diastolic blood pressure, with similar side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

A comparison of antihypertensive drug effects on the progression of extracranial carotid atherosclerosis. The Multicenter Isradipine Diuretic Atherosclerosis Study (MIDAS).

Author: GrimmR H, FlackJ M, ByingtonR, BondG, BruggerS

Antiatherogenic properties
Reduced stroke risk
Inadequate left ventricular hypertrophy regression
Insulin resistance
Metabolic disturbances

Isradipine is a new calcium antagonist effective in lowering blood pressure and potentially reducing the progression of atherosclerosis. The Multicenter Isradipine Diuretic Atherosclerosis Study (MIDAS) is comparing isradipine with hydrochlorothiazide to evaluate its effects on atherosclerosis in humans.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Effects of the new calcium entry blocker isradipine (PN 200-110) in essential hypertension.

Author: StaessenJ, LijnenP, FagardR, HespelP, TanW P, DevosP, AmeryA

Lowers blood pressure
Well tolerated
Facial erythema
Hot flushes

Isradipine was effective in lowering blood pressure in 16 patients with mild-to-moderate hypertension. It did not affect heart rate and was well-tolerated by most patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Efficacy and safety of isradipine in hypertension.

Author: ShepherdA M, CarrA A, DavidovM, HamiltonJ, SchnaperH, VelasquezM, BrockwayB, PrisantL M, HamiltonB, GonasunL

Effective monotherapy
Hypertension treatment
Safe for elderly
Mild adverse effects

Isradipine, a calcium channel blocker, was effective in lowering blood pressure in a dose-dependent manner in 203 hypertensive patients. The drug was well-tolerated with minimal side effects and was effective in a wide range of ages.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Improved blood pressure control with isradipine in hypertensive patients treated with pindolol.

Author: FrithzG, AströmB, DahlöfB, HanssonL, TollinC, HimanenP, SundstedtC D

Antihypertensive effect
Adverse events

Isradipine was an effective and well-tolerated adjunct to beta-blockers in hypertensive patients, reducing blood pressure without significantly affecting heart rate.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Cardiovascular and renal effects of single administration of three different doses of isradipine in hypertensive patients. Dose-response curves of the different effects.

Author: RupoliL, FruscioM, GradnikR, ChiancaR, LeonettiG, ZanchettiA

Antihypertensive effect
Increased heart rate

Isradipine, a new dihydropyridine calcium antagonist, showed a dose-dependent antihypertensive effect and increased sodium excretion and urine volume.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Hemodynamic and antianginal effects during rest and exercise of intravenous isradipine, a new dihydropyridine calcium antagonist.

Author: BurgerW, NeidelS, KoberG

Antianginal effect

Isradipine showed a greater reduction in blood pressure than nifedipine in patients with stable coronary heart disease, with similar hemodynamic effects during exercise.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Comparison of isradipine and nifedipine in chronic stable angina.

Author: HandlerC E, RosenthalE, TsagadopoulosD, NajmY

Effective anti-anginal
Reduced blood pressure during exercise
Reduced double product during exercise
Similar anti-anginal effects to nifedipine

Isradipine and nifedipine, two calcium channel blockers, were compared for their effects on angina and coronary artery disease. Both drugs showed similar anti-anginal effects, but isradipine was associated with a significantly lower increase in systolic blood pressure and double product during exercise.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Duration of effects of isradipine during twice daily therapy in angina pectoris.

Author: ThadaniU, ChrysantS, GorwitJ, GilesT, ArcherS, IteldB, SinghS, CopenD, WakefordC, HobbsS

Increase exercise tolerance
Drug-related adverse events

Isradipine, a calcium channel antagonist, was evaluated for its antianginal effects in 72 patients with chronic stable angina pectoris. Isradipine significantly increased exercise duration and time to ST-segment depression compared to placebo, demonstrating its effectiveness in improving exercise tolerance and reducing angina symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

A randomized comparative study of the electrophysiological and electrocardiographic effects of isradipine vs verapamil.

Author: TulloN G, LandauS, GoldmanI, CoutinhoN, SombergJ

Lowers blood pressure
Hypotension

Isradipine is a new dihydropyridine calcium antagonist that has minimal effects on cardiac electrophysiology. It effectively lowered blood pressure in 19 patients without significantly affecting heart rate or cardiac conduction.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Cardiac function improvement 24 hours after isradipine SRO in patients with chronic stable angina: a double-blind randomized study.

Author: DoatM, HacotJ P, PavinD, RighettiA

Angina relief
Improved ventricular function
Reduced ischemia

The study evaluated the long-term effects of slow-release oral Isradipine (5 mg) in 30 patients with stable chronic angina. Isradipine significantly improved left ventricular function at rest and during exercise, with beneficial effects lasting up to 24 hours after the last administration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

Acute hemodynamic and long-term clinical effects of isradipine in patients with coronary artery disease and chronic heart failure. A double-blind, placebo-controlled study.

Author: van den TorenE W, van VeldhuisenD J, van BruggenA, van den BroekS A, van GilstW H, LieK I

Improved hemodynamics

This study found that isradipine, a calcium antagonist, had a beneficial acute hemodynamic effect in patients with coronary artery disease and stable chronic heart failure, but it did not have any favorable clinical influence during prolonged treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

Pro-haemorrhagic effects of calcium antagonists: a comparison of isradipine and atenolol on ex vivo platelet function in hypertensive subjects.

Author: SmithA, McPhersonJ, TaylorM, MasonA, CarneyS, GilliesA

Reduced blood pressure

Isradipine, a calcium antagonist, may have a minor indirect effect on platelet function after several weeks of treatment, but its clinical significance is doubtful.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Isradipine in prediabetic hypertensive subjects.

Author: ByingtonR P, FurbergC D, CravenT E, PahorM, SowersJ R

Blood pressure control
Cardiovascular disease events

The study examined whether indices of glycemia influenced the effects of isradipine and diuretics on blood pressure control and cardiovascular disease events.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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