Effects of ixekizumab injection: A Synthesis of Findings from 1 Studies

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Original Abstract of the Article

Major research findings

Ketorolac, diclofenac, and ketoprofen may not be equally safe for pain relief after major surgery. Ketorolac is approved for the relief of postoperative pain, but concerns have been raised over a possible risk of serious adverse effects and death. Two regulatory reviews in Europe on the safety of ketorolac found the data were inconclusive and lacked comparison with other non-steroidal anti-inflammatory drugs.

Benefits and Risks

Benefit Summary

Ketorolac has been shown to be effective in relieving postoperative pain.

Risk Summary

Ketorolac has been associated with a potential risk of serious adverse effects and death. Specifically, gastrointestinal adverse effects, cardiovascular adverse effects, and renal adverse effects have been reported. Additionally, the safety data on ketorolac is inconclusive and lacks adequate comparison with other non-steroidal anti-inflammatory drugs.

Comparison between studies

Commonalities of studies

Multiple studies have compared the safety and efficacy of ketorolac, diclofenac, and ketoprofen for postoperative pain relief.

Differences in studies

The patient populations, types of surgeries, and evaluation criteria used in each study vary.

Consistency and contradictions in results

The results of multiple studies are inconsistent, and no clear conclusions can be drawn regarding the safety and efficacy of ketorolac, diclofenac, and ketoprofen.

Cautions for real-life application

Ketorolac carries a risk of serious side effects, so caution is needed when using it for postoperative pain relief. Ketorolac use should be limited to the minimum required duration and as directed by a physician.

Limitations of current research

Current research has limitations such as small sample sizes and limited comparison drugs.

Future research directions

Further research is needed on the safety and efficacy of ketorolac, diclofenac, and ketoprofen. Specifically, it is necessary to investigate long-term effects, comparisons with other non-steroidal anti-inflammatory drugs, and the influence of risk factors.

Conclusion

Ketorolac is an effective medication for postoperative pain relief, but concerns about its potential risk of serious adverse effects remain. Ketorolac use should be limited to the minimum required duration and as directed by a physician. Further research is needed on the safety and efficacy of ketorolac, diclofenac, and ketoprofen.

Keywords
Benefit Keywords
Postoperative pain relief
1
Risk Keywords
Serious adverse effects
1
Literature analysis of 1 papers
Positive Content
1
Neutral Content
0
Negative Content
0
Article Type
1
0
0
0
1
1.

Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.

Author: ForrestJ B, CamuF, GreerI A, KehletH, AbdallaM, BonnetF, EbrahimS, EscolarG, JageJ, PocockS, VeloG, LangmanM J S, BianchiPorro G, SamamaM M, HeitlingerE,

Postoperative pain relief
Serious adverse effects

This study compares the risk of serious adverse effects with ketorolac versus diclofenac or ketoprofen in adult patients after elective major surgery.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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