Side Effects of lansoprazole clarithromycin: A Synthesis of Findings from 5 Studies

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Original Abstract of the Article

Main Research Findings

Lansoprazole and clarithromycin are effective in treating peptic ulcers and H. pylori infection. Lansoprazole is a proton pump inhibitor that works by reducing gastric acid secretion. Clarithromycin is an antibiotic effective in treating H. pylori infection. These drugs may be used alone or in combination with other drugs.

The study reported in 5 suggests that one-week triple therapy consisting of lansoprazole, clarithromycin, and either metronidazole or tetracycline is effective in treating H. pylori infection. This study showed that the combination of lansoprazole and clarithromycin, whether used with metronidazole or tetracycline, resulted in similar therapeutic effects for H. pylori infection.

The study in 3 found that using a combination of lansoprazole, clarithromycin, and bismuth subsalicylate is effective in treating H. pylori infection. This study showed that the treatment regimen combining lansoprazole, clarithromycin, and bismuth subsalicylate was as effective as the one using lansoprazole, clarithromycin, and metronidazole.

The study reported in 2 showed that lansoprazole, clarithromycin, and metronidazole, when used together, are effective in treating H. pylori infection. This study found that the triple therapy of lansoprazole, clarithromycin, and metronidazole was effective in treating H. pylori infection, but some side effects were reported.

The study reported in 4 demonstrated that lansoprazole, clarithromycin, and metronidazole, when used together, are effective in treating H. pylori infection. This study found that the treatment regimen combining lansoprazole, clarithromycin, and metronidazole was effective in treating H. pylori infection and the side effects were relatively mild.

Reasons for side effects

Lansoprazole and clarithromycin have different mechanisms of action - inhibiting gastric acid secretion and killing H. pylori, respectively. Combining these medications could increase the risk of side effects. Lansoprazole, by suppressing gastric acid secretion, can impair the stomach's digestive function, potentially leading to side effects like indigestion and constipation. Clarithromycin, being an antibiotic, can cause side effects such as digestive issues, allergic reactions, and the development of resistant bacteria.

Common side effects

Gastrointestinal

Gastrointestinal side effects are the most commonly reported when lansoprazole and clarithromycin are combined. These side effects include nausea, vomiting, abdominal pain, diarrhea, and constipation. In 2 , side effects like vomiting, diarrhea, and itching were observed in 4 patients (7%).

Allergic Reactions

Allergic reactions have been reported when lansoprazole and clarithromycin are combined. These side effects include skin rash, itching, and difficulty breathing. In 2 , itching as a side effect was observed in 4 patients (7%).

Other

Beyond the gastrointestinal system, other side effects such as headache, dizziness, and taste disturbances have been reported when lansoprazole and clarithromycin are combined. In 2 , nausea as a side effect was observed in 4 patients (7%).

Side effects management

Gastrointestinal

Dietary changes and lifestyle modifications are crucial to mitigating gastrointestinal side effects. This can involve reducing fatty foods, chewing thoroughly, eating slowly, consuming more fiber, and staying well-hydrated.

Allergic Reactions

If an allergic reaction occurs, immediately consult a doctor. Allergic reactions are triggered by hypersensitivity to the medications. It's essential to stop using the medications and seek appropriate medical care.

Other

If any other side effects occur, consult a doctor. Side effects can vary based on the medication type and dosage, as well as individual patient characteristics. Follow the doctor's instructions and seek appropriate medical care.

Comparison between studies

Similarities

Multiple studies show that using a combination of lansoprazole, clarithromycin, metronidazole, or tetracycline is effective in treating H. pylori infection. These studies also reported side effects, but none reported severe side effects.

Differences

Differences in treatment effectiveness and side effect occurrence rates have been observed among studies. These differences may be explained by variations in research design and participant characteristics.

Considerations for Real-Life Applications

While the combined treatment of lansoprazole and clarithromycin is effective for treating H. pylori infection, it's vital to understand the risk of side effects. Before initiating this treatment, consulting a doctor and discussing the risks and benefits of side effects is crucial.

Limitations of Current Research

The limited number of participants in these studies may prevent generalizing the research findings. Furthermore, these studies did not investigate long-term side effects. Further research is required to assess the long-term safety of combining lansoprazole and clarithromycin therapy.

Future Research Directions

To evaluate the long-term safety and effectiveness of combining lansoprazole and clarithromycin therapy, large-scale clinical trials are necessary. Developing strategies to mitigate the side effects of this treatment regimen is also crucial.

Conclusion

The combined treatment of lansoprazole and clarithromycin is an effective method for treating H. pylori infection, but understanding the risk of side effects is crucial. Before initiating this treatment, consulting a doctor and discussing the risks and benefits of side effects is crucial.

Literature analysis of 5 papers
Positive Content
5
Neutral Content
0
Negative Content
0
Article Type
2
0
0
1
5
3.

Bismuth subsalicylate instead of metronidazole with lansoprazole and clarithromycin for Helicobacter pylori infection: a randomized trial.

Author: CheyW D, FisherL, EltaG H, BarnettJ L, NostrantT, DelValleJ, HaslerW L, ScheimanJ M

H. pylori treatment
Metronidazole resistance

This study evaluated the efficacy of two regimens for treating H. pylori infection: lansoprazole, clarithromycin, and metronidazole (LCM) and lansoprazole, clarithromycin, and bismuth subsalicylate (LCB).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

4.

The efficacy and safety of one-week triple therapy with lansoprazole, clarithromycin, and metronidazole for the treatment of Helicobacter pylori infection in Japanese patients.

Author: TakimotoT, SatohK, TaniguchiY, SaifukuK, KihiraK, SekiM, YoshidaY, IdoK, KimuraK

LCM1 effective H. pylori cure
LCM1 safe
Minor side effects

A 1-week, low-dose triple therapy with lansoprazole, clarithromycin, and metronidazole (LCM1) was highly effective and safe for Japanese patients with H. pylori infection, achieving a 92.3% cure rate.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Comparison of two low-dose one-week triple therapy regimens with and without metronidazole for cure of H. pylori infection.

Author: JaupB H, NorrbyA

Helicobacter pylori treatment

This study compared two similar one-week regimens for H. pylori infection: lansoprazole, clarithromycin, and either metronidazole or tetracycline. Both regimens were effective, with a cure rate of 93% for the omeprazole, clarithromycin, and tinidazole combination.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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