Effects of lansoprazole: A Synthesis of Findings from 18 Studies

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Original Abstract of the Article

Major Research Findings

Lansoprazole, a proton pump inhibitor, has been shown to effectively suppress gastric acid secretion in numerous studies. 5 found that lansoprazole is as effective as omeprazole in reducing gastric acidity in individuals with Helicobacter pylori infection. 2 demonstrated that lansoprazole can improve Helicobacter pylori infection and antral gastritis in duodenal ulcer patients. 3 investigated the efficacy of intravenous lansoprazole administration, concluding it to be effective in inhibiting gastric acid secretion. Lansoprazole has also been shown to be effective in healing duodenal ulcers, with 10 finding comparable healing rates to omeprazole. Moreover, 14 suggests that lansoprazole might be faster in alleviating gastroesophageal reflux symptoms than omeprazole. 16 highlights the importance of CYP2C19 genetic variation in determining lansoprazole’s pharmacokinetic profile.

Benefits and Risks

Benefit Summary

Lansoprazole has demonstrated effectiveness in treating various conditions related to excessive gastric acid production, including duodenal ulcers, gastric ulcers, and gastroesophageal reflux disease. 5 , 2 , 10 , 14 . Its efficacy in reducing gastric acidity and healing ulcers makes it a valuable option for managing these conditions.

Risk Summary

A potential risk associated with lansoprazole is an increase in serum gastrin levels, as observed in several studies like 12 . Additionally, some individuals may experience side effects such as skin rash and constipation as documented in 10 .

Comparison Across Studies

Commonalities Across Studies

A consistent finding across multiple studies is the effectiveness of lansoprazole in reducing gastric acid secretion. Numerous studies have demonstrated its efficacy in treating duodenal ulcers and other gastrointestinal conditions associated with excessive acid production.

Differences Across Studies

While several studies show lansoprazole to be comparable to omeprazole in its effectiveness, 14 suggests that lansoprazole may be faster in relieving gastroesophageal reflux symptoms. Furthermore, 16 indicates that CYP2C19 genetic variability can significantly affect lansoprazole’s pharmacokinetic profile.

Consistency and Contradictions in Results

The findings regarding lansoprazole’s effectiveness in managing gastric acidity and related conditions are generally consistent across various studies. However, there is some variability in its speed of action and the possibility of adverse effects like elevated gastrin levels. 12 , 14 . Further research is needed to better understand the factors influencing its therapeutic effects and potential risks in different individuals.

Points to Consider in Real-World Application

Lansoprazole can be a valuable treatment option for various gastrointestinal conditions, but it is crucial to use it as directed by a healthcare professional. 12 , 10 . It is essential to be aware of potential side effects and consult with your doctor if you experience any concerning symptoms. The use of lansoprazole should be personalized based on individual needs and medical history.

Limitations of Current Research

While considerable research has been conducted on lansoprazole, some aspects remain incompletely understood. For instance, the exact mechanism by which lansoprazole affects gastric lipase secretion and intragastric lipolysis requires further investigation. 15 . Additionally, the clinical significance of CYP2C19 genetic variability on lansoprazole’s pharmacokinetics requires more in-depth study. 16 . Furthermore, long-term effects of lansoprazole use warrant more extensive research to assess its safety and potential impact over extended periods.

Directions for Future Research

Future research should focus on better understanding the long-term effects of lansoprazole use, including its impact on gastrin levels and other potential consequences. 12 . Further investigation into the mechanism by which lansoprazole influences gastric lipase and intragastric lipolysis is also needed. 15 . Research is required to clarify the clinical significance of CYP2C19 genetic variability in determining lansoprazole’s effectiveness and potential adverse effects. 16 .

Conclusion

Lansoprazole has demonstrated effectiveness in suppressing gastric acid secretion and treating various gastrointestinal conditions like duodenal ulcers and gastroesophageal reflux disease. 5 , 2 , 10 , 14 . However, it is essential to use it as directed by a doctor and be aware of potential side effects. 12 , 10 . Further research is required to fully elucidate the long-term effects of lansoprazole and address other unanswered questions regarding its efficacy and safety.

Literature analysis of 18 papers
Positive Content
17
Neutral Content
0
Negative Content
1
Article Type
18
0
0
1
18
1.

The effects of lansoprazole, a new H+,K(+)-ATPase inhibitor, on gastric pH and serum gastrin.

Author: SandersS W, TolmanK G, GreskiP A, JenningsD E, HoyosP A, PageJ G

Gastric pH increase
Gastrin elevation

Lansoprazole, a proton pump inhibitor, significantly increases gastric pH after 7 days of dosing. In a study involving healthy male volunteers, lansoprazole doses of 10, 20, and 60mg increased median 24-hour gastric pH, with morning dosing resulting in higher pH than evening dosing.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

The effects of short-term lansoprazole therapy on Helicobacter pylori infection and antral gastritis in duodenal ulcer patients.

Author: JhalaN C, McFarlandM M, BrightmanS A, MoraleB, RubinW, AtkinsonB F

H. pylori treatment
Lansoprazole effective

This study investigated the effects of 4 weeks of lansoprazole therapy on Helicobacter pylori infection and antral gastritis in patients with duodenal ulcers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Studies of various administration methods for lansoprazole injection using 24-hour intragastric pH monitoring.

Author: InoueM, NakamuraM

Gastric acid inhibition

This study compared the acid secretion inhibitory effects of intravenous bolus injection and intravenous drip infusion of lansoprazole. Both methods were found to be effective in inhibiting gastric acid secretion.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Proton pump inhibitors for Helicobacter pylori eradication in patients with peptic ulcer.

Author: YamamotoI, FukudaY, OkuiM, TamuraK, ShimoyamaT

Helicobacter pylori eradication
Peptic ulcer healing

Lansoprazole combined with antibiotics effectively eradicated Helicobacter pylori in patients with peptic ulcers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Effects of omeprazole and lansoprazole on 24-hour intragastric pH in Helicobacter pylori-positive volunteers.

Author: VerdúE F, FraserR, ArmstrongD, BlumA L

Lansoprazole antisecretory efficacy
Omeprazole antisecretory efficacy

Omeprazole and lansoprazole were comparably effective antisecretory agents in H. pylori-positive subjects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Comparison of lansoprazole with omeprazole on 24-hour intragastric pH, acid secretion and serum gastrin in healthy volunteers.

Author: Bruley des VarannesS, LevyP, LartigueS, DellatolasF, LemaireM, GalmicheJ P

Inhibit acid secretion
Increase gastrin levels

This study compared the effects of lansoprazole and omeprazole, both proton pump inhibitors, on intragastric acidity and serum gastrin levels in 12 healthy volunteers. Both drugs effectively inhibited acid secretion, with lansoprazole showing a slightly greater reduction in acidity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

[Comparison of lansoprazole (30 mg) and omeprazole (20 mg) in the treatment of duodenal ulcer. A multicenter double-blind comparative trial].

Author: PetiteJ P, SlamaJ L, LichtH, LemerezM, CosteT, AndrieuJ, GrimaudJ C, JulienH, DupuisJ, SallerinV

Faster efficacy
Treat duodenal ulcer disease
Increased gastrin levels
Minor side effects

Lansoprazole (30 mg/d) is more effective in healing duodenal ulcers than omeprazole (20 mg/d) after two weeks, but both treatments have similar efficacy after 4 weeks.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

8.

The effects of lansoprazole, 30 or 60 mg daily, on intragastric pH and on endocrine function in healthy volunteers.

Author: DammannH G, von zur MühlenA, BalksH J, DamaschkeA, SteinhoffJ, HennigU, SchwarzJ A, FuchsW

Lowers gastric acid

Lansoprazole raised intragastric pH significantly and had no clinically relevant effects on endocrine function or adverse events.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Acute treatment of duodenal ulcer: experience with lansoprazole.

Author: MignonM, VallotT

Good tolerability
Rapid pain relief
Ulcer healing
Ulcer relapse

Lansoprazole was effective in treating duodenal ulcers and well-tolerated, with a relapse rate similar to omeprazole or H2-antagonists.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

Comparison of lansoprazole and omeprazole in the short-term management of duodenal ulcers in Taiwan.

Author: ChangF Y, ChiangC Y, TamT N, NgW W, LeeS D

Effective ulcer healing
Well tolerated
Constipation
Skin rash

Lansoprazole was as effective as omeprazole in healing duodenal ulcers and was well tolerated with minimal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

The effects of oral doses of lansoprazole and omeprazole on gastric pH.

Author: TolmanK G, SandersS W, BuchiK N, KarolM D, JenningsD E, RinghamG L

Gastric pH control
Gastrin elevation

Lansoprazole and omeprazole were compared for their effects on gastric pH in 17 healthy adult men. 30 mg lansoprazole had the most significant effect on gastric pH. All three regimens were associated with reversible elevations of serum gastrin.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Effects of long-term treatment with lansoprazole and omeprazole on serum gastrin and the fundic mucosa.

Author: Arroyo VillarinoM T, Lanas ArbeloaA, Esteva DíazF, Ortego Fernández de RetanaJ, Sainz SamitierR

Safe long-term
Mild hypergastrinemia

Long-term treatment with either omeprazole or lansoprazole for 6 months is safe and leads to mild hypergastrinemia. No significant differences were observed between the two drugs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

The comparative effects of lansoprazole, omeprazole, and ranitidine in suppressing gastric acid secretion.

Author: BlumR A, ShiH, KarolM D, Greski-RoseP A, HuntR H

Increased gastric pH

Lansoprazole 30 mg QD produced significantly higher mean 24-hour intragastric pH values compared to lansoprazole 15 mg QD, omeprazole 20 mg QD, or ranitidine 150 mg QID in 29 healthy male volunteers. Lansoprazole 30 mg also resulted in significantly greater mean percentages of time that the gastric pH was above 3.0 and 4.0. All treatment regimens were well tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Comparison of the effect of lansoprazole and omeprazole on intragastric acidity and gastroesophageal reflux in patients with gastroesophageal reflux disease.

Author: JanczewskaI, SagarM, SjöstedtS, HammarlundB, IwarzonM, SeensaluR

Esophagitis Healing
Faster Symptom Relief

Lansoprazole (LAN) was more effective in relieving symptoms of gastroesophageal reflux compared to omeprazole (OME) in patients with esophagitis, even though both drugs effectively healed esophagitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Effects of lansoprazole on human gastric lipase secretion and intragastric lipolysis in healthy human volunteers.

Author: RenouC, CarrièreF, VilleE, GrandvalP, Joubert-CollinM, LaugierR

Gastric acid reduction

Lansoprazole, a proton-pump inhibitor (PPI), reduces the production of gastric acid. This study investigated the effects of lansoprazole on human gastric lipase (HGL) secretion and intragastric lipolysis during the ingestion of meals by healthy volunteers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Comparison of the kinetic disposition of and serum gastrin change by lansoprazole versus rabeprazole during an 8-day dosing scheme in relation to CYP2C19 polymorphism.

Author: IeiriI, KishimotoY, OkochiH, MomiyamaK, MoritaT, KitanoM, MorisawaT, FukushimaY, NakagawaK, HasegawaJ, OtsuboK, IshizakiT

Drug interactions

The disposition kinetic behavior of lansoprazole and rabeprazole is co-segregated with CYP2C19.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

The effects of nocturnal acid breakthrough on Helicobacter pylori eradication.

Author: KimJin Il, ParkSoo-Heon, KimJae Kwang, ChungIn Sik, ChungKyu Won, SunHee Sik

H. pylori eradication

This study investigated the effects of nocturnal gastric acid breakthrough (NAB) on Helicobacter pylori eradication in peptic ulcer patients. Lansoprazole 60 mg once a day was more effective than lansoprazole 30 mg twice a day in reducing NAB, but NAB did not impact the eradication of H. pylori.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Comparison of the effects of single and repeated oral doses of lansoprazole and rabeprazole on ambulatory 24-hour intragastric pH in healthy volunteers.

Author: TolmanKeith G, TäubelJörg, WarringtonSteven, ChiuYi-Lin, PilmerBetsy L, PanWei-Jian

Gastrointestinal disease treatment

This study compared the pharmacokinetics and pharmacodynamics of single and repeated daily doses of lansoprazole and rabeprazole.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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