Side Effects of linaclotide: A Synthesis of Findings from 10 Studies

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This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

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Original Abstract of the Article

Main Research Findings

Linaclotide has been shown to be effective in treating chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C) in several studies. 7 Linaclotide has been approved by the U.S. Food and Drug Administration for both chronic constipation and IBS-C, and by the European Medicines Agency for IBS-C. 6 It has been shown to be effective in patients who do not respond well to other treatment options. 6

Reasons for Side Effects

Linaclotide is a drug that works by stimulating the production of a substance called cyclic guanosine monophosphate (cGMP) in the gut. 4 This stimulates the release of fluids into the intestines, making the stools softer and easier to pass. This mechanism of action can lead to side effects such as diarrhea.

Common Side Effects

Diarrhea

The most common side effect of linaclotide is diarrhea. 4 This side effect is caused by the increased fluid secretion in the intestines.

Abdominal Pain

Linaclotide may also cause abdominal pain. 4 This side effect may be caused by the increased intestinal motility that linaclotide promotes.

Other Side Effects

Linaclotide can also cause other side effects, such as nausea, vomiting, abdominal bloating, and constipation. 8 Less commonly, allergic reactions, such as rash and hives, have also been reported. 9

Side Effects Management

Diarrhea

If you experience diarrhea, you may need to reduce the dosage of linaclotide or stop taking it. 4 It is also important to stay hydrated.

Abdominal Pain

If you experience abdominal pain, you may need to reduce the dosage of linaclotide or stop taking it. 4 Diet and exercise may also help.

Other Side Effects

If you experience any other side effects, talk to your doctor. 8

Comparison Between Studies

Commonalities in Research

Several studies have shown that linaclotide is effective in treating chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C). 7 Linaclotide has been approved by the U.S. Food and Drug Administration for both chronic constipation and IBS-C, and by the European Medicines Agency for IBS-C. 6 It has been shown to be effective in patients who do not respond well to other treatment options. 6

Differences in Research

There are differences in the reported effectiveness and side effects of linaclotide between different studies. For example, one study found that linaclotide was associated with a higher rate of side effects, including diarrhea. 4 However, another study found that linaclotide caused very few side effects, including diarrhea. 8 These differences may be attributed to various factors such as study design and participant characteristics.

Considerations for Real-World Applications

Linaclotide is an effective drug for the treatment of constipation, but it can cause side effects like diarrhea. 4 Therefore, it is important to take linaclotide as directed by your doctor. Additionally, linaclotide is not recommended for pregnant or breastfeeding women, or for people with liver or kidney disease. 8 Also, linaclotide can interact with other medications, so consult your doctor if you are taking other medications.

Limitations of Current Research

There is a lack of sufficient research on linaclotide, especially long-term studies evaluating its effectiveness and safety. 9

Future Research Directions

Long-term studies are needed to evaluate the effectiveness and safety of linaclotide. 9 Research on drug interactions between linaclotide and other medications is also needed.

Conclusion

Linaclotide is an effective drug for treating chronic idiopathic constipation and irritable bowel syndrome with constipation. 7 However, it can cause side effects such as diarrhea, so it is important to take it as directed by your doctor. 4 More research is needed to understand the long-term effectiveness and safety of linaclotide. 9

Literature analysis of 10 papers
Positive Content
10
Neutral Content
0
Negative Content
0
Article Type
1
0
0
7
10
2.

Single-Dose Linaclotide Is Equal in Efficacy to Polyethylene Glycol for Bowel Preparation Prior to Capsule Endoscopy.

Author: SteinDaniel J, CoplandAndrew, McDanielDeborah, HaysR Ann

Small bowel visualization
Recorder failure

Linaclotide, a single-dose given 1 hour before capsule endoscopy, was equally effective as polyethylene glycol (PEG) in improving visualization and transit time in patients undergoing small bowel capsule endoscopy. Both regimens were well-tolerated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Recent advances in understanding and managing chronic constipation.

Author: PrichardDavid O, BharuchaAdil E

Constipation treatment
Undesirable side effects

Constipation is a common condition that can affect physical, mental, and social functioning. Current guidelines recommend empiric therapy, but limited surveys suggest that fewer than half of treated individuals are satisfied with treatment. Newer therapeutic agents, such as secretagogues and pro-kinetics, may offer more effective treatment options.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Comparison of acupuncture and other drugs for chronic constipation: A network meta-analysis.

Author: ZhuLingping, MaYunhui, DengXiaoyan

Chronic constipation treatment
Side effects

Acupuncture is more effective than drugs in treating chronic constipation and has the fewest side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Retracted PublicationCases where a publication has been formally withdrawn due to the discovery of serious errors or misconduct.

Language : English

6.

Review article: Linaclotide for the management of irritable bowel syndrome with constipation.

Author: LayerP, StanghelliniV

IBS-C treatment

This article discusses the use of linaclotide for the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic constipation. Linaclotide has recently been approved by the European Medicines Agency (EMA) and the US Food and Drug Administration for these conditions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Linaclotide: a novel compound for the treatment of irritable bowel syndrome with constipation.

Author: RothsteinRobin D, FriedenbergFrank K

Chronic constipation treatment
IBS-C treatment

This review discusses the use of linaclotide, a new medication approved in the US for both irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation. The article compares linaclotide to lubiprostone, the only other medication currently approved for IBS-C.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

Linaclotide, novel therapy for the treatment of chronic idiopathic constipation and constipation-predominant irritable bowel syndrome.

Author: Vazquez-RoqueMaria I, BourasErnest P

Constipation treatment
IBS-C treatment

Linaclotide, a secretagogue, shows promise in treating chronic constipation (CC) and irritable bowel syndrome with constipation (IBS-C). This novel drug has a low oral bioavailability, negligible systemic side effects, and acts locally in the intestinal lumen.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

Linaclotide, a synthetic guanylate cyclase C agonist, for the treatment of functional gastrointestinal disorders associated with constipation.

Author: Vazquez RoqueMaria, CamilleriMichael

Long-term efficacy
Long-term safety
Intolerance
Nausea

Linaclotide is a novel drug with a unique mechanism of action, low bioavailability, and local action in the intestinal epithelial cells. It has demonstrated long-term efficacy and safety for the treatment of chronic constipation and irritable bowel syndrome with constipation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

[New drugs for the treatment of constipation].

Author: AdamBirgit, LiebregtsTobias, GerkenGuido

Constipation treatment

This review discusses new therapeutic options for chronic idiopathic constipation and irritable bowel syndrome with constipation. It highlights prucalopride and lubiprostone, along with other promising medications currently under investigation. These new drugs offer alternatives for treating constipation after the withdrawal of tegaserod due to cardiac concerns.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

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