Effects of magnesium hydroxide: A Synthesis of Findings from 20 Studies

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Original Abstract of the Article

Major Research Findings

Magnesium hydroxide has been shown to have a variety of effects in different fields. It has been shown to improve heartburn, relieve constipation, prevent kidney stones, improve the burning properties of food, and even affect bacterial growth. 16 has shown that magnesium hydroxide promotes the absorption of glibenclamide, a drug that lowers blood sugar, and enhances its effect. In addition, 15 has reported that magnesium hydroxide neutralizes stomach acid and raises the pH of the esophagus and stomach.

On the other hand, 20 has shown that magnesium hydroxide affects the rumen microbiome in cattle and specifically changes the amount of bacteria involved in butyrate production. 18 has shown that nano-magnesium hydroxide affects the chemical form of cadmium in soil and inhibits cadmium uptake by plants. Magnesium hydroxide may also help fix heavy metals in soil.

While magnesium hydroxide has a variety of effects, its mechanism of action and specific effects are still under investigation, and further research is needed.

Benefits and Risks

Benefits Summary

Magnesium hydroxide is a substance that has the potential to be useful in a variety of settings. It has been suggested to be effective in improving heartburn caused by excess stomach acid, relieving constipation, and preventing kidney stones. It also has the potential to be helpful in fixing heavy metals in soil and improving the burning properties of food.

Risks Summary

Magnesium hydroxide is generally considered to be a safe substance, but there is a risk of diarrhea and magnesium toxicity from excessive intake. Interactions with certain medications have also been reported, so it is important to consult a doctor or pharmacist before taking it. In particular, people with kidney disease or heart disease should consult a doctor before taking magnesium hydroxide.

Comparison of Studies

Commonalities of Studies

Multiple studies have shown that magnesium hydroxide has a common effect of neutralizing stomach acid, relieving constipation, and increasing magnesium levels.

Differences of Studies

The effects of magnesium hydroxide have been shown to differ depending on the subject, administration method, and dosage. For example, 16 found that magnesium hydroxide promoted the absorption of glibenclamide, while 20 found that magnesium hydroxide affected the rumen microbiome in cattle. In this way, the effects of magnesium hydroxide can vary depending on the subject and situation.

Consistency and Contradictions of Results

The various effects of magnesium hydroxide are supported by numerous studies. However, some research results may be contradictory. For example, 16 and 20 have found that magnesium hydroxide has different effects on different organisms. This may be because the mechanism of action of magnesium hydroxide is complex and may be affected by a variety of factors. Further research is needed to elucidate the mechanism of action of magnesium hydroxide and clarify its effects and safety.

Notes on Real-Life Application

Magnesium hydroxide is used for applications such as improving heartburn, relieving constipation, and preventing kidney stones. However, magnesium hydroxide can cause side effects such as diarrhea and magnesium toxicity due to excessive intake and interactions with certain medications. Therefore, when using magnesium hydroxide, it is important to consult a doctor or pharmacist and take it as directed.

Limitations of Current Research

Current research has not fully elucidated the long-term effects of magnesium hydroxide or the differences in effects due to various factors. In addition, some studies have limited sample sizes, so caution is needed in generalizing their findings.

Future Directions for Research

Further research is needed to gain a deeper understanding of the various effects of magnesium hydroxide. For example, research into the mechanism of action of magnesium hydroxide, clarifying the differences in effects due to various factors, and research on long-term effects are important. Research to further assess the safety of magnesium hydroxide is also needed.

Conclusion

Magnesium hydroxide is a substance with the potential for a variety of effects. It has the potential to be helpful in a variety of settings, such as improving heartburn and constipation, preventing kidney stones, and even improving soil and burning properties of food. However, magnesium hydroxide also has the potential to cause side effects, such as diarrhea and magnesium toxicity, due to excessive intake and interactions with certain medications. Therefore, when using magnesium hydroxide, it is important to consult a doctor or pharmacist and follow their instructions. Future research is expected to clarify the safe and effective use of magnesium hydroxide.

Literature analysis of 20 papers
Positive Content
19
Neutral Content
0
Negative Content
1
Article Type
1
0
0
0
18
1.

Inhibitory effects of magnesium hydroxide on c-myc expression and cell proliferation induced by methylazoxymethanol acetate in rat colon.

Author: WangA, YoshimiN, TanakaT, MoriH

Cancer prevention

Magnesium hydroxide inhibits the expression of the c-myc proto-oncogene and cell proliferation in rat colon mucosa, suggesting a potential anti-carcinogenic effect against methylazoxymethanol acetate-induced colon carcinogenesis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Comparison of the effects of magnesium hydroxide and a bulk laxative on lipids, carbohydrates, vitamins A and E, and minerals in geriatric hospital patients in the treatment of constipation.

Author: KinnunenO, SalokannelJ

Improved glucose tolerance
Improved lipid profile
Improved uric acid levels
Hypomagnesemia

A crossover study compared the effects of magnesium hydroxide and a bulk laxative on elderly patients. Magnesium hydroxide was associated with a slight reduction in low values of high-density lipoprotein cholesterol and high values of triglycerides, while both laxatives had no significant difference in plasma lipids, whole blood minerals, or vitamins A and E. Magnesium hydroxide may be beneficial in patients with magnesium deficiency due to diuretics.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Versatile effects of magnesium hydroxide nanoparticles in PLGA scaffold-mediated chondrogenesis.

Author: ParkKwang-Sook, KimByoung-Ju, LihEugene, ParkWooram, LeeSoo-Hong, JoungYoon Ki, HanDong Keun

Cartilage regeneration
Orthopedic treatment

This study developed a new type of scaffold that can be used to help repair damaged cartilage. The scaffold is made of a synthetic material that is biodegradable and includes magnesium hydroxide nanoparticles to reduce acidification.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

The effects of oral magnesium hydroxide administration on rumen fluid in cattle.

Author: SmithGeoffrey W, CorreaMaria T

Microbial activity reduction
Rumen pH regulation

This study investigates the effects of oral magnesium hydroxide administration on rumen fluid in cattle. The results indicate that both powdered and bolus forms of magnesium hydroxide significantly increase rumen pH and decrease rumen microbial activity.

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Effects of magnesium hydroxide in renal stone disease.

Author: JohanssonG, BackmanU, DanielsonB G, FellströmB, LjunghallS, WikströmB

Stone formation inhibition
Side effects

Magnesium treatment significantly reduced recurrent renal calcium stone formation in patients without magnesium deficiency. Urinary magnesium excretion increased, and the magnesium/calcium ratio approached a value found in healthy subjects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

The effects of famotidine, ranitidine and magnesium hydroxide/aluminium hydroxide on gastric fluid pH in adult horses.

Author: MurrayM J, GrodinskyC

Gastric pH control

Famotidine, ranitidine, and antacid were compared for their ability to increase gastric fluid pH in horses. Both famotidine and ranitidine were more effective than antacid in increasing gastric fluid pH. Ranitidine tended to increase gastric fluid pH greater than 6 longer than famotidine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

The effects of magnesium hydroxide on the absorption and efficacy of two glibenclamide preparations.

Author: NeuvonenP J, KivistöK T

Improves glycemic control

Magnesium hydroxide significantly enhanced the absorption and efficacy of a non-micronised glibenclamide preparation, but had minimal effect on the absorption of a micronised glibenclamide preparation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

[Effects of the administration of magnesium hydroxide on gastric acidity in health volunteers].

Author: PassarettiS, MazzottiG, FranzoniM, TittobelloA

Reduce gastric acidity

This study assessed the real efficacy of magnesium hydroxide administration on gastric acidity using 24-hour gastric pH-metry in healthy volunteers. It found that 800 mg of magnesium hydroxide induced an immediate, effective, and prolonged antacid action, reaching a maximum pH value of 5 and lasting up to 40 minutes.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Italian

18.

[Effects of Nano-magnesium Hydroxide on the Forms of Cadmium in Different Types of Soil].

Author: DengJi-Bao, ZhangChun-Lai, XuWei-Hong

Reduce soil EX-Cd

This study investigated the effects of nano-magnesium hydroxide and common magnesium hydroxide on cadmium forms in different types of cadmium contaminated soils. The results show that both types of magnesium hydroxide reduced the soil exchange Cd form, with nano-magnesium hydroxide being more effective.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Chinese

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