Side Effects of mepolizumab injection: A Synthesis of Findings from 4 Studies

  1. Home
  2. Side Effects of mepolizumab injection
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of mepolizumab injection: A Synthesis of Findings from 4 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of mepolizumab injection: A Synthesis of Findings from 4 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Mepolizumab is approved for patients with severe asthma with an eosinophilic phenotype aged 12 or more (United States) or 6 or more (European Union) years, but its long-term use in children aged 6 to 11 years has not yet been assessed. 3

Mepolizumab is also used to treat eosinophilic sinusitis. 1

Benralizumab has been shown to be effective in treating severe eosinophilic asthma that is refractory to omalizumab and mepolizumab treatment. 2

Reasons for Side Effects

Biological agents such as mepolizumab work by targeting the immune system. Therefore, these drugs may cause allergic reactions and other side effects. 4

Common Side Effects

Headache

Headache has been reported as a side effect of mepolizumab and omalizumab. 1

Injection Site Reactions

Injection site reactions have been reported as a side effect of mepolizumab and omalizumab. 1

Pharyngitis

Pharyngitis has been reported as a side effect of dupilumab. 1

Epistaxis

Epistaxis has been reported as a side effect of dupilumab. 1

Asthma

Asthma has been reported as a side effect of dupilumab. 1

Anaphylaxis

There is a slightly increased risk of anaphylaxis with omalizumab and reslizumab, which has required the inclusion of a black box warning. 4

Hypersensitivity Reactions

Hypersensitivity reactions such as urticaria and very rarely serum sickness have occurred with omalizumab and reslizumab. 4

Side Effect Management

Anaphylaxis

Patients should be observed for a period of time after receiving omalizumab or reslizumab. Patients should also be provided with epinephrine auto-injectors for self-administration if needed. 4

Study Comparison

Study Similarities

These studies suggest that biological agents are effective in treating asthma and allergic diseases. However, these drugs may cause side effects such as allergic reactions.

Study Differences

These studies evaluated different biological agents. In addition, the patient populations and study designs vary. Therefore, it is not possible to directly compare the results of these studies.

Real-Life Application Notes

Biological agents are effective drugs for treating asthma and allergic diseases. However, these drugs may cause side effects such as allergic reactions. Therefore, it is important to consult with your doctor before taking biological agents. If you experience side effects such as allergic reactions while taking biological agents, consult your doctor immediately.

Current Research Limitations

The long-term safety of biological agents is not yet fully understood. Also, the effectiveness of these drugs may vary from patient to patient.

Future Research Directions

Further research is needed to investigate the long-term safety and effectiveness of biological agents. Research is also needed to improve the effectiveness of these drugs.

Conclusion

Biological agents are effective drugs for treating asthma and allergic diseases, but they may cause side effects such as allergic reactions. It is important to consult with your doctor when considering taking these drugs.

Literature analysis of 4 papers
Positive Content
4
Neutral Content
0
Negative Content
0
Article Type
0
0
1
2
3
1.

Adverse events of biological therapy in chronic rhinosinusitis with nasal polyps: A systematic review.

Author: AldajaniAhmad, AlroqiAhmad, AlromaihSaud, AloulahMohammad O, AlsalehSaad

Effective CRSwNP treatment
Limited adverse events
Headaches
Injection site reactions
Pharyngitis

This systematic review summarizes the safety and adverse events associated with the biological therapy of chronic rhinosinusitis with nasal polyps (CRSwNP).

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Long-term safety and pharmacodynamics of mepolizumab in children with severe asthma with an eosinophilic phenotype.

Author: GuptaAtul, IkedaMasanori, GengBob, AzmiJay, PriceRobert G, BradfordEric S, YanceySteven W, SteinfeldJonathan

Improved asthma control
Reduced asthma exacerbations
Reduced blood eosinophil counts
Adverse events

Mepolizumab, an anti-IL-5 monoclonal antibody, was well tolerated and effective in children aged 6 to 11 years with severe asthma with an eosinophilic phenotype. The drug reduced blood eosinophil counts and asthma exacerbations and improved asthma control over 52 weeks.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Hypersensitivity and adverse reactions to biologics for asthma and allergic diseases.

Author: JacksonKim, BahnaSami L

Asthma and allergic disease treatment
Anaphylaxis
Hypersensitivity reactions

This review article discusses the adverse effects (AE) of five biologics approved for asthma and/or allergic diseases: omalizumab, mepolizumab, reslizumab, benralizumab, and dupilumab.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.