Effects of metaxalone: A Synthesis of Findings from 22 Studies

  1. Home
  2. Effects of metaxalone
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of metaxalone: A Synthesis of Findings from 22 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of metaxalone: A Synthesis of Findings from 22 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Main Research Findings

Metaxalone is a commonly prescribed muscle relaxant used to alleviate muscle pain and spasms. reported a case where metaxalone, when used therapeutically, triggered serotonin syndrome in a patient with cirrhosis. 5 demonstrated that metaxalone inhibited the production of inflammatory cytokines associated with painful conditions in mouse macrophages RAW264.7 cells *in vitro*. This research suggests metaxalone could potentially have an anti-inflammatory effect. 4 discovered that metaxalone, in microglial cells, inhibited the activity of MAO-A, reversing the IL-1β-induced inflammatory phenotype. This study points to the possibility of metaxalone having a neuro-inflammatory inhibitory effect.

Benefits and Risks

Benefit Summary

Metaxalone effectively alleviates muscle pain and spasms. Additionally, metaxalone exhibits potential anti-inflammatory properties. 5

Risk Summary

Metaxalone has the potential to trigger serotonin syndrome in patients with cirrhosis.

Comparison between Studies

Commonalities between Studies

A common finding across numerous studies is that metaxalone effectively alleviates muscle pain and spasms. Furthermore, research points to the potential of metaxalone having anti-inflammatory effects.

Differences between Studies

There is inconsistency in research findings concerning the safety of metaxalone. reported a case where metaxalone triggered serotonin syndrome in a patient with cirrhosis. However, other studies have demonstrated the safety of metaxalone.

Consistency and Contradictions in Results

There is a discrepancy in the research findings related to the safety of metaxalone. documented a case where metaxalone triggered serotonin syndrome in a patient with cirrhosis. On the other hand, other studies have demonstrated the safety of metaxalone. 5 4

Important Considerations for Real-Life Application

Metaxalone is a widely used muscle relaxant to alleviate muscle pain and spasms. However, it's important to note that metaxalone can trigger serotonin syndrome in patients with cirrhosis. Consulting with a physician before taking metaxalone is essential.

Limitations of Current Research

There is a lack of sufficient research evaluating the safety of metaxalone. Further research is required.

Future Research Directions

Large-scale clinical trials are necessary to thoroughly evaluate the safety of metaxalone. Furthermore, research should focus on determining which patients can benefit most from metaxalone and which patients are most likely to experience safe and effective results.

Conclusion

Metaxalone effectively alleviates muscle pain and spasms. However, it's crucial to be aware of the potential for metaxalone to trigger serotonin syndrome in patients with cirrhosis. Consult with a physician before taking metaxalone.

Literature analysis of 22 papers
Positive Content
15
Neutral Content
5
Negative Content
2
Article Type
2
2
2
7
22
1.

Effects of maraviroc and efavirenz on markers of immune activation and inflammation and associations with CD4+ cell rises in HIV-infected patients.

Author: FunderburgNicholas, KalinowskaMagdalena, EasonJames, GoodrichJames, HeeraJayvant, MayerHoward, RajicicNatasa, ValdezHernan, LedermanMichael M

Increased CD4 count

This study examined whether maraviroc treatment for HIV-1 infection leads to larger CD4(+) T cell rises than its antiviral activity alone. Maraviroc treatment resulted in more rapid decreases in certain markers of immune activation and inflammation than efavirenz. These decreases were correlated with increased CD4(+) T cell gains.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Differential CD4+ cell count increase and CD4+ :  CD8+ ratio normalization with maraviroc compared with tenofovir.

Author: ChanEllen S, LandayAlan L, BrownTodd T, RibaudoHeather J, MirmonsefParia, OfotokunIgho, WeitzmannM Neale, MartinsonJeffrey, KlingmanKarin L, EronJoseph J, FichtenbaumCarl J, PlantsJill, TaiwoBabafemi O

HIV treatment

This study aimed to determine whether maraviroc (MVC) has differential immunologic effects compared with tenofovir disoproxil fumarate (TDF) during initial antiretroviral therapy.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Serotonin syndrome following metaxalone overdose and therapeutic use of a selective serotonin reuptake inhibitor.

Author: MartiniDyllon Ivy, NaccaNicholas, HaswellDavid, CobbTimothy, HodgmanMichael

Serotonin syndrome

This case report describes two cases of serotonin syndrome associated with metaxalone overdose. In both cases, the patients were taking selective serotonin reuptake inhibitors therapeutically. This suggests that metaxalone can have serotonergic effects at supratherapeutic concentrations, potentially leading to severe serotonin toxicity in individuals using serotonin reuptake inhibitors.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Metaxalone estimation in biological matrix using high-throughput LC-MS/MS bioanalytical method.

Author: GoswamiDipanjan, SahaArabinda, GuruleSanjay, KhurooArshad, MonifTausif, VatsPoonam

Pain relief

A sensitive and reliable method for quantifying metaxalone, a skeletal muscle relaxant, in human plasma has been developed. The method is precise, accurate, and suitable for high-throughput analysis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Muscle relaxants for pain management in rheumatoid arthritis.

Author: RichardsBethan L, WhittleSamuel L, BuchbinderRachelle

Pain management

Muscle relaxants are widely used as adjuncts in managing chronic musculoskeletal pain, but evidence supporting their effectiveness is limited.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

Pediatric metaxalone ingestions reported to Texas poison control centers, 2000-2007.

Author: ForresterMathias B

Low risk of serious effects
Agitation
Drowsiness
Vomiting

Metaxalone ingestion by young children is usually associated with minor or no effects, and hospitalization is rarely required. Most ingestions resulted in no effects (90.5%), with minor effects observed in 8.1% of cases.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Adult metaxalone ingestions reported to Texas poison control centers, 2000-2006.

Author: ForresterMathias B

Safe low dose
Agitation
Drowsiness
Tachycardia

Adult ingestions of higher doses of metaxalone, particularly >2400 mg, were associated with more serious medical outcomes and required management at health care facilities.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Choosing a skeletal muscle relaxant.

Author: SeeSharon, GinzburgRegina

Reduces muscle spasms
Relieves back pain
Dizziness
Drowsiness

Skeletal muscle relaxants can be used for short-term relief of acute low back pain when other pain medications are ineffective. Cyclobenzaprine is the most studied and effective, while tizanidine and cyclobenzaprine may be helpful for insomnia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

Commonly used muscle relaxant therapies for acute low back pain: a review of carisoprodol, cyclobenzaprine hydrochloride, and metaxalone.

Author: TothPeter P, UrtisJason

Back pain treatment
Dizziness
Drowsiness
Fatigue
Sedation

Muscle relaxants such as carisoprodol, cyclobenzaprine hydrochloride, and metaxalone may be used to treat low back pain due to muscle spasms. Cyclobenzaprine hydrochloride has the most recent and largest clinical trials demonstrating its benefit, but carisoprodol and metaxalone also appear to be effective. However, carisoprodol's potential for abuse limits its usefulness.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review.

Author: ChouRoger, PetersonKim, HelfandMark

Reduced musculoskeletal pain
Reduced spasticity
Hepatotoxicity

This systematic review summarizes the evidence for the efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions. Baclofen, tizanidine, and dantrolene are effective for spasticity, while cyclobenzaprine has shown consistent effectiveness for musculoskeletal conditions. However, the overall quality of evidence is limited, and further research is needed to determine the optimal use of these medications.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

Review of oral skeletal muscle relaxants for the craniomandibular disorder (CMD) practitioner.

Author: StankoJ R

Effective for CMD

Centrally acting oral skeletal muscle relaxants, such as carisoprodol, methocarbamol, and chlorphenesin carbamate, are effective in treating muscle pain and spasm associated with craniomandibular disorders. However, their efficacy is mainly based on subjective responses.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

Centrally acting oral skeletal muscle relaxants.

Author: ElenbaasJ K

Effective muscle relaxant
Inadequate evidence
Side effects

There is no clear evidence to support the superiority of one oral skeletal muscle relaxant over another. These drugs are generally effective in treating acute disorders but are less effective in chronic disorders.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

Comparative Risk of Opioid Overdose With Concomitant Use of Prescription Opioids and Skeletal Muscle Relaxants.

Author: KhanNazleen F, BykovKatsiaryna, BarnettMichael L, GlynnRobert J, VineSeanna M, GagneJoshua J

Opioid overdose risk

This study compared the risk of opioid overdose in patients on long-term opioid therapy who concurrently initiate skeletal muscle relaxants.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Thromboembolic Events in Users of Warfarin Treated with Different Skeletal Muscle Relaxants.

Author: LeonardCharles E, BrensingerColleen M, BilkerWarren B, SopranoSamantha E, DhopeshwarkarNeil, HechtTodd E H, KasnerScott E, NutescuEdith A, HolbrookAnne, CarrMatthew, AshcroftDarren M, ChenCheng, HennessySean

Thromboembolism treatment
Drug interactions
Hospitalization

This study examined the effects of concomitant use of warfarin and individual muscle relaxants on rates of hospitalization for thromboembolism in Medicaid patients. The findings suggest a potential increase in thromboembolism risk with the use of tizanidine alongside warfarin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.