Side Effects of moexipril: A Synthesis of Findings from 7 Studies

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Original Abstract of the Article

Major Research Findings

Multiple studies have shown that moexipril, either alone or in combination with hydrochlorothiazide, is effective in lowering blood pressure in elderly hypertensive patients and is generally well tolerated over the long term. 3 , 2 .

Reasons for Side Effects

Moexipril is an angiotensin-converting enzyme (ACE) inhibitor. It lowers blood pressure by inhibiting ACE, which reduces the production of angiotensin II. ACE inhibitors have several side effects that can occur due to the inhibition of ACE.

Common Side Effects

Cough

One of the most commonly reported side effects of moexipril is cough. 1 . This cough is believed to be caused by the inhibition of breakdown of substances like bradykinin by ACE.

Hypotension

Moexipril can cause low blood pressure, as it is designed to lower blood pressure. 3

Dizziness

Moexipril can cause dizziness. 3

Fatigue

Moexipril can cause fatigue. 2

Headache

Moexipril can cause headaches. 2

Side Effect Management

Cough

If you experience cough due to moexipril, consult your doctor. You might need to switch to a different blood pressure medication. 1

Hypotension

If you experience low blood pressure due to moexipril, consult your doctor. Your dosage might need to be adjusted. 3

Dizziness

If you experience dizziness due to moexipril, consult your doctor. Your dosage might need to be adjusted. 3

Comparison Between Studies

Commonalities

Multiple studies have demonstrated that moexipril, either alone or in combination with hydrochlorothiazide, effectively lowers blood pressure in elderly hypertensive patients and is generally well tolerated over the long term.

Differences

The frequency and type of side effects of moexipril can vary depending on the study. For instance, 3 reported a cough incidence of 12%, while 2 reported 5%. Additionally, 3 reported side effects such as fatigue, headaches, and dizziness, whereas 2 did not.

Points to Note Regarding Real-Life Application

Moexipril is an effective medication for treating hypertension, but it's essential to remember that it comes with the risk of side effects. When taking moexipril, it is crucial to follow your doctor's instructions and adhere to the prescribed dosage. Consult your doctor if you are concerned about side effects.

Limitations of Current Research

Research on the side effects of moexipril is still limited, particularly regarding long-term side effects.

Future Research Directions

Further research on the long-term side effects of moexipril is required. Additionally, developing new methods for mitigating the side effects of moexipril is necessary.

Conclusion

Moexipril is a valuable medication for treating hypertension, but it's important to remember the potential for side effects. When taking moexipril, always follow your doctor's instructions and maintain the prescribed dosage. If you have concerns about side effects, consult your doctor.

Literature analysis of 7 papers
Positive Content
7
Neutral Content
0
Negative Content
0
Article Type
3
1
1
1
7
1.

Angiotensin-converting enzyme inhibitor induced cough compared with placebo, and other antihypertensives: A systematic review, and network meta-analysis.

Author: HuYiyun, LiangLing, LiuShuang, KungJanice Y, BanhHoan Linh

Cardiac mortality and morbidity prevention
Dry cough

Angiotensin converting enzyme inhibitors (ACEIs) are known to cause dry cough. This systematic review and network meta-analysis ranked the risk of cough induced by different ACEIs and compared them to placebo, ARB, or CCB. Moexipril had the highest risk of cough (80.4%), while spirapril had the lowest (12.3%). ACEIs should be avoided in patients at risk of cough, and an ARB or CCB is a possible alternative.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

2.

Long-term efficacy and safety of moexipril in the treatment of hypertension.

Author: WhiteW B, FoxA A, StimpelM

Blood pressure reduction
Hypertension treatment
Cough
Dizziness
Fatigue
Headache

Moexipril, an angiotensin-converting enzyme inhibitor, effectively lowers blood pressure in hypertensive patients, both alone and in combination with hydrochlorothiazide. It is generally well-tolerated, with common side effects including fatigue, headache, dizziness, and increased cough.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Long-term safety and efficacy of moexipril alone and in combination with hydrochlorothiazide in elderly patients with hypertension.

Author: WhiteW B, StimpelM

Blood pressure control
Cough
Dizziness
Hypotension

Moexipril, an angiotensin converting enzyme inhibitor, is effective and well-tolerated for long-term treatment of hypertension in elderly patients. After 2 years, blood pressure decreased significantly in patients taking moexipril alone or in combination with hydrochlorothiazide. Side effects included hypotension, dizziness, and increased cough.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

A comparison of the antihypertensive effectiveness of a combination of moexipril or sustained-release verapamil with low-dose hydrochlorothiazide.

Author: ChrysantS G, StimpelM

Hydrochlorothiazide
Hypertension treatment
Moexipril
Verapamil SR

Both moexipril and verapamil SR produced an additive hypertensive effect when added to low-dose hydrochlorothiazide.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Preclinical safety studies of the combination moexipril hydrochloride/hydrochlorothiazide.

Author: GietlR, FrieheH, NeyP

Safe hypertension treatment
Kidney toxicity

The combination of moexipril hydrochloride and hydrochlorothiazide is a safe drug with no significant side effects or toxicity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

[Angiotensin converting enzyme inhibitor moexipril in the treatment of arterial hypertension. Possibilities of moexipril in the treatment of postmenopausal women].

Author: OstroumovaO D, PaukovS V, FrolovaL I

Bone metabolism improvement
Hypertension treatment
Side effects

This review examines the efficacy and safety of moexipril, an angiotensin-converting enzyme inhibitor, for the treatment of arterial hypertension. The authors discuss the advantages of moexipril, including its 24-hour duration of action, metabolic neutrality, and low rate of side effects.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Russian

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