Side Effects of montelukast: A Synthesis of Findings from 23 Studies

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Original Abstract of the Article

Major research findings

Montelukast is a widely used medication for asthma and allergic rhinitis. However, recent studies have suggested that montelukast may cause neuropsychiatric side effects. 15 , 18 , 12 , 1 These side effects have been reported in children and adults who took montelukast, and in severe cases, there are concerns that they could lead to suicidal thoughts and suicide attempts. 19 , 8 , 5

Neuropsychiatric side effects of montelukast often appear within a few weeks of starting the medication, but may also appear for the first time after several years. 12 , 7 These side effects can also affect children's growth and development and require special attention. 13

Reasons for side effects

The exact mechanism by which montelukast causes neuropsychiatric side effects is not yet fully understood. However, it has been suggested that montelukast may disrupt the balance of neurotransmitters in the brain. 1 Montelukast may also affect brain growth and development, which may cause side effects. 11

Common side effects

Sleep disorders

The most common side effect reported for montelukast is sleep disorders. 12 , 10 Specifically, insomnia, nightmares, and night terrors. 9

Mood changes

Taking montelukast can make you feel depressed, irritable, or angry. 12 It can also increase the risk of serious mental illnesses such as depression, anxiety disorders, and suicidal thoughts. 15 , 8

Behavioral abnormalities

Taking montelukast can cause behavioral abnormalities such as restlessness, hyperactivity, and aggression. 12 2

Hallucinations

Taking montelukast can cause hallucinations and delusions. 20

Other side effects

Taking montelukast can cause side effects such as headache, dizziness, nausea, abdominal pain, and rash. 10

Countermeasures for side effects

Sleep disorders

If you experience sleep disorders, talk to your doctor and adjust the dose of montelukast or switch to another medication. 17

Mood changes

If you experience mood changes, talk to your doctor and get treatment for mental illnesses such as depression and anxiety disorders. 17

Behavioral abnormalities

If you experience behavioral abnormalities, talk to your doctor and you may need to stop taking montelukast. 17

Hallucinations

If you experience hallucinations or delusions, see a doctor immediately. 17

Comparison between studies

Commonalities of studies

Many studies have shown that montelukast may cause neuropsychiatric side effects. 15 , 18 , 12 , 1

Differences in studies

There are variations between studies in terms of the risk of side effects of montelukast and the frequency with which side effects occur. 12 4 Some studies suggest that side effects of montelukast may be more common in certain age groups or genders. 12 , 3

Points to note about applying to real life

Montelukast is an effective medication, but it may cause neuropsychiatric side effects. 18 It is important to be aware of any changes in your body or mind while taking montelukast and consult a doctor immediately if you feel anything unusual. 19

Limitations of current research

Research on the neuropsychiatric side effects of montelukast is still insufficient. 4 In particular, the mechanism by which montelukast causes these side effects is not fully understood. 1 More research is needed to assess the risk of montelukast side effects. 4

Future research directions

Research on the neuropsychiatric side effects of montelukast should focus on the following points. 1

  • Elucidate the mechanism by which montelukast causes neuropsychiatric side effects.
  • More accurately assess the risk of montelukast side effects.
  • Develop methods to prevent or reduce side effects of montelukast.

Conclusion

Montelukast is an effective medication, but it may cause neuropsychiatric side effects. 17 It is important to be aware of any changes in your body or mind while taking montelukast and consult a doctor immediately if you feel anything unusual. 19 Research on the neuropsychiatric side effects of montelukast is still insufficient. 4 More research is needed in the future. 1

Literature analysis of 23 papers
Positive Content
9
Neutral Content
2
Negative Content
12
Article Type
0
0
0
3
22
2.

Medication-induced violence others towards.

Author:

Violent behavior

This article discusses the potential for various drugs to induce violent behavior in patients. The frequency of these adverse effects cannot be reliably assessed, but it is important to inform patients about the potential for violent behavior and to encourage them to report any behavioral changes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Psychiatric adverse drug reactions in the paediatric population.

Author: EkhartCorine, VriesTjalling de, HunselFlorence van

ADR characterisation
Psychiatric ADRs

This study analyzed pharmacovigilance reports to identify drugs causing psychiatric adverse drug reactions (ADRs) in children.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Psychiatric adverse drug reactions reported during a 10-year period in the Swedish pediatric population.

Author: BygdellMaria, BrunlöfGertrud, WallerstedtSusanna M, KindblomJenny M

None
Psychiatric ADRs
Suicidal conditions

Psychiatric ADRs in the pediatric population have been reported for a wide range of reactions and drugs and display age and sex differences including a higher number of suicidal reactions in boys. An association was seen between serious reactions and off-label drug use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Strategies for quantifying the relationship between medications and suicidal behaviour: what has been learned?

Author: GibbonsRobert D, MannJ John

Improved depression
Increased suicide risk

This opinion article examines the literature on methodological and statistical approaches to the design and analysis of suicidal event studies. While there is little evidence that drugs increase the risk of suicide, inadequate treatment of depression is associated with increased risk of suicidal behaviour in adults.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

[Adverse drug reactions of montelukast: from theory to practice. Case report].

Author: Caudevilla LafuentePilar, García ÍñiguezJuan P, Martín de VicenteCarlos

Adverse drug reactions
Sleep disorders

This study investigated adverse drug reactions (ADRs) related to montelukast in children with recurrent wheezing or asthma. Sleep disorders were the most frequent ADR, occurring in 5.7% of patients treated with montelukast.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : Spanish

11.

The anti-asthmatic drug, montelukast, modifies the neurogenic potential in the young healthy and irradiated brain.

Author: ErikssonYohanna, BoströmMartina, SandeliusÅsa, BlennowKaj, ZetterbergHenrik, KuhnGeorg, KalmMarie

Neuroprotective
Reduce CIR side effects
Decreased proliferation
Neuron loss

Montelukast, a leukotriene receptor antagonist, showed both beneficial and unfavorable effects in young mice after cranial irradiation (CIR). It protected against cell death and microglia activation in the acute phase but also resulted in lower proliferation in the hippocampus with longer treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

A database of pediatric drug effects to evaluate ontogenic mechanisms from child growth and development.

Author: GiangrecoNicholas P, TatonettiNicholas P

Adverse drug effects

This study emphasizes the challenges of evaluating drug safety in children, highlighting the importance of post-marketing monitoring. The study discusses how current drug safety-signal-detection methods need to account for the dynamic processes of growth and maturation in children.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

14.

Montelukast and neuropsychiatric events - a sequence symmetry analysis.

Author: FoxChristopher W, KhawChelsea L, GerkeAlicia K, LundBrian C

Montelukast use
Neuropsychiatric events

This study investigated the association between montelukast initiation and the risk of neuropsychiatric events (NEs) in adult patients using sequence symmetry analysis. The study found no association between montelukast initiation and increased risk of NEs, including antidepressants, benzodiazepines, hypnotics, antipsychotics, mood stabilizers, and buspirone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Drug-induced tics: An observational postmarketing study.

Author: TouafchiaDavy, MontastrucFrançois, Lapeyre-MestreMaryse, RousseauVanessa, ChebaneLeila, RevetAlexis

Drug-induced tic investigation
Drug-induced tics

This study investigated the association between drug use and tics. The study found that certain types of drugs, such as neuroleptics, psychostimulants, and anti-epileptics, were associated with an increased risk of tics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

18.

Psychiatric Adverse Effects of Montelukast-A Nationwide Cohort Study.

Author: JordanAlexander, ToennesenLouise Lindhardt, EklöfJosefin, SivapalanPradeesh, MeteranHowraman, BønnelykkeKlaus, UlrikCharlotte Suppli, Stæhr JensenJens-Ulrik

Neuropsychiatric adverse events

Montelukast use was associated with an increased risk of neuropsychiatric events, such as the use of neuropsychiatric medicine and hospital treatment, among younger individuals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Is This Medication Safe for My Child? How to Discuss Safety of Commonly Used Medications With Parents.

Author: SkonerDavid P, GolantAlexandra K, NortonAllison E, StukusDavid R

Allergic conditions
Asthma
Atopic dermatitis
Side effects

All medications have potential side effects. It's important to be aware of these side effects, especially when giving medication to children. This is because children may not be able to tell you if they are experiencing side effects. It's important to stay informed about the risks and benefits of medications and to work closely with your child's doctor.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Hallucination development with montelukast in a child with asthma: case presentation.

Author: KocyigitAysen, Gulcan OksuzBanu, YararFulya, UzunFunda, IgdeMahir, IslekIsmail

Asthma treatment
Hallucinations

This case report describes a child who experienced visual hallucinations after starting montelukast, a leukotriene receptor antagonist, for asthma. The hallucinations resolved within 48 hours after stopping the medication.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

Effect of competition bias in safety signal generation: analysis of a research database of spontaneous reports in France.

Author: ParienteAntoine, AvillachPaul, SalvoFrancesco, ThiessardFrantz, Miremont-SalaméGhada, Fourrier-ReglatAnnie, HaramburuFrançoise, BégaudBernard, MooreNicholas,

Reveal masked signals

Competition bias can occur in spontaneous reporting databases, potentially masking safety signals. Removing reports related to well-established drug-event associations can reveal previously masked signals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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