Side Effects of naldemedine: A Synthesis of Findings from 11 Studies

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Original Abstract of the Article

Major Research Findings

Naldemedine is a peripherally acting μ-opioid receptor antagonist indicated for the treatment of opioid-induced constipation. 6 、 9 、 1 、 8 、 4 、 7 、 3 、 10 、 2 、 5 Naldemedine has been shown to promote bowel movements and relieve constipation without compromising the analgesic effects of opioids. 7 、 10 Naldemedine is also believed to have a low risk of causing opioid withdrawal symptoms. 1 However, naldemedine can interact with other drugs, so it is important to consult your doctor before taking it. 8

Reasons for Side Effects

Naldemedine relieves constipation by blocking peripheral μ-opioid receptors. 6 However, this action can cause side effects in some patients. 8

Common Side Effects

Gastrointestinal

Gastrointestinal symptoms are common side effects of naldemedine. 7 Specifically, diarrhea, abdominal pain, nausea, and vomiting have been reported. 7 These symptoms are thought to be caused by naldemedine's promotion of bowel movement. 7

Nervous System

Nervous system symptoms have also been reported as side effects of naldemedine. 7 Specifically, headache, dizziness, and drowsiness have been reported. 7 These symptoms are thought to be caused by naldemedine's potential effects on the central nervous system. 7

Other

Other side effects of naldemedine have also been reported. 7 Specifically, rash, itching, and difficulty breathing have been reported. 7 These symptoms are thought to be caused by allergic reactions to naldemedine. 7

Side Effect Management

Gastrointestinal

If you experience severe gastrointestinal symptoms, consult your doctor. 7 Your doctor may reduce your dose or stop your treatment as needed. 7

Nervous System

If you experience severe nervous system symptoms, consult your doctor. 7 Your doctor may reduce your dose or stop your treatment as needed. 7 Also, avoid driving or operating dangerous machinery while taking naldemedine. 7

Other

If you experience any other side effects, consult your doctor. 7 Your doctor may reduce your dose or stop your treatment as needed. 7

Comparison Across Studies

Commonalities

Multiple studies have confirmed that naldemedine is effective in treating opioid-induced constipation. 6 、 9 、 1 、 8 、 4 、 7 、 3 、 10 、 2 、 5 Furthermore, studies have shown that naldemedine relieves constipation without compromising the analgesic effects of opioids. 7 、 10 In addition, multiple studies have pointed out that naldemedine can interact with other drugs, so it is important to consult your doctor before taking it. 8

Differences

There are differences in the frequency and types of side effects reported across studies. 7 This may be due to differences in the patient populations and study designs. 7

Important Considerations for Real-World Application

While naldemedine is an effective drug for treating opioid-induced constipation, it is important to understand the risk of side effects. 8 When taking naldemedine, it is essential to consult your doctor and follow the appropriate dosage and administration instructions. 8 Also, naldemedine can interact with other drugs, so it is important to consult your doctor before taking it and to check for potential interactions with other medications. 8

Limitations of Current Research

Research on naldemedine is still limited. 7 Further research is needed, especially regarding long-term safety and efficacy. 7

Future Research Directions

Research on the long-term safety and efficacy of naldemedine, as well as its interactions with other drugs, is needed. 7 Furthermore, research is necessary to determine whether naldemedine is effective for various patient populations. 7

Conclusion

Naldemedine is an effective drug for treating opioid-induced constipation. 6 、 9 、 1 、 8 、 4 、 7 、 3 、 10 、 2 、 5 However, because it carries the risk of side effects, it is essential to consult your doctor and follow the appropriate dosage and administration instructions when taking it. 8

Literature analysis of 11 papers
Positive Content
11
Neutral Content
0
Negative Content
0
Article Type
0
0
0
7
11
1.

Opioid withdrawal syndrome developing after long-term administration of naldemedine.

Author: IshidaMayumi, UchidaNozomu, YabunoAkira, HasegawaKosei, MizunumaNaoki, TakahashiTakao, OnishiHideki

Reduced OIC

Naldemedine, an oral peripheral μ opioid receptor antagonist, was developed to address opioid-induced constipation (OIC) without causing opioid withdrawal syndrome (OWS). This drug does not cross the blood-brain barrier, potentially reducing central nervous system-related withdrawal symptoms. The study suggests naldemedine as a promising treatment option for OIC with a reduced risk of OWS.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Safe Use of Opioids in Chronic Kidney Disease and Hemodialysis Patients: Tips and Tricks for Non-Pain Specialists.

Author: ColuzziFlaminia, CaputiFrancesca Felicia, BilleciDomenico, PastoreAntonio Luigi, CandelettiSanzio, RoccoMonica, RomualdiPatrizia

Pain management
Opioid-related side effects

This review focuses on the correct and safe use of opioids in patients with chronic kidney disease (CKD) and hemodialysis (HD).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Naldemedine for the Use of Management of Opioid Induced Constipation.

Author: UritsIvan, PatelAnjana, KiernanHayley Cornwall, ClayConner Joseph, MonteferranteNikolas, JungJai Won, BergerAmnon A, KassemHisham, HasoonJamal, KayeAlan D, KayeAdam M, ViswanathOmar

Opioid-induced constipation treatment

This review focuses on the use of naldemedine, a medication used to treat opioid-induced constipation, a common side effect of opioid medications. The review provides background information, evidence supporting the drug's effectiveness, and indications for its use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Naldemedine: A New Option for OIBD.

Author: ColuzziFlaminia, ScerpaMaria Sole, PergolizziJoseph

Constipation relief
No withdrawal symptoms
Pain management

Naldemedine, a peripherally acting mu-opioid receptor antagonist (PAMORA), has emerged as a well-tolerated treatment option for opioid-induced bowel dysfunction (OIBD), alleviating constipation without affecting analgesia or causing opioid withdrawal symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

Peripherally Acting μ-Opioid Receptor Antagonists for the Treatment of Opioid-Related Side Effects: Mechanism of Action and Clinical Implications.

Author: StreicherJohn M, BilskyEdward J

Opioid induced constipation
Opioid bowel dysfunction

Opioids can cause constipation, a common side effect that can negatively impact patients’ quality of life. New drugs called PAMORAs can reduce constipation without affecting the pain-relieving effects of opioids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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