Side Effects of nateglinide: A Synthesis of Findings from 12 Studies

  1. Home
  2. Side Effects of nateglinide
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of nateglinide: A Synthesis of Findings from 12 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of nateglinide: A Synthesis of Findings from 12 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Main Research Findings

Several studies have explored the use of opioid antagonists, such as naloxone and nalmefene, in managing opioid-related side effects. 4 , 3 , 5 . These studies have shown that these antagonists can effectively reduce side effects like nausea, vomiting, and sedation without impacting the pain-relieving effects of opioids. 11 , 9 . Additionally, research suggests that combining opioids with other medications, such as droperidol, might help minimize certain side effects like nausea and vomiting. 2 . However, a significant limitation is the lack of large-scale, well-designed randomized controlled trials, making it challenging to draw definitive conclusions and hindering the possibility of meta-analysis. 8 .

Reasons for Side Effects

Opioids primarily function by interacting with the central nervous system, leading to pain relief. However, their interaction with the brain also triggers various side effects like nausea, vomiting, constipation, and drowsiness. These effects are thought to arise from opioids binding to specific receptors in the brain. 10 .

Common Side Effects

Nausea and Vomiting

Opioids are known to cause nausea and vomiting. This occurs because they slow down muscle activity in the digestive system, delaying the emptying of the stomach. 10 . Opioid antagonists like naloxone and nalmefene have shown potential in alleviating this side effect. 4 . Additionally, combining opioids with other medications like droperidol might be beneficial. 2 .

Constipation

Opioids can lead to constipation by slowing down muscle activity in the digestive system. 8 . Measures to prevent constipation, such as increasing dietary fiber intake, staying hydrated, and engaging in regular exercise, can help manage this side effect. 8 . Laxatives can also be a helpful intervention. 8 .

Drowsiness

Opioids, due to their impact on the central nervous system, can cause drowsiness. 10 . Reducing the opioid dosage or adjusting the timing of administration can help alleviate this side effect. 10 . Furthermore, it is crucial to avoid activities that demand focus and judgment, such as driving or operating machinery, when experiencing drowsiness. 10 .

Countermeasures for Side Effects

Nausea and Vomiting

Nausea and vomiting can be mitigated by administering opioid antagonists like naloxone and nalmefene. 4 , 3 , 5 . Combining with other medications like droperidol can also be effective. 2 .

Constipation

Constipation can be managed by taking preventive measures like consuming a high-fiber diet, staying hydrated, and exercising regularly. 8 . Laxatives can also provide relief. 8 .

Drowsiness

Drowsiness can be reduced by lowering the opioid dosage or adjusting the administration time. 10 . It is essential to avoid activities that require concentration and judgment, such as driving or operating machinery, if drowsiness is experienced. 10 .

Comparison between Studies

Commonalities between Studies

A significant finding across many studies is the effectiveness of opioid antagonists in reducing opioid-related side effects. 4 , 3 , 5 , 9 . Furthermore, studies suggest that combining opioids with other medications or using specific combinations might help minimize side effects. 2 .

Differences between Studies

The specific opioid antagonists and combinations found to be effective vary between studies. 4 , 3 , 5 , 9 , 2 . Additionally, variations in patient populations and study designs across studies make it challenging to directly compare results. 8 .

Points to Note Regarding Application to Real Life

Opioids are powerful pain relievers, but they come with the potential for side effects. Therefore, it is crucial to adhere strictly to the doctor's instructions when using opioids and be vigilant about any potential side effects. 8 . It is also advisable to avoid activities requiring concentration and judgment, like driving or operating machinery, while using opioids. 10 .

Limitations of Current Research

Research on opioid side effects remains insufficient. There is a notable lack of large-scale and long-term studies. 8 .

Directions for Future Research

Further research on opioid side effects is crucial and necessitates conducting large-scale and long-term studies. 8 . Developing new methods to reduce opioid side effects and to accurately assess the risk of side effects is also highly important. 8 .

Conclusion

Opioids offer substantial pain relief, but they also carry the risk of side effects. It is essential to follow the doctor's instructions precisely and be mindful of potential side effects when using opioids. 8 . If you have concerns about side effects, consult your doctor. 8 .

Literature analysis of 12 papers
Positive Content
10
Neutral Content
0
Negative Content
2
Article Type
11
1
1
1
12
1.

Epidural morphine with butorphanol in pediatric patients.

Author: LawhornC D, BrownR E

Side effect reduction

Butorphanol 40 micrograms/kg added to epidural morphine 80 micrograms/kg was found to be effective in decreasing the occurrence of side effects caused by neuraxial opioids in pediatric patients. The study involved 20 children between the ages of 2 and 17 years undergoing spinal, abdominal, or thoracic procedures.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Patient-controlled analgesia with morphine and droperidol following caesarean section under spinal anaesthesia.

Author: RussellD, DuncanL A, FrameW T, HigginsS P, AsburyA J, MillarK

Reduced nausea
Reduced vomiting
Drowsiness

Droperidol, when added to morphine for patient-controlled analgesia (PCA) after caesarean section under spinal anesthesia, reduced the incidence of nausea and emesis. However, it also caused drowsiness in two patients, which limited the usefulness of the technique.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Comparison of intravenous nalbuphine infusion versus naloxone in the prevention of epidural morphine-related side effects.

Author: WangJ J, HoS T, TzengJ I

Postoperative pain management
Nausea and vomiting
Pruritus

This study compared the efficacy of nalbuphine and naloxone intravenous infusions in preventing epidural morphine-related side effects, such as nausea, vomiting, and pruritus.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Effects of prophylactic nalmefene on the incidence of morphine-related side effects in patients receiving intravenous patient-controlled analgesia.

Author: JoshiG P, DuffyL, ChehadeJ, WesevichJ, GajrajN, JohnsonE R

Reduces opioid-related side effects

This study was designed to determine the dose-response relation for nalmefene for the prevention of morphine-related side effects in patients receiving intravenous patient-controlled analgesia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Epidural naloxone reduces pruritus and nausea without affecting analgesia by epidural morphine in bupivacaine.

Author: ChoiJ H, LeeJ, BishopM J

Preserved analgesia
Reduced side effects
None reported

Epidural naloxone reduced morphine-induced side effects in a dose-dependent fashion without reversal of the analgesic effect.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Effect of combining naloxone and morphine for intravenous patient-controlled analgesia.

Author: SartainJames B, BarryJohn J, RichardsonChristopher A, BranaganHelen C

Reduced morphine side effects

This study investigated the effects of combining morphine and naloxone via patient-controlled analgesia (PCA) on morphine-related side effects. The combination of morphine and naloxone via PCA was found to decrease the incidence of side effects compared to morphine alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

[Patient-controlled analgesia with lornoxicam in patients undergoing gynecological surgery].

Author: GongZ Y, YeT H, QinX T, YuG X, GuoX Y, LuoA L

Effective pain relief
Fewer adverse events

Lornoxicam provides an alternative to morphine or tramadol for the treatment of postoperative pain, with fewer adverse events.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

8.

Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review.

Author: McNicolEwan, Horowicz-MehlerNathalie, FiskRuth A, BennettKyle, Gialeli-GoudasMaria, ChewPriscilla W, LauJoseph, CarrDaniel,

Constipation
Delirium
Myoclonus
Nausea
Pruritus
Respiratory depression
Sedation
Vomiting

This systematic review assessed the management of opioid side effects in cancer pain management and chronic noncancer pain. Well-designed trials are needed to provide evidence-based guidelines for managing opioid side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

Effects of epidural naloxone on pruritus induced by epidural morphine: a randomized controlled trial.

Author: JeonY, HwangJ, KangJ, HanS, RheeK, OhY

Reduced pruritus severity

Continuous epidural infusion of naloxone combined with morphine is effective in reducing the incidence and severity of pruritus induced by epidural morphine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Cognitive-affective and somatic side effects of morphine and pentazocine: side-effect profiles in healthy adults.

Author: RileyJoseph L, HastieBarbara A, GloverToni L, FillingimRoger B, StaudRoland, CampbellClaudia M

Cognitive side effects
Somatic side effects

This study examined the subjective effects of morphine and pentazocine on somatic and cognitive/affective side effects using questionnaires.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

11.

A small-dose naloxone infusion alleviates nausea and sedation without impacting analgesia via intravenous tramadol.

Author: JiaDong-Lin, NiCheng, XuTing, ZhangLi-Ping, GuoXiang-Yang

Reduced nausea
Reduced sedation
Reduced vomiting

A small dose of naloxone infusion reduced tramadol-induced side effects without reversing its analgesic effects in patients undergoing cervical vertebrae surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Does adding low doses of oral naltrexone to morphine alter the subsequent opioid requirements and side effects in trauma patients?

Author: FarahmandShervin, AhmadiOmid, DehpourAhmadreza, KhashayarPatricia

Reduced nausea

Ultra-low-dose naltrexone combined with morphine does not alter opioid requirements in patients with extremity trauma but may reduce the risk of nausea.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.