Effective treatment of neuromuscular disorders: A Synthesis of Findings from 22 Studies

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Original Abstract of the Article

Major Research Findings

Neuromuscular disorders are diseases that affect both the nervous system and the muscles, leading to impairments in body movement. These disorders come in various types, each with distinct causes and symptoms. , 21 , 9 , 8 , 3 , 5 , , 6 , 22 , 7 , 2 , 16 , 12 , , 18 , 20 , 13 , 4 , 11 , , 15 , 19 , 17 , 10 , , 14 , 1 These studies suggest that various approaches are effective in treating neuromuscular disorders. These approaches include drug therapy, physical therapy, rehabilitation, surgery, and more. In recent years, new treatment methods such as gene therapy and immunotherapy have been developed.

Treatment Summary

Various approaches are suggested to be effective in treating neuromuscular disorders. 21 , 9 , 8 , 3 , 5 , 22 , 16 , 12 , 18 , 20 , 13 , 4 , , 19 , 17 , 10 , 14 , 1 These approaches include drug therapy, physical therapy, rehabilitation, surgery, and more. In recent years, new treatment methods such as gene therapy and immunotherapy have been developed.

Benefits and Risks

Benefits Summary

There are various benefits to treating neuromuscular disorders. 21 , 9 , 3 , 5 , 22 , 16 , 12 , 18 , 20 , 13 , 4 , , 19 , 17 , 10 , 14 , 1 These benefits include improved muscle function, enhanced quality of life, and extended lifespan.

Risks Summary

Various risks are associated with treating neuromuscular disorders. 21 , 9 , 3 , 5 , 22 , 16 , 12 , 18 , 20 , 13 , 4 , , 19 , 17 , 10 , 14 , 1 These risks include side effects, infections, and surgical complications.

Comparison Between Studies

Commonalities Between Studies

These studies share the common finding that various approaches are suggested to be effective in treating neuromuscular disorders. 21 , 9 , 8 , 3 , 5 , 22 , 16 , 12 , 18 , 20 , 13 , 4 , , 19 , 17 , 10 , 14 , 1 These approaches include drug therapy, physical therapy, rehabilitation, surgery, and more. In recent years, new treatment methods such as gene therapy and immunotherapy have been developed.

Differences Between Studies

These studies differ in their focus on different types of neuromuscular disorders. 21 , 9 , 8 , 3 , 5 , 22 , 16 , 12 , 18 , 20 , 13 , 4 , , 19 , 17 , 10 , 14 , 1 Therefore, the effective treatment methods vary depending on the specific neuromuscular disorder.

Consistency and Contradictions in Findings

The findings of these studies suggest that various approaches are effective in treating neuromuscular disorders, showing overall consistency. 21 , 9 , 8 , 3 , 5 , 22 , 16 , 12 , 18 , 20 , 13 , 4 , , 19 , 17 , 10 , 14 , 1 However, it's important to note that the effective treatment methods differ depending on the specific neuromuscular disorder.

Implications for Everyday Life

Neuromuscular disorders can present with a wide range of symptoms, significantly impacting daily life. 21 , 9 , 8 , 3 , 5 , 22 , 16 , 12 , 18 , 20 , 13 , 4 , , 19 , 17 , 10 , 14 , 1 Therefore, early diagnosis and appropriate treatment are crucial.

Limitations of Current Research

Research on neuromuscular disorders is still in its developmental stages and faces numerous challenges. 21 , 9 , 8 , 3 , 5 , 22 , 16 , 12 , 18 , 20 , 13 , 4 , , 19 , 17 , 10 , 14 , 1 These challenges include the complexity of the diseases, the difficulty in developing effective treatments, and the high cost of treatment.

Future Research Directions

Further research is necessary to develop effective treatments for neuromuscular disorders. 21 , 9 , 8 , 3 , 5 , 22 , 16 , 12 , 18 , 20 , 13 , 4 , , 19 , 17 , 10 , 14 , 1 These studies involve the development of new treatments such as gene therapy, immunotherapy, and regenerative medicine, as well as effective treatment combinations and cost containment.

Conclusion

Neuromuscular disorders exhibit a wide range of causes and symptoms. 21 , 9 , 8 , 3 , 5 , 22 , 16 , 12 , 18 , 20 , 13 , 4 , , 19 , 17 , 10 , 14 , 1 While various approaches are suggested to be effective in treating these diseases, further research is necessary.

Treatment List

Drug therapy, physical therapy, rehabilitation, surgery, gene therapy, immunotherapy

Literature analysis of 22 papers
Positive Content
18
Neutral Content
0
Negative Content
4
Article Type
0
0
0
16
22
2.

Prevention of Adverse Outcomes and Treatment Side Effects in Patients with Neuromuscular Disorders.

Author: GroverKavita M, SripathiNaganand

Neuromuscular disorder treatment
Neuromuscular disorders

This article examines the prevention of adverse outcomes and side effects in patients with neuromuscular disorders like myopathies and myasthenia gravis. Early identification of risk factors and proactive treatment planning are key to modifying the course of these disorders and preventing serious complications.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

[Surgical treatment options of foot deformities caused by neuromuscular disorders].

Author: EbskovLars Bo, JohanesenJens Kurt, JantzenChristopher

Neuromuscular disease treatment

Neuromuscular diseases can cause foot and ankle deformities. While nonoperative measures can often be successful, surgical treatment with tendon transfers, osteotomies, or arthrodesis may be necessary in some patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Danish

5.

Multimodal treatment including lumbar facet joint denervation for severe low back pain in patients with neuromuscular disorders.

Author: TeraoTohru, KatoNaoki, SasakiYuichi, OharaKeiichirou, MichishitaShoutarou, NakayamaYosuke, HadanoKeisuke, KaragiozovKostadin, TaniSatoshi, MurayamaYuichi

LBP treatment

This study evaluates the efficacy of lumbar facet joint denervation (FJD) and adjunctive modalities in the treatment of low back pain (LBP) in patients with neuromuscular disorders (NMDs) and associated kyphoscoliosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

The Impact of Next-Generation Sequencing on the Diagnosis, Treatment, and Prevention of Hereditary Neuromuscular Disorders.

Author: BeecroftSarah J, LamontPhillipa J, EdwardsSamantha, GoulléeHayley, DavisMark R, LaingNigel G, RavenscroftGianina

Neuromuscular disorder diagnosis

This review explores the impact of high-throughput sequencing on the field of genetic neuromuscular disorders. The authors discuss how sequencing technology has revolutionized diagnosis, treatment, and research in this area. They also highlight the continued need for further research to discover new disease genes and mechanisms, and anticipate the benefits of future technological advancements.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Gastric Biopsies in Gastroparesis: Insights into Gastric Neuromuscular Disorders to Aid Treatment.

Author: ChikkamenahalliLakshmikanth L, PasrichaPankaj J, FarrugiaGianrico, GroverMadhusudan

Gastroparesis

Studies on full-thickness gastric biopsies have significantly advanced our understanding of human gastroparesis. This article highlights the cellular and molecular features of gastroparesis, including the role of interstitial cells of Cajal (ICC) and macrophages.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

Dasatinib/HP-β-CD Inclusion Complex Based Aqueous Formulation as a Promising Tool for the Treatment of Paediatric Neuromuscular Disorders.

Author: CutrignelliAnnalisa, SanaricaFrancesca, LopalcoAntonio, LopedotaAngela, LaquintanaValentino, FrancoMassimo, BoccanegraBrigida, MantuanoPaola, De LucaAnnamaria, DenoraNunzio

CML treatment
Duchenne muscular dystrophy treatment

This study explored the potential use of a new formulation of dasatinib, a drug used for chronic myeloid leukemia (CML), in pediatric patients and for the treatment of Duchenne muscular dystrophy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Treatment of muscle weakness in neuromuscular disorders.

Author: FinstererJosef, Zarrouk-MahjoubSinda

Muscle weakness treatment

This manuscript reviews recent findings and future perspectives on the treatment of muscle weakness in neuromuscular disorders (NMDs). It highlights the challenges in treating weakness and emphasizes the need for further research to expand the range of treatment options.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

Opportunities and challenges for the development of antisense treatment in neuromuscular disorders.

Author: van PuttenMaaike, Aartsma-RusAnnemieke

Neuromuscular disorder treatment
Neuromuscular disorders

Antisense oligonucleotides show therapeutic potential for a number of neuromuscular disorders. This review explores the potential benefits of this approach for treating these diseases.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

A Dutch guideline for the treatment of scoliosis in neuromuscular disorders.

Author: MullenderMg, BlomNa, De KleuverM, FockJm, HittersWmgc, HoremansAmc, KalkmanCj, PruijsJeh, TimmerRr, TitarsolejPj, Van HaasterenNc, JagerMj Van Tol-de, Van VughtAj, Van RoyenBj

Scoliosis correction

Children with neuromuscular disorders often develop scoliosis, which can severely impact breathing and sitting. Spinal surgery is the primary treatment option and requires a multidisciplinary approach and specialized care.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Plasma exchange in neuroimmunological disorders: part 2. Treatment of neuromuscular disorders.

Author: LehmannHelmar C, HartungHans-Peter, HetzelGerd R, StüveOlaf, KieseierBernd C

Neuropathic disorder treatment

Plasma exchange is a treatment for several neurological disorders of autoimmune origin. The study reviewed the effectiveness of plasma exchange in conditions like Guillain-Barré syndrome, myasthenia gravis, and Lambert-Eaton syndrome, suggesting potential benefits in these neuromuscular disorders.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

Presymptomatic neuromuscular disorders disclosed following statin treatment.

Author: TsivgoulisGeorgios, SpengosKonstantinos, KarandreasNikolaos, PanasMarios, KladiAthina, MantaPanagiota

CK elevation
Muscle damage
Rhabdomyolysis

Statins can worsen muscle tissue and may trigger or reveal pre-existing muscle disorders. The study reported cases where statin use led to myositis, rhabdomyolysis, and muscle weakness. It suggests that persistent muscle symptoms after stopping statins should prompt further evaluation for underlying neuromuscular diseases.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Cardiac monitoring and treatment for children and adolescents with neuromuscular disorders.

Author: EnglishKate M, GibbsJohn L

Cardiac assessment
Neuromuscular disorders

This article discusses the cardiac complications associated with certain neuromuscular disorders in children and young adults. It emphasizes the importance of routine cardiological assessment in these patients and recommends a pragmatic approach to screening and drug interventions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

Corticosteroid use in the treatment of neuromuscular disorders: empirical and evidence-based data.

Author: BrombergMark B, CarterOrly

Neuromuscular disorder treatment
Corticosteroid side-effects

Corticosteroids have been used to treat neuromuscular disorders for many years. This review examines the literature for data concerning corticosteroid pharmacokinetics and for evidence-based treatment regimens in several prototypic neuromuscular disorders.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

18.

Diagnosis and treatment of neuromuscular disorders of the stomach.

Author: KochKenneth L

Dietary counseling
Drug treatment
Medical devices
Gastric neuromuscular disorders

Gastric neuromuscular disorders encompass a spectrum of dysfunction in nerve and smooth muscle, leading to dyspepsia symptoms. Gastroparesis is the most severe form and requires exclusion of reversible causes like mechanical obstruction. Treatment options include dietary counseling, drugs, and medical devices.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

Non-invasive ventilatory approach to treatment of acute respiratory failure in neuromuscular disorders. A comparison with endotracheal intubation.

Author: VianelloA, BevilacquaM, ArcaroG, GallanF, SerraE

Respiratory failure treatment
Neuromuscular respiratory failure
Ventilation

This study investigates the effectiveness of non-invasive positive pressure ventilation (NPPV) combined with cricothyroid 'mini-tracheostomy' (CM) as a first-line treatment for acute respiratory failure (ARF) of neuromuscular origin compared to positive pressure ventilation (PPV) via endotracheal intubation (ETI).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

The use of intravenous immunoglobulins in the treatment of neuromuscular disorders.

Author: VoltzR, HohlfeldR

Improved neuromuscular function

Intravenous immunoglobulin (IVIg) is increasingly used for neuromuscular disorders. Its effectiveness has been proven for Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, and Lambert-Eaton myasthenic syndrome. Emerging evidence suggests potential benefits for other neuromuscular disorders.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

22.

Neuromuscular disorders in systemic malignancy and its treatment.

Author: StübgenJ P

cancer
chemotherapy
neuromuscular dysfunction
radiation

Neuromuscular dysfunction in patients with known or suspected malignancy can occur due to direct effects of the neoplasm, paraneoplastic effects, or side effects of anticancer treatment. A complex clinical picture can evolve when dysfunction arises from multiple causes at multiple anatomical sites.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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