Major Research Findings

Several natural products are known to accelerate the process of wound healing. found that glucosylated tetrahydrocurcumin (glucosyl-THC), a derivative of curcumin, significantly enhanced wound healing activity and reduced epithelialization time in rats. The improved bioavailability of the glucosyl compound was attributed to its enhanced percutaneous absorption. concluded that lactoferrin may be beneficial in the prevention and treatment of iron deficiency anemia in pregnant women. It is believed to normalize iron homeostasis by facilitating iron absorption and inhibiting inflammatory processes. suggested that integrative oncology therapies can help reduce future cancer risk and treatment-related adverse effects in young women with breast cancer.

Reasons for Side Effects

Side effects are a common concern with many medications, and natural products are no exception. Some factors that contribute to side effects include individual variations in metabolism, drug interactions, and the dosage of the substance. For example, 2 found that patients' beliefs about medications play a role in the occurrence of side effects. Additionally, the study of investigated potential drug interactions with methotrexate (MTX), a common rheumatoid arthritis medication. It concluded that MTX side effects may be enhanced or its efficacy reduced when used in combination with other drugs.

Common Side Effects

Digestive System

Side effects involving the digestive system, such as nausea, vomiting, diarrhea, and abdominal pain, are commonly reported in patients taking methotrexate, as shown in the study of 4 .

Liver

The study of 4 highlighted liver dysfunction, including elevated levels of AST and ALT, as a potential side effect of methotrexate treatment.

Blood

One common side effect of sulfasalazine is blood disorders, such as anemia, leukopenia, and thrombocytopenia, as demonstrated in the study of .

Nervous System

The study of mentioned that antidepressants may cause nervous system side effects, including headaches, dizziness, and drowsiness.

Other

In addition to the above, the study of 5 found that p-hydroxycinnamic diesters, while demonstrating cholesterol-lowering effects in mice fed a high-fat diet, also showed potential side effects such as liver inflammation and cell death. The study of observed similar side effects of liver inflammation and cell death with p-methoxycinnamic acid diesters in mice.

Side Effect Management

Digestive System

To manage digestive system side effects, dietary modifications and medications may be used. The study of 4 recommends frequent small meals and the use of medications like antiemetics and antacids to reduce digestive system side effects associated with methotrexate.

Liver

Regular monitoring of liver function is crucial to manage liver-related side effects. The study of 4 advocates for regular liver function tests to detect early signs of liver dysfunction caused by methotrexate.

Blood

Regular blood tests are recommended to manage blood-related side effects. The study of suggests the use of regular blood tests to detect early signs of blood disorders associated with sulfasalazine.

Nervous System

Adjusting medication dosages or switching to alternative medications may be employed to manage nervous system side effects. The study of recommends adjusting medication dosages or switching medications under the guidance of a physician to mitigate nervous system side effects from antidepressants.

Comparison Between Studies

Commonalities of Studies

Many studies highlight the potential benefits of using natural products for various health concerns.

Differences between Studies

It is important to acknowledge the variability in effects, side effects, safety, study subjects, and methodologies, making it challenging to directly compare results across different studies.

Precautions for Applying Research to Real Life

Natural products are not regulated as strictly as medications, and their effects and safety are not always well established. Therefore, it is crucial to consult with a healthcare professional before incorporating natural products into your routine. This is particularly important for pregnant women, breastfeeding mothers, and individuals with existing health conditions. Remember to start with a small amount and observe for any adverse reactions before increasing the dosage.

Limitations of Current Research

A significant limitation of many studies is that they rely on animal experiments and in vitro studies. Further research, particularly clinical trials involving humans, is necessary to confirm the effectiveness and safety of natural products.

Future Directions for Research

More in-depth research is required to fully understand the effects, safety, and mechanisms of action of natural products. Conducting human clinical trials is essential to establish efficacy, side effects, and safety. Elucidating the mechanisms of action will be instrumental in developing more effective and safe methods of using these natural products.

Conclusion

Natural products have a lot of potential for promoting health. However, their effectiveness and safety can vary. It is essential to consult with a healthcare professional before using any natural product and to carefully evaluate its potential benefits and risks.