Side Effects of ondansetron: A Synthesis of Findings from 14 Studies

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Original Abstract of the Article

Main Research Findings

Ondansetron is a drug commonly used to prevent nausea and vomiting after surgery. 2 , 3 . However, ondansetron can cause a variety of side effects, and in some cases, it can cause serious reactions such as anaphylactic shock. 4 . While it is expected to reduce nausea and vomiting, some studies have reported side effects such as diarrhea. 7 . Ondansetron is also often used in combination with dexamethasone to prevent nausea and vomiting associated with chemotherapy in children, but dexamethasone is sometimes prohibited in pediatric chemotherapy protocols. 11 . Additionally, ondansetron has been found to be associated with a higher risk of side effects such as catheter occlusion and swelling around the hypodermoclysis site when administered subcutaneously in palliative care for the elderly. 6 . Ondansetron can prolong the QT interval, so electrocardiographic monitoring may be necessary. 12 . Ondansetron has also been reported to cause dystonia, a neurological side effect. 3 . Ondansetron has also been reported to cause ileus, a gastrointestinal side effect. 10 .

Reasons for Side Effects

Ondansetron is a drug that inhibits the action of serotonin. Serotonin plays a role in suppressing nausea, but it is also involved in gastrointestinal motility and neurotransmission. Therefore, ondansetron may cause side effects such as diarrhea and neurological side effects, along with its effect of suppressing nausea. 2 , 7 , 3 . Ondansetron can also prolong the QT interval on electrocardiograms. This is because ondansetron affects the electrical activity of the heart. 12 .

Common Side Effects

Nausea

Ondansetron is used to suppress nausea, but some patients may experience worsening nausea. 7 .

Diarrhea

Ondansetron can cause diarrhea. This is because ondansetron promotes gastrointestinal motility. 7 .

Headache

Ondansetron can cause headaches. 2 .

Dizziness

Ondansetron can cause dizziness. 2 .

Constipation

Ondansetron can cause constipation. 2 .

Anaphylactic Shock

Ondansetron can cause anaphylactic shock. This is an allergic reaction to ondansetron. 4 .

Dystonia

Ondansetron can cause dystonia. This is an abnormal contraction of muscles. 3 .

Ileus

Ondansetron can cause ileus. This is a condition in which the movement of the intestines stops. 10 .

QT Interval Prolongation

Ondansetron can prolong the QT interval on electrocardiograms. This is because ondansetron affects the electrical activity of the heart. 12 .

Countermeasures for Side Effects

Nausea

If you experience severe nausea, consult a doctor. Your doctor may prescribe medication to relieve your nausea. 7 .

Diarrhea

If you experience severe diarrhea, consult a doctor. Your doctor may prescribe antidiarrheal medication. 7 .

Headache

If you experience severe headaches, consult a doctor. Your doctor may prescribe pain medication. 2 .

Dizziness

If you experience dizziness, move to a safe place. Rest and wait for the symptoms to improve before consulting a doctor. 2 .

Constipation

If you experience severe constipation, consult a doctor. Your doctor may prescribe laxatives. 2 .

Anaphylactic Shock

If you experience anaphylactic shock, consult a doctor immediately. Anaphylactic shock is a life-threatening emergency. 4 .

Dystonia

If you experience dystonia, consult a doctor immediately. Dystonia is an abnormal contraction of muscles. 3 .

Ileus

If you experience ileus, consult a doctor immediately. Ileus is a condition in which the movement of the intestines stops. 10 .

QT Interval Prolongation

If QT interval prolongation is confirmed, consult a doctor. Your doctor may discontinue ondansetron or switch to a different medication if necessary. 12 .

Comparison between Studies

Commonalities of Studies

Many studies have shown that ondansetron is effective in preventing postoperative nausea and vomiting. 2 , 1 , , 3 .

Differences between Studies

The frequency and severity of side effects from ondansetron vary depending on the study. 7 , 4 . The frequency and severity of side effects may also vary depending on the method and dosage of ondansetron administration. 6 .

Points to Note Regarding Application to Real Life

While ondansetron is effective in preventing postoperative nausea and vomiting, it can cause various side effects. If you are using ondansetron, it is important to consult a doctor and understand the risks and benefits of side effects before use. 2 , 7 , 4 , 3 .

Limitations of Current Research

Research on the side effects of ondansetron is still not sufficient. In particular, more research is needed on the long-term effects of side effects attributed to ondansetron. 11 , 10 .

Future Research Directions Needed

Further research on the side effects of ondansetron is needed. In particular, research is needed on the long-term effects of side effects, risk factors for side effects, prevention of side effects, and treatment of side effects. 14 , 13 , 9 .

Conclusion

Ondansetron is effective in preventing postoperative nausea and vomiting, but it can cause a variety of side effects. If you are using ondansetron, it is important to consult a doctor and understand the risks and benefits of side effects before use. 2 , 7 , 4 , 3 .

Literature analysis of 14 papers
Positive Content
9
Neutral Content
1
Negative Content
4
Article Type
1
1
1
2
9
1.

Ramosetron versus ondansetron in the prevention of chemotherapy-induced gastrointestinal side effects: A prospective randomized controlled study.

Author: ShiYuankai, HeXiaohui, YangSheng, AiBin, ZhangChanggong, HuangDingzhi, DongMei, LiuPeng, ZhouShengyu, HanXiaohong

Effective
Safe

Ramosetron is a long-lasting and safe antiemetic agent.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Toxicity and side effects of ondansetron.

Author: FinnA L

Reduce chemotherapy side effects
Safe for pediatric and adult
Ataxia
Convulsions
Increased transaminase
Subdued activity

This report reviews the safety of ondansetron, an anti-nausea medication, based on both preclinical and clinical studies. Ondansetron was shown to be safe for intravenous administration to both pediatric and adult patients receiving chemotherapy, with a better tolerability profile than metoclopramide.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Ondansetron-Induced Anaphylactic Shock: An In-Depth Analysis of a Rare Adverse Event.

Author: SuzukiYasuyuki, LiuShuang, IwataMari, YamamotoHideshi, NishidaKatsuko

Postoperative nausea and vomiting prevention
Anaphylactic shock

This article discusses a case of anaphylactic shock triggered by ondansetron, a drug commonly used to prevent postoperative nausea and vomiting. The authors suggest that the reaction may not be a traditional type I allergic reaction but could be mediated through Mas-related G protein-coupled receptor X2 (MRGPRX2).

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

5.

Hypersensitivity reaction to intravenous ondansetron: A case report.

Author: DevkotaSagar, PradhanUmesh, GajurelIshu

Hypersensitivity

This study presents a case report of a 6-year-old female patient who experienced a hypersensitivity reaction to ondansetron, a drug widely used for postoperative nausea and vomiting.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

6.

Factors Associated With the Occurrence of Adverse Effects Resulting From Hypodermoclysis in Older Adults in Palliative Care: A Cohort Study.

Author: de SouzaRaquel Eustaquia, Quispe MendozaIsabel Yovana, ReisAdriano Max Moreira, TavaresJoão Paulo de Almeida, GuimarãesGilberto de Lima, SiminoGiovana de Paula Rezende, MouraRavena Rieelly Araújo, da SilvaSilmar Maria

Palliative care
Catheter obstruction
Swelling

This study analyzed factors associated with local adverse effects from hypodermoclysis in older adults receiving palliative care. The incidence of adverse events was relatively low, with catheter obstruction and swelling being the most common. The use of ondansetron by hypodermoclysis was associated with increased adverse effects, while the use of 0.9% sodium chloride was protective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Antibiomania: A Rare Case of Metronidazole-Induced Mania.

Author: PuriPiyush, ParnamiPankul, ChitkaraAkshit, AthwalPal Satyajit Singh, KhetrapalSunil

Infections treatment
Mania

A case report describes a patient who developed mania after receiving metronidazole for amebic liver abscess. The manic symptoms resolved after discontinuing metronidazole and did not require psychotropic medications. This highlights the importance of awareness of potential neuropsychiatric side effects of antibiotics.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

10.

A Rare Complication of Ileus Following Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis: A Case Report.

Author: SampleJack, HammadFaris, GhazalehSami, BurlenJordan, NawrasAli

Pain management
Paralytic ileus

This case report describes a patient who developed a paralytic ileus, a condition that prevents the intestines from working properly, after undergoing a procedure called endoscopic ultrasound-guided celiac plexus neurolysis. While this procedure is generally safe, this case highlights the importance of being aware of rare side effects.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

11.

Efficacy, safety and feasibility of fosaprepitant for the prevention of chemotherapy-induced nausea and vomiting in pediatric patients receiving moderately and highly emetogenic chemotherapy - results of a non-interventional observation study.

Author: WillierSemjon, Cabanillas StanchiKarin Melanie, von HaveMartina, BinderVera, BlaeschkeFranziska, FeuchtJudith, FeuchtingerTobias, DöringMichaela

CINV

Chemotherapy-induced nausea and vomiting (CINV) is a common side effect in pediatric patients undergoing emetogenic chemotherapy. This study explores the use of ondansetron and fosaprepitant for antiemetic prophylaxis in children who cannot receive dexamethasone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

12.

Evaluation of the Effect of 5 QT-Positive Drugs on the JTpeak Interval - An Analysis of ECGs From the IQ-CSRC Study.

Author: DarpoBorje, BensonCharles, BrownRandy, DotaCorina, FerberGeorg, FerryJim, JarugulaVenkat, KeirnsJames, Ortemann-RenonCatherine, PhamThuan, RileySteve, SarapaNenad, TicktinMark, ZarebaWojciech, CoudercJean-Philippe

QT prolongation assessment
Reduced ECG monitoring

The JTpeak interval is a potential new biomarker for detecting mixed ion channel effects of drugs. This study found that pure hERG blockers prolonged both the QTc and JTpeak_c intervals, while drugs with mixed ion channel effects, like dolasetron and quinine, prolonged QTcF but not the JTpeak_c interval. This suggests that JTpeak could be used to differentiate drugs with different mechanisms of action, potentially reducing the need for late-stage ECG monitoring for mildly QT-prolonging drugs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Sex differences in the pharmacology of itch therapies-a narrative review.

Author: SchmidYasmin, NavariniAlexander, ThomasZita-Rose Manjaly, PfleidererBettina, KrähenbühlStephan, MuellerSimon M

Itch treatment

This review discusses the growing evidence of sex differences in the perception, clinical presentation, and treatment requirements of chronic itch. Further research is needed to understand how sex affects the pharmacology of itch treatments and to develop sex-adapted therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

Adverse side effects of dexamethasone in surgical patients.

Author: PoldermanJorinde Aw, Farhang-RaziViolet, Van DierenSusan, KrankePeter, DeVriesJ Hans, HollmannMarkus W, PreckelBenedikt, HermanidesJeroen

Early discharge
PONV prevention
Pain management
Postoperative complications

Dexamethasone is widely used in the perioperative period for various purposes, but its long-term effects are well-documented. This study explores whether a single steroid load during surgery has negative effects during the postoperative period.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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