Effective treatment of oral cancer: A Synthesis of Findings from 14 Studies

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Original Abstract of the Article

Major Research Findings

Treatment for oral cancer can have a negative impact on quality of life, particularly affecting functions like chewing. 10 highlights that treatments can impair masticatory ability, leading to a decline in quality of life. Oral mucositis, a painful condition affecting the mouth lining, is a common side effect of cancer therapies, including immunotherapy. 8 points out the prevalence of oral mucositis in immunotherapy for oral cancer. This can disrupt eating, speaking, and overall well-being, potentially necessitating treatment adjustments.

Low-level laser therapy has shown promise in mitigating oral mucositis induced by chemoradiotherapy. 4 investigates the use of Helium-Neon laser therapy as a prophylactic measure against oral mucositis in oral cancer patients undergoing chemoradiotherapy.

Gene therapy presents a potentially revolutionary approach for treating oral cancer. 13 suggests that gene therapy could target cancer cells with fewer side effects compared to traditional therapies, including surgery, radiotherapy, and chemotherapy. 12 explores the potential benefits of flavonoids from Chinese herbal medicine as an adjunctive therapy in oral cancer treatment.

Doxorubicin, a common chemotherapy drug, can be less effective against drug-resistant cancer cells. 14 investigates the use of Doxorubicin-loaded nanoparticles to overcome this resistance in oral cancer cells. The research shows that nanoparticles can effectively deliver the drug to resistant cells, potentially improving treatment outcomes.

Treatment Summary

Oral cancer treatments commonly involve surgery, radiotherapy, and chemotherapy. 5 explores the potential of targeted therapies and immunotherapies in oral cancer treatment. These treatments are chosen based on individual patient factors, including tumor location and stage. 9 summarizes the common treatment approaches for oral cavity and oropharyngeal cancers, highlighting the importance of tailoring treatment strategies to individual patient needs.

Benefits and Risks

Benefits Summary

Treatment for oral cancer aims to prevent the disease's progression and reduce the risk of recurrence. Early intervention is crucial for achieving better treatment outcomes. Moreover, advancements in treatment modalities, such as gene therapy and targeted therapies, offer the potential for reduced side effects and improved quality of life.

Risks Summary

Oral cancer treatments can have various side effects, including tissue damage from surgery, radiation damage from radiotherapy, and nausea and hair loss from chemotherapy. 6 highlights the benefits of dietary education programs in improving nutritional status and overall well-being in oral cancer patients after surgery. 7 highlights the risk of depression in oral cancer patients, highlighting the need for comprehensive care addressing mental health needs alongside physical health.

Comparison Between Studies

Commonalities

Multiple studies indicate that oral cancer treatments can significantly impact quality of life for patients.

Differences

Study discrepancies in patient populations, treatment methods, and assessment tools can make direct comparisons challenging.

Consistency and Contradictions in the Findings

The number of studies exploring oral cancer treatment is still relatively limited. Further research is needed to establish consistent and reliable findings.

Practical Implications

Seeking guidance from qualified healthcare professionals is crucial when making decisions about oral cancer treatment. Self-treating is not recommended. It is important to discuss potential benefits and risks with your doctor before starting any treatment.

Limitations of Current Research

The number of studies focusing on oral cancer treatment remains insufficient. Variations in patient populations, treatment strategies, and evaluation methods make it challenging to directly compare findings. The lack of long-term research evaluating treatment effectiveness is another limitation.

Future Research Directions

To obtain a more comprehensive understanding of the effects of oral cancer treatments, large-scale clinical trials are necessary. Developing new treatments that minimize side effects and enhance quality of life remains a key area of focus for future research.

Conclusion

Oral cancer treatment offers a range of options, and choosing the right treatment for each individual is crucial. Seeking guidance from healthcare professionals is essential. Be sure to discuss the potential benefits and risks of treatment options with your doctor before making any decisions.

Treatment List

Surgery, Radiotherapy, Chemotherapy, Gene Therapy, Immunotherapy, Targeted Therapy, Low-Level Laser Therapy, Dietary Education Programs

Literature analysis of 14 papers
Positive Content
11
Neutral Content
2
Negative Content
1
Article Type
2
4
7
8
14
1.

Preoperative chemoradiotherapy in the management of oral cancer: a review.

Author: KlugClemens, BerzaczyDominik, VoracekMartin, MillesiWerner

The study discussed the use of preoperative radiotherapy (RT) or chemoradiotherapy (CRT) followed by radical resection for oral and oropharyngeal squamous cell carcinomas.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

2.

Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.

Author: FurnessSusan, GlennyAnne-Marie, WorthingtonHelen V, PavittSue, OliverRichard, ClarksonJan E, MacluskeyMichaelina, ChanKelvin Kw, ConwayDavid I,

Oral cancer treatment

Cancers of the mouth and throat are often grouped together as oral cancers or head and neck cancers. Treatment for mouth cancer typically involves surgery followed by radiation therapy. Throat cancers are often more advanced at diagnosis and are treated with radiation or a combination of chemotherapy and radiation. Surgery for mouth cancer can cause disfigurement, and both surgery and radiation can lead to significant problems with eating, drinking, and speaking. New chemotherapy drugs, combinations of medications, and changes in the timing of surgery, radiation, and chemotherapy may potentially improve survival and quality of life for these patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

3.

Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.

Author: FurnessSusan, GlennyAnne-Marie, WorthingtonHelen V, PavittSue, OliverRichard, ClarksonJan E, MacluskeyMichaelina, ChanKelvin Kw, ConwayDavid I

Oral cancer treatment

Cancers of the mouth and throat are often grouped together as oral or head and neck cancers. Treatment for mouth cancer usually involves surgery followed by radiation, while throat cancer, often diagnosed at a more advanced stage, is typically treated with radiation or combined chemotherapy and radiation. These treatments can be disfiguring and cause significant side effects, impacting speech, eating, and drinking. New chemotherapy drugs, combinations of treatments, and changes in the order of treatments could potentially lead to improved survival and quality of life for these patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Low level helium neon laser therapy for chemoradiotherapy induced oral mucositis in oral cancer patients - a randomized controlled trial.

Author: GautamAjay Prashad, FernandesDonald J, VidyasagarMamidipudi S, MaiyaG Arun

Laser therapy
OM prevention

Low level Helium Neon (He-Ne) laser therapy was used to prevent and treat oral mucositis (OM) in patients receiving chemoradiotherapy (CRT) for oral cancer (OC). The results showed that prophylactic He-Ne laser therapy can reduce the incidence and severity of OM.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Interventions for the treatment of oral and oropharyngeal cancers: targeted therapy and immunotherapy.

Author: ChanKelvin K W, GlennyAnne-Marie, WeldonJo C, FurnessSusan, WorthingtonHelen V, WakefordHelen

Oral cancer treatment

Oral cancer is a common cancer with a poor survival rate (50% survival after five years). While research into targeted therapies is increasing, their effectiveness in treating oral cancers is not well understood. This review aims to evaluate the effectiveness and side effects of targeted therapies and immunotherapies for oral cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

6.

[The Effects of a Diet Education Program on Nutritional Status and Quality of Life in Oral Cancer Patients Who Underwent Surgery].

Author: LinHsiu-Hsiang, LinYu-Hua, HwangTzer-Zen, WangChih-Chun

Improved nutritional status
Improved quality of life

A dietary education program was effective in improving the nutritional status and quality of life of patients after oral cancer surgery. This suggests the importance of specialized nutritional support during cancer treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

7.

Development of depression in patients with oral cavity cancer: a systematic review.

Author: LansnerMira Westphal, JakobsenKathrine Kronberg, JensenJakob Schmidt, SandstenKarl Erik, GrønhøjChristian, von BuchwaldChristian

Depression risk

Three studies on depression among patients treated for oral squamous cell carcinoma (OSCC) were reviewed. The European studies found that 28% of patients experienced depressive symptoms, while the Indian study showed a significant increase in depression symptoms after treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

8.

Oral mucositis. Is it present in the immunotherapy of the immune checkpoint pd1/pd-l1 against oral cancer? A systematic review.

Author: Peña-CardellesJ-F, Salgado-PeralvoA-O, Garrido-MartínezP, Cebrián-CarreteroJ-L, Pozo-KreilingerJ-J, Moro-RodríguezJ-E

OM in oral cancer immunotherapy

This study investigates the prevalence of oral mucositis in oral cancer immunotherapy compared to its prevalence in standard therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.

Author: ParmarAmbika, MacluskeyMichaelina, Mc GoldrickNiall, ConwayDavid I, GlennyAnne-Marie, ClarksonJanet E, WorthingtonHelen V, ChanKelvin Kw

Oral cancer treatment

Oral and throat cancers are common head and neck cancers. Treatment typically involves surgery followed by radiation for oral cancers, and radiation or combined chemo-radiation for throat cancers. Surgery can be disfiguring, and both surgery and radiation have side effects. New medications, combinations of treatments, and changes in the order of treatment may improve survival and quality of life for these patients. This review updates earlier research on this topic.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

Mastication in health-related quality of life in patients treated for oral cancer: A systematic review.

Author: VermaireJorine A, PartoredjoAbbergayle S K, de GrootReilly J, BrandHenk S, SpeksnijderCaroline M

This review evaluated the impact of oral cancer treatment on masticatory ability and quality of life (QoL). The study found a wide variation in methodologies and patient groups, making it difficult to compare outcome scores. The study highlights the need for more comparable research to better understand the relationship between treatment, masticatory ability, and QoL in oral cancer patients.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

Chinese herbal medicine compound of flavonoids adjunctive treatment for oral cancer.

Author: HuangYi-Chao, SungMin-Yi, LinTsung-Kun, KuoChan-Yen, HsuYi-Chiung

Oral cancer treatment

This study evaluated 27 chemotherapeutic drugs and 63 Chinese herbal medicines for their effectiveness in treating oral cancer, particularly oral squamous cell carcinoma. The study highlights the potential of natural flavonoids, found in Chinese herbal medicines, to induce apoptosis in oral cancer cells and suggests that these compounds may offer a promising avenue for developing innovative adjuvant therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

Gene therapy as a treatment of oral cancer: An insight.

Author: ModakBaishakhi, SolomonMonica C, KarmakarShaswata, PolleyShreyasi

Gene therapy for oral cancer
Secondary malignancies
Toxicities

This review discusses gene therapy as a potential treatment modality for oral cancer. It examines the types of gene therapy, delivery methods, and techniques used, as well as the pros and cons of this approach.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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