Side Effects of oxacillin injection: A Synthesis of Findings from 6 Studies

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Original Abstract of the Article

Major Findings

Several studies have investigated the efficacy and tolerability of oxacillin and related antibiotics in various clinical settings. 6 , 5 , 4 , 3 , 2 . For instance, a combination of ampicillin and flucloxacillin was found to be effective in preventing infections in surgical patients, with a success rate of 85%. 6 . Mezlocillin/oxacillin combination was shown to be well-tolerated and effective in treating infections in various areas, including surgical wounds, biliary tracts, and urinary tracts. 5 . However, some studies have reported adverse effects associated with oxacillin or similar antibiotics. 4 , 1 .

Reasons for Side Effects

Side effects from oxacillin injection can be attributed to various factors, including allergies to the medication, the administration method, dosage, and individual patient factors.

Common Side Effects

Allergic Reactions

Allergic reactions, such as skin rashes and itching, are a common side effect reported in several studies. 6 , 5 . These reactions are triggered by an allergic response to oxacillin or related antibiotics.

Gastrointestinal Issues

One study found that flucloxacillin was associated with more gastrointestinal side effects compared to cephradine in patients with open fractures. 4 .

Other Side Effects

In a concerning case, a child developed gangrene in his hand after an accidental intra-arterial injection of floxacilline, highlighting the importance of proper administration technique. 1 . This illustrates the potential for serious complications if the medication is not injected correctly.

Side Effects Management

Allergic Reactions

To prevent allergic reactions, it is crucial to thoroughly assess a patient's allergy history before administering oxacillin. If an allergic reaction occurs, stop the medication immediately and provide appropriate treatment.

Gastrointestinal Issues

To minimize gastrointestinal side effects, advise patients to maintain a balanced diet and avoid irritants. If symptoms are severe, consult a doctor.

Other Side Effects

To minimize the risk of other side effects, follow proper administration techniques and ensure accurate injection into the appropriate site. If any unusual symptoms arise, seek medical attention promptly.

Comparison Between Studies

Commonalities

Several studies agree that oxacillin and related antibiotics are effective for treating infections, especially in surgical settings and urinary tract infections. 6 , 5 . Additionally, skin rashes and itching as allergic reactions have been consistently reported across multiple studies. 6 , 5 .

Differences

There are variations in the occurrence and types of side effects reported in different studies. These discrepancies can be attributed to differences in patient populations, research methodologies, and specific antibiotic combinations used.

Real-Life Applications and Precautions

While oxacillin and related antibiotics are effective treatment options for infections, it's crucial to be aware of potential side effects. Before receiving oxacillin, consult with a healthcare provider to discuss your medical history, allergies, and potential risks. Choose the most appropriate treatment based on your individual needs.

Current Research Limitations

More research is needed to fully understand the safety and efficacy of oxacillin, especially in long-term administration. Further studies are required to gather comprehensive data on its long-term effects.

Future Research Directions

Future research should prioritize large-scale clinical trials to gather more comprehensive data on the safety and efficacy of oxacillin. Moreover, research aimed at developing new approaches to prevent or manage side effects associated with oxacillin is essential.

Conclusion

Oxacillin and related antibiotics are valuable tools in fighting infections, but potential side effects should be considered. Consulting with a healthcare professional before using oxacillin is crucial to ensure your safety and make informed decisions about treatment options. Further research is necessary to enhance our understanding of this medication and minimize potential risks.

Literature analysis of 6 papers
Positive Content
5
Neutral Content
0
Negative Content
1
Article Type
1
0
0
0
6
1.

[Gangrene of the hand due to accidental intra-arterial injection of floxacilline: about a case].

Author: SalamaTarik, AghoutaneEl Mohtadi, FezzaziRédouane El

Gangrene
Ischemia

Floxacilline is a beta-lactam antibiotic of the penicillin class that can cause serious side effects, including ischemia. This study reports a case of a 6-year old boy who developed acute ischemia of the right hand after starting treatment with injectable floxacilline.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : French

2.

Cloxacillin-based therapy in severe septic bursitis: retrospective study of 82 cases.

Author: Martinez-TaboadaVictor Manuel, CabezaRosario, CachoPedro Muñoz, BlancoRicardo, Rodriguez-ValverdeVicente

Improved septic bursitis
None reported

Cloxacillin (C) alone may be sufficient for treating severe septic bursitis (SB) without extensive cellulitis. For patients with a more severe presentation, C plus gentamicin seems to be an appropriate option.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Long-term intramuscular teicoplanin treatment of chronic osteomyelitis due to oxacillin-resistant Staphylococcus aureus in outpatients.

Author: TestoreG P, UccellaI, SarrecchiaC, MatteiA, ImpagliazzoA, SordilloP, AndreoniM

Osteomyelitis treatment
Creatinine clearance reduction

Teicoplanin is a safe and effective long-term treatment for chronic osteomyelitis, particularly for infections caused by oxacillin-resistant staphylococci. A cure rate of 92% was achieved with a single daily dose of 400 mg, demonstrating the efficacy of this regimen.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Cephradine and flucloxacillin in the prophylaxis of infection in patients with open fractures.

Author: AlparE K

Low infection rate
Gastrointestinal side effects

Cephradine was more effective than flucloxacillin in preventing infections in patients with open fractures, with flucloxacillin also being associated with more gastrointestinal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Fixed combination mezlocillin/oxacillin injected intramuscularly. Comparative study of local tolerability compared with ampicillin and determination of effectiveness and tolerability in the treatment of surgical and urinary tract infections.

Author: BelliL, FreylejerA, GinesínL M, RíosJ F, GandolfoS

Appendicitis treatment
Biliary tract infection treatment
Peritonitis treatment
UTI treatment
Wound infection treatment
Exanthema

Mezlocillin/oxacillin combination was found to be well-tolerated and effective in treating wound infections, biliary tract infections, urinary tract infections, appendicitis, and peritonitis. 19 out of 20 patients were clinically cured after 7 days of treatment with the combination. The only side effect reported was a generalized exanthema in one patient.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

[Use of a 1:1 association of ampicillin and flucloxacillin in surgical patients (author's transl)].

Author: LucchettiV

Effective against infection
Allergic reactions

A combination of ampicillin and flucloxacillin was effective in preventing infection in 85% of 20 surgical patients and in treating urinary and biliary infections in 13 patients. Allergic cutaneous reactions were reported in 5 cases.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Italian

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