Main Research Findings

Benzathine penicillin G injection has been shown to be an effective treatment for streptococcal pharyngitis and to prevent recurrence of dermato-lymphangio-adenitis (DLA) in limb lymphedema. 1 , 2

Reasons for Side Effects

Side effects of benzathine penicillin G injection can be caused by various factors, including the drug’s ingredients, administration method, and individual patient’s susceptibility. Injection site inflammation and pain may occur due to local irritation of the drug. Muscle necrosis, a rarer side effect, is thought to be caused by the drug’s impact on muscle tissue or individual differences in response. 1

Common Side Effects

Injection Site Pain

The most common side effect of benzathine penicillin G injection is injection site pain. This is due to local irritation of the drug. 1

Injection Site Inflammation

Injection site inflammation is another common side effect of benzathine penicillin G injection. It is caused by an inflammatory response due to local irritation of the drug. 1

Muscle Necrosis

A rare side effect of benzathine penicillin G injection is muscle necrosis. This is thought to be caused by the drug’s impact on muscle tissue or individual differences in response. 1

Side Effects Management

Management of Injection Site Pain and Inflammation

To reduce injection site pain and inflammation, cold compresses and pain relievers can be used. 1

Management of Muscle Necrosis

To prevent muscle necrosis, it is crucial to thoroughly assess the patient’s condition before administering the drug and adjust the dosage if necessary. 1

Comparison Between Studies

Commonalities

Both studies demonstrate the effectiveness of benzathine penicillin G injection and report that side effects are rare. 1 , 2

Differences

While study 1 reports a case of muscle necrosis following benzathine penicillin G injection, study 2 does not mention muscle necrosis as a side effect. Study 2 reports the effectiveness of long-term benzathine penicillin G injection for preventing recurrence of dermato-lymphangio-adenitis (DLA) in limb lymphedema.

Real-Life Application Considerations

Benzathine penicillin G injection should be administered with appropriate methods and considering the patient’s condition. Injection site pain and inflammation are relatively common side effects, but if they become severe, consult a doctor. Muscle necrosis is a rare side effect, but if it occurs, prompt treatment is necessary. 1

Current Research Limitations

There is limited research on muscle necrosis and further research is needed. 1

Future Research Directions

Further research is needed to understand the mechanisms of muscle necrosis caused by benzathine penicillin G injection and to develop prevention methods. 1

Conclusion

Benzathine penicillin G injection is an effective treatment for streptococcal pharyngitis and for preventing recurrence of dermato-lymphangio-adenitis (DLA) in limb lymphedema, but there is a risk of rare side effects, such as muscle necrosis. 1 , 2 . It is essential to thoroughly assess the patient’s condition before administering the drug and adjust the dosage if necessary. If you are concerned about side effects, consult your doctor.