Effects of pirbuterol acetate oral inhalation: A Synthesis of Findings from 4 Studies

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Original Abstract of the Article

Main Research Findings

Pirbuterol is a beta-2 adrenergic agonist that has been shown to be effective in treating chronic obstructive pulmonary disease (COPD). 1 , 3 , 4 , 2

Studies have shown that both oral and inhaled pirbuterol can improve lung function in COPD patients. 1 , 2

Pirbuterol is similar in structure to albuterol and has a comparable duration of action when inhaled, but it is less potent than albuterol by weight. 3

Pirbuterol has been shown to improve both right and left ventricular ejection fractions in patients with chronic bronchitis. 2

Benefits and Risks

Benefits Summary

Pirbuterol may improve lung function and heart function in COPD patients. 1 , 3 , 4 , 2

Risks Summary

Pirbuterol may increase heart rate. 1

Comparison Between Studies

Commonalities

Several studies have shown that pirbuterol is effective in improving lung function in COPD patients. 1 , 3 , 4 , 2

Differences

There are differences between studies in terms of the route of administration, dosage, and patient population. 1 , 3 , 4 , 2

Consistency and Contradictions in Results

Several studies have shown that pirbuterol is effective in improving lung function in COPD patients, but there are differences in the degree of effectiveness and the incidence of side effects. 1 , 3 , 4 , 2

Considerations for Real-Life Application

Pirbuterol may be a useful medication for improving lung function in COPD patients, but the potential for side effects should be considered. 1 , 3 , 4 , 2

Limitations of Current Research

There is a lack of research on the long-term effects and safety of pirbuterol. 1 , 3 , 4 , 2

Future Research Directions

Further research is needed to evaluate the long-term effects and safety of pirbuterol, the optimal dosage, and the incidence of side effects. 1 , 3 , 4 , 2

Conclusion

Pirbuterol may be a useful medication for improving lung function in COPD patients. However, the potential for side effects should be considered. When considering the use of pirbuterol, it is important to consult with a physician to understand the benefits and risks. 1 , 3 , 4 , 2

Literature analysis of 4 papers
Positive Content
4
Neutral Content
0
Negative Content
0
Article Type
2
0
0
1
4
1.

The effect of six months of daily treatment with the beta-2 agonist oral pirbuterol on pulmonary hemodynamics in patients with chronic hypoxic cor pulmonale receiving long-term oxygen therapy.

Author: BiernackiW, PrinceK, WhyteK, MacNeeW, FlenleyD C

Cardiac output increase
Heart rate increase
RVEF increase

This double-blind study in 11 patients with chronic obstructive pulmonary disease (COPD) evaluated the acute and long-term effects of the oral beta-2 agonist pirbuterol on pulmonary hemodynamics and ventricular ejection fractions. An acute dose of pirbuterol increased heart rate, cardiac output, and right ventricular ejection fraction without affecting mean pulmonary arterial pressure. Long-term treatment with pirbuterol did not significantly alter any of these variables. The study suggests that pirbuterol may be a safe and effective treatment option for COPD, with no evidence of long-term adverse cardiovascular effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Effects of oral and inhaled salbutamol and oral pirbuterol on right and left ventricular function in chronic bronchitis.

Author: WinterR J, LangfordJ A, RuddR M

LVEF improvement
RVEF improvement

Oral salbutamol and pirbuterol improve right and left ventricular ejection fractions in patients with chronic bronchitis. Inhaled salbutamol has no significant effect on cardiac function.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Pirbuterol hydrochloride: evaluation of beta adrenergic agonist activity in reversible obstructive pulmonary disease and congestive heart failure.

Author: WeberR W, NelsonH S

Treats heart failure
Treats pulmonary disease
Tolerance

Pirbuterol is a beta 2 adrenergic agonist that is effective in treating chronic obstructive pulmonary disease. It is comparable to albuterol in terms of duration of action, potency, and side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Pirbuterol, a selecttve beta2 adrenergic bronchodilator.

Author: MooreP F, ConstantineJ W, BarthW E

Anti-anaphylactic
Bronchodilator
Tachycardia

Pirbuterol, a new beta2 adrenergic agonist bronchodilator, was found to be more selective for pulmonary tissue than salbutamol and isoproterenol, and effective by oral, intravenous, and inhalation routes of administration.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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