Effective treatment of post-polio syndrome: A Synthesis of Findings from 23 Studies

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Original Abstract of the Article

Major research findings

Post-polio syndrome (PPS) is a neurological disorder that can affect survivors of paralytic poliomyelitis decades after the initial infection. The main symptoms are chronic pain and fatigue. 2 , 5 The effectiveness of pharmacological treatment and rehabilitation management in PPS is not yet established. 3 , 4 However, some research suggests that anthroposophic multimodal treatment may be able to alleviate chronic pain in PPS outpatients. 2 Additionally, several studies suggest that IVIg (intravenous immunoglobulin) may be effective in managing pain in PPS patients. 10 , 16 On the other hand, exercise therapy and cognitive behavioral therapy failed to reduce severe fatigue in PPS patients. 15

treatment summary

Treatments for PPS include pharmacotherapy, rehabilitation, anthroposophic multimodal treatment, IVIg, exercise therapy, and cognitive behavioral therapy. 3 , 4 , 2 , 10 , 16 , 15 However, the effectiveness of these treatments has not been established. 3 , 4

Benefits and Risks

Benefits Summary

Anthroposophic multimodal treatment may be able to alleviate chronic pain in PPS outpatients. 2 IVIg may be effective in managing pain in PPS patients. 10 , 16

Risks Summary

Exercise therapy and cognitive behavioral therapy failed to reduce severe fatigue in PPS patients. 15

Comparison of Studies

Commonalities of Studies

Many studies show that the main symptoms of PPS patients are chronic pain and fatigue. 2 , 5 In addition, the effectiveness of pharmacotherapy and rehabilitation management in PPS is not established. 3 , 4

Differences of Studies

Some studies suggest that anthroposophic multimodal treatment and IVIg may be effective in treating PPS. 2 , 10 , 16 On the other hand, some studies suggest that exercise therapy and cognitive behavioral therapy are not effective. 15

Consistency and Inconsistencies of Results

The effectiveness of PPS treatments is inconsistent across studies. 3 , 4 While some research suggests that anthroposophic multimodal treatment and IVIg may be effective, other studies demonstrate that exercise therapy and cognitive behavioral therapy are ineffective. 2 , 10 , 16 , 15

Notes on Practical Application

PPS treatment varies from patient to patient, so it's essential to consult with your doctor to choose the appropriate treatment. 3 , 4

Current Limitations of Research

Research on treatments for PPS is still insufficient. 3 , 4 Therefore, more research is needed. 3 , 4

Future Research Directions

More research is needed to validate the effectiveness of treatments for PPS. 3 , 4 Research on the pathogenesis of PPS is also essential. 3 , 4

Conclusion

Treatments for PPS have not yet been established. 3 , 4 However, some research suggests that anthroposophic multimodal treatment and IVIg may be effective. 2 , 10 , 16 PPS treatment varies from patient to patient, so it's essential to consult with your doctor to choose the appropriate treatment. 3 , 4

List of Treatments

Pharmacotherapy, rehabilitation, anthroposophic multimodal treatment, IVIg, exercise therapy, cognitive behavioral therapy. 3 , 4 , 2 , 10 , 16 , 15

Literature analysis of 23 papers
Positive Content
20
Neutral Content
2
Negative Content
1
Article Type
7
5
6
10
23
1.

Intravenous immunoglobulin for post-polio syndrome: a randomised controlled trial.

Author: GonzalezHenrik, SunnerhagenKatharina Stibrant, SjöbergInger, KaponidesGeorgios, OlssonTomas, BorgKristian

Post-polio syndrome treatment

The study investigated the use of intravenous immunoglobulin in post-polio syndrome, given the underlying inflammatory process indicated by proinflammatory cytokines within the CNS.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

A twelve-week, four-arm, randomized, double-blind, placebo-controlled, phase 2 prospective clinical trial to evaluate the efficacy and safety of an anthroposophic multimodal treatment on chronic pain in outpatients with postpolio syndrome.

Author: GhelmanRicardo, AkiyamaIvete Y, de SouzaValeria T, FalcãoJussara, OrgoliniVera, HosomiJorge K, QuadrosAbrahão A J, OliveiraAcary S B

Improved quality of life
Increased resilience
Reduced pain
Dysphagia

An anthroposophic multimodal treatment for chronic pain in patients with postpoliomyelitis syndrome was safe and effective, with pain reduction occurring earlier in the group receiving a combination of nonpharmacological therapies and an experimental transdermal gel.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Treatment for postpolio syndrome.

Author: KoopmanFieke Sophia, BeelenAnita, GilhusNils Erik, de VisserMarianne, NolletFrans

Postpolio syndrome

This updated review examines the effectiveness of pharmacological treatment and rehabilitation management for postpolio syndrome (PPS). PPS is a complex condition affecting survivors of polio, and the study investigates the best approaches for managing its symptoms and improving physical functioning.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Treatment for postpolio syndrome.

Author: KoopmanFieke Sophia, UegakiKimi, GilhusNils Erik, BeelenAnita, de VisserMarianne, NolletFrans

PPS Treatment

Intravenous immunoglobulin, lamotrigine, muscle strengthening exercises and static magnetic fields may be beneficial for postpolio syndrome (PPS). However, more research is needed to investigate the effectiveness of these treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

[Treatment on fatigue of patients with postpolio syndrome. A systematic review].

Author: Aguila-MaturanaAna M, Alegre-De MiquelCayetano

Reduced fatigue

Several treatments have been shown to be effective in reducing fatigue in post-polio syndrome patients. Lamotrigine, bromocriptine, aerobic and flexibility exercises, hydrokinesitherapy, and technical aids have been found to improve fatigue symptoms. However, further research is needed to better understand the long-term effects and optimal use of these treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Spanish

6.

Treatment of patients with postpolio syndrome in a warm climate.

Author: StrumseY A S, StanghelleJ K, UtneL, AhlvinP, SvendsbyE K

Postpolio syndrome treatment

Treatment of patients with postpolio syndrome in a warm climate was associated with significant improvements in both physical tests and subjective ratings.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

[Treatment of patients with postpolio syndrome in warm climate].

Author: StrumseY A, StanghelleJ K, UtneL, AhlvinP, SvendsbyE K

Improved physical function
Reduced pain

Treatment in a warm climate may be beneficial for patients with postpolio syndrome. In a study of 88 patients, those treated in a rehabilitation center in Tenerife for four weeks showed significant improvements in physical tests and subjective ratings compared to those treated in Norway or those who received standard care.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Norwegian

10.

Effectiveness of Intravenous Immunoglobulin for Management of Pain in Patients with Postpolio Syndrome.

Author: ChangMin Cheol, ParkJin-Sung, HwangJong-Moon, ParkDonghwi

Improved function
Pain reduction

Intravenous immunoglobulin (IVIG) may be beneficial for managing pain in patients with postpolio syndrome (PPS). Four studies reported pain reduction after IVIG treatment. Three studies also showed improvement in muscle strength and function. More high-quality studies are needed to confirm the benefits of IVIG.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

Ultrasound-Guided Carpal Tunnel Release Using Dynamic Expansion of the Transverse Safe Zone in a Patient With Postpolio Syndrome: A Case Report.

Author: HenningTroy, LuedersDaniel, ChangKate, YangLynda

Improved functional independence
Altered functional independence

This case report demonstrates the successful use of ultrasound-guided carpal tunnel release in a patient with postpolio syndrome. This technique allowed the patient to immediately weight bear through his hands after the procedure, facilitating a quicker recovery at home.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews.

Author: GeneenLouise J, MooreR Andrew, ClarkeClare, MartinDenis, ColvinLesley A, SmithBlair H

Improved functioning
Improved health
Reduced pain severity
Chronic pain

This review discussed the growing evidence supporting the use of exercise programs for managing chronic pain, highlighting their potential benefits for reducing pain severity and improving overall health.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

14.

Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews.

Author: GeneenLouise J, MooreR Andrew, ClarkeClare, MartinDenis, ColvinLesley A, SmithBlair H

Chronic pain treatment
Chronic pain severity

This review discussed the growing evidence supporting the use of exercise programs for managing chronic pain, highlighting their potential benefits for reducing pain severity and improving overall health.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

No Reduction of Severe Fatigue in Patients With Postpolio Syndrome by Exercise Therapy or Cognitive Behavioral Therapy: Results of an RCT.

Author: KoopmanFieke S, VoornEric L, BeelenAnita, BleijenbergGijs, de VisserMarianne, BrehmMerel A, NolletFrans

Post-polio fatigue

A multicenter, single-blinded, randomized controlled trial of 68 severely fatigued patients with postpolio syndrome (PPS) found that neither exercise therapy (ET) nor cognitive behavioral therapy (CBT) were superior to usual care (UC) in reducing fatigue.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Intravenous immunoglobulin for postpolio syndrome: a systematic review and meta-analysis.

Author: HuangYao-Hsien, ChenHung-Chou, HuangKuang-Wei, ChenPo-Chih, HuChaur-Jong, TsaiChin-Piao, TamKa-Wai, KuanYi-Chun

IVIg for PPS

Intravenous immunoglobulin (IVIg) administration may be a potential treatment option for postpolio syndrome (PPS) due to its immunomodulatory effects and the possible role of chronic inflammation in PPS development.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

Feasibility of Lung Volume Recruitment in Early Neuromuscular Weakness: A Comparison Between Amyotrophic Lateral Sclerosis, Myotonic Dystrophy, and Postpolio Syndrome.

Author: KaminskaMarta, BrowmanFranceen, TrojanDaria A, GengeAngela, BenedettiAndrea, PetrofBasil J

Feasible treatment
Improve respiratory mechanics
No negative QOL impact

Daily lung volume recruitment (LVR) is a feasible and well-tolerated cough assistance technique for individuals with neuromuscular disorders (NMDs) who have early-stage respiratory impairment and do not yet require noninvasive ventilation (NIV). In a 3-month study, 74% of subjects were willing to continue LVR, and there was no negative impact on quality of life. LVR may improve respiratory system mechanics, which warrants further research to determine if it can delay ventilatory failure in individuals with NMDs.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Effects of a Tailored Positive Psychology Intervention on Well-Being and Pain in Individuals With Chronic Pain and a Physical Disability: A Feasibility Trial.

Author: MüllerRachel, GertzKevin J, MoltonIvan R, TerrillAlexandra L, BombardierCharles H, EhdeDawn M, JensenMark P

Improved well-being
Reduced pain intensity
Reduced pain interference
None reported

A computer-based positive psychology intervention for improving well-being and pain-related outcomes in individuals with physical disabilities and chronic pain is feasible, acceptable, and potentially efficacious.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

19.

Normal serum levels of immune complexes in postpolio patients.

Author: MelinEva, SohrabianAzita, RönnelidJohan, BorgKristian

Postpolio syndrome treatment

This study investigated the presence of immune complexes in patients with postpolio syndrome, suggesting an autoimmune process following the initial polio infection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

A randomized controlled trial of IV immunoglobulin in patients with postpolio syndrome.

Author: BertolasiLaura, FrassonEmma, TurriMara, GajofattoAlberto, BordignonMonia, ZanolinElisabetta, MartiniMillo, PimazzoniFabiana, FerlisiMonica, ZanussoGianluigi, RossiMassimo, MonacoSalvatore

Improved HRQoL

A single IVIg course did not improve physical component scores of the Short-Form-36 (SF-36) in patients with postpolio syndrome (PPS), but it did improve mental component scores and role physical and emotional domains. However, the improvements in mental component scores, role physical and emotional domains were only observed at 2 months and not at 4 months.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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