Effective treatment of pregnancy: A Synthesis of Findings from 9 Studies

  1. Home
  2. Effective treatment of pregnancy
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effective treatment of pregnancy: A Synthesis of Findings from 9 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effective treatment of pregnancy: A Synthesis of Findings from 9 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Treatment of overt hyperthyroidism during pregnancy is mandatory and appears to reduce some potential maternal-fetal complications, such as preeclampsia, low birth weight, spontaneous abortion, and preterm birth, although there is still a residual risk of negative outcomes. 9 .

Cutaneous laser treatment during pregnancy appears to be safe for both mother and fetus, with no cases of maternal or fetal morbidity or mortality, premature labor, or identifiable fetal stress reported. 6 .

Medical management of early pregnancy loss (miscarriage) is a cost-effective alternative to surgical procedures and can be achieved through expectant management, medications, or surgical procedures. 8 . One of the medications used for early pregnancy loss treatment, mifepristone, is uniquely regulated by the Food and Drug Administration and may be a particularly effective option. 8 .

Fetal immobilization during fetal surgery and invasive procedures can be achieved through medication administration to the mother or directly to the fetus. This improves procedural success and reduces the ongoing risk to the pregnancy. 7 .

While pharmacotherapy is required for the treatment of pregnancy-associated hypertension, the long-term effects of in-utero exposure to antihypertensive agents on child health outcomes remain largely unknown. 5 .

Antidepressant medication exposure during pregnancy has been associated with a slightly increased risk of preterm delivery, lower birth weight, and lower Apgar scores at 1 and 5 minutes. However, the differences in outcomes between exposed and unexposed groups were small and typically within the normal ranges. 2 .

Sequential treatment with mifepristone and misoprostol for early pregnancy failure (EPF) appears to lead to higher complete evacuation rates than misoprostol alone. 4 .

Glucose control during pregnancy is crucial for women with diabetes, as it helps to reduce the risk of complications for both mother and offspring. A fasting glucose target of <90 mg/dL is associated with a lower risk of macrosomia and other outcomes in women with gestational diabetes during the third trimester. 3 .

Treatment Summary

Treatment of overt hyperthyroidism during pregnancy is mandatory and appears to reduce some potential maternal-fetal complications. 9 .

Cutaneous laser treatment during pregnancy appears to be safe for both mother and fetus. 6 .

Medical management of early pregnancy loss (miscarriage) is a cost-effective alternative to surgical procedures and can be achieved through expectant management, medications, or surgical procedures. 8 . One of the medications used for early pregnancy loss treatment, mifepristone, is uniquely regulated by the Food and Drug Administration and may be a particularly effective option. 8 .

Fetal immobilization during fetal surgery and invasive procedures can be achieved through medication administration to the mother or directly to the fetus. This improves procedural success and reduces the ongoing risk to the pregnancy. 7 .

While pharmacotherapy is required for the treatment of pregnancy-associated hypertension, the long-term effects of in-utero exposure to antihypertensive agents on child health outcomes remain largely unknown. 5 .

Antidepressant medication exposure during pregnancy has been associated with a slightly increased risk of preterm delivery, lower birth weight, and lower Apgar scores at 1 and 5 minutes. However, the differences in outcomes between exposed and unexposed groups were small and typically within the normal ranges. 2 .

Sequential treatment with mifepristone and misoprostol for early pregnancy failure (EPF) appears to lead to higher complete evacuation rates than misoprostol alone. 4 .

Glucose control during pregnancy is crucial for women with diabetes, as it helps to reduce the risk of complications for both mother and offspring. A fasting glucose target of <90 mg/dL is associated with a lower risk of macrosomia and other outcomes in women with gestational diabetes during the third trimester. 3 .

Benefits and Risks

Benefit Summary

Treatment of overt hyperthyroidism during pregnancy can potentially improve maternal and fetal outcomes. 9 .

Cutaneous laser treatment during pregnancy appears to be safe for both mother and fetus. 6 .

Mifepristone, among other medications, can be a cost-effective and effective treatment option for early pregnancy loss (miscarriage). 8 .

Risk Summary

The long-term effects of in-utero exposure to antihypertensive agents on child health outcomes remain largely unknown. 5 .

Antidepressant medication exposure during pregnancy has been associated with a slightly increased risk of preterm delivery, lower birth weight, and lower Apgar scores at 1 and 5 minutes. However, the differences in outcomes between exposed and unexposed groups were small and typically within the normal ranges. 2 .

Comparison between Studies

Commonalities of Studies

All studies investigated the impact of specific treatments during pregnancy on maternal and fetal outcomes. 9 6 8 7 5 2 4 3 .

Differences in Studies

Each study focused on specific pregnancy complications or treatments. 9 6 8 7 5 2 4 3 .

Consistency and Contradictions in Results

Some studies suggested that certain treatments during pregnancy might improve maternal and fetal outcomes. 9 6 8 . However, other studies indicated that certain treatments during pregnancy might have adverse effects on maternal and fetal outcomes. 5 2 . These conflicting results highlight the need for further research to fully understand how specific treatments during pregnancy impact maternal and fetal outcomes. 9 6 8 5 2 .

Considerations for Applying Results in Everyday Life

These research findings can be valuable for understanding how specific treatments during pregnancy may impact maternal and fetal outcomes. 9 6 8 7 5 2 4 3 . However, these studies underscore the need for further research to fully comprehend how specific treatments during pregnancy affect maternal and fetal outcomes. 9 6 8 7 5 2 4 3 .

Limitations of Current Research

These studies have certain limitations. 9 6 8 7 5 2 4 3 . For instance, some studies have small sample sizes, making it difficult to generalize findings to broader populations. 9 6 8 7 5 2 4 3 . Additionally, some studies might not have accounted for all significant factors, potentially introducing bias into their results. 9 6 8 7 5 2 4 3 .

Future Directions for Research

Further research is clearly needed to fully understand how specific treatments during pregnancy impact maternal and fetal outcomes. 9 6 8 7 5 2 4 3 . In particular, research exploring long-term effects is essential. 5 2 . Studies comparing the safety and efficacy of various treatments are also necessary. 9 6 8 7 5 2 4 3 .

Conclusion

Further research is needed to fully understand how specific treatments during pregnancy affect maternal and fetal outcomes. 9 6 8 7 5 2 4 3 . These studies provide valuable information to guide decision-making between healthcare providers and patients regarding pregnancy treatments. 9 6 8 7 5 2 4 3 . However, further research is essential to fully understand how specific treatments affect maternal and fetal outcomes. 9 6 8 7 5 2 4 3 .

Treatment List

Hyperthyroidism treatment during pregnancy, Laser therapy, Mifepristone, Antihypertensive medication, Antidepressant medication, Misoprostol, Glucose control, Expectant management

Literature analysis of 9 papers
Positive Content
9
Neutral Content
0
Negative Content
0
Article Type
1
4
8
6
8
1.

Medical treatments for incomplete miscarriage (less than 24 weeks).

Author: NeilsonJames P, GyteGillian Ml, HickeyMartha, VazquezJuan C, DouLixia

Miscarriage treatment

Miscarriage occurs in 10-15% of pregnancies. The traditional treatment after a miscarriage has been surgery to remove any remaining pregnancy tissue. However, medications and a wait-and-see approach (expectant care) may be effective, safe, and acceptable alternatives.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

Selected pregnancy and delivery outcomes after exposure to antidepressant medication: a systematic review and meta-analysis.

Author: RossLori E, GrigoriadisSophie, MamisashviliLana, VonderportenEmily H, RoereckeMichael, RehmJürgen, DennisCindy-Lee, KorenGideon, SteinerMeir, MousmanisPatricia, CheungAmy

Depression treatment
Lower Apgar scores
Lower birth weight
Preterm delivery
Spontaneous abortion

Prenatal antidepressant exposure was not significantly associated with spontaneous abortion, but was associated with lower gestational age, preterm delivery, lower birth weight, and lower Apgar scores.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

3.

Glucose targets in pregnant women with diabetes: a systematic review and meta-analysis.

Author: PrutskyGabriela J, DomecqJuan Pablo, WangZhen, Carranza LeonBarbara G, ElraiyahTarig, NabhanMohammed, SundareshVishnu, VellaAdrian, MontoriVictor M, MuradM Hassan

Reduced macrosomia risk
Data inconclusive

A review of 34 studies found that a fasting glucose target of <90 mg/dL was associated with a lower risk of macrosomia in women with gestational diabetes during the third trimester. However, data were sparse and inconclusive for other glucose targets and for women with pregestational diabetes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

The added value of mifepristone to non-surgical treatment regimens for uterine evacuation in case of early pregnancy failure: a systematic review of the literature.

Author: van den BergJoyce, GordonBernardus B M, SnijdersMarcus P M L, VandenbusscheFrank P H A, CoppusSjors F P J

Early pregnancy failure treatment

Early pregnancy failure (EPF) is a common complication. While surgical intervention carries risks, medical treatment with misoprostol alone has limited success rates. This study examines whether sequential treatment with mifepristone and misoprostol improves outcomes compared to misoprostol alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

In-utero exposure to antihypertensive medication and neonatal and child health outcomes: a systematic review.

Author: FittonCatherine A, SteinerMarkus F C, AucottLorna, PellJill P, MackayDaniel F, FlemingMichael, McLayJames S

Pregnancy hypertension treatment
Long-term effects on child

This abstract addresses the challenges of pharmacotherapy during pregnancy, particularly for the treatment of pregnancy-associated hypertension. It emphasizes the need for research to understand the long-term effects on children exposed to antihypertensive agents in utero.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

6.

Utilization of Laser Therapy During Pregnancy: A Systematic Review of the Maternal and Fetal Effects Reported From 1960 to 2017.

Author: WilkersonEric C, Van AckerMonica M, BloomBradley S, GoldbergDavid J

Fetal safety
Maternal safety
Premature rupture of membranes

Cutaneous laser treatment during pregnancy appears to be safe for both mother and fetus. A review of 22 publications reporting the use of various laser wavelengths in 380 pregnant women found no cases of maternal or fetal morbidity or mortality, premature labor, or identifiable fetal stress.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

7.

Perioperative pharmacological interventions for fetal immobilisation during fetal surgery and invasive procedures.

Author: AndrewarthaKate, GrivellRosalie M

In-utero treatment for fetal issues

This study examines the use of medication for fetal immobilization during in-utero procedures for antenatal fetal conditions. Advances in ultrasound have led to an increase in the diagnosis of fetal issues, and some conditions require in-utero treatment to improve outcomes. This study focuses on the evidence for medication used to immobilize the fetus during these procedures.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

8.

Medical management of early pregnancy loss is cost-effective compared with office uterine aspiration.

Author: NagendraDivyah, GutmanSarah M, KoelperNathanael C, Loza-AvalosSandra E, SonalkarSarita, SchreiberCourtney A, HarvieHeidi S

Treatment for early pregnancy loss

Early pregnancy loss is common, affecting approximately 1 million people in the United States annually. This study discussed different treatment options for early pregnancy loss, including expectant management, medications, and surgical procedures.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Effect of Hyperthyroidism Control During Pregnancy on Maternal and Fetal Outcome: A Systematic Review and Meta-Analysis.

Author: Alves JuniorJose Mario, BernardoWanderley Marques, WardLaura Sterian, VillagelinDanilo

Reduced low birth weight
Reduced preeclampsia
Reduced preterm birth
Reduced spontaneous abortion

Treating overt hyperthyroidism during pregnancy appears to reduce the incidence of preeclampsia, low birth weight, spontaneous abortion, and preterm birth compared with euthyroid pregnancies.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.