Side Effects of reslizumab injection: A Synthesis of Findings from 1 Studies

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Original Abstract of the Article

Key Research Findings

A systematic review of 13 studies on the safety of biological therapies for chronic rhinosinusitis with nasal polyps (CRSwNP) found that while these treatments can be effective, they also come with potential side effects. The review included 12 randomized controlled trials and one cross-sectional study, involving a total of 2282 patients. 1

Reasons for Side Effects

Biological therapies work by modulating the immune system, which can lead to side effects as a consequence of this modulation. 1

Common Side Effects

Headaches

Headaches were a common side effect reported in studies using dupilumab, omalizumab, and mepolizumab. 1

Injection Site Reactions

Injection site reactions were a common side effect reported in studies using omalizumab. 1

Pharyngitis

The most common side effect reported in the dupilumab trial was pharyngitis, affecting 22.4% of patients. 1

Epistaxis

Epistaxis was reported as a side effect in the dupilumab trial, affecting 5.1% of patients. 1

Asthma

Asthma was reported as a side effect in the dupilumab trial, affecting 1.7% of patients. In mepolizumab studies, asthma developed in 2.2% of patients. 1

Nasal Polyps/Congestion/Pharyngitis/Infections

Mepolizumab and reslizumab studies reported that 40% of patients experienced complications such as nasal polyps, congestion, pharyngitis, and infections. 1

Managing Side Effects

Headaches

If you experience headaches, consult your doctor. They may prescribe appropriate pain relievers. 1

Injection Site Reactions

If you experience injection site reactions, consult your doctor. Cold compresses and steroid creams can be helpful. 1

Pharyngitis

If you experience pharyngitis, consult your doctor. Gargle solutions and throat lozenges can be effective. 1

Epistaxis

If you experience epistaxis, consult your doctor. Measures to stop the nosebleed can be helpful. 1

Asthma

If you experience asthma, consult your doctor. Asthma medications will be prescribed. 1

Nasal Polyps/Congestion/Pharyngitis/Infections

If you experience nasal polyps, congestion, pharyngitis, or infections, consult your doctor. Appropriate treatment will be chosen. 1

Comparing Studies

Commonalities

Many studies found that biological therapies were effective in treating CRSwNP. 1

Differences

There were differences between studies in terms of the biological therapies used and the types and frequencies of side effects observed. 1

Real-Life Application Considerations

While biological therapies can be effective treatment options for CRSwNP, it's important to be aware of the potential side effects. 1

Current Research Limitations

There is still a lack of sufficient research on the long-term safety and efficacy of biological therapies. 1

Future Research Directions

Further research is needed on the long-term safety and efficacy of biological therapies. 1

Conclusion

Biological therapies can be promising treatment options for CRSwNP, but it's crucial to be aware of the potential side effects. Further research on the long-term safety and efficacy of these therapies is warranted. 1

Literature analysis of 1 papers
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Adverse events of biological therapy in chronic rhinosinusitis with nasal polyps: A systematic review.

Author: AldajaniAhmad, AlroqiAhmad, AlromaihSaud, AloulahMohammad O, AlsalehSaad

Effective CRSwNP treatment
Limited adverse events
Headaches
Injection site reactions
Pharyngitis

This systematic review summarizes the safety and adverse events associated with the biological therapy of chronic rhinosinusitis with nasal polyps (CRSwNP).

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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