Causes of reye syndrome: A Synthesis of Findings from 7 Studies

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Original Abstract of the Article

Major Research Findings

Reye's syndrome is a rare but potentially life-threatening condition characterized by liver failure and brain swelling. It is more common in infants and children, and was previously linked to aspirin use. However, research has shown that other factors besides aspirin can also contribute to Reye's syndrome. 5 In fact, it is now understood that Reye's syndrome can be caused by a variety of factors, including inherited metabolic disorders, viral infections, and medications.

Reasons for the Causes

Reye's syndrome is often caused by dysfunction of mitochondria, the powerhouses of cells. When mitochondria don't work properly, it can lead to problems like fatty buildup in the liver, brain swelling, and other complications.

Common Causes

Aspirin

Aspirin is the most common cause of Reye's syndrome that has been statistically proven. Giving aspirin to children with viral infections can significantly increase their risk of developing Reye's syndrome. Aspirin can interfere with mitochondrial function, potentially causing Reye's syndrome.

Viral Infections

Viral infections can be a trigger for Reye's syndrome. The most common viral infections linked to Reye's syndrome are influenza and chickenpox. Viral infections can disrupt mitochondrial function and lead to Reye's syndrome.

Metabolic Disorders

Metabolic disorders can play a role in causing Reye's syndrome. Some metabolic disorders linked to Reye's syndrome include problems with fatty acid metabolism, urea cycle defects, and mitochondrial diseases. These metabolic disorders can interfere with mitochondrial function and contribute to Reye's syndrome.

Medications

Some medications can cause Reye's syndrome. Medications linked to Reye's syndrome include valproic acid and nimesulide. 5 These medications can interfere with mitochondrial function and lead to Reye's syndrome.

Causes and Treatments

Avoid Aspirin Use

Avoid giving aspirin to children as it can increase their risk of Reye's syndrome. If your child needs a fever reducer, use other medications like acetaminophen.

Viral Infection Prevention

Get vaccinated against viral infections like influenza and chickenpox to help reduce the risk of Reye's syndrome. If you get a viral infection, seek appropriate medical treatment as directed by your doctor.

Managing Metabolic Disorders

If you have metabolic disorders like problems with fatty acid metabolism, urea cycle defects, or mitochondrial diseases, it's important to manage them effectively. These conditions should be managed under the guidance of a specialist.

Medication Use Precautions

If you're taking medications like valproic acid or nimesulide, talk to your doctor about the risk of Reye's syndrome. Use these medications safely as instructed by your doctor. 5

Comparison of Studies

Similarities

Many research studies have concluded that Reye's syndrome can be caused by mitochondrial dysfunction. 7 Studies also agree that Reye's syndrome can be triggered by a variety of factors, including viral infections, metabolic disorders, and medications.

Differences

Some studies have focused on identifying specific causes of Reye's syndrome. For example, some studies suggest that valproic acid could be a cause. 6 Other studies suggest that viral infections and metabolic disorders might be causes. However, pinpointing the exact cause of Reye's syndrome is often challenging.

Applying the Research in Everyday Life

Reye's syndrome is a rare condition, but its symptoms are serious. To minimize the risk of Reye's syndrome, avoid giving aspirin to children and get vaccinated against viral infections. If your child needs aspirin, consult your doctor. If you notice any symptoms of Reye's syndrome, seek medical attention immediately. 6

Limitations of Current Research

The study of Reye's syndrome is still ongoing. Identifying the exact causes of Reye's syndrome remains difficult. 7 Research on preventing and treating Reye's syndrome is also not yet fully developed.

Future Research Directions

More research is needed to understand the specific causes of Reye's syndrome. Research on preventing and treating Reye's syndrome is also crucial. These studies will help us to understand Reye's syndrome better and improve treatment for affected individuals.

Conclusion

Reye's syndrome is a rare but serious condition. To reduce the risk of Reye's syndrome, avoid giving aspirin to children, get vaccinated against viral infections, and seek medical attention promptly if you or your child experience symptoms of Reye's syndrome. , , 6

Literature analysis of 7 papers
Positive Content
4
Neutral Content
1
Negative Content
2
Article Type
0
3
4
3
7
1.

Interventions for the management of dry mouth: topical therapies.

Author: FurnessSusan, WorthingtonHelen V, BryanGemma, BirchenoughSarah, McMillanRoddy

Ineffective for dry mouth

There is no strong evidence that any topical therapy is effective for relieving dry mouth. Oxygenated glycerol triester (OGT) spray was more effective than an electrolyte spray in reducing mouth dryness. Chewing gum may increase saliva production in those with residual secretory capacity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

Interventions for the management of dry mouth: non-pharmacological interventions.

Author: FurnessSusan, BryanGemma, McMillanRoddy, WorthingtonHelen V

Xerostomia treatment
Xerostomia causes

Dry mouth (xerostomia) can be caused by medications, illnesses, or cancer treatments. While traditional treatments exist, non-medication approaches such as acupuncture or mild electrical stimulation are also being explored to improve symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

3.

Interventions for the management of dry mouth: non-pharmacological interventions.

Author: FurnessSusan, BryanGemma, McMillanRoddy, BirchenoughSarah, WorthingtonHelen V

Xerostomia treatment
Xerostomia causes

Dry mouth (xerostomia) can be caused by medications, illnesses, or cancer treatments. While traditional treatments exist, non-medication approaches such as acupuncture or mild electrical stimulation are also being explored to improve symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Herbal Medicine for Xerostomia in Cancer Patients: A Systematic Review of Randomized Controlled Trials.

Author: ParkBongki, NohHyeonseok, ChoiDong-Jun

Improved salivary function
Reduced dry mouth severity

Herbal medicine showed potential benefits for improving salivary function and reducing xerostomia in cancer patients. However, more high-quality trials are needed to confirm these findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

[Reye syndrome and sudden death symptoms after oral administration of nimesulide due to upper respiratory tract infection in a boy].

Author: FengLi-Fang, ChenXiao-Hong, LiDong-Xiao, LiXi-Yuan, SongJin-Qing, JinYing, YangYan-Ling

Metabolic disease diagnosis
Nimesulide-induced crisis

A 6-year-old boy developed Reye syndrome and sudden death symptoms after taking nimesulide. The boy was diagnosed with multiple acyl-CoA dehydrogenase deficiency, an inherited metabolic disease.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Chinese

6.

[21-year-old woman with Reye's syndrome after influenza].

Author: LinkA, KaplanB T, BöhmM

Deteriorating consciousness
Increased ammonia
Increased transaminases

A 21-year-old woman developed progressively deteriorating consciousness after having influenza. Investigations revealed increased transaminases and ammonia levels, suggesting a possible liver issue.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

7.

Thioredoxin-binding protein-2 deficiency enhances methionine-choline deficient diet-induced hepatic steatosis but inhibits steatohepatitis in mice.

Author: AhsanMd Kaimul, OkuyamaHiroaki, HoshinoYuma, OkaShin-Ichi, MasutaniHiroshi, YodoiJunji, NakamuraHajime

NASH prevention
NASH treatment
Nonalcoholic fatty liver disease
Oxidative stress

This study investigated the role of TRX-binding protein-2 (TBP-2) in the development of nonalcoholic steatohepatitis (NASH). TBP-2 deficiency in mice was associated with severe steatosis but attenuated oxidative stress, neutrophil infiltration, and hepatic fibrosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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