Side Effects of rifabutin: A Synthesis of Findings from 27 Studies

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Original Abstract of the Article

Main Research Findings

Rifabutin is an antibiotic used to treat tuberculosis and mycobacterial infections. Rifabutin is structurally similar to rifampicin and shares many of its properties. 16 , 27 . Several studies have shown that rifabutin is effective in treating tuberculosis and has good tolerability. 13 , 5 . In addition, rifabutin has been shown to be an effective alternative when rifampicin is contraindicated. 8 .

Reasons for Side Effects

The side effects of rifabutin are thought to be related to the drug's mechanism of action. Rifabutin exerts its antibacterial effect by binding to bacterial RNA polymerase and inhibiting protein synthesis. 7 . This mechanism of action can also affect human cells, leading to side effects.

Common Side Effects

Leukopenia

One of the most common side effects of rifabutin is leukopenia. 13 . This is because rifabutin affects hematopoietic cells in the bone marrow. . Leukopenia can increase the risk of infection. .

Thrombocytopenia

Rifabutin can also cause thrombocytopenia. . This is because rifabutin affects megakaryocytes in the bone marrow. Thrombocytopenia can increase the risk of bleeding.

Hepatic dysfunction

Rifabutin can cause hepatic dysfunction. . This is because rifabutin is metabolized by the liver. Hepatic dysfunction can cause symptoms such as jaundice and abdominal pain.

Ocular inflammation

Rifabutin can cause ocular inflammation. 19 . This is because rifabutin affects the eyes. Ocular inflammation can cause symptoms such as decreased vision and pain.

Corneal endothelial deposits

Rifabutin can cause corneal endothelial deposits. 16 . This is because rifabutin affects the cornea. Corneal endothelial deposits can cause symptoms such as decreased vision and blurred vision.

Side Effects Management

Leukopenia

If you experience symptoms of leukopenia, stop taking rifabutin and consult a doctor. In addition, it is important to maintain good hygiene, such as hand washing, to prevent infection.

Thrombocytopenia

If you experience symptoms of thrombocytopenia, stop taking rifabutin and consult a doctor. In addition, be careful when handling sharp objects to prevent bleeding.

Hepatic dysfunction

If you experience symptoms of hepatic dysfunction, stop taking rifabutin and consult a doctor. In addition, avoid alcohol consumption to reduce the burden on the liver.

Ocular inflammation

If you experience symptoms of ocular inflammation, stop taking rifabutin and consult an ophthalmologist. In addition, avoid eye strain to reduce the burden on the eyes.

Corneal endothelial deposits

If you experience symptoms of corneal endothelial deposits, stop taking rifabutin and consult an ophthalmologist. If symptoms such as blurred vision do not improve, follow the instructions of an ophthalmologist and receive treatment.

Comparison between studies

Common points

Several studies have shown that rifabutin is effective in treating tuberculosis and has good tolerability. 13 , 5 . However, side effects such as leukopenia and thrombocytopenia have been reported. 13 , .

Differences

The incidence of side effects from rifabutin varies depending on the study. 13 , . This is thought to be due to differences in factors such as the age, sex, health status, and dosage of rifabutin of the study subjects.

Cautions for application in real life

Rifabutin should be taken as directed by your doctor. Do not stop or change your dosage without consulting your doctor. Also, before taking rifabutin, talk to your doctor about your health and any other medications you are taking. In particular, pregnant or breastfeeding women should consult a doctor before taking rifabutin.

Limitations of current research

Research on rifabutin is still insufficient. In particular, further research is needed on long-term side effects.

Future research directions

Further research is needed to evaluate the long-term side effects of rifabutin. Research is also needed to establish the optimal dosage and administration method for safe use of rifabutin.

Conclusion

Rifabutin is an effective drug for the treatment of tuberculosis and mycobacterial infections. However, it can cause side effects such as leukopenia, thrombocytopenia, hepatic dysfunction, and ocular inflammation. When taking rifabutin, follow your doctor's instructions and consult a doctor immediately if you experience any side effects.

Literature analysis of 27 papers
Positive Content
23
Neutral Content
0
Negative Content
4
Article Type
3
0
0
8
26
1.

Efficacy and safety of low-dose rifabutin-based 7-day triple therapy as a third- or later-line Helicobacter pylori eradication regimen.

Author: InokuchiKazumi, MoriHideki, MatsuzakiJuntaro, HirataKenro, HaradaYosuke, SaitoYoshimasa, SuzukiHidekazu, KanaiTakanori, MasaokaTatsuhiro

H. pylori eradication

This study evaluated the efficacy and safety of a 7-day rifabutin, amoxicillin, and vonoprazan triple therapy for treating refractory Helicobacter pylori infection. The study found the regimen to be effective and safe, suggesting it may be a valuable option for third- or later-line treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

2.

Efficacy of rifabutin-based triple therapy as second-line treatment to eradicate helicobacter pylori infection.

Author: Navarro-JaraboJosé M, FernándezNuria, SousaFrancisca L, CabreraEncarnación, CastroManuel, RamírezLuz M, RiveraRobin, UbiñaEsther, VeraFrancisco, MéndezIsabel, Rivas-RuizFrancisco, MorenoJosé L, Perea-MillaEmilio

Helicobacter pylori treatment

Rifabutin is effective in multi-resistant patients after various treatment cycles for Helicobacter pylori (HP) infection. This study seeks to compare the effectiveness of a treatment regimen including rifabutin versus conventional quadruple therapy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Rifabutin Containing Triple Therapy and Rifabutin with Bismuth Containing Quadruple Therapy for Third-Line Treatment of Helicobacter pylori Infection: Two Pilot Studies.

Author: CiccaglioneAntonio Francesco, TavaniRoberta, GrossiLaurino, CelliniLuigina, ManzoliLamberto, MarzioLeonardo

H. pylori eradication

The addition of bismuth subcitrate to a triple therapy that includes proton pump inhibitors, amoxicillin, and rifabutin in patients who are treated for the third time for H. pylori infection resulted in a 30% therapeutic gain.

Clinical StudyResearch involving human participants to assess the safety, efficacy, and effects of an intervention/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Rifabutin in combination with clofazimine, isoniazid and ethambutol in the treatment of AIDS patients with infections due to opportunist mycobacteria. Groupe d'Etude et de Traitement des Infections à Mycobacteries Résistantes.

Author: DautzenbergB, TruffotC, MignonA, RozenbaumW, KatlamaC, PerronneC, ParrotR, GrossetJ

Effective treatment
Safe treatment
Death
Relapse

The study evaluated the safety and efficacy of a four-drug combination for treating Mycobacterium avium complex (MAC) infection in 96 AIDS patients. The combination was generally well-tolerated, and some patients showed improvement in fever and weight loss. However, 34 patients died before treatment was completed, and MAC infection was considered to be the cause of death in 5 cases.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

7.

The influence of rifabutin on human and bacterial membrane models: implications for its mechanism of action.

Author: PinheiroMarina, NunesCláudia, CaioJoão M, MoiteiroCristina, LúcioMarlene, BrezesinskiGerald, ReisSalette

Antibiotic activity
Bacterial membrane integrity compromise

This study investigates the interaction of the antibiotic Rifabutin (RFB) with phospholipid membrane models using small- and wide-angle X-ray scattering. The findings suggest that RFB perturbs lipid bilayers, particularly in bacterial membrane models, which may contribute to its antibiotic activity and potential side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Rifabutin Use in <i>Staphylococcus</i> Biofilm Infections: A Case Series.

Author: DoubJames B, HeilEmily L, Ntem-MensahAfua, NeeleyRenaldo, ChingPatrick R

Biofilm infection treatment

Rifabutin therapy was well tolerated with no side effects and no recurrence of staphylococcal infections in 10 patients with biofilm infections where rifampin was contraindicated.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

9.

[Development of antituberculous drugs: current status and future prospects].

Author: TomiokaHaruaki, NambaKenji

Combat MDR-TB
Enhance patient compliance
Eradicate dormant MTB
Improve clinical outcome

This symposium reviewed the development of new antituberculous drugs and strategies for combating tuberculosis, including the identification of new drug targets, chemical genomics approaches, drug delivery systems, and immunomodulatory therapy.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Japanese

10.

[Adverse ocular drug reactions of systemic antimicrobial agents].

Author: HuberM, StahlmannR

Intraocular inflammation
Neuropathies
Visual disturbances

Antimicrobial therapy can cause adverse ocular drug reactions. It is important for physicians and patients to be aware of potential symptoms and consequences as early detection can improve reversibility.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

11.

Rifabutin-based 'rescue therapy' for Helicobacter pylori infected patients after failure of standard regimens.

Author: PerriF, FestaV, ClementeR, QuitadamoM, AndriulliA

Helicobacter pylori eradication
Triple therapy failure

Current treatments for Helicobacter pylori infection after standard triple therapies are not always effective. Alternative strategies are needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Rifabutin-Containing Triple Therapy Versus Bismuth Quadruple Therapy for Helicobacter pylori Rescue Treatment: A Multicenter, Randomized Controlled Trial.

Author: ChenJinnan, GuoYixian, HuangYu, DingZhaohui, WangJing, LiangXiao, XuPing, HanYaohua, LuHong

H. pylori eradication
Higher compliance
Side effects

This study compared the efficacy and safety of rifabutin-containing triple therapy with bismuth quadruple therapy for the rescue treatment of Helicobacter pylori. The study found that both treatments achieved similar eradication rates, but rifabutin triple therapy was associated with fewer side effects and higher compliance. Therefore, rifabutin triple therapy is a viable alternative to bismuth quadruple therapy for rescue treatment of H. pylori.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

[The tolerability and therapeutic efficacy of rifabutin in the treatment of pulmonary tuberculosis].

Author: ParolaD, Dell'OrsoD, GiovagnoliS, BianconiS, TerzanoC

TB eradication
Leukopenia

Rifabutin (RBT) was well tolerated and effective in treating pulmonary tuberculosis (TB) in 25 patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Italian

14.

Use of rifabutin in combination with atovaquone, clindamycin, pyrimethamine, or sulfadiazine for treatment of toxoplasmic encephalitis in mice.

Author: AraujoF G, SuzukiY, RemingtonJ S

Reduced side effects
Toxoplasmosis treatment

This study investigated the effectiveness of combinations of rifabutin with other drugs in treating toxoplasmic encephalitis in a mouse model. Rifabutin combined with atovaquone or clindamycin was more effective than either drug alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

16.

Human immunodeficiency virus-positive patient with bilateral corneal endothelial deposits.

Author: BoyerStephen P, GayDax A

Corneal endothelial deposits

This report describes a unique case of bilateral corneal endothelial deposits in a patient with HIV, possibly related to the medication rifabutin. Rifabutin is known to cause endothelial deposits, and this report highlights the potential for drug-induced ocular side effects in patients with HIV.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

[Disseminated infection with Mycobacterium avium complex (MAC) in HIV infection].

Author: FätkenheuerG, SalzbergerB, DiehlV

Treats MAC infection

This article provides information about Mycobacterium avium complex (MAC) infection in HIV-infected patients. MAC infection is one of the most frequent opportunistic infections in HIV-positive individuals with low CD4 counts. Blood cultures are the most appropriate diagnostic procedure.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

18.

Single-capsule bismuth-based quadruple therapy as a rescue therapy for <i>Helicobacter pylori</i> eradication.

Author: CorreiaCatarina, AlmeidaNuno, LealCarina, BranquinhoDiogo, FernandesAlexandra, Gravito-SoaresElisa, CalhauCarlos, BastosIsabel, VasconcelosHelena, FigueiredoPedro

H. pylori eradication

This study aims to evaluate the efficacy and safety of a bismuth-based quadruple therapy as a second-line or rescue therapy for Helicobacter pylori (H. pylori) infection in Portugal.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Drug-induced ocular inflammatory diseases.

Author: FraunfelderFrederick W

Ocular inflammation

Ocular inflammation can be caused by several medications. This abstract discusses a sampling of drugs representing medication classes associated with ocular inflammation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

20.

Mannosylated nanoparticulate carriers of rifabutin for alveolar targeting.

Author: NimjeNavneet, AgarwalAbhinav, SaraogiGaurav Kant, LariyaNarendra, RaiGopal, AgrawalHimanshu, AgrawalG P

Targeted drug delivery

Mannose-conjugated solid lipid nanoparticles (SLNs) were developed for targeted delivery of rifabutin to alveolar tissues. The SLNs showed six times enhanced uptake in alveolar macrophages and prolonged circulation in vivo, suggesting their potential for effective and safe delivery of rifabutin.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Efficacy and safety of rifabutin-containing 'rescue therapy' for resistant Helicobacter pylori infection.

Author: BorodyT J, PangG, WettsteinA R, ClancyR, HerdmanK, SuraceR, LlorenteR, NgC

Effective against H. pylori
Well tolerated

A 12-day course of rifabutin with an increased dose of amoxicillin and pantoprazole is well-tolerated and highly effective against dual-resistant H. pylori infection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Drug-induced uveitis.

Author: Cordero-ComaMiguel, Salazar-MéndezRaquel, Garzo-GarcíaIrene, YilmazTaygan

Drug-induced uveitis

This article discusses drug-induced uveitis, an often overlooked or misdiagnosed adverse reaction to medication. It emphasizes the importance of identifying the inciting agents to aid in the diagnosis of uveitis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

25.

A pharmacokinetic study of intermittent rifabutin dosing with a combination of ritonavir and saquinavir in patients infected with human immunodeficiency virus.

Author: GallicanoK, KhaliqY, CarignanG, TsengA, WalmsleyS, CameronD W

Treats HIV

Intermittent rifabutin dosing regimens (300 mg every 7 days or 150 mg every 3 days) for 8 weeks were safe and manageable for concurrent therapy with ritonavir and saquinavir, with minimal effects on protease inhibitor exposures.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Heat shock proteins and acute leukemias.

Author: ThomasXavier, CamposLydia, LeQuoc-Hung, GuyotatDenis

Apoptosis modulation
Cancer treatment
Drug resistance

Heat shock proteins (HSPs) are important for protecting cells from stress. However, they can also promote the resistance of leukemia cells to treatment. This study found that lower levels of HSPs were associated with higher remission rates and longer survival in leukemia patients. This suggests that targeting HSPs could be a new approach to treating leukemia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

27.

Rifabutin: where do we stand in 2016?

Author: CrabolYoann, CatherinotEmilie, VezirisNicolas, JullienVincent, LortholaryOlivier

Acceptable tolerance
Contribution to rifampicin-resistant TB
Equivalent activity/efficacy to rifampicin
Lower liver induction

This review found that rifabutin has comparable efficacy and tolerability to rifampicin in treating tuberculosis and non-tuberculous mycobacterial diseases. Rifabutin offers advantages in patients with specific conditions, such as AIDS, organ transplantation, or intolerance to rifampicin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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