Side Effects of rotigotine transdermal patch: A Synthesis of Findings from 5 Studies

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Original Abstract of the Article

Main Research Findings

Rotigotine transdermal patch is a non-ergoline dopamine agonist used to treat Parkinson's disease (PD) and restless legs syndrome (RLS). Multiple studies have shown that rotigotine transdermal patch has several advantages over oral dopamine receptor agonists, including sustained dopamine levels, reduced side effects, and ease of administration. 4 However, rotigotine transdermal patch also has side effects.

Reasons for Side Effects

The side effects of rotigotine transdermal patch are due to its action on dopamine receptors. Dopamine is a neurotransmitter involved in many important brain functions, including movement, mood, learning, and memory. Rotigotine transdermal patch activates dopamine receptors, which can affect these brain functions and lead to various side effects.

Common Side Effects

Nausea and Vomiting

One of the most common side effects of rotigotine transdermal patch is nausea and vomiting. 5 This is thought to be because rotigotine activates dopamine receptors in the digestive system. Anti-emetic drugs like domperidone can be used to reduce these side effects. 5

Dizziness

Rotigotine transdermal patch can cause dizziness. This is thought to be because rotigotine activates dopamine receptors in the inner ear. If dizziness persists, consult your doctor.

Sleepiness

Rotigotine transdermal patch can cause sleepiness. This is thought to be because rotigotine activates dopamine receptors in the brain. Caution is advised when driving or operating dangerous machinery while taking rotigotine.

Worsening of RLS

Worsening of RLS has been reported as a side effect of rotigotine transdermal patch. 2 This is thought to be because rotigotine can worsen RLS symptoms by activating dopamine receptors. Consult your doctor if RLS symptoms do not improve.

Dyskinesia

Dyskinesia has been reported as a side effect of rotigotine transdermal patch. 4 Dyskinesia is thought to be because rotigotine can cause involuntary movements by activating dopamine receptors in the brain. Consult your doctor if you experience concerning dyskinesia symptoms.

Side Effect Management

Nausea and Vomiting

Nausea and vomiting caused by rotigotine transdermal patch can be reduced by using anti-emetic drugs. 5

Dizziness

If dizziness persists, consult your doctor.

Sleepiness

Caution is advised when driving or operating dangerous machinery while taking rotigotine.

Worsening of RLS

Consult your doctor if RLS symptoms do not improve.

Dyskinesia

Consult your doctor if you experience concerning dyskinesia symptoms.

Comparison of Studies

Commonalities Among Studies

Multiple studies have shown that rotigotine transdermal patch is effective in treating Parkinson's disease and RLS. 4 However, rotigotine transdermal patch can cause side effects such as nausea and vomiting, dizziness, and sleepiness. 5

Differences Among Studies

There is some variation in reports of RLS worsening due to rotigotine transdermal patch. 2 Some studies suggest that rotigotine transdermal patch may worsen RLS, while others report that worsening is rare. 4

Implications for Everyday Life

When taking rotigotine transdermal patch, be mindful of side effects such as nausea and vomiting, dizziness, and sleepiness. Also, be aware that side effects such as worsening of RLS and dyskinesia have been reported. If you experience any concerning side effects, consult your doctor.

Limitations of Current Research

Research on rotigotine transdermal patch is still insufficient. In particular, research on long-term safety and effectiveness is lacking. Further research is also needed on combining rotigotine transdermal patch with other therapies.

Future Research Directions

Research is needed on the long-term safety and effectiveness of rotigotine transdermal patch. Research on combining rotigotine transdermal patch with other therapies is also needed. Furthermore, research is necessary to reduce side effects from rotigotine transdermal patch.

Conclusion

Rotigotine transdermal patch is an effective treatment for Parkinson's disease and RLS, but it can cause side effects such as nausea and vomiting, dizziness, and sleepiness. When taking rotigotine transdermal patch, be aware of side effects and consult your doctor if needed.

Literature analysis of 5 papers
Positive Content
5
Neutral Content
0
Negative Content
0
Article Type
1
0
0
2
5
1.

Switching from an oral dopamine receptor agonist to rotigotine transdermal patch: a review of clinical data with a focus on patient perspective.

Author: ChungSun Ju, AsgharnejadMahnaz, BauerLars, BenitezArturo, BoroojerdiBabak, HeidbredeTanja, LittleAllison, KimHan Joon

Improved treatment options
Symptom control

This review examines the evidence on switching from oral dopamine receptor agonists (DAs) to rotigotine transdermal patch in patients with Parkinson's disease (PD) and restless legs syndrome (RLS). It summarizes available data on dose equivalency, switching schedules, safety, tolerability, and efficacy, providing a suggested tool for clinicians.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Treatment of moderate to severe restless legs syndrome: 2-year safety and efficacy of rotigotine transdermal patch.

Author: HöglBirgit, OertelWolfgang H, Stiasny-KolsterKarin, GeislerPeter, BenešHeike, García-BorregueroDiego, TrenkwalderClaudia, PoeweWerner, SchollmayerErwin, KohnenRalf

Improved RLS symptoms

Transdermal rotigotine, a dopamine agonist, was safe and effective in treating moderate to severe restless legs syndrome (RLS) for up to 2 years.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Influence of domperidone on pharmacokinetics, safety and tolerability of the dopamine agonist rotigotine.

Author: BraunMarina, CawelloWilli, BoekensHilmar, HorstmannRolf

Nausea reduction

Concomitant use of domperidone did not change the pharmacokinetic parameters describing systemic exposure and renal elimination of rotigotine. Therefore, no dose adjustment of rotigotine transdermal patch is necessary with concomitant use of domperidone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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