Side Effects of s-adenosyl-l-methionine (same): A Synthesis of Findings from 8 Studies

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This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

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Original Abstract of the Article

Major Research Findings

S-adenosyl-L-methionine (SAMe) has shown promise as a treatment for depression. Some studies have found SAMe to be more effective than placebo and as effective as tricyclic antidepressants in treating major depressive disorder (MDD) when administered parenterally. SAMe may also be beneficial as an adjunct therapy for antidepressant nonresponders. 6 Furthermore, SAMe has been shown to reverse depression-like behavior in rats with chronic mild stress-induced anhedonia. SAMe may also have potential in treating neuropsychiatric symptoms in 22q11.2 deletion syndrome.

Reasons for Side Effects

SAMe is a naturally occurring substance that serves as a key source of methyl groups within the body. Methyl groups play a critical role in many metabolic processes, and SAMe is involved in neurotransmitter synthesis and neural cell growth and differentiation. Side effects of SAMe are thought to be related to these actions.

Common Side Effects

Gastrointestinal

SAMe can cause gastrointestinal side effects. Nausea, vomiting, diarrhea, and constipation have been reported.

Nervous System

SAMe can also cause nervous system side effects. Headache, dizziness, drowsiness, anxiety, and agitation have been reported.

Other

Other side effects of SAMe have been observed. Rash, itching, and weight gain have been reported.

Side Effect Management

Gastrointestinal Side Effects

Eating a meal before taking SAMe may help to reduce nausea and vomiting. If you experience diarrhea or constipation, consult your doctor.

Nervous System Side Effects

If you experience headache or dizziness after taking SAMe, rest. If you experience drowsiness, anxiety, or agitation, talk to your doctor.

Other Side Effects

If you experience rash, itching, or weight gain after taking SAMe, consult your doctor.

Comparison of Studies

Similarities

Many studies have indicated that SAMe is effective in treating depression. Additionally, SAMe has generally been shown to be safe and well-tolerated.

Differences

The route of administration of SAMe may influence its effectiveness and side effects. Furthermore, the extent of SAMe's effects and side effects may vary depending on the study.

Real-World Application Considerations

While SAMe has shown promise in treating depression, it is crucial to avoid self-treating with it. If you are considering taking SAMe, it is essential to consult a physician.

Limitations of Current Research

The long-term efficacy and safety of SAMe remain unclear. Further research is needed to determine the optimal dosage and administration methods for SAMe.

Future Research Directions

Studies are needed to assess the long-term efficacy and safety of SAMe. Additionally, research is required to establish optimal dosage and administration methods for SAMe.

Conclusion

SAMe has shown promise in treating depression. However, self-treating is not recommended. Consult your doctor if you are considering taking SAMe.

Literature analysis of 8 papers
Positive Content
6
Neutral Content
2
Negative Content
0
Article Type
3
1
2
2
8
1.

A randomised trial of differentiated prednisolone treatment in active rheumatoid arthritis. Clinical benefits and skeletal side effects.

Author: HansenM, PodenphantJ, FlorescuA, StoltenbergM, BorchA, KlugerE, SørensenS F, HansenT M

Protective effect against bone loss
Reduced disease activity
Spinal bone loss

Prednisolone treatment for rheumatoid arthritis shows mixed results. While it reduces disease activity, its effect on radiological progression is unclear. It also causes spinal bone loss, but protects against bone loss in the hand and forearm.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Prediction of nonspecific side effects in rheumatoid arthritis patients by beliefs about medicines.

Author: NestoriucYvonne, OravE John, LiangMatthew H, HorneRobert, BarskyArthur J

Negative beliefs side effects

Patients' negative beliefs about arthritis medication predicted increased side effects, especially when starting new medications. Identifying patients with negative beliefs is important to avoid premature drug discontinuation.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

3.

Systematic review and meta-analysis of the efficacy and safety of leflunomide and methotrexate in the treatment of rheumatoid arthritis.

Author: Alfaro-LaraRoberto, Espinosa-OrtegaHector Fabricio, Arce-SalinasCésar Alejandro,

RA treatment
GI complaints
Increased liver enzymes

Methotrexate and leflunomide have similar efficacy as first-line disease-modifying antirheumatic drugs (DMARDs) for rheumatoid arthritis (RA). A meta-analysis of 1984 patients from 73 trials found that methotrexate was associated with a greater reduction in swollen joint count, while leflunomide was linked to a higher incidence of increased liver enzymes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Side effects of methotrexate therapy for rheumatoid arthritis: A systematic review.

Author: WangWanying, ZhouHua, LiuLiang

RA treatment
Gastrointestinal toxicity
Malignant diseases

Methotrexate is an effective treatment for rheumatoid arthritis (RA), but can cause side effects ranging from mild to severe. Careful monitoring and dose adjustments can help minimize these risks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

A double-blind, randomized, placebo-controlled clinical trial of S-adenosyl-L-methionine (SAMe) versus escitalopram in major depressive disorder.

Author: MischoulonDavid, PriceLawrence H, CarpenterLinda L, TyrkaAudrey R, PapakostasGeorge I, BaerLee, DordingChristina M, ClainAlisabet J, DurhamKelley, WalkerRosemary, LudingtonElizabeth, FavaMaurizio

Gastrointestinal side effects

Neither S-adenosyl-L-methionine (SAMe) nor escitalopram demonstrated significant advantage over placebo in treating major depressive disorder.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

6.

S-adenosyl-L-methionine (SAMe) as an adjunct for resistant major depressive disorder: an open trial following partial or nonresponse to selective serotonin reuptake inhibitors or venlafaxine.

Author: AlpertJonathan E, PapakostasGeorge, MischoulonDavid, WorthingtonJohn J, PetersenTimothy, MahalYasmin, BurnsAlana, BottiglieriTeodoro, NierenbergAndrew A, FavaMaurizio

Depression relief
GI symptoms
Headaches

Augmentation of selective serotonin reuptake inhibitors or venlafaxine with S-adenosyl-L-methionine may be a promising treatment option for resistant depression.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

A Systematic Review on the Effect of Nutraceuticals on Antidepressant-Induced Sexual Dysfunctions: From Basic Principles to Clinical Applications.

Author: ConcertoCarmen, RodolicoAlessandro, MeoValeria, ChiappettaDonatella, BonelliMarina, MineoLudovico, SaittaGiulia, StutoSebastiano, SignorelliMaria Salvina, PetraliaAntonino, LanzaGiuseppe, AgugliaEugenio

AISD treatment

This systematic review examined the effectiveness of nutraceuticals for managing antidepressant-induced sexual dysfunctions (AISD). The review found potential benefits from Maca Root, SAMe, and Saffron. Rosa Damascena appeared more effective in men than women. Further research with larger samples is needed to confirm these findings and investigate confounding factors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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