Main Research Findings

Saxagliptin is a medication used to improve blood sugar control in adults with type 2 diabetes. 1 A study found that saxagliptin consistently improved blood sugar control, as measured by lower levels of HbA1c, fasting plasma glucose, and postprandial glucose, compared to control groups. The study also found that saxagliptin had no significant effect on body weight, blood pressure, lipid levels, or other markers of cardiovascular risk.

Scopolamine transdermal patches are a medication used to treat nausea and vomiting. 3 One study reported a case of dystonic reaction after discontinuing the use of scopolamine transdermal patches while still using other antiemetic medications such as prochlorperazine, metoclopramide, and ondansetron. The study suggests that withdrawing anticholinergic medications after using antiemetics that block dopamine receptors may unmask dystonic reactions. The study also suggests that scopolamine transdermal patches may be used to treat acute dystonic reactions.

Scopolamine transdermal patches can affect pupil size if they come into contact with the eyes. 2 One study reported a case of anisocoria (unequal pupil size) after contact with a scopolamine patch.

Benefits and Risks

Benefits Summary

Saxagliptin is effective in improving blood sugar control in patients with type 2 diabetes. 1 Scopolamine transdermal patches are effective in treating nausea and vomiting. 3

Risks Summary

Saxagliptin can cause side effects such as weight gain, hypoglycemia, and gastrointestinal symptoms. 1 Scopolamine transdermal patches can cause side effects such as dystonic reactions and anisocoria. 3 2

Comparison Between Studies

Similarities Between Studies

All three studies investigated the safety and effectiveness of scopolamine transdermal patches.

Differences Between Studies

Study 1 investigated saxagliptin, a medication for type 2 diabetes. Studies 3 and 2 were case reports on the safety and effectiveness of scopolamine transdermal patches. Study 3 investigated the potential of scopolamine transdermal patches to treat acute dystonic reactions, while study 2 investigated the potential of scopolamine transdermal patches to cause anisocoria.

Consistency and Contradictions in Results

All three studies indicate that scopolamine transdermal patches demonstrate safety and effectiveness while also highlighting the potential for side effects.

Considerations for Real-World Application

It is important to be aware of the risk of side effects such as dystonic reactions and anisocoria when using scopolamine transdermal patches. It is also important to avoid contact with the eyes as it can affect pupil size. 2

Limitations of Current Studies

Study 1 is currently conducting a long-term cardiovascular outcome trial to investigate the potential of saxagliptin to reduce cardiovascular risk. Studies 3 and 2 are case reports on the safety and effectiveness of scopolamine transdermal patches, and more case studies are needed.

Future Research Directions

Long-term cardiovascular outcome trials are needed to investigate the potential of saxagliptin to reduce cardiovascular risk. More case studies are needed to assess the safety and effectiveness of scopolamine transdermal patches.

Conclusion

Saxagliptin is an effective medication for improving blood sugar control in patients with type 2 diabetes. 1 Scopolamine transdermal patches are effective in treating nausea and vomiting, but they can cause side effects such as dystonic reactions and anisocoria. 3 2 It is important to be aware of the potential for side effects when using these medications.