Major Research Findings

Secukinumab is an effective treatment for plaque psoriasis, as shown in multiple studies. It works by blocking the action of a protein called interleukin 17A (IL-17A), which helps to improve the symptoms of plaque psoriasis. Secukinumab has also been reported to be effective in treating psoriatic arthritis, a type of arthritis associated with plaque psoriasis, and erythrodermic psoriasis, a more severe form of plaque psoriasis. 3

Reasons for Side Effects

Secukinumab is an immunosuppressant drug, so there is an increased risk of infections as a side effect. It also suppresses the activity of IL-17A, which reduces skin inflammation but may also weaken the skin's immune function. Therefore, using secukinumab may cause abnormal reactions in the skin. 1

Common Side Effects

Infections

Secukinumab suppresses the immune system, so the risk of infection is increased. While using secukinumab, be careful of infections and consult a doctor immediately if you experience symptoms of an infection. 1

Abnormal Skin Reactions

Secukinumab can weaken the immune function of the skin. Therefore, abnormal skin reactions can occur when using secukinumab. For example, 2 reports a case of drug-induced lupus erythematosus after using secukinumab. Also, 1 reports a case of lichen planus after using secukinumab. These side effects do not occur in all people using secukinumab, but you should be aware of them while using it.

Other Side Effects

Secukinumab can cause side effects such as injection site reactions, headache, nausea, and fatigue. 1

Countermeasures for Side Effects

Infection Prevention

While using secukinumab, be careful of infections and consult a doctor immediately if you experience symptoms of an infection. Also, be sure to practice infection control measures such as hand washing. 1

Dealing with Abnormal Skin Reactions

If you experience any abnormal skin reactions while using secukinumab, consult a doctor immediately. 2

Dealing with Other Side Effects

If you experience side effects such as headache or nausea while using secukinumab, consult a doctor. 1

Comparison between Studies

Commonalities among Studies

Multiple studies have shown that secukinumab is effective in treating plaque psoriasis. Secukinumab has also been reported to be effective in treating psoriatic arthritis and erythrodermic psoriasis, a more severe form of plaque psoriasis. In addition, these studies have reported infection, abnormal skin reactions, and injection site reactions as common side effects of secukinumab.

Differences between Studies

There are differences in the specific types and frequencies of side effects reported in each study. For example, 2 reports a case of drug-induced lupus erythematosus after using secukinumab, but this side effect is not reported in other studies. In addition, 1 reports a case of lichen planus after using secukinumab, but this side effect is not reported in other studies.

Precautions for Real-Life Applications

Secukinumab is an effective treatment for plaque psoriasis, but it also carries the risk of side effects. When using secukinumab, it is necessary to consult a doctor and carefully consider the risks and benefits before using it.

Limitations of Current Research

Secukinumab is a relatively new drug, and there is not enough data yet to determine its long-term safety and efficacy. Also, not all cases of secukinumab side effects have been reported. Furthermore, it is not yet fully understood how secukinumab interacts with other drugs.

Future Directions for Research

Research is needed to evaluate the long-term safety and efficacy of secukinumab. It is also necessary to conduct research to further investigate the side effects of secukinumab. Further research is also needed to investigate how secukinumab interacts with other drugs.

Conclusion

Secukinumab is an effective treatment for plaque psoriasis, but it also carries the risk of side effects. When using secukinumab, it is necessary to consult a doctor and carefully consider the risks and benefits before using it. There is not yet enough data to determine the long-term safety and efficacy of secukinumab. Therefore, when using secukinumab, it is important to follow your doctor's instructions and get regular checkups.