Side Effects of selegiline transdermal patch: A Synthesis of Findings from 5 Studies

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Original Abstract of the Article

Major research findings

Several studies have shown that the selegiline transdermal system (STS) is effective in treating major depressive disorder (MDD). 2 , 4 , 3 . STS has the advantage of being safer and easier to use than traditional oral selegiline. 4 . STS, through transdermal absorption, can maintain more stable blood concentrations while minimizing the impact on the digestive system. 1 .

Reasons for side effects

Side effects of STS are caused by selegiline inhibiting monoamine oxidase (MAO). MAO is involved in the breakdown of neurotransmitters such as norepinephrine, dopamine, and serotonin. Inhibition of MAO can increase the concentration of these neurotransmitters, potentially leading to side effects.

Common side effects

Patch application site irritation

Patch application site irritation is the most common side effect of STS. 1 .

Insomnia

Insomnia is a common side effect of STS. 1 .

Side effects countermeasures

Patch application site irritation

To reduce patch application site irritation, it is important to cleanse and dry the skin before applying the patch. 1 . It is also effective to change the patch application site regularly. 1 . If the patch application site irritation is severe, consult a doctor.

Insomnia

To reduce insomnia, it is important to avoid coffee and alcohol before bed and to maintain a regular sleep schedule. 1 . If insomnia does not improve, consult a doctor.

Comparison between studies

Common points of studies

Multiple studies have shown that STS is effective in treating MDD. 2 , 4 , 3 . These studies have also shown that STS has the advantage of being safer and easier to use than oral selegiline. 4 .

Differences in studies

Each study has different STS dosages, study periods, and subject characteristics. Therefore, it is difficult to directly compare the study results. However, these studies are important evidence showing that STS is effective in treating MDD.

Precautions for applying to real life

STS should be used under the guidance of a doctor. When using STS, be sure to tell your doctor the following information:

  • Medications you are currently taking
  • Past medical history
  • Whether you are pregnant or breastfeeding
When using STS, it is important to follow your doctor's instructions, such as dietary restrictions. 1 . If you feel unwell while using STS, consult your doctor immediately.

Current limitations of research

There has not been enough research on STS. In particular, further research is needed on long-term safety and effectiveness.

Future research directions

Further research is needed to assess the long-term safety and effectiveness of STS. Research is also needed to establish optimal guidelines on STS dosage and administration.

Conclusion

STS is an effective medication for treating MDD. However, it is important to use STS carefully under the guidance of a doctor. By understanding side effects and risks, and using STS according to your doctor's instructions, STS can help improve your symptoms of MDD and live a better life.

Literature analysis of 5 papers
Positive Content
4
Neutral Content
1
Negative Content
0
Article Type
2
0
0
3
5
1.

Translating the evidence on atypical depression into clinical practice.

Author: Hyman RapaportMark

MAOI depression tx
MAOI side effects
tyramine diet risk

This abstract discusses the use of selegiline transdermal system (STS) in treating major depressive disorder (MDD) with atypical symptoms. STS is a second-generation monoamine oxidase inhibitor (MAOI) with a favorable side effect profile compared to first-generation MAOIs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

2.

Selegiline transdermal system for the treatment of major depressive disorder: an 8-week, double-blind, placebo-controlled, flexible-dose titration trial.

Author: FeigerAlan D, RickelsKarl, RynnMoira A, ZimbroffDan L, RobinsonDonald S

Depression treatment
Insomnia

The study investigated the efficacy, safety, and tolerability of the selegiline transdermal system (STS) for treating major depressive disorder (MDD). The results showed that STS was significantly more effective than placebo in improving depression symptoms, with a modest treatment effect primarily due to insomnia side effects. The study concluded that STS has an improved margin of safety compared with oral monoamine oxidase inhibitors and represents a useful addition to the existing array of antidepressants.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Transdermal selegiline in major depression: a double-blind, placebo-controlled, parallel-group study in outpatients.

Author: BodkinJ Alexander, AmsterdamJay D

Effective depression treatment
Well-tolerated
Application site reactions

Transdermal selegiline is an effective and well-tolerated treatment for adult outpatients with major depression. The treatment was effective as early as week 1 and no typical side effects of monoamine oxidase inhibitor antidepressants were observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Critical appraisal of selegiline transdermal system for major depressive disorder.

Author: CristanchoMario A, ThaseMichael E

Improved depression treatment
Side effects

The selegiline transdermal delivery system, the first antidepressant patch, has a safe profile and may be a viable option for difficult-to-treat conditions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Transdermal Route: A Viable Option for Systemic Delivery of Antidepressants.

Author: TijaniAkeemat O, NunezEstefany, SinghKaryn, KhannaGarima, PuriAshana

Depression treatment
Improved tolerance
Sustained drug release

Transdermal delivery of antidepressants has potential for improving treatment of depression, offering benefits like sustained release, reduced dosing frequency, and improved adherence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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