Side Effects of siddha yoga: A Synthesis of Findings from 8 Studies

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Original Abstract of the Article

Major Findings

Siddha Yoga may reduce the side effects of methotrexate (MTX) in the treatment of rheumatoid arthritis (RA). 3 Siddha Yoga has also been shown to improve cancer-related fatigue and functional scale. 5 On the other hand, there is no clear conclusion on whether RA itself is a risk factor for adverse drug reactions during sulfasalazine therapy.

Reasons for Side Effects

The reasons for the side effects of Siddha Yoga are not yet fully understood. However, Siddha Yoga may cause side effects because it may regulate the immune system or enhance the body's natural healing abilities. 6 Also, the side effects of Siddha Yoga vary depending on the individual patient's constitution, health status, and other medications being used. 8

Common Side Effects

Gastrointestinal System

Gastrointestinal symptoms are the most commonly reported side effects of MTX therapy. 4 These include nausea, vomiting, abdominal pain, and diarrhea. 4

Liver

Liver side effects have also been reported with MTX therapy. 4 Liver function may decline or hepatitis may develop. 4

Blood

Blood side effects such as decreased white blood cells and platelets have also been reported with MTX therapy. 4

Side Effect Management

Gastrointestinal System

Dietary therapy and lifestyle modification are effective in reducing gastrointestinal side effects from MTX therapy. 4 For example, eat small meals several times a day and avoid high-fat foods. 4 It is also important to avoid alcohol. 4

Liver

To reduce liver side effects from MTX therapy, it is important to have regular blood tests to monitor liver function. 4 It is also important to avoid alcohol to avoid putting extra strain on the liver. 4

Blood

To reduce blood side effects from MTX therapy, it is important to have regular blood tests to monitor white blood cell and platelet counts. 4 It is also important to be aware of infections and get vaccinated. 4

Comparison of Studies

Commonalities

Multiple studies have shown that Siddha Yoga may be effective in the treatment of RA and cancer. 3 5

Differences

Conclusions about the effectiveness and side effects of Siddha Yoga may vary depending on the study. This may be due to differences in study design and subjects.

Note on Application to Real Life

While Siddha Yoga may be effective in the treatment of RA and cancer, there is also a risk of side effects. 4 Therefore, it is important to practice Siddha Yoga under the guidance of a doctor or specialist. 8 Also, it is important to consult a doctor if Siddha Yoga is used in conjunction with other treatments.

Limitations of Current Research

There is still insufficient research on Siddha Yoga. 8 Larger-scale and longer-term studies are needed in the future. 8

Future Research Directions

Further research is needed to elucidate the mechanisms of Siddha Yoga and its side effects. 6 In addition, standardized protocols and evaluation methods need to be developed to assess the safety and efficacy of Siddha Yoga. 8

Conclusion

Siddha Yoga may be effective in the treatment of RA and cancer, but there is also a risk of side effects. 4 It is important to practice Siddha Yoga under the guidance of a doctor or specialist. 8

Literature analysis of 8 papers
Positive Content
6
Neutral Content
1
Negative Content
1
Article Type
4
1
2
1
8
1.

A randomised trial of differentiated prednisolone treatment in active rheumatoid arthritis. Clinical benefits and skeletal side effects.

Author: HansenM, PodenphantJ, FlorescuA, StoltenbergM, BorchA, KlugerE, SørensenS F, HansenT M

Protective effect against bone loss
Reduced disease activity
Spinal bone loss

Prednisolone treatment for rheumatoid arthritis shows mixed results. While it reduces disease activity, its effect on radiological progression is unclear. It also causes spinal bone loss, but protects against bone loss in the hand and forearm.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Prediction of nonspecific side effects in rheumatoid arthritis patients by beliefs about medicines.

Author: NestoriucYvonne, OravE John, LiangMatthew H, HorneRobert, BarskyArthur J

Negative beliefs side effects

Patients' negative beliefs about arthritis medication predicted increased side effects, especially when starting new medications. Identifying patients with negative beliefs is important to avoid premature drug discontinuation.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

3.

Systematic review and meta-analysis of the efficacy and safety of leflunomide and methotrexate in the treatment of rheumatoid arthritis.

Author: Alfaro-LaraRoberto, Espinosa-OrtegaHector Fabricio, Arce-SalinasCésar Alejandro,

RA treatment
GI complaints
Increased liver enzymes

Methotrexate and leflunomide have similar efficacy as first-line disease-modifying antirheumatic drugs (DMARDs) for rheumatoid arthritis (RA). A meta-analysis of 1984 patients from 73 trials found that methotrexate was associated with a greater reduction in swollen joint count, while leflunomide was linked to a higher incidence of increased liver enzymes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Side effects of methotrexate therapy for rheumatoid arthritis: A systematic review.

Author: WangWanying, ZhouHua, LiuLiang

RA treatment
Gastrointestinal toxicity
Malignant diseases

Methotrexate is an effective treatment for rheumatoid arthritis (RA), but can cause side effects ranging from mild to severe. Careful monitoring and dose adjustments can help minimize these risks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

Long-term yogic intervention decreases serum interleukins IL-10 and IL-1β and improves cancer-related fatigue and functional scale during radiotherapy/chemotherapy in breast cancer patients: a randomized control study.

Author: JainMayank, MishraArchana, YadavVishnu, ShyamHari, KumarShailendra, MishraSatyendra Kumar, RamakantPooja

Improved immune function
Reduced fatigue

This study investigated the effect of yogic intervention at different time intervals during radiotherapy/chemotherapy on pro- and anti-inflammatory interleukins, cancer-related fatigue, and functional scale among patients with stage II/III breast cancer. The study found that yoga may improve fatigue and immunological profile in breast cancer survivors.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Influence of Yoga and Ayurveda on self-rated sleep in a geriatric population.

Author: ManjunathN K, TellesShirley

Improved sleep quality

Sleep in older persons is characterized by decreased ability to stay asleep, resulting in fragmented sleep and reduced daytime alertness. Pharmacological treatment of insomnia in older persons is associated with hazardous side effects. Hence, the present study was designed to compare the effects of Yoga and Ayurveda on the self rated sleep in a geriatric population.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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